The Relationship between Total Bilirubin Levels and Total Mortality in Older Adults: The United States National Health and Nutrition Examination Survey (NHANES) 1999-2004
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"The Relationship between Total Bilirubin Levels and Total Mortality in Older Adults: The United States National Health and Nutrition Examination Survey (NHANES) 1999-2004", "type"=>"journal", "authors"=>[{"first_name"=>"Kwok-Leung", "last_name"=>"Ong"}, {"first_name"=>"Matthew A.", "last_name"=>"Allison"}, {"first_name"=>"Bernard M. Y.", "last_name"=>"Cheung"}, {"first_name"=>"Ben J.", "last_name"=>"Wu"}, {"first_name"=>"Philip J.", "last_name"=>"Barter"}, {"first_name"=>"Kerry-Anne", "last_name"=>"Rye"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"372981440", "sgr"=>"84899628727", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"1932-6203", "pmid"=>"24728477", "doi"=>"10.1371/journal.pone.0094479"}, "id"=>"e5847266-c1c8-3135-b186-8a585e548ec4", "abstract"=>"OBJECTIVE: Due to its anti-oxidant and anti-inflammatory properties, bilirubin has been associated with reduced cardiovascular risk. A recent study demonstrated an L-shaped association of pre-treatment total bilirubin levels with total mortality in a statin-treated cohort. We therefore investigated the association of total bilirubin levels with total mortality in a nationally representative sample of older adults from the general population. METHODS: A total of 4,303 participants aged ≥ 60 years from the United States National Health and Nutrition Examination Survey 1999-2004 with mortality data followed up through December 31, 2006 were included in this analysis, with a mean follow-up period of 4.5 years. RESULTS: Participants with total bilirubin levels of 0.1-0.4 mg/dl had the highest mortality rate (19.8%). Compared with participants with total bilirubin levels of 0.5-0.7 mg/dl and in a multivariable regression model, a lower total bilirubin level of 0.1-0.4 mg/dl was associated with higher risk of total mortality (hazard ratios, 1.36; 95% confidence interval, 1.07-1.72; P = 0.012), while higher levels (≥ 0.8 mg/dl) also tended to be associated with higher risk of total mortality, but this did not reach statistical significance (hazard ratios, 1.24; 95% confidence interval, 0.98-1.56; P = 0.072). CONCLUSION: In this nationally representative sample of older adults, the association of total bilirubin levels with total mortality was the highest among those with a level between 0.1 and 0.4 mg/dl. Further studies are needed to investigate whether higher total bilirubin levels could be associated with a higher mortality risk, compared to a level of 0.5-0.7 mg/dl.", "link"=>"http://www.mendeley.com/research/relationship-between-total-bilirubin-levels-total-mortality-older-adults-united-states-national-heal", "reader_count"=>10, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Other"=>2, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Other"=>2, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>3, "Arts and Humanities"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "group_count"=>1}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84899628727"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84899628727?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84899628727&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84899628727&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84899628727", "dc:identifier"=>"SCOPUS_ID:84899628727", "eid"=>"2-s2.0-84899628727", "dc:title"=>"The relationship between total Bilirubin levels and total mortality in older adults: The United States national health and nutrition examination survey (NHANES) 1999-2004", "dc:creator"=>"Ong K.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"9", "prism:issueIdentifier"=>"4", "prism:pageRange"=>nil, "prism:coverDate"=>"2014-04-11", "prism:coverDisplayDate"=>"11 April 2014", "prism:doi"=>"10.1371/journal.pone.0094479", "citedby-count"=>"13", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of New South Wales (UNSW) Australia", "affiliation-city"=>"Sydney", "affiliation-country"=>"Australia"}, {"@_fa"=>"true", "affilname"=>"The University of Sydney", "affiliation-city"=>"Sydney", "affiliation-country"=>"Australia"}], "pubmed-id"=>"24728477", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e94479", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0094479", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"37", "xml_views"=>"12", "html_views"=>"272"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"85"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"84"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"98"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"62"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"68"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"54"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"49"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"68"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"93"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"52"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"80"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"71"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"68"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"57"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"33"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"81"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"87"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"41"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"62"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"61", "xml_views"=>"1", "html_views"=>"54"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"82", "xml_views"=>"2", "html_views"=>"50"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"46", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"25", "xml_views"=>"3", "html_views"=>"226"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"295"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"36", "xml_views"=>"3", "html_views"=>"38"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"79", "xml_views"=>"1", "html_views"=>"45"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"101", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"80", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"67", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"45", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"43"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"48"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1461543"], "description"=>"<p>ACEI  =  angiotensin-converting enzyme inhibitor; ARB  =  angiotensin receptor blocker; BMI  =  body mass index; CCB  =  calcium channel blocker; CI  =  confidence interval; CVD  =  cardiovascular disease; eGFR  =  estimated glomerular filtration rate; HDL  =  high-density lipoprotein; SE  =  standard error.</p><p>Data are expressed as mean or percent (standard error), unless otherwise noted.</p>a<p>Includes bile acid sequestrants, cholesterol adsorption inhibitors, and other types of lipid-lowering medications.</p>b<p>Data are expressed as geometric mean (95% CI).</p>c<p>Estimated from the Cox regression model after adjusted for age, sex, race/ethnicity, and survey period, where appropriate.</p>d<p>Estimates are unreliable due to coefficient of variation > 0.3.</p>", "links"=>[], "tags"=>["epidemiology", "Biomarker epidemiology", "Cardiovascular disease epidemiology", "Clinical epidemiology", "Epidemiology of aging", "Gastroenterology and hepatology", "Liver diseases", "research design", "Cohort studies", "Prospective studies", "united", "states", "older", "adults"], "article_id"=>996660, "categories"=>["Biological Sciences"], "users"=>["Kwok-Leung Ong", "Matthew A. Allison", "Bernard M. Y. Cheung", "Ben J. Wu", "Philip J. Barter", "Kerry-Anne Rye"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094479.t001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_Characteristics_in_United_States_Older_Adults_by_Mortality_Status_1999_8211_2004_/996660", "title"=>"Clinical Characteristics in United States Older Adults by Mortality Status, 1999–2004.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-11 03:25:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/1461540"], "description"=>"<p>CI  =  confidence interval; HR  =  hazard ratio.</p>a<p>Participants with total bilirubin levels of 0.5–0.7 mg/dl were used as the referent group for comparison. All data were adjusted for survey period, age, sex, race/ethnicity, body mass index, education, smoking, regular alcohol consumption, history of cardiovascular disease, diabetes, albuminuria, cancer, fibrates, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, diuretics, calcium channel blockers, high-density lipoprotein cholesterol, serum albumin, blood urea nitrogen, estimated glomerular filtration rate, C-reactive protein, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, uric acid, white blood cell count, and hemoglobin.</p>", "links"=>[], "tags"=>["epidemiology", "Biomarker epidemiology", "Cardiovascular disease epidemiology", "Clinical epidemiology", "Epidemiology of aging", "Gastroenterology and hepatology", "Liver diseases", "research design", "Cohort studies", "Prospective studies", "higher", "bilirubin", "smoking", "united", "states", "older"], "article_id"=>996657, "categories"=>["Biological Sciences"], "users"=>["Kwok-Leung Ong", "Matthew A. Allison", "Bernard M. Y. Cheung", "Ben J. Wu", "Philip J. Barter", "Kerry-Anne Rye"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094479.t004", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Associations_of_Lower_and_Higher_Total_Bilirubin_Levels_With_Total_Mortality_by_Race_ethnicity_and_Smoking_Status_in_United_States_Older_Adults_1999_2004_a_/996657", "title"=>"Associations of Lower and Higher Total Bilirubin Levels With Total Mortality by Race/ethnicity and Smoking Status in United States Older Adults, 1999–2004.<sup>a</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-11 03:25:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/1461539"], "description"=>"<p>The cumulative survival curve for total mortality from the Cox regression model after full adjustment (model 4 of <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0094479#pone-0094479-t003\" target=\"_blank\">Table 3</a>).</p>", "links"=>[], "tags"=>["epidemiology", "Biomarker epidemiology", "Cardiovascular disease epidemiology", "Clinical epidemiology", "Epidemiology of aging", "Gastroenterology and hepatology", "Liver diseases", "research design", "Cohort studies", "Prospective studies", "cumulative", "cox", "regression"], "article_id"=>996656, "categories"=>["Biological Sciences"], "users"=>["Kwok-Leung Ong", "Matthew A. Allison", "Bernard M. Y. Cheung", "Ben J. Wu", "Philip J. Barter", "Kerry-Anne Rye"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094479.g001", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_cumulative_survival_curve_for_total_mortality_from_the_Cox_regression_model_after_full_adjustment_model_4_of_Table_3_/996656", "title"=>"The cumulative survival curve for total mortality from the Cox regression model after full adjustment (model 4 of Table 3).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-11 03:25:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/1461545", "https://ndownloader.figshare.com/files/1461546", "https://ndownloader.figshare.com/files/1461547", "https://ndownloader.figshare.com/files/1461548"], "description"=>"<div><p>Objective</p><p>Due to its anti-oxidant and anti-inflammatory properties, bilirubin has been associated with reduced cardiovascular risk. A recent study demonstrated an L-shaped association of pre-treatment total bilirubin levels with total mortality in a statin-treated cohort. We therefore investigated the association of total bilirubin levels with total mortality in a nationally representative sample of older adults from the general population.</p><p>Methods</p><p>A total of 4,303 participants aged ≥60 years from the United States National Health and Nutrition Examination Survey 1999–2004 with mortality data followed up through December 31, 2006 were included in this analysis, with a mean follow-up period of 4.5 years.</p><p>Results</p><p>Participants with total bilirubin levels of 0.1–0.4 mg/dl had the highest mortality rate (19.8%). Compared with participants with total bilirubin levels of 0.5–0.7 mg/dl and in a multivariable regression model, a lower total bilirubin level of 0.1–0.4 mg/dl was associated with higher risk of total mortality (hazard ratios, 1.36; 95% confidence interval, 1.07–1.72; P = 0.012), while higher levels (≥0.8 mg/dl) also tended to be associated with higher risk of total mortality, but this did not reach statistical significance (hazard ratios, 1.24; 95% confidence interval, 0.98–1.56; P = 0.072).</p><p>Conclusion</p><p>In this nationally representative sample of older adults, the association of total bilirubin levels with total mortality was the highest among those with a level between 0.1 and 0.4 mg/dl. Further studies are needed to investigate whether higher total bilirubin levels could be associated with a higher mortality risk, compared to a level of 0.5–0.7 mg/dl.</p></div>", "links"=>[], "tags"=>["epidemiology", "Biomarker epidemiology", "Cardiovascular disease epidemiology", "Clinical epidemiology", "Epidemiology of aging", "Gastroenterology and hepatology", "Liver diseases", "research design", "Cohort studies", "Prospective studies", "bilirubin", "older", "united", "states", "nutrition"], "article_id"=>996662, "categories"=>["Biological Sciences"], "users"=>["Kwok-Leung Ong", "Matthew A. Allison", "Bernard M. Y. Cheung", "Ben J. Wu", "Philip J. Barter", "Kerry-Anne Rye"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0094479.s001", "https://dx.doi.org/10.1371/journal.pone.0094479.s002", "https://dx.doi.org/10.1371/journal.pone.0094479.s003", "https://dx.doi.org/10.1371/journal.pone.0094479.s004"], "stats"=>{"downloads"=>2, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Relationship_between_Total_Bilirubin_Levels_and_Total_Mortality_in_Older_Adults_The_United_States_National_Health_and_Nutrition_Examination_Survey_NHANES_1999_2004_/996662", "title"=>"The Relationship between Total Bilirubin Levels and Total Mortality in Older Adults: The United States National Health and Nutrition Examination Survey (NHANES) 1999-2004", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-04-11 03:25:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/1461542"], "description"=>"<p>SE  =  standard error.</p>a<p>Unweighted numbers.</p>", "links"=>[], "tags"=>["epidemiology", "Biomarker epidemiology", "Cardiovascular disease epidemiology", "Clinical epidemiology", "Epidemiology of aging", "Gastroenterology and hepatology", "Liver diseases", "research design", "Cohort studies", "Prospective studies", "united", "states", "older"], "article_id"=>996659, "categories"=>["Biological Sciences"], "users"=>["Kwok-Leung Ong", "Matthew A. Allison", "Bernard M. Y. Cheung", "Ben J. Wu", "Philip J. Barter", "Kerry-Anne Rye"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094479.t002", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Percentages_of_Total_Death_in_United_States_Older_Adults_1999_8211_2004_/996659", "title"=>"Percentages of Total Death in United States Older Adults, 1999–2004.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-11 03:25:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/1461541"], "description"=>"<p>HR  =  hazard ratio; CI  =  confidence interval.</p>a<p>Adjusted for survey period, age, sex, and race/ethnicity (n = 4,303).</p>b<p>Further adjusted for body mass index, education, smoking, and regular alcohol consumption (n = 3,928).</p>c<p>Further adjusted for history of cardiovascular disease, diabetes, albuminuria, cancer, fibrates, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, diuretics, and calcium channel blockers (n = 3,764).</p>d<p>Further adjusted for high-density lipoprotein cholesterol, serum albumin, blood urea nitrogen, estimated glomerular filtration rate, C-reactive protein, alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, uric acid, white blood cell count, and hemoglobin (n = 3,758).</p>", "links"=>[], "tags"=>["epidemiology", "Biomarker epidemiology", "Cardiovascular disease epidemiology", "Clinical epidemiology", "Epidemiology of aging", "Gastroenterology and hepatology", "Liver diseases", "research design", "Cohort studies", "Prospective studies", "bilirubin", "united", "states", "older"], "article_id"=>996658, "categories"=>["Biological Sciences"], "users"=>["Kwok-Leung Ong", "Matthew A. Allison", "Bernard M. Y. Cheung", "Ben J. Wu", "Philip J. Barter", "Kerry-Anne Rye"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094479.t003", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_of_Total_Bilirubin_Levels_With_Total_Mortality_in_United_States_Older_Adults_1999_8211_2004_/996658", "title"=>"Association of Total Bilirubin Levels With Total Mortality in United States Older Adults, 1999–2004.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-11 03:25:36"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"32", "full-text"=>"28", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"41", "full-text"=>"44", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"46", "full-text"=>"45", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"37", "full-text"=>"41", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"38", "full-text"=>"39", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"58", "full-text"=>"64", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"55", "full-text"=>"55", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"34", "full-text"=>"36", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"45", "full-text"=>"51", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"38", "full-text"=>"45", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"14", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"26", "full-text"=>"15", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"35", "full-text"=>"34", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"35", "full-text"=>"33", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"48", "full-text"=>"43", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"29", "full-text"=>"30", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"42", "full-text"=>"40", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"60", "full-text"=>"64", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"47", "full-text"=>"50", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"27", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"47", "full-text"=>"44", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"34", "full-text"=>"35", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"29", "full-text"=>"30", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"35", "full-text"=>"39", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"44", "full-text"=>"48", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"49", "full-text"=>"52", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"76", "full-text"=>"82", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"69", "full-text"=>"64", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"53", "full-text"=>"58", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"52", "full-text"=>"52", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"40", "full-text"=>"41", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"63", "full-text"=>"64", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"63", "full-text"=>"69", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"98", "full-text"=>"100", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"113", "full-text"=>"117", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"101", "full-text"=>"107", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"117", "full-text"=>"121", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"103", "full-text"=>"113", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"99", "full-text"=>"101", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"176", "full-text"=>"185", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"171", "full-text"=>"179", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"394", "full-text"=>"418", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"339", "full-text"=>"352", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"230", "full-text"=>"243", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"253", "full-text"=>"264", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"221", "full-text"=>"235", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"220", "full-text"=>"223", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"310", "full-text"=>"323", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"385", "full-text"=>"417", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"323", "full-text"=>"337", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"505", "full-text"=>"527", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"431", "full-text"=>"470", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"479", "full-text"=>"496", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"484", "full-text"=>"503", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"505", "full-text"=>"529", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"347", "full-text"=>"364", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"317", "full-text"=>"338", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Biology and life sciences/Population biology", "average_usage"=>[312, 475]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[285]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[266]}, {"subject_area"=>"/Medicine and health sciences/Cardiology", "average_usage"=>[246]}, {"subject_area"=>"/Medicine and health sciences/Gastroenterology and hepatology", "average_usage"=>[246]}, {"subject_area"=>"/People and places", "average_usage"=>[302]}, {"subject_area"=>"/People and places/Demography", "average_usage"=>[309]}, {"subject_area"=>"/People and places/Population groupings", "average_usage"=>[300]}]}
Loading … Spinner

Net::HTTPTooManyRequests

Source
Scopus
Time
2019-08-27 21:07:07 UTC
Target URL
https://api.elsevier.com/content/search/index:SCOPUS?query=DOI(10.1371%2Fjournal.pone.0094479)
Trace

/app/models/concerns/networkable.rb:21:in `get_result'
/app/models/source.rb:165:in `get_data'
/app/models/retrieval_status.rb:47:in `perform_get_data'
/app/jobs/source_job.rb:52:in `block (2 levels) in perform'
/app/jobs/source_job.rb:51:in `block in perform'
/app/jobs/source_job.rb:35:in `each'
/app/jobs/source_job.rb:35:in `perform'