Faecal Microbiota Composition in Adults Is Associated with the FUT2 Gene Determining the Secretor Status
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{"title"=>"Faecal microbiota composition in adults is associated with the FUT2 gene determining the secretor status", "type"=>"journal", "authors"=>[{"first_name"=>"Pirjo", "last_name"=>"Wacklin", "scopus_author_id"=>"26030696400"}, {"first_name"=>"Jarno", "last_name"=>"Tuimala", "scopus_author_id"=>"6602567598"}, {"first_name"=>"Janne", "last_name"=>"Nikkilä", "scopus_author_id"=>"55969609300"}, {"first_name"=>"Sebastian", "last_name"=>"Tims", "scopus_author_id"=>"26653746200"}, {"first_name"=>"Harri", "last_name"=>"Mäkivuokko", "scopus_author_id"=>"8533230500"}, {"first_name"=>"Noora", "last_name"=>"Alakulppi", "scopus_author_id"=>"6505963288"}, {"first_name"=>"Pia", "last_name"=>"Laine", "scopus_author_id"=>"55221879000"}, {"first_name"=>"Mirjana", "last_name"=>"Rajilic-Stojanovic", "scopus_author_id"=>"16319789000"}, {"first_name"=>"Lars", "last_name"=>"Paulin", "scopus_author_id"=>"7006639820"}, {"first_name"=>"Willem M.", "last_name"=>"De Vos", "scopus_author_id"=>"35495729400"}, {"first_name"=>"Jaana", "last_name"=>"Mättö", "scopus_author_id"=>"55953064000"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84899648332", "doi"=>"10.1371/journal.pone.0094863", "pui"=>"372981533", "pmid"=>"24733310", "scopus"=>"2-s2.0-84899648332", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"fcdce1e9-719e-3b3b-802d-9d50c09b5ce8", "abstract"=>"The human intestine is colonised with highly diverse and individually defined microbiota, which likely has an impact on the host well-being. Drivers of the individual variation in the microbiota compositions are multifactorial and include environmental, host and dietary factors. We studied the impact of the host secretor status, encoded by fucosyltransferase 2 (FUT2) -gene, on the intestinal microbiota composition. Secretor status determines the expression of the ABH and Lewis histo-blood group antigens in the intestinal mucosa. The study population was comprised of 14 non-secretor (FUT2 rs601338 genotype AA) and 57 secretor (genotypes GG and AG) adult individuals of western European descent. Intestinal microbiota was analyzed by PCR-DGGE and for a subset of 12 non-secretor subjects and 12 secretor subjects additionally by the 16S rRNA gene pyrosequencing and the HITChip phylogenetic microarray analysis. All three methods showed distinct clustering of the intestinal microbiota and significant differences in abundances of several taxa representing dominant microbiota between the non-secretors and the secretors as well as between the FUT2 genotypes. In addition, the non-secretors had lower species richness than the secretors. The soft clustering of microbiota into enterotypes (ET) 1 and 3 showed that the non-secretors had a higher probability of belonging to ET1 and the secretors to ET3. Our study shows that secretor status and FUT2 polymorphism are associated with the composition of human intestinal microbiota, and appears thus to be one of the key drivers affecting the individual variation of human intestinal microbiota.", "link"=>"http://www.mendeley.com/research/faecal-microbiota-composition-adults-associated-fut2-gene-determining-secretor-status", "reader_count"=>84, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>4, "Researcher"=>17, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>6, "Student > Master"=>13, "Other"=>6, "Student > Bachelor"=>7, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>2, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>4, "Researcher"=>17, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>6, "Student > Master"=>13, "Other"=>6, "Student > Bachelor"=>7, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>2, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Biochemistry, Genetics and Molecular Biology"=>16, "Nursing and Health Professions"=>3, "Agricultural and Biological Sciences"=>32, "Medicine and Dentistry"=>17, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>2, "Psychology"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>5}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>17}, "Chemistry"=>{"Chemistry"=>2}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>32}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>16}, "Unspecified"=>{"Unspecified"=>6}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Netherlands"=>1, "Austria"=>1, "United States"=>2, "Ireland"=>1, "United Kingdom"=>1, "South Africa"=>1}, "group_count"=>6}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1463973"], "description"=>"<p>The plots are based on the PCR-DGGE analysis with universal primers. The centroids of each group are indicated by triangles. P-values show statistical significance in ANOVA test. The RDA plots of DGGE analysis with the specific bacterial groups are shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0094863#pone.0094863.s001\" target=\"_blank\">Figures S1</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0094863#pone.0094863.s002\" target=\"_blank\">S2</a>.</p>", "links"=>[], "tags"=>["ecology", "Ecological metrics", "microbial ecology", "Computational biology", "Evolutionary biology", "Evolutionary systematics", "phylogenetics", "population genetics", "Genetic polymorphism", "genetics", "microbiology", "Medical microbiology", "Bioassays and physiological analysis", "microarrays", "Gastroenterology and hepatology", "microbiota", "secretors", "non-secretors", "aa", "ag", "gg"], "article_id"=>998888, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Pirjo Wacklin", "Jarno Tuimala", "Janne Nikkilä", "Sebastian Tims", "Harri Mäkivuokko", "Noora Alakulppi", "Pia Laine", "Mirjana Rajilic-Stojanovic", "Lars Paulin", "Willem M. de Vos", "Jaana Mättö"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094863.g001", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RDA_plots_of_dominant_microbiota_composition_in_the_secretors_black_and_the_non_secretors_white_A_and_the_FUT2_genotypes_AA_white_AG_grey_and_GG_black_B_/998888", "title"=>"RDA plots of dominant microbiota composition in the secretors (black) and the non-secretors (white) (A) and the <i>FUT2</i> genotypes, AA (white), AG (grey) and GG (black) (B).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-14 04:00:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1463978"], "description"=>"<p>The statistical significance is indicated for a comparison of the secretors/<i>FUT2</i> genotypes AG and GG to the non-secretors/<i>FUT2</i> genotype AA. The taxa significantly differing in both indicator species analysis and ANOVA test are underlined.</p>", "links"=>[], "tags"=>["ecology", "Ecological metrics", "microbial ecology", "Computational biology", "Evolutionary biology", "Evolutionary systematics", "phylogenetics", "population genetics", "Genetic polymorphism", "genetics", "microbiology", "Medical microbiology", "Bioassays and physiological analysis", "microarrays", "Gastroenterology and hepatology", "abundances", "bacterial", "genera", "trend-like", "differences", "non-secretors", "secretors", "genotypes", "aa", "ag", "gg"], "article_id"=>998893, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Pirjo Wacklin", "Jarno Tuimala", "Janne Nikkilä", "Sebastian Tims", "Harri Mäkivuokko", "Noora Alakulppi", "Pia Laine", "Mirjana Rajilic-Stojanovic", "Lars Paulin", "Willem M. de Vos", "Jaana Mättö"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094863.g003", "stats"=>{"downloads"=>0, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mean_relative_abundances_of_the_bacterial_genera_showing_significant_ANOVA_indicator_species_analysis_p_FUT2_genotypes_AA_n_12_AG_n_7_GG_n_5_/998893", "title"=>"Mean relative abundances of the bacterial genera showing significant (ANOVA/indicator species analysis, p<0.05) or trend-like differences (p<0.09) between the non-secretors (n = 12) and the secretors (n = 12) or between the <i>FUT2</i> genotypes AA (n = 12), AG (n = 7), GG (n = 5).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-14 04:00:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1463976"], "description"=>"<p>Plots are calculated from the relative abundances of taxa obtained by the 16S rRNA gene pyrosequencing. The centroids of each group are indicated by triangles. P-values show statistical significance in ANOVA test.</p>", "links"=>[], "tags"=>["ecology", "Ecological metrics", "microbial ecology", "Computational biology", "Evolutionary biology", "Evolutionary systematics", "phylogenetics", "population genetics", "Genetic polymorphism", "genetics", "microbiology", "Medical microbiology", "Bioassays and physiological analysis", "microarrays", "Gastroenterology and hepatology", "microbiota", "non-secretors", "secretors", "aa", "ag", "gg"], "article_id"=>998891, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Pirjo Wacklin", "Jarno Tuimala", "Janne Nikkilä", "Sebastian Tims", "Harri Mäkivuokko", "Noora Alakulppi", "Pia Laine", "Mirjana Rajilic-Stojanovic", "Lars Paulin", "Willem M. de Vos", "Jaana Mättö"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094863.g002", "stats"=>{"downloads"=>2, "page_views"=>28, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RDA_plots_of_microbiota_composition_in_the_non_secretors_white_and_the_secretors_black_A_and_among_FUT2_genotypes_AA_white_AG_grey_and_GG_black_B_/998891", "title"=>"RDA plots of microbiota composition in the non-secretors (white) and the secretors (black) (A) and among <i>FUT2</i> genotypes, AA (white), AG (grey) and GG (black) (B).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-14 04:00:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1463985", "https://ndownloader.figshare.com/files/1463986", "https://ndownloader.figshare.com/files/1463987", "https://ndownloader.figshare.com/files/1463988", "https://ndownloader.figshare.com/files/1463989", "https://ndownloader.figshare.com/files/1463990", "https://ndownloader.figshare.com/files/1463991", "https://ndownloader.figshare.com/files/1463992", "https://ndownloader.figshare.com/files/1463993", "https://ndownloader.figshare.com/files/1463994", "https://ndownloader.figshare.com/files/1463995", "https://ndownloader.figshare.com/files/1463996", "https://ndownloader.figshare.com/files/1463997", "https://ndownloader.figshare.com/files/1463998", "https://ndownloader.figshare.com/files/1463999", "https://ndownloader.figshare.com/files/1464000", "https://ndownloader.figshare.com/files/1464001", "https://ndownloader.figshare.com/files/1464002"], "description"=>"<div><p>The human intestine is colonised with highly diverse and individually defined microbiota, which likely has an impact on the host well-being. Drivers of the individual variation in the microbiota compositions are multifactorial and include environmental, host and dietary factors. We studied the impact of the host secretor status, encoded by <i>fucosyltransferase 2</i> (<i>FUT2</i>) -gene, on the intestinal microbiota composition. Secretor status determines the expression of the ABH and Lewis histo-blood group antigens in the intestinal mucosa. The study population was comprised of 14 non-secretor (<i>FUT2</i> rs601338 genotype AA) and 57 secretor (genotypes GG and AG) adult individuals of western European descent. Intestinal microbiota was analyzed by PCR-DGGE and for a subset of 12 non-secretor subjects and 12 secretor subjects additionally by the 16S rRNA gene pyrosequencing and the HITChip phylogenetic microarray analysis. All three methods showed distinct clustering of the intestinal microbiota and significant differences in abundances of several taxa representing dominant microbiota between the non-secretors and the secretors as well as between the <i>FUT2</i> genotypes. In addition, the non-secretors had lower species richness than the secretors. The soft clustering of microbiota into enterotypes (ET) 1 and 3 showed that the non-secretors had a higher probability of belonging to ET1 and the secretors to ET3. Our study shows that secretor status and <i>FUT2</i> polymorphism are associated with the composition of human intestinal microbiota, and appears thus to be one of the key drivers affecting the individual variation of human intestinal microbiota.</p></div>", "links"=>[], "tags"=>["ecology", "Ecological metrics", "microbial ecology", "Computational biology", "Evolutionary biology", "Evolutionary systematics", "phylogenetics", "population genetics", "Genetic polymorphism", "genetics", "microbiology", "Medical microbiology", "Bioassays and physiological analysis", "microarrays", "Gastroenterology and hepatology", "faecal", "microbiota", "adults", "determining", "secretor"], "article_id"=>998900, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Pirjo Wacklin", "Jarno Tuimala", "Janne Nikkilä", "Sebastian Tims", "Harri Mäkivuokko", "Noora Alakulppi", "Pia Laine", "Mirjana Rajilic-Stojanovic", "Lars Paulin", "Willem M. de Vos", "Jaana Mättö"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0094863.s001", "https://dx.doi.org/10.1371/journal.pone.0094863.s002", "https://dx.doi.org/10.1371/journal.pone.0094863.s003", "https://dx.doi.org/10.1371/journal.pone.0094863.s004", "https://dx.doi.org/10.1371/journal.pone.0094863.s005", "https://dx.doi.org/10.1371/journal.pone.0094863.s006", "https://dx.doi.org/10.1371/journal.pone.0094863.s007", "https://dx.doi.org/10.1371/journal.pone.0094863.s008", "https://dx.doi.org/10.1371/journal.pone.0094863.s009", "https://dx.doi.org/10.1371/journal.pone.0094863.s010", "https://dx.doi.org/10.1371/journal.pone.0094863.s011", "https://dx.doi.org/10.1371/journal.pone.0094863.s012", "https://dx.doi.org/10.1371/journal.pone.0094863.s013", "https://dx.doi.org/10.1371/journal.pone.0094863.s014", "https://dx.doi.org/10.1371/journal.pone.0094863.s015", "https://dx.doi.org/10.1371/journal.pone.0094863.s016", "https://dx.doi.org/10.1371/journal.pone.0094863.s017", "https://dx.doi.org/10.1371/journal.pone.0094863.s018"], "stats"=>{"downloads"=>32, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Faecal_Microbiota_Composition_in_Adults_Is_Associated_with_the_FUT2_Gene_Determining_the_Secretor_Status/998900", "title"=>"Faecal Microbiota Composition in Adults Is Associated with the <i>FUT2</i> Gene Determining the Secretor Status", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-04-14 04:00:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/1463980"], "description"=>"<p>The RDA plots were based on genus-like/level 2 intensities of HITChip analysis. The centroids of each group are indicated by triangles. P-values show statistical significance in ANOVA test.</p>", "links"=>[], "tags"=>["ecology", "Ecological metrics", "microbial ecology", "Computational biology", "Evolutionary biology", "Evolutionary systematics", "phylogenetics", "population genetics", "Genetic polymorphism", "genetics", "microbiology", "Medical microbiology", "Bioassays and physiological analysis", "microarrays", "Gastroenterology and hepatology", "rda", "microbiota", "non-secretors", "secretors", "individuals", "aa", "ag", "gg"], "article_id"=>998895, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Pirjo Wacklin", "Jarno Tuimala", "Janne Nikkilä", "Sebastian Tims", "Harri Mäkivuokko", "Noora Alakulppi", "Pia Laine", "Mirjana Rajilic-Stojanovic", "Lars Paulin", "Willem M. de Vos", "Jaana Mättö"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094863.g004", "stats"=>{"downloads"=>0, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_RDA_plots_of_microbiota_composition_in_the_non_secretors_white_and_the_secretors_black_A_and_among_the_individuals_with_FUT2_genotypes_AA_white_AG_grey_and_GG_black_B_/998895", "title"=>"The RDA plots of microbiota composition in the non-secretors (white) and the secretors (black) (A) and among the individuals with <i>FUT2</i> genotypes, AA (white), AG (grey) and GG (black) (B).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-04-14 04:00:43"}

PMC Usage Stats | Further Information

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Relative Metric

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