AAV-Mediated Gene Transfer of the Obesity-Associated Gene Etv5 in Rat Midbrain Does Not Affect Energy Balance or Motivated Behavior
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{"title"=>"AAV-mediated gene transfer of the obesity-associated gene Etv5 in rat midbrain does not affect energy balance or motivated behavior", "type"=>"journal", "authors"=>[{"first_name"=>"Arjen J.", "last_name"=>"Boender", "scopus_author_id"=>"37064196400"}, {"first_name"=>"Nivard A.", "last_name"=>"Koning", "scopus_author_id"=>"56131726600"}, {"first_name"=>"José K.", "last_name"=>"Van Den Heuvel", "scopus_author_id"=>"15069763200"}, {"first_name"=>"Mieneke C M", "last_name"=>"Luijendijk", "scopus_author_id"=>"18037723600"}, {"first_name"=>"Andrea J.", "last_name"=>"Van Rozen", "scopus_author_id"=>"6603407790"}, {"first_name"=>"Susanne E.", "last_name"=>"La Fleur", "scopus_author_id"=>"6602684208"}, {"first_name"=>"Roger A H", "last_name"=>"Adan", "scopus_author_id"=>"7004481045"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"24710089", "doi"=>"10.1371/journal.pone.0094159", "pui"=>"372955868", "issn"=>"19326203", "sgr"=>"84899441087", "scopus"=>"2-s2.0-84899441087"}, "id"=>"95979245-28cb-3931-89d1-09f7769201d6", "abstract"=>"Several genome-wide association studies have implicated the transcription factor E-twenty- six version 5 (Etv5) in the regulation of body mass index. Further substantiating the role of Etv5 in feeding behavior are the findings that targeted disruption of Etv5 in mice leads to decreased body weight gain and that expression of Etv5 is decreased in the ventral tegmental area and substantia nigra pars compacta (VTA/SNpc) after food restriction. As Etv5 has been suggested to influence dopaminergic neurotransmission by driving the expression of genes that are responsible for the synthesis and release of dopamine, we investigated if expression levels of Etv5 are dependent on nutritional state and subsequently influence the expression levels of tyrosine hydroxylase. While it was shown that Etv5 expression in the VTA/SNpc increases after central administration of leptin and that Etv5 was able to drive expression of tyrosine hydroxylase in vitro, AAV-mediated gene transfer of Etv5 into the VTA/SNpc of rats did not alter expression of tyrosine hydroxylase in vivo. Moreover, AAV-mediated gene transfer of Etv5 in the VTA/SNpc did not affect measures of energy balance or performances in a progressive ratio schedule. Thus, these data do not support a role for increased expression of Etv5 in the VTA/SNpc in the regulation of feeding behavior.", "link"=>"http://www.mendeley.com/research/aavmediated-gene-transfer-obesityassociated-gene-etv5-rat-midbrain-not-affect-energy-balance-motivat", "reader_count"=>10, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>2, "Professor"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>2, "Professor"=>3}, "reader_count_by_subject_area"=>{"Mathematics"=>1, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>1, "Neuroscience"=>1, "Social Sciences"=>1, "Computer Science"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Computer Science"=>{"Computer Science"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1453081"], "description"=>"<p>(A,B) Depicted are the daily means of active lever presses and obtained sucrose pellets (+SEM) of AAV-GFP and AAV-ETV5 animals under CHOW and RFS exposure. AAV-ETV5 did not have an effect on the amount of (A) active lever presses or (B) obtained sucrose pellets under exposure to CHOW or food restriction (RFS).</p>", "links"=>[], "tags"=>["Biochemistry", "metabolism", "Energy metabolism", "genetics", "neuroscience", "cognitive science", "Cognitive psychology", "motivation", "Behavioral neuroscience", "nutrition", "organisms", "animals", "vertebrates", "mammals", "rodents", "rats", "physiology", "Physiological parameters", "Body weight", "obesity", "Physiological processes", "psychology", "behavior", "Mental health and psychiatry", "Metabolic disorders", "Public and occupational health", "Behavioral and social aspects of health", "Model organisms", "Animal models", "aav-etv5", "pr"], "article_id"=>989603, "categories"=>["Biological Sciences"], "users"=>["Arjen J. Boender", "Nivard A. Koning", "José K. van den Heuvel", "Mieneke C. M. Luijendijk", "Andrea J. van Rozen", "Susanne E. la Fleur", "Roger A. H. Adan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094159.g005", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Infusion_of_AAV_ETV5_in_the_VTA_SNpc_has_no_effect_on_performance_in_a_PR_schedule_/989603", "title"=>"Infusion of AAV-ETV5 in the VTA/SNpc has no effect on performance in a PR schedule.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-07 03:30:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1453083"], "description"=>"<p>(A) Representative pictures of <i>Th</i> expression. (B) Infusion of AAV-ETV5 did not influence <i>Th</i> expression significantly in either the VTA or SNpc. Bars represent average percentage (+SEM) of <i>Th</i> expression of AAV-CTRL animals.</p>", "links"=>[], "tags"=>["Biochemistry", "metabolism", "Energy metabolism", "genetics", "neuroscience", "cognitive science", "Cognitive psychology", "motivation", "Behavioral neuroscience", "nutrition", "organisms", "animals", "vertebrates", "mammals", "rodents", "rats", "physiology", "Physiological parameters", "Body weight", "obesity", "Physiological processes", "psychology", "behavior", "Mental health and psychiatry", "Metabolic disorders", "Public and occupational health", "Behavioral and social aspects of health", "Model organisms", "Animal models"], "article_id"=>989605, "categories"=>["Biological Sciences"], "users"=>["Arjen J. Boender", "Nivard A. Koning", "José K. van den Heuvel", "Mieneke C. M. Luijendijk", "Andrea J. van Rozen", "Susanne E. la Fleur", "Roger A. H. Adan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094159.g006", "stats"=>{"downloads"=>0, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Increased_expression_of_Etv5_in_the_VTA_SNpc_has_no_effect_on_Th_expression_/989605", "title"=>"Increased expression of <i>Etv5</i> in the VTA/SNpc has no effect on <i>Th</i> expression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-07 03:30:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1453071"], "description"=>"<p>Depicted are the mean expression levels (+SEM) of <i>Etv5</i> in the (A) VTA and (B) the SNpc in percentage of baseline values after exposure to CHOW or HFHS diets and central administration of leptin or saline. Dietary exposure did not affect <i>Etv5</i> expression in the VTA or the SNpc, while central leptin administration did affect expression of <i>Etv5</i> in both the VTA and the SNpc.* indicate a significant difference of p<0.05 and *** indicate a significant difference of p<0.01.</p>", "links"=>[], "tags"=>["Biochemistry", "metabolism", "Energy metabolism", "genetics", "neuroscience", "cognitive science", "Cognitive psychology", "motivation", "Behavioral neuroscience", "nutrition", "organisms", "animals", "vertebrates", "mammals", "rodents", "rats", "physiology", "Physiological parameters", "Body weight", "obesity", "Physiological processes", "psychology", "behavior", "Mental health and psychiatry", "Metabolic disorders", "Public and occupational health", "Behavioral and social aspects of health", "Model organisms", "Animal models", "leptin", "irrespective"], "article_id"=>989592, "categories"=>["Biological Sciences"], "users"=>["Arjen J. Boender", "Nivard A. Koning", "José K. van den Heuvel", "Mieneke C. M. Luijendijk", "Andrea J. van Rozen", "Susanne E. la Fleur", "Roger A. H. Adan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094159.g001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Central_leptin_administration_affects_Etv5_expression_irrespective_of_diet_/989592", "title"=>"Central leptin administration affects <i>Etv5</i> expression, irrespective of diet.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-07 03:30:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1453072"], "description"=>"<p>Depicted are the mean normalized levels (+SEM) of luciferase activity after increasing amounts of pAAV-ETV5 or pAAV-CTRL. Increasing amounts of pAAV-GFP did not influence luciferase activity, while pAAV-ETV5 did increase luciferase activity, for all concentrations of pAAV-ETV5. *** indicate a significant difference of p<0.01.</p>", "links"=>[], "tags"=>["Biochemistry", "metabolism", "Energy metabolism", "genetics", "neuroscience", "cognitive science", "Cognitive psychology", "motivation", "Behavioral neuroscience", "nutrition", "organisms", "animals", "vertebrates", "mammals", "rodents", "rats", "physiology", "Physiological parameters", "Body weight", "obesity", "Physiological processes", "psychology", "behavior", "Mental health and psychiatry", "Metabolic disorders", "Public and occupational health", "Behavioral and social aspects of health", "Model organisms", "Animal models"], "article_id"=>989594, "categories"=>["Biological Sciences"], "users"=>["Arjen J. Boender", "Nivard A. Koning", "José K. van den Heuvel", "Mieneke C. M. Luijendijk", "Andrea J. van Rozen", "Susanne E. la Fleur", "Roger A. H. Adan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094159.g002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_pAAV_ETV5_is_able_to_drive_expression_from_the_TH_promoter_/989594", "title"=>"pAAV-ETV5 is able to drive expression from the TH-promoter.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-07 03:30:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1453074"], "description"=>"<p>(A,B) Representative pictures of <i>Th</i> expression. Infusion of (A) AAV-ETV5 but not (B) AAV-GFP leads to increased expression of <i>Etv5</i> in the VTA/SNpc. (C) Infusion of AAV-ETV5 did significantly increase <i>Etv5</i> expression in both the VTA and SNpc. Bars represent average percentage (+SEM) of <i>Etv5</i> expression of AAV-CTRL animal, with *** indicating a significant difference of p<0.01. (D) Representative picture of GFP expression. AAV-GFP did lead to GFP expression in the VTA/SNpc.</p>", "links"=>[], "tags"=>["Biochemistry", "metabolism", "Energy metabolism", "genetics", "neuroscience", "cognitive science", "Cognitive psychology", "motivation", "Behavioral neuroscience", "nutrition", "organisms", "animals", "vertebrates", "mammals", "rodents", "rats", "physiology", "Physiological parameters", "Body weight", "obesity", "Physiological processes", "psychology", "behavior", "Mental health and psychiatry", "Metabolic disorders", "Public and occupational health", "Behavioral and social aspects of health", "Model organisms", "Animal models", "aav-etv5", "leads", "vta"], "article_id"=>989596, "categories"=>["Biological Sciences"], "users"=>["Arjen J. Boender", "Nivard A. Koning", "José K. van den Heuvel", "Mieneke C. M. Luijendijk", "Andrea J. van Rozen", "Susanne E. la Fleur", "Roger A. H. Adan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094159.g003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Infusion_of_AAV_ETV5_leads_to_increased_expression_of_Etv5_in_both_the_VTA_and_SNpc_/989596", "title"=>"Infusion of AAV-ETV5 leads to increased expression of <i>Etv5</i> in both the VTA and SNpc.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-07 03:30:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1453076"], "description"=>"<p>(A,B) Depicted are the mean body weight and total caloric intake (±SEM) of AAV-GFP and AAV-ETV5 animals in the weeks after surgery. Under none of the dietary exposures AAV-ETV5 influenced (A) body weight or (B) total caloric intake. (C,D) Depicted are the average locomotor activities and body temperatures (+SEM) of AAV-GFP and AAV-ETV5 in the light and dark phase. Both (C) locomotor activity and (D) body temperature were unaffected by infusion of AAV-ETV5 in the VTA/SNpc. Abbreviations: RFS =  restricted feeding schedule, REF =  refeeding diet, HFHS =  high-fat high-sucrose diet.</p>", "links"=>[], "tags"=>["Biochemistry", "metabolism", "Energy metabolism", "genetics", "neuroscience", "cognitive science", "Cognitive psychology", "motivation", "Behavioral neuroscience", "nutrition", "organisms", "animals", "vertebrates", "mammals", "rodents", "rats", "physiology", "Physiological parameters", "Body weight", "obesity", "Physiological processes", "psychology", "behavior", "Mental health and psychiatry", "Metabolic disorders", "Public and occupational health", "Behavioral and social aspects of health", "Model organisms", "Animal models", "aav-etv5", "alterations"], "article_id"=>989598, "categories"=>["Biological Sciences"], "users"=>["Arjen J. Boender", "Nivard A. Koning", "José K. van den Heuvel", "Mieneke C. M. Luijendijk", "Andrea J. van Rozen", "Susanne E. la Fleur", "Roger A. H. Adan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094159.g004", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Infusion_of_AAV_ETV5_in_the_VTA_SNpc_does_not_lead_to_alterations_in_energy_balance_/989598", "title"=>"Infusion of AAV-ETV5 in the VTA/SNpc does not lead to alterations in energy balance.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-07 03:30:44"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[282]}, {"subject_area"=>"/Biology and life sciences/Biomechanics", "average_usage"=>[303, 468]}, {"subject_area"=>"/Biology and life sciences/Nutrition", "average_usage"=>[289]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[285]}, {"subject_area"=>"/Medicine and health sciences/Nutrition", "average_usage"=>[285]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[271]}]}
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