An Ontology-Based, Mobile-Optimized System for Pharmacogenomic Decision Support at the Point-of-Care
Publication Date
May 02, 2014
Journal
PLOS ONE
Authors
Jose Antonio Miñarro Giménez, Kathrin Blagec, Richard D. Boyce, Klaus Peter Adlassnig, et al
Volume
9
Issue
5
Pages
e93769
DOI
https://dx.plos.org/10.1371/journal.pone.0093769
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0093769
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/24787444
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008421
Europe PMC
http://europepmc.org/abstract/MED/24787444
Web of Science
000336655700008
Scopus
84900453857
Mendeley
http://www.mendeley.com/research/ontologybased-mobileoptimized-system-pharmacogenomic-decision-support-pointofcare
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Mendeley | Further Information

{"title"=>"An ontology-based, mobile-optimized system for pharmacogenomic decision support at the point-of-care", "type"=>"journal", "authors"=>[{"first_name"=>"Jose Antonio", "last_name"=>"Miñarro-Giménez", "scopus_author_id"=>"26422426900"}, {"first_name"=>"Kathrin", "last_name"=>"Blagec", "scopus_author_id"=>"56158022500"}, {"first_name"=>"Richard D.", "last_name"=>"Boyce", "scopus_author_id"=>"17343699800"}, {"first_name"=>"Klaus Peter", "last_name"=>"Adlassnig", "scopus_author_id"=>"7003385915"}, {"first_name"=>"Matthias", "last_name"=>"Samwald", "scopus_author_id"=>"55876919000"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1932-6203", "pui"=>"373072292", "sgr"=>"84900453857", "doi"=>"10.1371/journal.pone.0093769", "scopus"=>"2-s2.0-84900453857", "pmid"=>"24787444"}, "id"=>"e8219ab9-5e6f-35e0-8175-86c84b1baba0", "abstract"=>"BACKGROUND: The development of genotyping and genetic sequencing techniques and their evolution towards low costs and quick turnaround have encouraged a wide range of applications. One of the most promising applications is pharmacogenomics, where genetic profiles are used to predict the most suitable drugs and drug dosages for the individual patient. This approach aims to ensure appropriate medical treatment and avoid, or properly manage, undesired side effects.RESULTS: We developed the Medicine Safety Code (MSC) service, a novel pharmacogenomics decision support system, to provide physicians and patients with the ability to represent pharmacogenomic data in computable form and to provide pharmacogenomic guidance at the point-of-care. Pharmacogenomic data of individual patients are encoded as Quick Response (QR) codes and can be decoded and interpreted with common mobile devices without requiring a centralized repository for storing genetic patient data. In this paper, we present the first fully functional release of this system and describe its architecture, which utilizes Web Ontology Language 2 (OWL 2) ontologies to formalize pharmacogenomic knowledge and to provide clinical decision support functionalities.CONCLUSIONS: The MSC system provides a novel approach for enabling the implementation of personalized medicine in clinical routine", "link"=>"http://www.mendeley.com/research/ontologybased-mobileoptimized-system-pharmacogenomic-decision-support-pointofcare", "reader_count"=>46, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Librarian"=>2, "Researcher"=>13, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>3, "Student > Master"=>10, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Librarian"=>2, "Researcher"=>13, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>3, "Student > Master"=>10, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Agricultural and Biological Sciences"=>2, "Arts and Humanities"=>1, "Business, Management and Accounting"=>1, "Chemical Engineering"=>1, "Chemistry"=>1, "Computer Science"=>8, "Economics, Econometrics and Finance"=>1, "Engineering"=>2, "Nursing and Health Professions"=>5, "Biochemistry, Genetics and Molecular Biology"=>4, "Medicine and Dentistry"=>13, "Neuroscience"=>1, "Physics and Astronomy"=>1, "Social Sciences"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Social Sciences"=>{"Social Sciences"=>4}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Chemical Engineering"=>{"Chemical Engineering"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Engineering"=>{"Engineering"=>2}, "Chemistry"=>{"Chemistry"=>1}, "Neuroscience"=>{"Neuroscience"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Computer Science"=>{"Computer Science"=>8}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}}, "reader_count_by_country"=>{"Netherlands"=>1, "Portugal"=>1}, "group_count"=>4}

Scopus | Further Information

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