CiteULike

Mendeley | Further Information

{"title"=>"Comparative analyses of lung transcriptomes in patients with alveolar capillary dysplasia with misalignment of pulmonary veins and in Foxf1 heterozygous knockout mice", "type"=>"journal", "authors"=>[{"first_name"=>"Partha", "last_name"=>"Sen", "scopus_author_id"=>"7402920479"}, {"first_name"=>"Avinash V.", "last_name"=>"Dharmadhikari", "scopus_author_id"=>"52663524400"}, {"first_name"=>"Tadeusz", "last_name"=>"Majewski", "scopus_author_id"=>"7004036731"}, {"first_name"=>"Mahmoud A.", "last_name"=>"Mohammad", "scopus_author_id"=>"26645039800"}, {"first_name"=>"Tanya V.", "last_name"=>"Kalin", "scopus_author_id"=>"12445632900"}, {"first_name"=>"Joanna", "last_name"=>"Zabielska", "scopus_author_id"=>"56134988500"}, {"first_name"=>"Xiaomeng", "last_name"=>"Ren", "scopus_author_id"=>"7401875616"}, {"first_name"=>"Molly", "last_name"=>"Bray", "scopus_author_id"=>"7103256556"}, {"first_name"=>"Hannah M.", "last_name"=>"Brown", "scopus_author_id"=>"36616218400"}, {"first_name"=>"Stephen", "last_name"=>"Welty", "scopus_author_id"=>"7003487433"}, {"first_name"=>"Sundararajah", "last_name"=>"Thevananther", "scopus_author_id"=>"6603561329"}, {"first_name"=>"Claire", "last_name"=>"Langston", "scopus_author_id"=>"7006755685"}, {"first_name"=>"Przemyslaw", "last_name"=>"Szafranski", "scopus_author_id"=>"56425894400"}, {"first_name"=>"Monica J.", "last_name"=>"Justice", "scopus_author_id"=>"7006288500"}, {"first_name"=>"Vladimir V.", "last_name"=>"Kalinichenko", "scopus_author_id"=>"7005273198"}, {"first_name"=>"Anna", "last_name"=>"Gambin", "scopus_author_id"=>"6602211021"}, {"first_name"=>"John", "last_name"=>"Belmont", "scopus_author_id"=>"7006437037"}, {"first_name"=>"Pawel", "last_name"=>"Stankiewicz", "scopus_author_id"=>"56091724200"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84899530145", "pui"=>"372974752", "doi"=>"10.1371/journal.pone.0094390", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84899530145", "pmid"=>"24722050"}, "id"=>"63d7f47d-2e94-32e0-8f68-0588a069ced4", "abstract"=>"Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins (ACDMPV) is a developmental disorder of the lungs, primarily affecting their vasculature. FOXF1 haploinsufficiency due to heterozygous genomic deletions and point mutations have been reported in most patients with ACDMPV. The majority of mice with heterozygous loss-of-function of Foxf1 exhibit neonatal lethality with evidence of pulmonary hemorrhage in some of them. By comparing transcriptomes of human ACDMPV lungs with control lungs using expression arrays, we found that several genes and pathways involved in lung development, angiogenesis, and in pulmonary hypertension development, were deregulated. Similar transcriptional changes were found in lungs of the postnatal day 0.5 Foxf1+/- mice when compared to their wildtype littermate controls; 14 genes, COL15A1, COL18A1, COL6A2, ESM1, FSCN1, GRINA, IGFBP3, IL1B, MALL, NOS3, RASL11B, MATN2, PRKCDBP, and SIRPA, were found common to both ACDMPV and Foxf1 heterozygous lungs. Our results advance knowledge toward understanding of the molecular mechanism of ACDMPV, lung development, and its vasculature pathology. These data may also be useful for understanding etiologies of other lung disorders, e.g. pulmonary hypertension, bronchopulmonary dysplasia, or cancer.", "link"=>"http://www.mendeley.com/research/comparative-analyses-lung-transcriptomes-patients-alveolar-capillary-dysplasia-misalignment-pulmonar", "reader_count"=>17, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>5, "Professor"=>4, "Other"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>5, "Professor"=>4, "Other"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>2}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}

ORCID | Further Information

CrossRef

• http://doi.org/10.1016/j.semcdb.2019.10.006
• http://doi.org/10.1242/bio.019208
• http://doi.org/10.1038/pr.2016.244
• http://doi.org/10.1152/ajplung.00268.2015
• http://doi.org/10.1002/dvdy.298
• http://doi.org/10.1007/s00439-016-1655-9
• http://doi.org/10.1002/biof.1561
• http://doi.org/10.1002/ppul.23425
• http://doi.org/10.1007/s00439-019-02073-x
• http://doi.org/10.1007/s40778-020-00175-1
• http://doi.org/10.3389/fbioe.2018.00076
• http://doi.org/10.1164/rccm.201810-1897OC
• http://doi.org/10.1164/rccm.201812-2312OC

DataCite

Europe PMC Citations | Further Information

Europe PMC Database Citations | Further Information

{"UNIPROT"=>2}

PubMed Central

• 4467301

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84899530145"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84899530145?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84899530145&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84899530145&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84899530145", "dc:identifier"=>"SCOPUS_ID:84899530145", "eid"=>"2-s2.0-84899530145", "dc:title"=>"Comparative analyses of lung transcriptomes in patients with alveolar capillary dysplasia with misalignment of pulmonary veins and in Foxf1 heterozygous knockout mice", "dc:creator"=>"Sen P.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"9", "prism:issueIdentifier"=>"4", "prism:pageRange"=>nil, "prism:coverDate"=>"2014-04-10", "prism:coverDisplayDate"=>"10 April 2014", "prism:doi"=>"10.1371/journal.pone.0094390", "citedby-count"=>"18", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Baylor College of Medicine", "affiliation-city"=>"Houston", "affiliation-country"=>"United States"}], "pubmed-id"=>"24722050", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e94390", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true, "freetoread"=>{"value"=>[{"$"=>"all"}, {"$"=>"publisherfullgold"}, {"$"=>"repository"}, {"$"=>"repositoryvor"}, {"$"=>"repositoryam"}]}, "freetoreadLabel"=>{"value"=>[{"$"=>"All Open Access"}, {"$"=>"Gold"}, {"$"=>"Green"}]}}

Web of Science® | Further Information

Article Coverage

Article Coverage Curated

Facebook

• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0094390", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments

Nature

Reddit

ScienceSeeker | Further Information

Twitter

• {"id"=>"465770490976796672", "text"=>"There is a new #ACDResearch article published in @PLOSONE funded by our NORD @RareDiseases grants #FundraisingResult http://t.co/eNq8idtFor", "created_at"=>"2014-05-12T08:28:33Z", "user"=>"ACDAssociation", "user_name"=>"ACDA", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1893662645/ACDA_new_logo_normal.jpg"}
• {"id"=>"465770615455371264", "text"=>"There is a new #ACDResearch article published in @PLOSONE funded by our NORD @RareDiseases grants #FundraisingResult http://t.co/SkeU6mdZbi", "created_at"=>"2014-05-12T08:29:02Z", "user"=>"TDavidAshwellF", "user_name"=>"DavidAshwellFound", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1731789778/David_Ashwell_Logo_normal.png"}
• {"id"=>"465771352528785409", "text"=>"There is a new #ACDResearch article published in @PLOSONE funded by our NORD grants. Thank you for all your... http://t.co/2mRehExdw6", "created_at"=>"2014-05-12T08:31:58Z", "user"=>"ACDAssociation", "user_name"=>"ACDA", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1893662645/ACDA_new_logo_normal.jpg"}
• {"id"=>"465772085714100224", "text"=>"RT @ACDAssociation: There is a new #ACDResearch article published in @PLOSONE funded by our NORD grants. Thank you for all your... http://…", "created_at"=>"2014-05-12T08:34:53Z", "user"=>"Lakenutrition", "user_name"=>"Dr Amelia A Lake", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1701995988/dr_a_lake_normal.jpg"}
• {"id"=>"465772204463259649", "text"=>"RT @ACDAssociation: There is a new #ACDResearch article published in @PLOSONE funded by our NORD @RareDiseases grants #FundraisingResult ht…", "created_at"=>"2014-05-12T08:35:21Z", "user"=>"Lakenutrition", "user_name"=>"Dr Amelia A Lake", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1701995988/dr_a_lake_normal.jpg"}
• {"id"=>"465772243457699840", "text"=>"RT @TDavidAshwellF: There is a new #ACDResearch article published in @PLOSONE funded by our NORD @RareDiseases grants #FundraisingResult ht…", "created_at"=>"2014-05-12T08:35:31Z", "user"=>"Lakenutrition", "user_name"=>"Dr Amelia A Lake", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1701995988/dr_a_lake_normal.jpg"}
• {"id"=>"465781442908520448", "text"=>"RT @ACDAssociation: There is a new #ACDResearch article published in @PLOSONE funded by our NORD grants. Thank you for all your... http://…", "created_at"=>"2014-05-12T09:12:04Z", "user"=>"TDavidAshwellF", "user_name"=>"DavidAshwellFound", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1731789778/David_Ashwell_Logo_normal.png"}
• {"id"=>"465781471626936320", "text"=>"RT @ACDAssociation: There is a new #ACDResearch article published in @PLOSONE funded by our NORD @RareDiseases grants #FundraisingResult ht…", "created_at"=>"2014-05-12T09:12:11Z", "user"=>"TDavidAshwellF", "user_name"=>"DavidAshwellFound", "user_profile_image"=>"http://pbs.twimg.com/profile_images/1731789778/David_Ashwell_Logo_normal.png"}
• {"id"=>"468120300945965057", "text"=>"RT @ACDAssociation: There is a new #ACDResearch article published in @PLOSONE funded by our NORD grants. Thank you for all your... http://…", "created_at"=>"2014-05-18T20:05:51Z", "user"=>"PLOSONE", "user_name"=>"PLOS ONE", "user_profile_image"=>"http://pbs.twimg.com/profile_images/2429958559/mzjl6as5u2m09r2erof6_normal.jpeg"}

Wikipedia

Wordpress.com | Further Information

Counter

• {"month"=>"4", "year"=>"2014", "pdf_views"=>"31", "xml_views"=>"10", "html_views"=>"190"}
• {"month"=>"5", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"2", "html_views"=>"258"}
• {"month"=>"6", "year"=>"2014", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"76"}
• {"month"=>"7", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"69"}
• {"month"=>"8", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"67"}
• {"month"=>"9", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"46"}
• {"month"=>"10", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"74"}
• {"month"=>"11", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"3", "html_views"=>"80"}
• {"month"=>"12", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"114"}
• {"month"=>"1", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"83"}
• {"month"=>"2", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"52"}
• {"month"=>"3", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"66"}
• {"month"=>"4", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"166"}
• {"month"=>"5", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"75"}
• {"month"=>"6", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"159"}
• {"month"=>"7", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"55"}
• {"month"=>"8", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"122"}
• {"month"=>"9", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"65"}
• {"month"=>"10", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"77"}
• {"month"=>"11", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"80"}
• {"month"=>"12", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"69"}
• {"month"=>"1", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"78"}
• {"month"=>"2", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"18"}
• {"month"=>"3", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"57"}
• {"month"=>"4", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"20"}
• {"month"=>"5", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"15"}
• {"month"=>"6", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
• {"month"=>"7", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"13"}
• {"month"=>"8", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"17"}
• {"month"=>"9", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"39"}
• {"month"=>"10", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"25"}
• {"month"=>"11", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"21"}
• {"month"=>"12", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"21"}
• {"month"=>"1", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"19"}
• {"month"=>"2", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"21"}
• {"month"=>"3", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"36"}
• {"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"16"}
• {"month"=>"5", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"25"}
• {"month"=>"6", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"23"}
• {"month"=>"7", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"17"}
• {"month"=>"8", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"13"}
• {"month"=>"9", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"15"}
• {"month"=>"10", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"33"}
• {"month"=>"11", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"60"}
• {"month"=>"12", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"41"}
• {"month"=>"1", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"22"}
• {"month"=>"2", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"6"}
• {"month"=>"3", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"6"}
• {"month"=>"4", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"10"}
• {"month"=>"5", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"10"}
• {"month"=>"6", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"10"}
• {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"3"}
• {"month"=>"8", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"2", "html_views"=>"4"}
• {"month"=>"9", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"16"}
• {"month"=>"10", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"11"}
• {"month"=>"11", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"7"}
• {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
• {"month"=>"1", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"8"}
• {"month"=>"2", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"14"}
• {"month"=>"3", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"4"}
• {"month"=>"4", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"6"}
• {"month"=>"5", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"7"}
• {"month"=>"6", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"10"}
• {"month"=>"7", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"8"}
• {"month"=>"8", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"2"}
• {"month"=>"9", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"6"}
• {"month"=>"10", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"16"}
• {"month"=>"11", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
• {"month"=>"12", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"5"}
• {"month"=>"1", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"4"}
• {"month"=>"2", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"1"}
• {"month"=>"3", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"7"}
• {"month"=>"4", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"1"}
• {"month"=>"5", "year"=>"2020", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"2"}
• {"month"=>"6", "year"=>"2020", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"1"}
• {"month"=>"7", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"2"}
• {"month"=>"8", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
• {"month"=>"9", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"4"}
• {"month"=>"10", "year"=>"2020", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"3"}
• {"month"=>"11", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"2"}
• {"month"=>"12", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"4"}
• {"month"=>"1", "year"=>"2021", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"7"}
• {"month"=>"2", "year"=>"2021", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"17"}

Figshare

• {"files"=>["https://ndownloader.figshare.com/files/1458718"], "description"=>"<p>Deregulated genes involved in (A) Cellular movement, immune cell trafficking, inflammatory response; (B) Cellular development, cellular growth and proliferation, tumor morphology; (C) Cellular development, hematological system development and function, immune cell trafficking; (D) Cardiovascular disease, inflammatory response and cellular movement; (E) Carbohydrate metabolism, lipid metabolism and molecular transport.</p>", "links"=>[], "tags"=>["anatomy", "Cardiovascular anatomy", "Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Gene regulatory networks", "genetics", "gene expression", "DNA transcription", "Heredity", "haploinsufficiency", "Animal genetics", "Genetics of disease", "genomics", "Human genetics", "mutation", "cardiology", "Pulmonology", "Model organisms", "Animal models", "Mouse models", "involving", "deregulated", "genes", "acdmpv", "lungs", "down-regulated", "up-regulated"], "article_id"=>994439, "categories"=>["Biological Sciences"], "users"=>["Partha Sen", "Avinash V. Dharmadhikari", "Tadeusz Majewski", "Mahmoud A. Mohammad", "Tanya V. Kalin", "Joanna Zabielska", "Xiaomeng Ren", "Molly Bray", "Hannah M. Brown", "Stephen Welty", "Sundararajah Thevananther", "Claire Langston", "Przemyslaw Szafranski", "Monica J. Justice", "Vladimir V. Kalinichenko", "Anna Gambin", "John Belmont", "Pawel Stankiewicz"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094390.g002", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Networks_involving_deregulated_genes_in_ACDMPV_lungs_identified_using_IPA_down_regulated_genes_are_shown_in_green_and_up_regulated_genes_are_shown_in_red_/994439", "title"=>"Networks involving deregulated genes in ACDMPV lungs identified using IPA; down-regulated genes are shown in green and up-regulated genes are shown in red.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-10 02:55:17"}
• {"files"=>["https://ndownloader.figshare.com/files/1458732", "https://ndownloader.figshare.com/files/1458734", "https://ndownloader.figshare.com/files/1458735", "https://ndownloader.figshare.com/files/1458736", "https://ndownloader.figshare.com/files/1458737", "https://ndownloader.figshare.com/files/1458738", "https://ndownloader.figshare.com/files/1458739", "https://ndownloader.figshare.com/files/1458740", "https://ndownloader.figshare.com/files/1458741"], "description"=>"<div><p>Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins (ACDMPV) is a developmental disorder of the lungs, primarily affecting their vasculature. <i>FOXF1</i> haploinsufficiency due to heterozygous genomic deletions and point mutations have been reported in most patients with ACDMPV. The majority of mice with heterozygous loss-of-function of <i>Foxf1</i> exhibit neonatal lethality with evidence of pulmonary hemorrhage in some of them. By comparing transcriptomes of human ACDMPV lungs with control lungs using expression arrays, we found that several genes and pathways involved in lung development, angiogenesis, and in pulmonary hypertension development, were deregulated. Similar transcriptional changes were found in lungs of the postnatal day 0.5 <i>Foxf1</i>^+/− mice when compared to their wildtype littermate controls; 14 genes, <i>COL15A1, COL18A1, COL6A2, ESM1, FSCN1, GRINA, IGFBP3, IL1B, MALL, NOS3, RASL11B, MATN2, PRKCDBP,</i> and <i>SIRPA,</i> were found common to both ACDMPV and <i>Foxf1</i> heterozygous lungs. Our results advance knowledge toward understanding of the molecular mechanism of ACDMPV, lung development, and its vasculature pathology. These data may also be useful for understanding etiologies of other lung disorders, e.g. pulmonary hypertension, bronchopulmonary dysplasia, or cancer.</p></div>", "links"=>[], "tags"=>["anatomy", "Cardiovascular anatomy", "Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Gene regulatory networks", "genetics", "gene expression", "DNA transcription", "Heredity", "haploinsufficiency", "Animal genetics", "Genetics of disease", "genomics", "Human genetics", "mutation", "cardiology", "Pulmonology", "Model organisms", "Animal models", "Mouse models", "comparative", "transcriptomes", "patients", "alveolar", "capillary", "dysplasia", "misalignment", "pulmonary", "veins", "heterozygous", "knockout", "mice"], "article_id"=>994453, "categories"=>["Biological Sciences"], "users"=>["Partha Sen", "Avinash V. Dharmadhikari", "Tadeusz Majewski", "Mahmoud A. Mohammad", "Tanya V. Kalin", "Joanna Zabielska", "Xiaomeng Ren", "Molly Bray", "Hannah M. Brown", "Stephen Welty", "Sundararajah Thevananther", "Claire Langston", "Przemyslaw Szafranski", "Monica J. Justice", "Vladimir V. Kalinichenko", "Anna Gambin", "John Belmont", "Pawel Stankiewicz"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0094390.s001", "https://dx.doi.org/10.1371/journal.pone.0094390.s002", "https://dx.doi.org/10.1371/journal.pone.0094390.s003", "https://dx.doi.org/10.1371/journal.pone.0094390.s004", "https://dx.doi.org/10.1371/journal.pone.0094390.s005", "https://dx.doi.org/10.1371/journal.pone.0094390.s006", "https://dx.doi.org/10.1371/journal.pone.0094390.s007", "https://dx.doi.org/10.1371/journal.pone.0094390.s008", "https://dx.doi.org/10.1371/journal.pone.0094390.s009"], "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Comparative_Analyses_of_Lung_Transcriptomes_in_Patients_with_Alveolar_Capillary_Dysplasia_with_Misalignment_of_Pulmonary_Veins_and_in_Foxf1_Heterozygous_Knockout_Mice/994453", "title"=>"Comparative Analyses of Lung Transcriptomes in Patients with Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins and in <i>Foxf1</i> Heterozygous Knockout Mice", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-04-10 02:55:17"}
• {"files"=>["https://ndownloader.figshare.com/files/1458728"], "description"=>"<p>No clinical or genetic information is available for patients 7 and 8.</p>", "links"=>[], "tags"=>["anatomy", "Cardiovascular anatomy", "Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Gene regulatory networks", "genetics", "gene expression", "DNA transcription", "Heredity", "haploinsufficiency", "Animal genetics", "Genetics of disease", "genomics", "Human genetics", "mutation", "cardiology", "Pulmonology", "Model organisms", "Animal models", "Mouse models"], "article_id"=>994449, "categories"=>["Biological Sciences"], "users"=>["Partha Sen", "Avinash V. Dharmadhikari", "Tadeusz Majewski", "Mahmoud A. Mohammad", "Tanya V. Kalin", "Joanna Zabielska", "Xiaomeng Ren", "Molly Bray", "Hannah M. Brown", "Stephen Welty", "Sundararajah Thevananther", "Claire Langston", "Przemyslaw Szafranski", "Monica J. Justice", "Vladimir V. Kalinichenko", "Anna Gambin", "John Belmont", "Pawel Stankiewicz"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094390.t001", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ACDMPV_patient_sample_information_/994449", "title"=>"ACDMPV patient sample information.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-10 02:55:17"}
• {"files"=>["https://ndownloader.figshare.com/files/1458726"], "description"=>"<p><b>(A)</b> Heat map comparing expression of 14 overlapping genes in ACDMPV lung samples and control lung samples; (B) Heat map comparing expression of 14 overlapping genes in <i>Foxf1</i>^+/− lung samples and control lung samples.</p>", "links"=>[], "tags"=>["anatomy", "Cardiovascular anatomy", "Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Gene regulatory networks", "genetics", "gene expression", "DNA transcription", "Heredity", "haploinsufficiency", "Animal genetics", "Genetics of disease", "genomics", "Human genetics", "mutation", "cardiology", "Pulmonology", "Model organisms", "Animal models", "Mouse models", "genes", "acdmpv", "lungs"], "article_id"=>994446, "categories"=>["Biological Sciences"], "users"=>["Partha Sen", "Avinash V. Dharmadhikari", "Tadeusz Majewski", "Mahmoud A. Mohammad", "Tanya V. Kalin", "Joanna Zabielska", "Xiaomeng Ren", "Molly Bray", "Hannah M. Brown", "Stephen Welty", "Sundararajah Thevananther", "Claire Langston", "Przemyslaw Szafranski", "Monica J. Justice", "Vladimir V. Kalinichenko", "Anna Gambin", "John Belmont", "Pawel Stankiewicz"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094390.g005", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Deregulated_genes_common_to_both_ACDMPV_lungs_and_P0_5_Foxf1_8722_lungs_/994446", "title"=>"Deregulated genes common to both ACDMPV lungs and P0.5 <i>Foxf1^+/−</i> lungs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-10 02:55:17"}
• {"files"=>["https://ndownloader.figshare.com/files/1458722"], "description"=>"<p>Deregulated genes involved in (A) Inflammatory response, cellular movement, cardiovascular disease; (B) Cell-to-cell signaling and interaction, cellular movement, hematological system development and function; (C) Embryonic development, organ development; (D) Cardiovascular system development and function, organ development, cellular movement; down-regulated genes are shown in green and up-regulated gens are shown in red.</p>", "links"=>[], "tags"=>["anatomy", "Cardiovascular anatomy", "Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Gene regulatory networks", "genetics", "gene expression", "DNA transcription", "Heredity", "haploinsufficiency", "Animal genetics", "Genetics of disease", "genomics", "Human genetics", "mutation", "cardiology", "Pulmonology", "Model organisms", "Animal models", "Mouse models", "involving", "deregulated", "genes", "lungs"], "article_id"=>994443, "categories"=>["Biological Sciences"], "users"=>["Partha Sen", "Avinash V. Dharmadhikari", "Tadeusz Majewski", "Mahmoud A. Mohammad", "Tanya V. Kalin", "Joanna Zabielska", "Xiaomeng Ren", "Molly Bray", "Hannah M. Brown", "Stephen Welty", "Sundararajah Thevananther", "Claire Langston", "Przemyslaw Szafranski", "Monica J. Justice", "Vladimir V. Kalinichenko", "Anna Gambin", "John Belmont", "Pawel Stankiewicz"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094390.g004", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Networks_involving_deregulated_genes_in_Foxf1_8722_lungs_identified_using_IPA_/994443", "title"=>"Networks involving deregulated genes in <i>Foxf1^+/−</i> lungs identified using IPA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-10 02:55:17"}
• {"files"=>["https://ndownloader.figshare.com/files/1458721"], "description"=>"<p>(A) Heat map for genes differentially expressed (fdr <0.05, fold change >/ =  2 or Foxf1^+/− lungs (n = 6) and littermate control lungs (n = 6); Decreased gene expression is shown in green and increased gene expression is shown in red; <i>Foxf1</i>^+/− lung samples and wildtype lung samples cluster as two separate groups. (B) Top significant gene ontology (biological processes) terms associated with deregulated genes from DAVID analysis. (C) qRT-PCR validation for down-regulated genes (<i>Sema3C, Dll4,</i> and <i>Hgf</i>) and up-regulated genes <i>(Cma1</i> and <i>Ren1</i>); n = 6 for each group; * =  p value <0.05; ** = p value <0.001.</p>", "links"=>[], "tags"=>["anatomy", "Cardiovascular anatomy", "Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Gene regulatory networks", "genetics", "gene expression", "DNA transcription", "Heredity", "haploinsufficiency", "Animal genetics", "Genetics of disease", "genomics", "Human genetics", "mutation", "cardiology", "Pulmonology", "Model organisms", "Animal models", "Mouse models", "microarray", "david", "qrt-pcr"], "article_id"=>994442, "categories"=>["Biological Sciences"], "users"=>["Partha Sen", "Avinash V. Dharmadhikari", "Tadeusz Majewski", "Mahmoud A. Mohammad", "Tanya V. Kalin", "Joanna Zabielska", "Xiaomeng Ren", "Molly Bray", "Hannah M. Brown", "Stephen Welty", "Sundararajah Thevananther", "Claire Langston", "Przemyslaw Szafranski", "Monica J. Justice", "Vladimir V. Kalinichenko", "Anna Gambin", "John Belmont", "Pawel Stankiewicz"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094390.g003", "stats"=>{"downloads"=>5, "page_views"=>272, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Foxf1_8722_mouse_lung_microarray_analysis_heat_map_clustering_DAVID_analysis_and_qRT_PCR_validation_/994442", "title"=>"<i>Foxf1</i>^+/− mouse lung microarray analysis: heat map, clustering, DAVID analysis, and qRT-PCR validation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-10 02:55:17"}
• {"files"=>["https://ndownloader.figshare.com/files/1458716"], "description"=>"<p>(A) Heat map for genes differentially expressed (adjusted p-value <0.05, fold change approximately >/ =  2 or </p>", "links"=>[], "tags"=>["anatomy", "Cardiovascular anatomy", "Computational biology", "genome analysis", "Transcriptome analysis", "Genome expression analysis", "Gene regulatory networks", "genetics", "gene expression", "DNA transcription", "Heredity", "haploinsufficiency", "Animal genetics", "Genetics of disease", "genomics", "Human genetics", "mutation", "cardiology", "Pulmonology", "Model organisms", "Animal models", "Mouse models", "microarray", "david", "ihc"], "article_id"=>994437, "categories"=>["Biological Sciences"], "users"=>["Partha Sen", "Avinash V. Dharmadhikari", "Tadeusz Majewski", "Mahmoud A. Mohammad", "Tanya V. Kalin", "Joanna Zabielska", "Xiaomeng Ren", "Molly Bray", "Hannah M. Brown", "Stephen Welty", "Sundararajah Thevananther", "Claire Langston", "Przemyslaw Szafranski", "Monica J. Justice", "Vladimir V. Kalinichenko", "Anna Gambin", "John Belmont", "Pawel Stankiewicz"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094390.g001", "stats"=>{"downloads"=>1, "page_views"=>31, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ACDMPV_lung_microarray_analysis_heat_map_clustering_DAVID_analysis_and_IHC_validation_/994437", "title"=>"ACDMPV lung microarray analysis: heat map, clustering, DAVID analysis, and IHC validation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-10 02:55:17"}

PMC Usage Stats | Further Information

• {"unique-ip"=>"36", "full-text"=>"44", "pdf"=>"18", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
• {"unique-ip"=>"19", "full-text"=>"36", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
• {"unique-ip"=>"22", "full-text"=>"15", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"22", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
• {"unique-ip"=>"24", "full-text"=>"25", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
• {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
• {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"3", "year"=>"2015", "month"=>"6"}
• {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
• {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
• {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
• {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
• {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
• {"unique-ip"=>"21", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"8", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
• {"unique-ip"=>"25", "full-text"=>"26", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
• {"unique-ip"=>"19", "full-text"=>"23", "pdf"=>"13", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
• {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
• {"unique-ip"=>"47", "full-text"=>"29", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
• {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
• {"unique-ip"=>"27", "full-text"=>"23", "pdf"=>"7", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
• {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
• {"unique-ip"=>"24", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
• {"unique-ip"=>"21", "full-text"=>"16", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
• {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
• {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
• {"unique-ip"=>"12", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
• {"unique-ip"=>"17", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
• {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
• {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
• {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
• {"unique-ip"=>"5", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
• {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
• {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
• {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
• {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
• {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
• {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
• {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
• {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
• {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
• {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
• {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
• {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
• {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
• {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
• {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
• {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
• {"unique-ip"=>"18", "full-text"=>"12", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
• {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
• {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
• {"unique-ip"=>"7", "full-text"=>"14", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
• {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
• {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
• {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
• {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
• {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
• {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
• {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
• {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
• {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
• {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
• {"unique-ip"=>"25", "full-text"=>"28", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
• {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
• {"unique-ip"=>"16", "full-text"=>"21", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
• {"unique-ip"=>"24", "full-text"=>"29", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
• {"unique-ip"=>"7", "full-text"=>"3", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"32", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
• {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"3"}
• {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
• {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
• {"unique-ip"=>"7", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
• {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
• {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
• {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
• {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
• {"unique-ip"=>"13", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
• {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
• {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2021", "month"=>"1"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[285]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[306, 482]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[285]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[289]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[287]}]}

F1000Prime