Maternal Genetic Variation Accounts in Part for the Associations of Maternal Size during Pregnancy with Offspring Cardiometabolic Risk in Adulthood
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{"title"=>"Maternal genetic variation accounts in part for the associations of maternal size during pregnancy with offspring cardiometabolic risk in adulthood", "type"=>"journal", "authors"=>[{"first_name"=>"Pandora L.", "last_name"=>"Wander", "scopus_author_id"=>"18438637300"}, {"first_name"=>"Hagit", "last_name"=>"Hochner", "scopus_author_id"=>"6507046275"}, {"first_name"=>"Colleen M.", "last_name"=>"Sitlani", "scopus_author_id"=>"26434434800"}, {"first_name"=>"Daniel A.", "last_name"=>"Enquobahrie", "scopus_author_id"=>"9839444500"}, {"first_name"=>"Thomas", "last_name"=>"Lumley", "scopus_author_id"=>"7003921176"}, {"first_name"=>"Gabriela M.", "last_name"=>"Lawrence", "scopus_author_id"=>"55947903300"}, {"first_name"=>"Ayala", "last_name"=>"Burger", "scopus_author_id"=>"7202055337"}, {"first_name"=>"Bella", "last_name"=>"Savitsky", "scopus_author_id"=>"57190276803"}, {"first_name"=>"Orly", "last_name"=>"Manor", "scopus_author_id"=>"7004445362"}, {"first_name"=>"Vardiella", "last_name"=>"Meiner", "scopus_author_id"=>"6701661143"}, {"first_name"=>"Stephanie", "last_name"=>"Hesselson", "scopus_author_id"=>"16177503700"}, {"first_name"=>"Pui Y.", "last_name"=>"Kwok", "scopus_author_id"=>"22976024000"}, {"first_name"=>"David S.", "last_name"=>"Siscovick", "scopus_author_id"=>"7005419833"}, {"first_name"=>"Yechiel", "last_name"=>"Friedlander", "scopus_author_id"=>"7004613237"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84899953013", "pui"=>"373038508", "doi"=>"10.1371/journal.pone.0091835", "isbn"=>"1932-6203", "sgr"=>"84899953013", "pmid"=>"24670385"}, "id"=>"18259443-6fb0-397d-acb1-f0dbd4c9fa29", "abstract"=>"BACKGROUND: Maternal pre-pregnancy body-mass index (ppBMI) and gestational weight gain (GWG) are associated with cardiometabolic risk (CMR) traits in the offspring. The extent to which maternal genetic variation accounts for these associations is unknown.\\n\\nMETHODS/RESULTS: In 1249 mother-offspring pairs recruited from the Jerusalem Perinatal Study, we used archival data to characterize ppBMI and GWG and follow-up data from offspring to assess CMR, including body mass index (BMI), waist circumference, glucose, insulin, blood pressure, and lipid levels, at an average age of 32. Maternal genetic risk scores (GRS) were created using a subset of SNPs most predictive of ppBMI, GWG, and each CMR trait, selected among 1384 single-nucleotide polymorphisms (SNPs) characterizing variation in 170 candidate genes potentially related to fetal development and/or metabolic risk. We fit linear regression models to examine the associations of ppBMI and GWG with CMR traits with and without adjustment for GRS. Compared to unadjusted models, the coefficient for the association of a one-standard-deviation (SD) difference in GWG and offspring BMI decreased by 41% (95%CI -81%, -11%) from 0.847 to 0.503 and the coefficient for a 1SD difference in GWG and WC decreased by 63% (95%CI -318%, -11%) from 1.196 to 0.443. For other traits, there were no statistically significant changes in the coefficients for GWG with adjustment for GRS. None of the associations of ppBMI with CMR traits were significantly altered by adjustment for GRS.\\n\\nCONCLUSIONS: Maternal genetic variation may account in part for associations of GWG with offspring BMI and WC in young adults.", "link"=>"http://www.mendeley.com/research/maternal-genetic-variation-accounts-part-associations-maternal-size-during-pregnancy-offspring-cardi", "reader_count"=>15, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Master"=>6, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Master"=>6, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>4, "Psychology"=>1, "Social Sciences"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1436547"], "description"=>"<div><p>Background</p><p>Maternal pre-pregnancy body-mass index (ppBMI) and gestational weight gain (GWG) are associated with cardiometabolic risk (CMR) traits in the offspring. The extent to which maternal genetic variation accounts for these associations is unknown.</p><p>Methods/Results</p><p>In 1249 mother-offspring pairs recruited from the Jerusalem Perinatal Study, we used archival data to characterize ppBMI and GWG and follow-up data from offspring to assess CMR, including body mass index (BMI), waist circumference, glucose, insulin, blood pressure, and lipid levels, at an average age of 32. Maternal genetic risk scores (GRS) were created using a subset of SNPs most predictive of ppBMI, GWG, and each CMR trait, selected among 1384 single-nucleotide polymorphisms (SNPs) characterizing variation in 170 candidate genes potentially related to fetal development and/or metabolic risk. We fit linear regression models to examine the associations of ppBMI and GWG with CMR traits with and without adjustment for GRS. Compared to unadjusted models, the coefficient for the association of a one-standard-deviation (SD) difference in GWG and offspring BMI decreased by 41% (95%CI −81%, −11%) from 0.847 to 0.503 and the coefficient for a 1SD difference in GWG and WC decreased by 63% (95%CI −318%, −11%) from 1.196 to 0.443. For other traits, there were no statistically significant changes in the coefficients for GWG with adjustment for GRS. None of the associations of ppBMI with CMR traits were significantly altered by adjustment for GRS.</p><p>Conclusions</p><p>Maternal genetic variation may account in part for associations of GWG with offspring BMI and WC in young adults.</p></div>", "links"=>[], "tags"=>["Evolutionary biology", "population genetics", "Genetic polymorphism", "genetics", "Human genetics", "Genetic association studies", "nutrition", "physiology", "Physiological parameters", "Body weight", "obesity", "epidemiology", "Cardiovascular disease epidemiology", "Genetic epidemiology", "women's health", "Maternal health", "pregnancy", "Obstetrics and gynecology", "accounts", "associations", "maternal", "offspring", "cardiometabolic"], "article_id"=>975437, "categories"=>["Biological Sciences"], "users"=>["Pandora L. Wander", "Hagit Hochner", "Colleen M. Sitlani", "Daniel A. Enquobahrie", "Thomas Lumley", "Gabriela M. Lawrence", "Ayala Burger", "Bella Savitsky", "Orly Manor", "Vardiella Meiner", "Stephanie Hesselson", "Pui Y. Kwok", "David S. Siscovick", "Yechiel Friedlander"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091835", "stats"=>{"downloads"=>12, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Maternal_Genetic_Variation_Accounts_in_Part_for_the_Associations_of_Maternal_Size_during_Pregnancy_with_Offspring_Cardiometabolic_Risk_in_Adulthood/975437", "title"=>"Maternal Genetic Variation Accounts in Part for the Associations of Maternal Size during Pregnancy with Offspring Cardiometabolic Risk in Adulthood", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-26 03:27:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1436545"], "description"=>"<p>All coefficients are for a 1-standard deviation change in level of the exposure variable (PBMI 1SD = 3.71, GWG 1SD = 4.61).</p><p>*Values were log-transformed to better approximate a normal distribution. To simplify interpretation, back-transformed results are presented and show the ratio of geometric mean of the outcome associated with a one-SD increase in BMI or GWG.</p><p>All models were adjusted for sex, ethnicity, offspring birthweight, maternal disease during pregnancy, parity, maternal smoking during pregnancy, family SES during pregnancy, gestational weeks at birth, maternal age at pregnancy, maternal education, offspring physical activity, offspring smoking status, and offspring education.</p><p>Pre-pregnancy BMI models were also adjusted for gestational weight gain, and GWG models for BMI.</p><p>All models used inverse probability weighting to account for stratified sampling.</p><p>In the models with scores, genetic scores predicting exposure and outcome are included. Scores were generated using the lasso algorithm, incorporating SNPs with no more than 5% missingness.</p><p>Confidence intervals for the % change in β were obtained via bootstrapping and based on quantiles of bootstrap replicates.</p>", "links"=>[], "tags"=>["Evolutionary biology", "population genetics", "Genetic polymorphism", "genetics", "Human genetics", "Genetic association studies", "nutrition", "physiology", "Physiological parameters", "Body weight", "obesity", "epidemiology", "Cardiovascular disease epidemiology", "Genetic epidemiology", "women's health", "Maternal health", "pregnancy", "Obstetrics and gynecology", "maternal", "pre-pregnancy", "bmi", "gestational", "offspring", "cardiometabolic", "phenotypes"], "article_id"=>975435, "categories"=>["Biological Sciences"], "users"=>["Pandora L. Wander", "Hagit Hochner", "Colleen M. Sitlani", "Daniel A. Enquobahrie", "Thomas Lumley", "Gabriela M. Lawrence", "Ayala Burger", "Bella Savitsky", "Orly Manor", "Vardiella Meiner", "Stephanie Hesselson", "Pui Y. Kwok", "David S. Siscovick", "Yechiel Friedlander"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091835.t002", "stats"=>{"downloads"=>5, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Association_between_maternal_pre_pregnancy_BMI_and_gestational_weight_gain_and_offspring_cardiometabolic_phenotypes_at_age_32_with_and_without_maternal_genetic_score_contribution_/975435", "title"=>"Association between maternal pre-pregnancy BMI and gestational weight gain and offspring cardiometabolic phenotypes at age 32, with and without maternal genetic score contribution.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-26 03:27:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/1436546"], "description"=>"<p>Values are expressed as mean (SD) or percent.</p><p>*Diabetes, hypertension, heart disease, or pre-eclampsia.</p><p>**Includes self-report of moderate or vigorous physical activity lasting at least 20 minutes, 3 or more time a week.</p>", "links"=>[], "tags"=>["Evolutionary biology", "population genetics", "Genetic polymorphism", "genetics", "Human genetics", "Genetic association studies", "nutrition", "physiology", "Physiological parameters", "Body weight", "obesity", "epidemiology", "Cardiovascular disease epidemiology", "Genetic epidemiology", "women's health", "Maternal health", "pregnancy", "Obstetrics and gynecology", "stratified", "offspring"], "article_id"=>975436, "categories"=>["Biological Sciences"], "users"=>["Pandora L. Wander", "Hagit Hochner", "Colleen M. Sitlani", "Daniel A. Enquobahrie", "Thomas Lumley", "Gabriela M. Lawrence", "Ayala Burger", "Bella Savitsky", "Orly Manor", "Vardiella Meiner", "Stephanie Hesselson", "Pui Y. Kwok", "David S. Siscovick", "Yechiel Friedlander"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0091835.t001", "stats"=>{"downloads"=>3, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Characteristics_at_birth_and_age_32_stratified_by_offspring_sex_/975436", "title"=>"Characteristics at birth and age 32, stratified by offspring sex.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-03-26 03:27:59"}

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