A Prospective Cohort Study of Antipsychotic Medications in Pregnancy: The First 147 Pregnancies and 100 One Year Old Babies
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{"title"=>"A prospective cohort study of antipsychotic medications in pregnancy: The first 147 pregnancies and 100 one year old babies", "type"=>"journal", "authors"=>[{"first_name"=>"Jayashri", "last_name"=>"Kulkarni", "scopus_author_id"=>"7005618802"}, {"first_name"=>"Roisin", "last_name"=>"Worsley", "scopus_author_id"=>"55256583600"}, {"first_name"=>"Heather", "last_name"=>"Gilbert", "scopus_author_id"=>"23034261000"}, {"first_name"=>"Emorfia", "last_name"=>"Gavrilidis", "scopus_author_id"=>"23034496300"}, {"first_name"=>"Tamsyn E.", "last_name"=>"Van Rheenen", "scopus_author_id"=>"55631496900"}, {"first_name"=>"Wei", "last_name"=>"Wang", "scopus_author_id"=>"22959032400"}, {"first_name"=>"Kay", "last_name"=>"McCauley", "scopus_author_id"=>"55335369700"}, {"first_name"=>"Paul", "last_name"=>"Fitzgerald", "scopus_author_id"=>"7202233054"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84900442169", "doi"=>"10.1371/journal.pone.0094788", "isbn"=>"1932-6203", "pmid"=>"24787688", "issn"=>"19326203", "scopus"=>"2-s2.0-84900442169", "pui"=>"373072301"}, "id"=>"a89b437d-0227-3663-a868-64ef425f0527", "abstract"=>"BACKGROUND: Many women diagnosed with varying psychiatric disorders take antipsychotic medications during pregnancy. The safety of antipsychotic medications in pregnancy is largely unknown.\\n\\nMETHODS: We established the National Register of Antipsychotic Medications in Pregnancy in 2005. Women who are pregnant and taking an antipsychotic medication are interviewed every 6 weeks during pregnancy and then followed until their babies are one year old. The baby's progress is closely followed for the first year of life.\\n\\nFINDINGS: As of April 18 2012, 147 pregnancies had been followed through to completion. There were 142 live births and data is available for 100 one year old babies. 18% of babies were born preterm, with a higher dose of antipsychotic medication correlating to an increased likelihood of premature delivery; 43% of babies required special care nursery or intensive care after birth; 37% had any degree of respiratory distress and 15% of babies developed withdrawal symptoms. Congenital anomalies were seen in eight babies. Most pregnancies resulted in the birth of live, healthy babies. The use of mood stabilisers or higher doses of antipsychotics during pregnancy increased the likelihood of babies experiencing respiratory distress or admission to Special Care Nursery or Neonatal Intensive Care Units.\\n\\nCONCLUSION: There is a great need for safety and efficacy information about the use of antipsychotic medications in pregnancy. Live, healthy babies are the most common outcome following the use of antipsychotic medication in pregnancy, but clinicians should be particularly mindful of neonatal problems such as respiratory distress.", "link"=>"http://www.mendeley.com/research/prospective-cohort-study-antipsychotic-medications-pregnancy-first-147-pregnancies-100-one-year-old", "reader_count"=>64, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>6, "Student > Doctoral Student"=>9, "Researcher"=>11, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>6, "Student > Master"=>8, "Other"=>5, "Student > Bachelor"=>7, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>6, "Student > Doctoral Student"=>9, "Researcher"=>11, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>6, "Student > Master"=>8, "Other"=>5, "Student > Bachelor"=>7, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Nursing and Health Professions"=>5, "Medicine and Dentistry"=>31, "Agricultural and Biological Sciences"=>2, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>5, "Psychology"=>13, "Social Sciences"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>31}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>4}, "Psychology"=>{"Psychology"=>13}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>5}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>5}}, "reader_count_by_country"=>{"Turkey"=>1, "United States"=>1, "Brazil"=>1, "Australia"=>2, "Spain"=>2}, "group_count"=>5}

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