Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study
Publication Date
April 08, 2014
Journal
PLOS ONE
Authors
Akkelies E. Dijkstra, Joanna Smolonska, Maarten Van Den Berge, Ciska Wijmenga, et al
Volume
9
Issue
4
Pages
e91621
DOI
https://dx.plos.org/10.1371/journal.pone.0091621
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0091621
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/24714607
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979657
Europe PMC
http://europepmc.org/abstract/MED/24714607
Web of Science
000334160900002
Scopus
84899579701
Mendeley
http://www.mendeley.com/research/susceptibility-chronic-mucus-hypersecretion-genome-wide-association-study
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Mendeley | Further Information

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Marike", "last_name"=>"Boezen", "scopus_author_id"=>"55348045900"}, {"first_name"=>"Dirkje S.", "last_name"=>"Postma", "scopus_author_id"=>"35432055700"}, {"first_name"=>"B. Z.", "last_name"=>"Alizadeh", "scopus_author_id"=>"14069866300"}, {"first_name"=>"R. A.", "last_name"=>"De Boer", "scopus_author_id"=>"8572907800"}, {"first_name"=>"M.", "last_name"=>"Bruinenberg", "scopus_author_id"=>"6602585466"}, {"first_name"=>"L.", "last_name"=>"Franke", "scopus_author_id"=>"56310093600"}, {"first_name"=>"P.", "last_name"=>"Van Der Harst", "scopus_author_id"=>"6602378288"}, {"first_name"=>"H. L.", "last_name"=>"Hillege", "scopus_author_id"=>"7004140531"}, {"first_name"=>"M. M.", "last_name"=>"Van Der Klauw", "scopus_author_id"=>"55961899400"}, {"first_name"=>"G.", "last_name"=>"Navis", "scopus_author_id"=>"7006576566"}, {"first_name"=>"J.", "last_name"=>"Ormel", "scopus_author_id"=>"35313394700"}, {"first_name"=>"Jgm", "last_name"=>"Rosmalen", "scopus_author_id"=>"6603760981"}, {"first_name"=>"J. P.", "last_name"=>"Slaets", "scopus_author_id"=>"7003664501"}, {"first_name"=>"H.", "last_name"=>"Snieder", "scopus_author_id"=>"7006990967"}, {"first_name"=>"R. P.", "last_name"=>"Stolk", "scopus_author_id"=>"55800586400"}, {"first_name"=>"Bhr", "last_name"=>"Wolffenbuttel", "scopus_author_id"=>"7005975255"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84899579701", "sgr"=>"84899579701", "pui"=>"372971530", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"24714607", "doi"=>"10.1371/journal.pone.0091621"}, "id"=>"a29485ee-3910-3c68-88ea-e720531b79e0", "abstract"=>"BACKGROUND: Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. It is associated with smoking, but it is unknown why only a minority of smokers develops CMH. A plausible explanation for this phenomenon is a predisposing genetic constitution. Therefore, we performed a genome wide association (GWA) study of CMH in Caucasian populations.\\n\\nMETHODS: GWA analysis was performed in the NELSON-study using the Illumina 610 array, followed by replication and meta-analysis in 11 additional cohorts. In total 2,704 subjects with, and 7,624 subjects without CMH were included, all current or former heavy smokers (≥20 pack-years). Additional studies were performed to test the functional relevance of the most significant single nucleotide polymorphism (SNP).\\n\\nRESULTS: A strong association with CMH, consistent across all cohorts, was observed with rs6577641 (p = 4.25×10(-6), OR = 1.17), located in intron 9 of the special AT-rich sequence-binding protein 1 locus (SATB1) on chromosome 3. The risk allele (G) was associated with higher mRNA expression of SATB1 (4.3×10(-9)) in lung tissue. Presence of CMH was associated with increased SATB1 mRNA expression in bronchial biopsies from COPD patients. SATB1 expression was induced during differentiation of primary human bronchial epithelial cells in culture.\\n\\nCONCLUSIONS: Our findings, that SNP rs6577641 is associated with CMH in multiple cohorts and is a cis-eQTL for SATB1, together with our additional observation that SATB1 expression increases during epithelial differentiation provide suggestive evidence that SATB1 is a gene that affects CMH.", "link"=>"http://www.mendeley.com/research/susceptibility-chronic-mucus-hypersecretion-genome-wide-association-study", "reader_count"=>19, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>1, "Professor"=>1, "Other"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>1, "Professor"=>1, "Other"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>6, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>5, "Computer Science"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Netherlands"=>1, "Japan"=>1, "Germany"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1454631"], "description"=>"<p>Expression of <i>SATB1</i>, the identified gene in our study, <i>MUC5AC</i> a marker of mucus, and <i>FOXJ1</i>, representing ciliated cells in epithelial cell culture on air liquid interface.</p>", "links"=>[], "tags"=>["Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Genome-wide association studies", "genetics", "genomics", "Functional genomics", "psychology", "addiction", "Drug addiction", "Recreational drug addiction", "epidemiology", "Clinical epidemiology", "Environmental epidemiology", "Epidemiological methods and statistics", "Genetic epidemiology", "Lifecourse epidemiology", "Pulmonology", "Chronic Obstructive Pulmonary Disease", "Environmental and occupational lung diseases", "Respiratory infections", "mrna", "mucociliary", "airway", "epithelial", "differentiation"], "article_id"=>990880, "categories"=>["Biological Sciences"], "users"=>["Akkelies E. Dijkstra", "Joanna Smolonska", "Maarten van den Berge", "Ciska Wijmenga", "Pieter Zanen", "Marjan A. Luinge", "Mathieu Platteel", "Jan-Willem Lammers", "Magnus Dahlback", "Kerrie Tosh", "Pieter S. Hiemstra", "Peter J. Sterk", "Avi Spira", "Jorgen Vestbo", "Borge G. Nordestgaard", "Marianne Benn", "Sune F. Nielsen", "Morten Dahl", "W. Monique Verschuren", "H. Susan J. Picavet", "Henriette A. Smit", "Michael Owsijewitsch", "Hans U. Kauczor", "Harry J. de Koning", "Eva Nizankowska-Mogilnicka", "Filip Mejza", "Pawel Nastalek", "Cleo C. van Diemen", "Michael H. Cho", "Edwin K. Silverman", "James D. Crapo", "Terri H. Beaty", "David A. Lomas", "Per Bakke", "Amund Gulsvik", "Yohan Bossé", "M. A. Obeidat", "Daan W. Loth", "Lies Lahousse", "Fernando Rivadeneira", "Andre G. Uitterlinden", "Andre Hofman", "Bruno H. Stricker", "Guy G. Brusselle", "Cornelia M. van Duijn", "Uilke Brouwer", "Gerard H. Koppelman", "Judith M. Vonk", "Martijn C. Nawijn", "Harry J. M. Groen", "Wim Timens", "H. Marike Boezen", "Dirkje S. Postma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091621.g006", "stats"=>{"downloads"=>2, "page_views"=>26, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SATB1_MUC5AC_and_FOXJ1_mRNA_expression_levels_during_mucociliary_human_airway_epithelial_cell_differentiation_n_2_donors_/990880", "title"=>"<i>SATB1</i>, <i>MUC5AC</i> and <i>FOXJ1</i> mRNA expression levels during mucociliary human airway epithelial cell differentiation (n = 2 donors).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-08 03:42:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1454626"], "description"=>"<p>Vertically left, the identification cohort and the replication cohorts included in the meta-analysis. The boxes represent the precision and the horizontal lines represent the confidence intervals. The squares represent the pooled effect estimate from the meta-analysis of all cohorts. The horizontal axis shows the scale of the effects.</p>", "links"=>[], "tags"=>["Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Genome-wide association studies", "genetics", "genomics", "Functional genomics", "psychology", "addiction", "Drug addiction", "Recreational drug addiction", "epidemiology", "Clinical epidemiology", "Environmental epidemiology", "Epidemiological methods and statistics", "Genetic epidemiology", "Lifecourse epidemiology", "Pulmonology", "Chronic Obstructive Pulmonary Disease", "Environmental and occupational lung diseases", "Respiratory infections", "rs6577641", "mucus", "hypersecretion", "replication"], "article_id"=>990875, "categories"=>["Biological Sciences"], "users"=>["Akkelies E. Dijkstra", "Joanna Smolonska", "Maarten van den Berge", "Ciska Wijmenga", "Pieter Zanen", "Marjan A. Luinge", "Mathieu Platteel", "Jan-Willem Lammers", "Magnus Dahlback", "Kerrie Tosh", "Pieter S. Hiemstra", "Peter J. Sterk", "Avi Spira", "Jorgen Vestbo", "Borge G. Nordestgaard", "Marianne Benn", "Sune F. Nielsen", "Morten Dahl", "W. Monique Verschuren", "H. Susan J. Picavet", "Henriette A. Smit", "Michael Owsijewitsch", "Hans U. Kauczor", "Harry J. de Koning", "Eva Nizankowska-Mogilnicka", "Filip Mejza", "Pawel Nastalek", "Cleo C. van Diemen", "Michael H. Cho", "Edwin K. Silverman", "James D. Crapo", "Terri H. Beaty", "David A. Lomas", "Per Bakke", "Amund Gulsvik", "Yohan Bossé", "M. A. Obeidat", "Daan W. Loth", "Lies Lahousse", "Fernando Rivadeneira", "Andre G. Uitterlinden", "Andre Hofman", "Bruno H. Stricker", "Guy G. Brusselle", "Cornelia M. van Duijn", "Uilke Brouwer", "Gerard H. Koppelman", "Judith M. Vonk", "Martijn C. Nawijn", "Harry J. M. Groen", "Wim Timens", "H. Marike Boezen", "Dirkje S. Postma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091621.g003", "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Forest_plot_showing_evidence_of_association_for_rs6577641_with_chronic_mucus_hypersecretion_in_the_identification_and_replication_cohorts_/990875", "title"=>"Forest plot showing evidence of association for rs6577641 with chronic mucus hypersecretion in the identification and replication cohorts.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-08 03:42:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1454640"], "description"=>"<p>P-value is fixed p-value if p-value for heterogeneity (Q) >0.005, and random p-value if p-value for heterogeneity (Q) <0.005; OR is Odds Ratio; OR is fixed OR if p-value for heterogeneity (Q) >0.005, and random OR if p-value for heterogeneity (Q) <0.005; Q is p-value for heterogeneity;</p><p>N = number of cohorts;</p><p>*means that the corresponding SNP is an intron in this gene.</p>", "links"=>[], "tags"=>["Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Genome-wide association studies", "genetics", "genomics", "Functional genomics", "psychology", "addiction", "Drug addiction", "Recreational drug addiction", "epidemiology", "Clinical epidemiology", "Environmental epidemiology", "Epidemiological methods and statistics", "Genetic epidemiology", "Lifecourse epidemiology", "Pulmonology", "Chronic Obstructive Pulmonary Disease", "Environmental and occupational lung diseases", "Respiratory infections", "snps", "cmh", "replication", "cohorts", "corrected", "smoking"], "article_id"=>990889, "categories"=>["Biological Sciences"], "users"=>["Akkelies E. Dijkstra", "Joanna Smolonska", "Maarten van den Berge", "Ciska Wijmenga", "Pieter Zanen", "Marjan A. Luinge", "Mathieu Platteel", "Jan-Willem Lammers", "Magnus Dahlback", "Kerrie Tosh", "Pieter S. Hiemstra", "Peter J. Sterk", "Avi Spira", "Jorgen Vestbo", "Borge G. Nordestgaard", "Marianne Benn", "Sune F. Nielsen", "Morten Dahl", "W. Monique Verschuren", "H. Susan J. Picavet", "Henriette A. Smit", "Michael Owsijewitsch", "Hans U. Kauczor", "Harry J. de Koning", "Eva Nizankowska-Mogilnicka", "Filip Mejza", "Pawel Nastalek", "Cleo C. van Diemen", "Michael H. Cho", "Edwin K. Silverman", "James D. Crapo", "Terri H. Beaty", "David A. Lomas", "Per Bakke", "Amund Gulsvik", "Yohan Bossé", "M. A. Obeidat", "Daan W. Loth", "Lies Lahousse", "Fernando Rivadeneira", "Andre G. Uitterlinden", "Andre Hofman", "Bruno H. Stricker", "Guy G. Brusselle", "Cornelia M. van Duijn", "Uilke Brouwer", "Gerard H. Koppelman", "Judith M. Vonk", "Martijn C. Nawijn", "Harry J. M. Groen", "Wim Timens", "H. Marike Boezen", "Dirkje S. Postma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091621.t006", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Meta_analysis_of_top_SNPs_associated_with_CMH_across_replication_cohorts_and_across_identification_and_replication_cohorts_corrected_for_smoking_and_sex_/990889", "title"=>"Meta-analysis of top SNPs associated with CMH across replication cohorts and across identification and replication cohorts, corrected for smoking and sex.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-08 03:42:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1454639"], "description"=>"<p>*To assess the effect of the SNP rs6577641 on gene expression, a Kruskal-Wallis test was performed. This test generates a p-value, but does not give a direction of the effect. To assess the direction of the effect, a Spearman's correlation test was performed. Next, a Z-score was calculated for each center and a meta-analysis performed for each of the three <i>SATB1</i> probes across all centers. Finally, a meta-analysis for all three <i>SATB1</i> probes was performed across all centers. This generated a Z-score of −5.87 and a corresponding p-value of 4.3*10<sup>−9</sup>, indicating that the susceptibility G allele of the SNP rs6577641 increases <i>SATB1</i> expression.</p>", "links"=>[], "tags"=>["Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Genome-wide association studies", "genetics", "genomics", "Functional genomics", "psychology", "addiction", "Drug addiction", "Recreational drug addiction", "epidemiology", "Clinical epidemiology", "Environmental epidemiology", "Epidemiological methods and statistics", "Genetic epidemiology", "Lifecourse epidemiology", "Pulmonology", "Chronic Obstructive Pulmonary Disease", "Environmental and occupational lung diseases", "Respiratory infections", "rs6577641", "mrna"], "article_id"=>990888, "categories"=>["Biological Sciences"], "users"=>["Akkelies E. Dijkstra", "Joanna Smolonska", "Maarten van den Berge", "Ciska Wijmenga", "Pieter Zanen", "Marjan A. Luinge", "Mathieu Platteel", "Jan-Willem Lammers", "Magnus Dahlback", "Kerrie Tosh", "Pieter S. Hiemstra", "Peter J. Sterk", "Avi Spira", "Jorgen Vestbo", "Borge G. Nordestgaard", "Marianne Benn", "Sune F. Nielsen", "Morten Dahl", "W. Monique Verschuren", "H. Susan J. Picavet", "Henriette A. Smit", "Michael Owsijewitsch", "Hans U. Kauczor", "Harry J. de Koning", "Eva Nizankowska-Mogilnicka", "Filip Mejza", "Pawel Nastalek", "Cleo C. van Diemen", "Michael H. Cho", "Edwin K. Silverman", "James D. Crapo", "Terri H. Beaty", "David A. Lomas", "Per Bakke", "Amund Gulsvik", "Yohan Bossé", "M. A. Obeidat", "Daan W. Loth", "Lies Lahousse", "Fernando Rivadeneira", "Andre G. Uitterlinden", "Andre Hofman", "Bruno H. Stricker", "Guy G. Brusselle", "Cornelia M. van Duijn", "Uilke Brouwer", "Gerard H. Koppelman", "Judith M. Vonk", "Martijn C. Nawijn", "Harry J. M. Groen", "Wim Timens", "H. Marike Boezen", "Dirkje S. Postma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091621.t007", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Meta_analysis_of_the_effect_of_rs6577641_on_mRNA_expression_levels_of_SATB1_in_the_lung_/990888", "title"=>"Meta-analysis of the effect of rs6577641 on mRNA expression levels of <i>SATB1</i> in the lung<sup>*</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-08 03:42:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1454637"], "description"=>"<p>*SNP not selected for replication because of strong linkage disequilibrium with another SNP.</p>", "links"=>[], "tags"=>["Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Genome-wide association studies", "genetics", "genomics", "Functional genomics", "psychology", "addiction", "Drug addiction", "Recreational drug addiction", "epidemiology", "Clinical epidemiology", "Environmental epidemiology", "Epidemiological methods and statistics", "Genetic epidemiology", "Lifecourse epidemiology", "Pulmonology", "Chronic Obstructive Pulmonary Disease", "Environmental and occupational lung diseases", "Respiratory infections", "cmh", "gwas-i", "nelson"], "article_id"=>990886, "categories"=>["Biological Sciences"], "users"=>["Akkelies E. Dijkstra", "Joanna Smolonska", "Maarten van den Berge", "Ciska Wijmenga", "Pieter Zanen", "Marjan A. Luinge", "Mathieu Platteel", "Jan-Willem Lammers", "Magnus Dahlback", "Kerrie Tosh", "Pieter S. Hiemstra", "Peter J. Sterk", "Avi Spira", "Jorgen Vestbo", "Borge G. Nordestgaard", "Marianne Benn", "Sune F. Nielsen", "Morten Dahl", "W. Monique Verschuren", "H. Susan J. Picavet", "Henriette A. Smit", "Michael Owsijewitsch", "Hans U. Kauczor", "Harry J. de Koning", "Eva Nizankowska-Mogilnicka", "Filip Mejza", "Pawel Nastalek", "Cleo C. van Diemen", "Michael H. Cho", "Edwin K. Silverman", "James D. Crapo", "Terri H. Beaty", "David A. Lomas", "Per Bakke", "Amund Gulsvik", "Yohan Bossé", "M. A. Obeidat", "Daan W. Loth", "Lies Lahousse", "Fernando Rivadeneira", "Andre G. Uitterlinden", "Andre Hofman", "Bruno H. Stricker", "Guy G. Brusselle", "Cornelia M. van Duijn", "Uilke Brouwer", "Gerard H. Koppelman", "Judith M. Vonk", "Martijn C. Nawijn", "Harry J. M. Groen", "Wim Timens", "H. Marike Boezen", "Dirkje S. Postma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091621.t004", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_SNPs_associated_with_CMH_with_a_p_value_8722_4_present_in_GWAS_I_and_in_GWAS_II_in_the_NELSON_identification_cohort_/990886", "title"=>"SNPs associated with CMH with a p-value<10<sup>−4</sup>, present in GWAS-I and in GWAS-II, in the NELSON identification cohort.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-08 03:42:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1454634"], "description"=>"<p>CMH = Chronic mucus hypersecretion;</p><p>*lung function is based on FEV<sub>1</sub>/IVC;</p><p>**all individuals in this cohort have COPD;</p>#<p>based on lung function of 700 subjects who returned for follow-up study 4 years later.</p>", "links"=>[], "tags"=>["Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Genome-wide association studies", "genetics", "genomics", "Functional genomics", "psychology", "addiction", "Drug addiction", "Recreational drug addiction", "epidemiology", "Clinical epidemiology", "Environmental epidemiology", "Epidemiological methods and statistics", "Genetic epidemiology", "Lifecourse epidemiology", "Pulmonology", "Chronic Obstructive Pulmonary Disease", "Environmental and occupational lung diseases", "Respiratory infections", "cmh-cases", "-controls"], "article_id"=>990883, "categories"=>["Biological Sciences"], "users"=>["Akkelies E. Dijkstra", "Joanna Smolonska", "Maarten van den Berge", "Ciska Wijmenga", "Pieter Zanen", "Marjan A. Luinge", "Mathieu Platteel", "Jan-Willem Lammers", "Magnus Dahlback", "Kerrie Tosh", "Pieter S. Hiemstra", "Peter J. Sterk", "Avi Spira", "Jorgen Vestbo", "Borge G. Nordestgaard", "Marianne Benn", "Sune F. Nielsen", "Morten Dahl", "W. Monique Verschuren", "H. Susan J. Picavet", "Henriette A. Smit", "Michael Owsijewitsch", "Hans U. Kauczor", "Harry J. de Koning", "Eva Nizankowska-Mogilnicka", "Filip Mejza", "Pawel Nastalek", "Cleo C. van Diemen", "Michael H. Cho", "Edwin K. Silverman", "James D. Crapo", "Terri H. Beaty", "David A. Lomas", "Per Bakke", "Amund Gulsvik", "Yohan Bossé", "M. A. Obeidat", "Daan W. Loth", "Lies Lahousse", "Fernando Rivadeneira", "Andre G. Uitterlinden", "Andre Hofman", "Bruno H. Stricker", "Guy G. Brusselle", "Cornelia M. van Duijn", "Uilke Brouwer", "Gerard H. Koppelman", "Judith M. Vonk", "Martijn C. Nawijn", "Harry J. M. Groen", "Wim Timens", "H. Marike Boezen", "Dirkje S. Postma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091621.t003", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_and_clinical_characteristics_of_CMH_cases_and_controls_with_8805_20_pack_years_present_in_the_meta_analysis_/990883", "title"=>"Demographic and clinical characteristics of CMH-cases and -controls with ≥20 pack-years, present in the meta-analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-08 03:42:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1454633"], "description"=>"<p>Questions used to define chronic mucus hypersecretion in the corresponding cohorts.</p>", "links"=>[], "tags"=>["Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Genome-wide association studies", "genetics", "genomics", "Functional genomics", "psychology", "addiction", "Drug addiction", "Recreational drug addiction", "epidemiology", "Clinical epidemiology", "Environmental epidemiology", "Epidemiological methods and statistics", "Genetic epidemiology", "Lifecourse epidemiology", "Pulmonology", "Chronic Obstructive Pulmonary Disease", "Environmental and occupational lung diseases", "Respiratory infections", "mucus", "hypersecretion", "corresponding"], "article_id"=>990882, "categories"=>["Biological Sciences"], "users"=>["Akkelies E. Dijkstra", "Joanna Smolonska", "Maarten van den Berge", "Ciska Wijmenga", "Pieter Zanen", "Marjan A. Luinge", "Mathieu Platteel", "Jan-Willem Lammers", "Magnus Dahlback", "Kerrie Tosh", "Pieter S. Hiemstra", "Peter J. Sterk", "Avi Spira", "Jorgen Vestbo", "Borge G. Nordestgaard", "Marianne Benn", "Sune F. Nielsen", "Morten Dahl", "W. Monique Verschuren", "H. Susan J. Picavet", "Henriette A. Smit", "Michael Owsijewitsch", "Hans U. Kauczor", "Harry J. de Koning", "Eva Nizankowska-Mogilnicka", "Filip Mejza", "Pawel Nastalek", "Cleo C. van Diemen", "Michael H. Cho", "Edwin K. Silverman", "James D. Crapo", "Terri H. Beaty", "David A. Lomas", "Per Bakke", "Amund Gulsvik", "Yohan Bossé", "M. A. Obeidat", "Daan W. Loth", "Lies Lahousse", "Fernando Rivadeneira", "Andre G. Uitterlinden", "Andre Hofman", "Bruno H. Stricker", "Guy G. Brusselle", "Cornelia M. van Duijn", "Uilke Brouwer", "Gerard H. Koppelman", "Judith M. Vonk", "Martijn C. Nawijn", "Harry J. M. Groen", "Wim Timens", "H. Marike Boezen", "Dirkje S. Postma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091621.t001", "stats"=>{"downloads"=>5, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Questions_used_to_define_chronic_mucus_hypersecretion_in_the_corresponding_cohorts_/990882", "title"=>"Questions used to define chronic mucus hypersecretion in the corresponding cohorts.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-08 03:42:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1454642"], "description"=>"<div><p>Background</p><p>Chronic mucus hypersecretion (CMH) is associated with an increased frequency of respiratory infections, excess lung function decline, and increased hospitalisation and mortality rates in the general population. It is associated with smoking, but it is unknown why only a minority of smokers develops CMH. A plausible explanation for this phenomenon is a predisposing genetic constitution. Therefore, we performed a genome wide association (GWA) study of CMH in Caucasian populations.</p><p>Methods</p><p>GWA analysis was performed in the NELSON-study using the Illumina 610 array, followed by replication and meta-analysis in 11 additional cohorts. In total 2,704 subjects with, and 7,624 subjects without CMH were included, all current or former heavy smokers (≥20 pack-years). Additional studies were performed to test the functional relevance of the most significant single nucleotide polymorphism (SNP).</p><p>Results</p><p>A strong association with CMH, consistent across all cohorts, was observed with rs6577641 (p = 4.25×10<sup>−6</sup>, OR = 1.17), located in intron 9 of the <i>special AT-rich sequence-binding protein 1 locus</i> (<i>SATB1</i>) on chromosome 3. The risk allele (G) was associated with higher mRNA expression of <i>SATB1</i> (4.3×10<sup>−9</sup>) in lung tissue. Presence of CMH was associated with increased <i>SATB1</i> mRNA expression in bronchial biopsies from COPD patients. <i>SATB1</i> expression was induced during differentiation of primary human bronchial epithelial cells in culture.</p><p>Conclusions</p><p>Our findings, that SNP rs6577641 is associated with CMH in multiple cohorts and is a <i>cis</i>-eQTL for <i>SATB1</i>, together with our additional observation that <i>SATB1</i> expression increases during epithelial differentiation provide suggestive evidence that <i>SATB1</i> is a gene that affects CMH.</p></div>", "links"=>[], "tags"=>["Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Genome-wide association studies", "genetics", "genomics", "Functional genomics", "psychology", "addiction", "Drug addiction", "Recreational drug addiction", "epidemiology", "Clinical epidemiology", "Environmental epidemiology", "Epidemiological methods and statistics", "Genetic epidemiology", "Lifecourse epidemiology", "Pulmonology", "Chronic Obstructive Pulmonary Disease", "Environmental and occupational lung diseases", "Respiratory infections", "mucus", "genome"], "article_id"=>990891, "categories"=>["Biological Sciences"], "users"=>["Akkelies E. Dijkstra", "Joanna Smolonska", "Maarten van den Berge", "Ciska Wijmenga", "Pieter Zanen", "Marjan A. Luinge", "Mathieu Platteel", "Jan-Willem Lammers", "Magnus Dahlback", "Kerrie Tosh", "Pieter S. Hiemstra", "Peter J. Sterk", "Avi Spira", "Jorgen Vestbo", "Borge G. Nordestgaard", "Marianne Benn", "Sune F. Nielsen", "Morten Dahl", "W. Monique Verschuren", "H. Susan J. Picavet", "Henriette A. Smit", "Michael Owsijewitsch", "Hans U. Kauczor", "Harry J. de Koning", "Eva Nizankowska-Mogilnicka", "Filip Mejza", "Pawel Nastalek", "Cleo C. van Diemen", "Michael H. Cho", "Edwin K. Silverman", "James D. Crapo", "Terri H. Beaty", "David A. Lomas", "Per Bakke", "Amund Gulsvik", "Yohan Bossé", "M. A. Obeidat", "Daan W. Loth", "Lies Lahousse", "Fernando Rivadeneira", "Andre G. Uitterlinden", "Andre Hofman", "Bruno H. Stricker", "Guy G. Brusselle", "Cornelia M. van Duijn", "Uilke Brouwer", "Gerard H. Koppelman", "Judith M. Vonk", "Martijn C. Nawijn", "Harry J. M. Groen", "Wim Timens", "H. Marike Boezen", "Dirkje S. Postma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091621", "stats"=>{"downloads"=>3, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Susceptibility_to_Chronic_Mucus_Hypersecretion_a_Genome_Wide_Association_Study_/990891", "title"=>"Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-08 03:42:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1454628"], "description"=>"<p>Percentage of subjects with chronic mucus hypersecretion (CMH) within genotypes (AA, AG and GG) of rs6577641 in the identification cohort (NELSON), and distributed among ex- and current smokers.</p>", "links"=>[], "tags"=>["Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Genome-wide association studies", "genetics", "genomics", "Functional genomics", "psychology", "addiction", "Drug addiction", "Recreational drug addiction", "epidemiology", "Clinical epidemiology", "Environmental epidemiology", "Epidemiological methods and statistics", "Genetic epidemiology", "Lifecourse epidemiology", "Pulmonology", "Chronic Obstructive Pulmonary Disease", "Environmental and occupational lung diseases", "Respiratory infections", "subjects", "mucus", "hypersecretion", "genotypes", "ag", "rs6577641", "cohort", "distributed", "ex-"], "article_id"=>990876, "categories"=>["Biological Sciences"], "users"=>["Akkelies E. Dijkstra", "Joanna Smolonska", "Maarten van den Berge", "Ciska Wijmenga", "Pieter Zanen", "Marjan A. Luinge", "Mathieu Platteel", "Jan-Willem Lammers", "Magnus Dahlback", "Kerrie Tosh", "Pieter S. Hiemstra", "Peter J. Sterk", "Avi Spira", "Jorgen Vestbo", "Borge G. Nordestgaard", "Marianne Benn", "Sune F. Nielsen", "Morten Dahl", "W. Monique Verschuren", "H. Susan J. Picavet", "Henriette A. Smit", "Michael Owsijewitsch", "Hans U. Kauczor", "Harry J. de Koning", "Eva Nizankowska-Mogilnicka", "Filip Mejza", "Pawel Nastalek", "Cleo C. van Diemen", "Michael H. Cho", "Edwin K. Silverman", "James D. Crapo", "Terri H. Beaty", "David A. Lomas", "Per Bakke", "Amund Gulsvik", "Yohan Bossé", "M. A. Obeidat", "Daan W. Loth", "Lies Lahousse", "Fernando Rivadeneira", "Andre G. Uitterlinden", "Andre Hofman", "Bruno H. Stricker", "Guy G. Brusselle", "Cornelia M. van Duijn", "Uilke Brouwer", "Gerard H. Koppelman", "Judith M. Vonk", "Martijn C. Nawijn", "Harry J. M. Groen", "Wim Timens", "H. Marike Boezen", "Dirkje S. Postma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091621.g004", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Percentage_of_subjects_with_chronic_mucus_hypersecretion_CMH_within_genotypes_AA_AG_and_GG_of_rs6577641_in_the_identification_cohort_NELSON_and_distributed_among_ex_and_current_smokers_/990876", "title"=>"Percentage of subjects with chronic mucus hypersecretion (CMH) within genotypes (AA, AG and GG) of rs6577641 in the identification cohort (NELSON), and distributed among ex- and current smokers.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-08 03:42:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1454624"], "description"=>"<p>Quantile-quantile plot and Manhattan plot of GWA results for association of SNPs with CMH in NELSON, corrected for center and smoking habits (C and D).</p>", "links"=>[], "tags"=>["Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Genome-wide association studies", "genetics", "genomics", "Functional genomics", "psychology", "addiction", "Drug addiction", "Recreational drug addiction", "epidemiology", "Clinical epidemiology", "Environmental epidemiology", "Epidemiological methods and statistics", "Genetic epidemiology", "Lifecourse epidemiology", "Pulmonology", "Chronic Obstructive Pulmonary Disease", "Environmental and occupational lung diseases", "Respiratory infections", "manhattan", "gwa", "snps", "cmh", "nelson", "amplified", "bloodbank", "controls", "corrected"], "article_id"=>990873, "categories"=>["Biological Sciences"], "users"=>["Akkelies E. Dijkstra", "Joanna Smolonska", "Maarten van den Berge", "Ciska Wijmenga", "Pieter Zanen", "Marjan A. Luinge", "Mathieu Platteel", "Jan-Willem Lammers", "Magnus Dahlback", "Kerrie Tosh", "Pieter S. Hiemstra", "Peter J. Sterk", "Avi Spira", "Jorgen Vestbo", "Borge G. Nordestgaard", "Marianne Benn", "Sune F. Nielsen", "Morten Dahl", "W. Monique Verschuren", "H. Susan J. Picavet", "Henriette A. Smit", "Michael Owsijewitsch", "Hans U. Kauczor", "Harry J. de Koning", "Eva Nizankowska-Mogilnicka", "Filip Mejza", "Pawel Nastalek", "Cleo C. van Diemen", "Michael H. Cho", "Edwin K. Silverman", "James D. Crapo", "Terri H. Beaty", "David A. Lomas", "Per Bakke", "Amund Gulsvik", "Yohan Bossé", "M. A. Obeidat", "Daan W. Loth", "Lies Lahousse", "Fernando Rivadeneira", "Andre G. Uitterlinden", "Andre Hofman", "Bruno H. Stricker", "Guy G. Brusselle", "Cornelia M. van Duijn", "Uilke Brouwer", "Gerard H. Koppelman", "Judith M. Vonk", "Martijn C. Nawijn", "Harry J. M. Groen", "Wim Timens", "H. Marike Boezen", "Dirkje S. Postma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091621.g002", "stats"=>{"downloads"=>1, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Quantile_quantile_plot_and_Manhattan_plot_of_GWA_results_for_association_of_SNPs_with_CMH_in_NELSON_amplified_with_bloodbank_controls_and_corrected_for_center_A_and_B_/990873", "title"=>"Quantile-quantile plot and Manhattan plot of GWA results for association of SNPs with CMH in NELSON amplified with bloodbank controls and corrected for center (A and B).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-08 03:42:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1454636"], "description"=>"<p>MAF = minor allele frequency in NELSON;</p><p>*Direction of effect per cohort: each sign reflects one cohort, direction of effect is presented by: + = (OR>1.05), − = (OR<0.95), 0 = (0.95Table 2; OR is odds ratio; Q is p-value for heterogeneity;</p>#<p>means corresponding SNP is located in an intron in this gene.</p>", "links"=>[], "tags"=>["Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Genome-wide association studies", "genetics", "genomics", "Functional genomics", "psychology", "addiction", "Drug addiction", "Recreational drug addiction", "epidemiology", "Clinical epidemiology", "Environmental epidemiology", "Epidemiological methods and statistics", "Genetic epidemiology", "Lifecourse epidemiology", "Pulmonology", "Chronic Obstructive Pulmonary Disease", "Environmental and occupational lung diseases", "Respiratory infections", "snps", "cmh", "replication", "cohorts", "corresponding"], "article_id"=>990885, "categories"=>["Biological Sciences"], "users"=>["Akkelies E. Dijkstra", "Joanna Smolonska", "Maarten van den Berge", "Ciska Wijmenga", "Pieter Zanen", "Marjan A. Luinge", "Mathieu Platteel", "Jan-Willem Lammers", "Magnus Dahlback", "Kerrie Tosh", "Pieter S. Hiemstra", "Peter J. Sterk", "Avi Spira", "Jorgen Vestbo", "Borge G. Nordestgaard", "Marianne Benn", "Sune F. Nielsen", "Morten Dahl", "W. Monique Verschuren", "H. Susan J. Picavet", "Henriette A. Smit", "Michael Owsijewitsch", "Hans U. Kauczor", "Harry J. de Koning", "Eva Nizankowska-Mogilnicka", "Filip Mejza", "Pawel Nastalek", "Cleo C. van Diemen", "Michael H. Cho", "Edwin K. Silverman", "James D. Crapo", "Terri H. Beaty", "David A. Lomas", "Per Bakke", "Amund Gulsvik", "Yohan Bossé", "M. A. Obeidat", "Daan W. Loth", "Lies Lahousse", "Fernando Rivadeneira", "Andre G. Uitterlinden", "Andre Hofman", "Bruno H. Stricker", "Guy G. Brusselle", "Cornelia M. van Duijn", "Uilke Brouwer", "Gerard H. Koppelman", "Judith M. Vonk", "Martijn C. Nawijn", "Harry J. M. Groen", "Wim Timens", "H. Marike Boezen", "Dirkje S. Postma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091621.t005", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Meta_analysis_of_top_SNPs_associated_with_CMH_in_replication_cohorts_in_identification_and_replication_cohorts_and_corresponding_direction_of_effect_in_all_cohorts_and_associated_feature_and_gene_s_/990885", "title"=>"Meta-analysis of top SNPs associated with CMH in replication cohorts, in identification and replication cohorts and corresponding direction of effect in all cohorts and associated feature and gene(s).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-08 03:42:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1454621"], "description"=>"<p>We performed GWA studies in the NELSON cohort and in additional healthy controls. CMH was analyzed using logistic regression with adjustment for center (Groningen and Utrecht). Since current smoking can affect the presence of CMH, we additionally performed the GWAS in the NELSON cohort correcting for center and smoking. SNPs with a p-value<10-4 present in both GWA studies were selected for replication. To test for generalizability of associations with CMH in other populations, we compared our results with data in CMH-cases and controls with a smoking history of ≥20 pack-years with eleven replication populations using logistic regression with adjustment for sex and current smoking. Finally, we performed a meta-analysis on shared SNPs across the NELSON identification population and the 11 replication populations.</p>", "links"=>[], "tags"=>["Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Genome-wide association studies", "genetics", "genomics", "Functional genomics", "psychology", "addiction", "Drug addiction", "Recreational drug addiction", "epidemiology", "Clinical epidemiology", "Environmental epidemiology", "Epidemiological methods and statistics", "Genetic epidemiology", "Lifecourse epidemiology", "Pulmonology", "Chronic Obstructive Pulmonary Disease", "Environmental and occupational lung diseases", "Respiratory infections"], "article_id"=>990870, "categories"=>["Biological Sciences"], "users"=>["Akkelies E. Dijkstra", "Joanna Smolonska", "Maarten van den Berge", "Ciska Wijmenga", "Pieter Zanen", "Marjan A. Luinge", "Mathieu Platteel", "Jan-Willem Lammers", "Magnus Dahlback", "Kerrie Tosh", "Pieter S. Hiemstra", "Peter J. Sterk", "Avi Spira", "Jorgen Vestbo", "Borge G. Nordestgaard", "Marianne Benn", "Sune F. Nielsen", "Morten Dahl", "W. Monique Verschuren", "H. Susan J. Picavet", "Henriette A. Smit", "Michael Owsijewitsch", "Hans U. Kauczor", "Harry J. de Koning", "Eva Nizankowska-Mogilnicka", "Filip Mejza", "Pawel Nastalek", "Cleo C. van Diemen", "Michael H. Cho", "Edwin K. Silverman", "James D. Crapo", "Terri H. Beaty", "David A. Lomas", "Per Bakke", "Amund Gulsvik", "Yohan Bossé", "M. A. Obeidat", "Daan W. Loth", "Lies Lahousse", "Fernando Rivadeneira", "Andre G. Uitterlinden", "Andre Hofman", "Bruno H. Stricker", "Guy G. Brusselle", "Cornelia M. van Duijn", "Uilke Brouwer", "Gerard H. Koppelman", "Judith M. Vonk", "Martijn C. Nawijn", "Harry J. M. Groen", "Wim Timens", "H. Marike Boezen", "Dirkje S. Postma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091621.g001", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_design_/990870", "title"=>"Study design.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-08 03:42:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1454635"], "description"=>"<p>Populations and corresponding period of data collection, type of population, genotyping platform and soft-ware used for imputation.</p><p>NA = not applicable.</p>", "links"=>[], "tags"=>["Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Genome-wide association studies", "genetics", "genomics", "Functional genomics", "psychology", "addiction", "Drug addiction", "Recreational drug addiction", "epidemiology", "Clinical epidemiology", "Environmental epidemiology", "Epidemiological methods and statistics", "Genetic epidemiology", "Lifecourse epidemiology", "Pulmonology", "Chronic Obstructive Pulmonary Disease", "Environmental and occupational lung diseases", "Respiratory infections"], "article_id"=>990884, "categories"=>["Biological Sciences"], "users"=>["Akkelies E. Dijkstra", "Joanna Smolonska", "Maarten van den Berge", "Ciska Wijmenga", "Pieter Zanen", "Marjan A. Luinge", "Mathieu Platteel", "Jan-Willem Lammers", "Magnus Dahlback", "Kerrie Tosh", "Pieter S. Hiemstra", "Peter J. Sterk", "Avi Spira", "Jorgen Vestbo", "Borge G. Nordestgaard", "Marianne Benn", "Sune F. Nielsen", "Morten Dahl", "W. Monique Verschuren", "H. Susan J. Picavet", "Henriette A. Smit", "Michael Owsijewitsch", "Hans U. Kauczor", "Harry J. de Koning", "Eva Nizankowska-Mogilnicka", "Filip Mejza", "Pawel Nastalek", "Cleo C. van Diemen", "Michael H. Cho", "Edwin K. Silverman", "James D. Crapo", "Terri H. Beaty", "David A. Lomas", "Per Bakke", "Amund Gulsvik", "Yohan Bossé", "M. A. Obeidat", "Daan W. Loth", "Lies Lahousse", "Fernando Rivadeneira", "Andre G. Uitterlinden", "Andre Hofman", "Bruno H. Stricker", "Guy G. Brusselle", "Cornelia M. van Duijn", "Uilke Brouwer", "Gerard H. Koppelman", "Judith M. Vonk", "Martijn C. Nawijn", "Harry J. M. Groen", "Wim Timens", "H. Marike Boezen", "Dirkje S. Postma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091621.t002", "stats"=>{"downloads"=>21, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overview_of_populations_/990884", "title"=>"Overview of populations.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-08 03:42:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1454630"], "description"=>"<p>Bronchial biopsy mRNA-expression levels of SATB1 in COPD patients with chronic mucus hypersecretion (n = 38) compared to patients without chronic mucus hypersecretion (n = 39).</p>", "links"=>[], "tags"=>["Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Genome-wide association studies", "genetics", "genomics", "Functional genomics", "psychology", "addiction", "Drug addiction", "Recreational drug addiction", "epidemiology", "Clinical epidemiology", "Environmental epidemiology", "Epidemiological methods and statistics", "Genetic epidemiology", "Lifecourse epidemiology", "Pulmonology", "Chronic Obstructive Pulmonary Disease", "Environmental and occupational lung diseases", "Respiratory infections", "biopsy", "mrna-expression", "satb1", "copd", "patients", "mucus", "hypersecretion", "compared"], "article_id"=>990879, "categories"=>["Biological Sciences"], "users"=>["Akkelies E. Dijkstra", "Joanna Smolonska", "Maarten van den Berge", "Ciska Wijmenga", "Pieter Zanen", "Marjan A. Luinge", "Mathieu Platteel", "Jan-Willem Lammers", "Magnus Dahlback", "Kerrie Tosh", "Pieter S. Hiemstra", "Peter J. Sterk", "Avi Spira", "Jorgen Vestbo", "Borge G. Nordestgaard", "Marianne Benn", "Sune F. Nielsen", "Morten Dahl", "W. Monique Verschuren", "H. Susan J. Picavet", "Henriette A. Smit", "Michael Owsijewitsch", "Hans U. Kauczor", "Harry J. de Koning", "Eva Nizankowska-Mogilnicka", "Filip Mejza", "Pawel Nastalek", "Cleo C. van Diemen", "Michael H. Cho", "Edwin K. Silverman", "James D. Crapo", "Terri H. Beaty", "David A. Lomas", "Per Bakke", "Amund Gulsvik", "Yohan Bossé", "M. A. Obeidat", "Daan W. Loth", "Lies Lahousse", "Fernando Rivadeneira", "Andre G. Uitterlinden", "Andre Hofman", "Bruno H. Stricker", "Guy G. Brusselle", "Cornelia M. van Duijn", "Uilke Brouwer", "Gerard H. Koppelman", "Judith M. Vonk", "Martijn C. Nawijn", "Harry J. M. Groen", "Wim Timens", "H. Marike Boezen", "Dirkje S. Postma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091621.g005", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bronchial_biopsy_mRNA_expression_levels_of_SATB1_in_COPD_patients_with_chronic_mucus_hypersecretion_n_8202_8202_38_compared_to_patients_without_chronic_mucus_hypersecretion_n_8202_8202_39_/990879", "title"=>"Bronchial biopsy mRNA-expression levels of SATB1 in COPD patients with chronic mucus hypersecretion (n = 38) compared to patients without chronic mucus hypersecretion (n = 39).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-08 03:42:16"}

PMC Usage Stats | Further Information

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