A Meta-Analysis of the Diagnostic Accuracy of Two Commercial NS1 Antigen ELISA Tests for Early Dengue Virus Detection
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"A meta-analysis of the diagnostic accuracy of two commercial NS1 antigen ELISA tests for early dengue virus detection", "type"=>"journal", "authors"=>[{"first_name"=>"Vivaldo G.", "last_name"=>"Da Costa", "scopus_author_id"=>"55958719200"}, {"first_name"=>"Ariany C.", "last_name"=>"Marques-Silva", "scopus_author_id"=>"56143475800"}, {"first_name"=>"Marcos L.", "last_name"=>"Moreli", "scopus_author_id"=>"6508140376"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84899649255", "issn"=>"19326203", "pui"=>"372981390", "isbn"=>"1932-6203", "sgr"=>"84899649255", "pmid"=>"24728377", "doi"=>"10.1371/journal.pone.0094655"}, "id"=>"1372513c-c95c-3c9b-a3d3-1304a10b8cc3", "abstract"=>"BACKGROUND: Dengue virus (DENV) NS1 antigen detection is regarded as an early diagnostic marker. Accordingly, several studies have evaluated the performance of tests that utilize NS1 capture, but the results of individual studies may be limited due to the restricted sample size of the patients recruited. Therefore, our objective was to perform a meta-analysis of the diagnostic accuracy of two commercial NS1 ELISAs (Panbio and Platelia).\\n\\nMETHODS AND RESULTS: Studies of interest were found in PubMed, Embase and Google Scholar databases using defined inclusion/exclusion criteria. A total of 30 studies containing 12,105 total enrolled patients were included. The results were as follows: 1) Panbio assays showed low overall performance, sensitivity 66% (95% confidence interval (CI) 61-71), specificity 99% (95% CI 96-100), positive likelihood ratio (LR+) 98 (95% CI 20-464), negative likelihood ratio (LR-) 0.3 (95% CI 0.2-0.4), diagnostic odds ratio (DOR) 289 (95% CI 59-1412); 2) Platelia assays showed high overall performance, sensitivity 74% (95% CI 63-82), specificity 99% (95% CI 97-100), LR+ 175 (95% CI 28-1099), LR- 0.3 (95% CI 0.2-0.4), DOR 663 (95% CI 98-4478). The lowest sensitivity values were for secondary infections (57% [95% CI 47-67] and 66% [95% CI 53-77] for Panbio and Platelia, respectively) and for the detection of DENV4. Regarding clinical manifestations, the sensitivity of Platelia was 69% (95% CI 43-86) and 60% (95% CI 48-70) for fever and dengue hemorrhagic fever, respectively. In addition, the sensitivity of both tests was slightly lower for samples from Southeast Asia and Oceania.\\n\\nCONCLUSION: DENV1 samples gave higher sensitivity results for both tests. We observed that factors negatively influencing the tests, such as the type of infection, geographical origins of samples and viral serotypes, require further investigation to optimize the diagnostic accuracy.", "link"=>"http://www.mendeley.com/research/metaanalysis-diagnostic-accuracy-two-commercial-ns1-antigen-elisa-tests-early-dengue-virus-detection", "reader_count"=>66, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>19, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>7, "Student > Master"=>8, "Other"=>1, "Student > Bachelor"=>16, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>19, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>7, "Student > Master"=>8, "Other"=>1, "Student > Bachelor"=>16, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Agricultural and Biological Sciences"=>16, "Philosophy"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Chemistry"=>1, "Computer Science"=>1, "Economics, Econometrics and Finance"=>1, "Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>2, "Mathematics"=>1, "Medicine and Dentistry"=>30, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>30}, "Social Sciences"=>{"Social Sciences"=>1}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Engineering"=>{"Engineering"=>2}, "Chemistry"=>{"Chemistry"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Philosophy"=>{"Philosophy"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Colombia"=>1, "Vietnam"=>1, "Egypt"=>1, "Mexico"=>1, "United Kingdom"=>1}, "group_count"=>6}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84899649255"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84899649255?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84899649255&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84899649255&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84899649255", "dc:identifier"=>"SCOPUS_ID:84899649255", "eid"=>"2-s2.0-84899649255", "dc:title"=>"A meta-analysis of the diagnostic accuracy of two commercial NS1 antigen ELISA tests for early dengue virus detection", "dc:creator"=>"Da Costa V.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"9", "prism:issueIdentifier"=>"4", "prism:pageRange"=>nil, "prism:coverDate"=>"2014-04-11", "prism:coverDisplayDate"=>"11 April 2014", "prism:doi"=>"10.1371/journal.pone.0094655", "citedby-count"=>"13", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Universidade Federal de Goias", "affiliation-city"=>"Goiania", "affiliation-country"=>"Brazil"}], "pubmed-id"=>"24728377", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e94655", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0094655", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"103", "xml_views"=>"5", "html_views"=>"403"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"68", "xml_views"=>"1", "html_views"=>"287"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"33", "xml_views"=>"1", "html_views"=>"172"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"165"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"28", "xml_views"=>"2", "html_views"=>"209"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"154"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"119"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"157"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"167"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"118"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"85"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"83"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"90"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"81"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"77"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"76"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"50"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"76"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"48"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"60"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"44"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"30"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"41"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"52"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"46"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"2", "html_views"=>"31"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"23"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"3", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"24"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"32"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"18"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1461913", "https://ndownloader.figshare.com/files/1461914", "https://ndownloader.figshare.com/files/1461915", "https://ndownloader.figshare.com/files/1461916", "https://ndownloader.figshare.com/files/1461917", "https://ndownloader.figshare.com/files/1461918"], "description"=>"<div><p>Background</p><p>Dengue virus (DENV) NS1 antigen detection is regarded as an early diagnostic marker. Accordingly, several studies have evaluated the performance of tests that utilize NS1 capture, but the results of individual studies may be limited due to the restricted sample size of the patients recruited. Therefore, our objective was to perform a meta-analysis of the diagnostic accuracy of two commercial NS1 ELISAs (Panbio and Platelia).</p><p>Methods and Results</p><p>Studies of interest were found in PubMed, Embase and Google Scholar databases using defined inclusion/exclusion criteria. A total of 30 studies containing 12,105 total enrolled patients were included. The results were as follows: 1) Panbio assays showed low overall performance, sensitivity 66% (95% confidence interval (CI) 61–71), specificity 99% (95% CI 96–100), positive likelihood ratio (LR+) 98 (95% CI 20–464), negative likelihood ratio (LR-) 0.3 (95% CI 0.2–0.4), diagnostic odds ratio (DOR) 289 (95% CI 59–1412); 2) Platelia assays showed high overall performance, sensitivity 74% (95% CI 63–82), specificity 99% (95% CI 97–100), LR+ 175 (95% CI 28–1099), LR- 0.3 (95% CI 0.2–0.4), DOR 663 (95% CI 98–4478). The lowest sensitivity values were for secondary infections (57% [95% CI 47–67] and 66% [95% CI 53–77] for Panbio and Platelia, respectively) and for the detection of DENV4. Regarding clinical manifestations, the sensitivity of Platelia was 69% (95% CI 43–86) and 60% (95% CI 48–70) for fever and dengue hemorrhagic fever, respectively. In addition, the sensitivity of both tests was slightly lower for samples from Southeast Asia and Oceania.</p><p>Conclusion</p><p>DENV1 samples gave higher sensitivity results for both tests. We observed that factors negatively influencing the tests, such as the type of infection, geographical origins of samples and viral serotypes, require further investigation to optimize the diagnostic accuracy.</p></div>", "links"=>[], "tags"=>["microbiology", "Virology", "Diagnostic medicine", "Clinical laboratory sciences", "Infectious diseases", "Viral diseases", "meta-analysis", "diagnostic", "ns1", "antigen", "elisa", "dengue"], "article_id"=>996986, "categories"=>["Biological Sciences"], "users"=>["Vivaldo G. da Costa", "Ariany C. Marques-Silva", "Marcos L. Moreli"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0094655.s001", "https://dx.doi.org/10.1371/journal.pone.0094655.s002", "https://dx.doi.org/10.1371/journal.pone.0094655.s003", "https://dx.doi.org/10.1371/journal.pone.0094655.s004", "https://dx.doi.org/10.1371/journal.pone.0094655.s005", "https://dx.doi.org/10.1371/journal.pone.0094655.s006"], "stats"=>{"downloads"=>17, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_Meta_Analysis_of_the_Diagnostic_Accuracy_of_Two_Commercial_NS1_Antigen_ELISA_Tests_for_Early_Dengue_Virus_Detection_/996986", "title"=>"A Meta-Analysis of the Diagnostic Accuracy of Two Commercial NS1 Antigen ELISA Tests for Early Dengue Virus Detection", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-04-11 03:43:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1461904"], "description"=>"<p>Proportions of studies rated as “yes”, “no”, or “unclear” for each QUADAS item.</p>", "links"=>[], "tags"=>["microbiology", "Virology", "Diagnostic medicine", "Clinical laboratory sciences", "Infectious diseases", "Viral diseases", "methodological", "items", "included"], "article_id"=>996977, "categories"=>["Biological Sciences"], "users"=>["Vivaldo G. da Costa", "Ariany C. Marques-Silva", "Marcos L. Moreli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094655.g002", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_assessment_of_methodological_quality_items_shown_for_all_included_studies_/996977", "title"=>"The assessment of methodological quality items shown for all included studies.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-11 03:43:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1461902"], "description"=>"<p>Flowchart of the steps performed in the meta-analysis.</p>", "links"=>[], "tags"=>["microbiology", "Virology", "Diagnostic medicine", "Clinical laboratory sciences", "Infectious diseases", "Viral diseases", "steps", "performed"], "article_id"=>996975, "categories"=>["Biological Sciences"], "users"=>["Vivaldo G. da Costa", "Ariany C. Marques-Silva", "Marcos L. Moreli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094655.g001", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flowchart_of_the_steps_performed_in_the_meta_analysis_/996975", "title"=>"Flowchart of the steps performed in the meta-analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-11 03:43:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1461912"], "description"=>"<p>Abbreviations: Ref, Reference studies; y, year; Sen., Sensitivity; Spec., Specificity; NR, Not reported; M, Multicenter; HI, Hemagglutination inhibition; ICG, Immunochromatographic; VI, Virus isolation.</p>", "links"=>[], "tags"=>["microbiology", "Virology", "Diagnostic medicine", "Clinical laboratory sciences", "Infectious diseases", "Viral diseases", "included"], "article_id"=>996985, "categories"=>["Biological Sciences"], "users"=>["Vivaldo G. da Costa", "Ariany C. Marques-Silva", "Marcos L. Moreli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094655.t001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_the_included_studies_/996985", "title"=>"Summary of the included studies.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-04-11 03:43:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1461911"], "description"=>"<p>A pre-test probability of 37% for dengue disease was fixed, which was estimated by the number of symptomatic cases in selected studies. (A) Panbio had a post-test probability of 98%. For Platelia kits (B) post-test probability was 99%, ie, with an estimated prevalence of 37%, if this patient tests positive, the post-test probability that she truly has dengue would be 99% (solid line in red). On the other hand, if patient tests negative, the post-test probability that she truly has dengue would be 17% (A) or 13% (B) (blue dotted line). The results were obtained by the following calculations: pretest odds = prevalence/1-prevalence; post-test odds = pretest odds x LR- (LR+); post-test probability = post-test odds/1+post-test odds. LR, likelihood ratio.</p>", "links"=>[], "tags"=>["microbiology", "Virology", "Diagnostic medicine", "Clinical laboratory sciences", "Infectious diseases", "Viral diseases", "nomogram", "post-test"], "article_id"=>996984, "categories"=>["Biological Sciences"], "users"=>["Vivaldo G. da Costa", "Ariany C. Marques-Silva", "Marcos L. Moreli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094655.g005", "stats"=>{"downloads"=>4, "page_views"=>81, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fagan_s_nomogram_for_the_calculation_of_post_test_probabilities_/996984", "title"=>"Fagan's nomogram for the calculation of post-test probabilities.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-11 03:43:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1461908"], "description"=>"<p>Forest plot of the sensitivity of each study and pooled sensitivity for studies that distinguished clinical features of patients infected with DENV into DF (A) and DHF (B). The sensitivity is represented by the circles in squares and the horizontal lines represent the point estimate (95% CI for each included study). Diamonds represent the pooled estimate (95% CI).</p>", "links"=>[], "tags"=>["microbiology", "Virology", "Diagnostic medicine", "Clinical laboratory sciences", "Infectious diseases", "Viral diseases", "platelia"], "article_id"=>996982, "categories"=>["Biological Sciences"], "users"=>["Vivaldo G. da Costa", "Ariany C. Marques-Silva", "Marcos L. Moreli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094655.g004", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Forest_plot_of_the_sensitivity_of_Platelia_kit_/996982", "title"=>"Forest plot of the sensitivity of Platelia kit.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-11 03:43:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/1461906"], "description"=>"<p>Panbio (A) and Platelia (B) kits. The circle diameter (study estimate) is proportional to the weight given to each study. Summary sensitivity and specificity is marked by a red square.</p>", "links"=>[], "tags"=>["microbiology", "Virology", "Diagnostic medicine", "Clinical laboratory sciences", "Infectious diseases", "Viral diseases", "displaying", "diagnostic", "included"], "article_id"=>996979, "categories"=>["Biological Sciences"], "users"=>["Vivaldo G. da Costa", "Ariany C. Marques-Silva", "Marcos L. Moreli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094655.g003", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HSROC_plot_displaying_diagnostic_accuracy_results_of_included_studies_/996979", "title"=>"HSROC plot displaying diagnostic accuracy results of included studies.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-11 03:43:55"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"40", "full-text"=>"43", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"42", "full-text"=>"49", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"78", "full-text"=>"82", "pdf"=>"36", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"22", "full-text"=>"26", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"25", "full-text"=>"25", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"2", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"49", "full-text"=>"42", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"31", "full-text"=>"26", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"26", "full-text"=>"28", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"33", "full-text"=>"31", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"26", "full-text"=>"24", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"25", "full-text"=>"20", "pdf"=>"12", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"31", "full-text"=>"31", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"29", "full-text"=>"25", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"23", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"37", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"8", "cited-by"=>"3", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"21", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"6", "cited-by"=>"2", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"19", "full-text"=>"22", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"14", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"16", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"16", "cited-by"=>"2", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Medicine and health sciences/Diagnostic medicine", "average_usage"=>[257]}, {"subject_area"=>"/Medicine and health sciences/Infectious diseases", "average_usage"=>[319]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[278]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[271]}, {"subject_area"=>"/Physical sciences/Mathematics", "average_usage"=>[286]}]}
Loading … Spinner
There are currently no alerts