Evaluation Physical Characteristics and Comparison Antimicrobial and Anti-Inflammation Potentials of Dental Root Canal Sealers Containing Hinokitiol In Vitro
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{"title"=>"Evaluation physical characteristics and comparison antimicrobial and anti-inflammation potentials of dental root canal sealers containing hinokitiol in vitro", "type"=>"journal", "authors"=>[{"first_name"=>"Yin Hua", "last_name"=>"Shih", "scopus_author_id"=>"8532139500"}, {"first_name"=>"Dan Jae", "last_name"=>"Lin", "scopus_author_id"=>"35319861400"}, {"first_name"=>"Kuo Wei", "last_name"=>"Chang", "scopus_author_id"=>"7404878414"}, {"first_name"=>"Shih Min", "last_name"=>"Hsia", "scopus_author_id"=>"13409857600"}, {"first_name"=>"Shun Yao", "last_name"=>"Ko", "scopus_author_id"=>"7403325389"}, {"first_name"=>"Shyh Yuan", "last_name"=>"Lee", "scopus_author_id"=>"7601410722"}, {"first_name"=>"Shui Sang", "last_name"=>"Hsue", "scopus_author_id"=>"15750424000"}, {"first_name"=>"Tong Hong", "last_name"=>"Wang", "scopus_author_id"=>"56209070600"}, {"first_name"=>"Yi Ling", "last_name"=>"Chen", "scopus_author_id"=>"56209319400"}, {"first_name"=>"Tzong Ming", "last_name"=>"Shieh", "scopus_author_id"=>"7006148228"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84902596808", "doi"=>"10.1371/journal.pone.0094941", "sgr"=>"84902596808", "pmid"=>"24915566", "issn"=>"19326203", "pui"=>"373337791"}, "id"=>"092e6cc2-cf2f-3093-9add-458e0219f4b9", "abstract"=>"Hinokitiol displays potent antimicrobial activity. It has been used in toothpaste and oral-care gel to improve the oral lichen planus and reduce halitosis. The aim of this study was to evaluate the antimicrobial activity of 3 different dental root canal sealers with hinokitiol (sealers+H) and their physical and biological effects. AH Plus (epoxy amine resin-based, AH), Apexit Plus (calcium-hydroxide-based, AP), and Canals (zinc-oxide-eugenol-based, CA), were used in this study. The original AH and CA exhibited strong anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity, but AP did not. The setting time, working time, flowability, film thickness, and solubility of each sealer+0.2%H complied with ISO 6876:2001. CA+0.2%H exhibited high cytotoxicity, but the others sealers+0.2%H did not. Because hinokitiol combined with Zn2+ in CA creates a synergistic effect. The physical tests of AP+0.5%-1%H complied with ISO 6876:2001, improved antimicrobial activity, inhibited inflammation genes cyclooxygenase-2 (COX-2) and hypoxia-inducible factor-1alpha (HIF-1alpha) mRNA in MG-63 cells and human gingival fibroblasts (HGF), and down-regulated lysyl oxidase (LOX) mRNA of HGF. In summary, AH and CA demonstrated strong antimicrobial activity, but AP did not. Application of hinokitiol increases AH anti-MRSA activity should less than 0.2% for keep well flowability. AP+0.5%-1% hinokitiol exhibited strong physical, antibacterial, and anti-inflammation potentials, and inhibited S. aureus abscess formation. Applying an appreciable proportion of hinokitiol to epoxy-amine-resin-based and calcium-hydroxide-based root canal sealers is warranted, but the enhanced cytotoxicity and synergistic effect must be considered.", "link"=>"http://www.mendeley.com/research/evaluation-physical-characteristics-comparison-antimicrobial-antiinflammation-potentials-dental-root", "reader_count"=>18, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Materials Science"=>2, "Medicine and Dentistry"=>9, "Agricultural and Biological Sciences"=>1, "Arts and Humanities"=>1, "Business, Management and Accounting"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1528600"], "description"=>"<p>Bacterial growth curves after hinokitiol treatment for 24<i>A. actinomycetemcomitans</i> (Aa), and <i>S. mutans</i> (Sm). The y-axis is OD 600, and the x-axis is time (secs). Vehicle (0.1% DMSO) and 20 µg/mL hinokitiol (20 µg/mL H) were tested. Three independent experiments were performed in triplicate.</p>", "links"=>[], "tags"=>["biotechnology", "biomaterials", "cell biology", "Molecular cell biology", "immunology", "Immune response", "inflammation", "immunity", "microbiology", "Microbial control", "Clinical medicine", "Complementary and alternative medicine", "Oral medicine", "Oral diseases", "Materials Science", "Materials physics", "inhibited", "bacterial"], "article_id"=>1052141, "categories"=>["Biological Sciences"], "users"=>["Yin-Hua Shih", "Dan-Jae Lin", "Kuo-Wei Chang", "Shih-Min Hsia", "Shun-Yao Ko", "Shyh-Yuan Lee", "Shui-Sang Hsue", "Tong-Hong Wang", "Yi-Ling Chen", "Tzong-Ming Shieh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094941.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hinokitiol_inhibited_oral_bacterial_growth_/1052141", "title"=>"Hinokitiol inhibited oral bacterial growth.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-10 03:00:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1528614"], "description"=>"<p>Commercial dental sealer components list.</p>", "links"=>[], "tags"=>["biotechnology", "biomaterials", "cell biology", "Molecular cell biology", "immunology", "Immune response", "inflammation", "immunity", "microbiology", "Microbial control", "Clinical medicine", "Complementary and alternative medicine", "Oral medicine", "Oral diseases", "Materials Science", "Materials physics", "dental", "sealer", "components"], "article_id"=>1052155, "categories"=>["Biological Sciences"], "users"=>["Yin-Hua Shih", "Dan-Jae Lin", "Kuo-Wei Chang", "Shih-Min Hsia", "Shun-Yao Ko", "Shyh-Yuan Lee", "Shui-Sang Hsue", "Tong-Hong Wang", "Yi-Ling Chen", "Tzong-Ming Shieh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094941.t001", "stats"=>{"downloads"=>6, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Commercial_dental_sealer_components_list_/1052155", "title"=>"Commercial dental sealer components list.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-10 03:00:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1528613"], "description"=>"<p>Entries are mean values with standard deviations in parentheses, and sample size (Mean (SD)). An unpaired <i>t</i> test was used to determine significant differences of the physical characteristics among the sealers contained various hinokitiol dosages in each group. The sample size of each group were 3 to 10. The asterisk indicates <i>P</i><0.05, the double asterisk indicates <i>P</i><0.01, and the triple asterisk indicates <i>P</i><0.001.</p>", "links"=>[], "tags"=>["biotechnology", "biomaterials", "cell biology", "Molecular cell biology", "immunology", "Immune response", "inflammation", "immunity", "microbiology", "Microbial control", "Clinical medicine", "Complementary and alternative medicine", "Oral medicine", "Oral diseases", "Materials Science", "Materials physics", "sealers", "contained", "hinokitiol"], "article_id"=>1052154, "categories"=>["Biological Sciences"], "users"=>["Yin-Hua Shih", "Dan-Jae Lin", "Kuo-Wei Chang", "Shih-Min Hsia", "Shun-Yao Ko", "Shyh-Yuan Lee", "Shui-Sang Hsue", "Tong-Hong Wang", "Yi-Ling Chen", "Tzong-Ming Shieh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094941.t002", "stats"=>{"downloads"=>4, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Physical_tests_of_the_sealers_contained_0_2_hinokitiol_Mean_SD_/1052154", "title"=>"Physical tests of the sealers contained 0.2% hinokitiol (Mean (SD)).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-10 03:00:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1528608"], "description"=>"<p>(A) MTT test analysis of the cytotoxicity of extraction of the sealers (AP and AP+0.2%–2%H) conditional medium treated to MG-63 for 24 h (left panel), 3-days (middle panel), and 7-days (right panel). Two folds serial dilution of these conditional media (0%, 25%, 50%, and 100%) were tested. Three independent experiments were performed in triplicate.</p>", "links"=>[], "tags"=>["biotechnology", "biomaterials", "cell biology", "Molecular cell biology", "immunology", "Immune response", "inflammation", "immunity", "microbiology", "Microbial control", "Clinical medicine", "Complementary and alternative medicine", "Oral medicine", "Oral diseases", "Materials Science", "Materials physics", "apexit", "containing", "hinokitiol"], "article_id"=>1052149, "categories"=>["Biological Sciences"], "users"=>["Yin-Hua Shih", "Dan-Jae Lin", "Kuo-Wei Chang", "Shih-Min Hsia", "Shun-Yao Ko", "Shyh-Yuan Lee", "Shui-Sang Hsue", "Tong-Hong Wang", "Yi-Ling Chen", "Tzong-Ming Shieh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094941.g005", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cytotoxicity_of_Apexit_Plus_containing_0_2_8211_2_hinokitiol_were_increased_by_time_and_dose_/1052149", "title"=>"Cytotoxicity of Apexit Plus containing 0.2%–2% hinokitiol were increased by time and dose.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-10 03:00:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1528604"], "description"=>"<p>(A) Agar diffusion test analysis of anti-MRSA activity of the sealers (AH, AP, CA, AH+0.2%H, AP+0.2%H, and CA+0.2%H). Dot line, the diameter of the specimen (5 mm); column, mean of more than triplicate analysis; bars, SE. (B) Direct contact test analysis of the effect of close contact between test bacteria and the sealers on the kinetics of bacterial outgrowth. Control was normal MRSA growth, A was Group A (with sealers in the wells), and B was Group B (transfer 15 µl TSB from Group A and without sealers in the wells). Unpaired <i>t</i> test. Significant difference between the different based sealers marked as “*”, and between the sealer and sealer+0.2%H marked as “#”. **, <i>P</i><0.01; *** or ###, <i>P</i><0.001.</p>", "links"=>[], "tags"=>["biotechnology", "biomaterials", "cell biology", "Molecular cell biology", "immunology", "Immune response", "inflammation", "immunity", "microbiology", "Microbial control", "Clinical medicine", "Complementary and alternative medicine", "Oral medicine", "Oral diseases", "Materials Science", "Materials physics", "apexit", "hinokitiol", "canals"], "article_id"=>1052145, "categories"=>["Biological Sciences"], "users"=>["Yin-Hua Shih", "Dan-Jae Lin", "Kuo-Wei Chang", "Shih-Min Hsia", "Shun-Yao Ko", "Shyh-Yuan Lee", "Shui-Sang Hsue", "Tong-Hong Wang", "Yi-Ling Chen", "Tzong-Ming Shieh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094941.g003", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Anti_MRSA_activity_of_AH_Plus_and_Apexit_Plus_contain_0_2_hinokitiol_were_increased_but_Canals_contain_0_2_hinokitiol_was_not_/1052145", "title"=>"Anti-MRSA activity of AH Plus and Apexit Plus contain 0.2% hinokitiol were increased, but Canals contain 0.2% hinokitiol was not.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-10 03:00:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1528601"], "description"=>"<p>The MG-63 were treated with the extract of the sealers (AH, AP, CA, AH+0.2%H, AP+0.2%H, and CA+0.2%H) conditional medium for 24 h, and the cytotoxicity was analyzed by MTT test. Two folds serial dilution of these conditional media (0%, 25%, 50%, and 100%) were tested. Three independent experiments were performed in triplicate. Unpaired <i>t</i> test. Significant difference between the different based sealers marked as “*”, and between the sealer and sealer+0.2%H marked as “#”. * or #, <i>P</i><0.05; **, <i>P</i><0.01; ###, <i>P</i><0.001.</p>", "links"=>[], "tags"=>["biotechnology", "biomaterials", "cell biology", "Molecular cell biology", "immunology", "Immune response", "inflammation", "immunity", "microbiology", "Microbial control", "Clinical medicine", "Complementary and alternative medicine", "Oral medicine", "Oral diseases", "Materials Science", "Materials physics", "dental", "canal", "sealers", "hinokitiol"], "article_id"=>1052142, "categories"=>["Biological Sciences"], "users"=>["Yin-Hua Shih", "Dan-Jae Lin", "Kuo-Wei Chang", "Shih-Min Hsia", "Shun-Yao Ko", "Shyh-Yuan Lee", "Shui-Sang Hsue", "Tong-Hong Wang", "Yi-Ling Chen", "Tzong-Ming Shieh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094941.g002", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cytotoxicity_of_dental_canal_sealers_contain_0_2_hinokitiol_were_increased_/1052142", "title"=>"Cytotoxicity of dental canal sealers contain 0.2% hinokitiol were increased.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-10 03:00:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1528616"], "description"=>"<div><p>Hinokitiol displays potent antimicrobial activity. It has been used in toothpaste and oral-care gel to improve the oral lichen planus and reduce halitosis. The aim of this study was to evaluate the antimicrobial activity of 3 different dental root canal sealers with hinokitiol (sealers+H) and their physical and biological effects. AH Plus (epoxy amine resin-based, AH), Apexit Plus (calcium-hydroxide-based, AP), and Canals (zinc-oxide-eugenol-based, CA), were used in this study. The original AH and CA exhibited strong anti-methicillin-resistant <i>Staphylococcus aureus</i> (anti-MRSA) activity, but AP did not. The setting time, working time, flowability, film thickness, and solubility of each sealer+0.2%H complied with ISO 6876:2001. CA+0.2%H exhibited high cytotoxicity, but the others sealers+0.2%H did not. Because hinokitiol combined with Zn<sup>2+</sup> in CA creates a synergistic effect. The physical tests of AP+0.5%–1%H complied with ISO 6876:2001, improved antimicrobial activity, inhibited inflammation genes <i>cyclooxygenase-2</i> (COX-2) and <i>hypoxia-inducible factor-1α</i> (HIF-1α) mRNA in MG-63 cells and human gingival fibroblasts (HGF), and down-regulated <i>lysyl oxidase</i> (LOX) mRNA of HGF. In summary, AH and CA demonstrated strong antimicrobial activity, but AP did not. Application of hinokitiol increases AH anti-MRSA activity should less than 0.2% for keep well flowability. AP+0.5%–1% hinokitiol exhibited strong physical, antibacterial, and anti-inflammation potentials, and inhibited <i>S. aureus</i> abscess formation. Applying an appreciable proportion of hinokitiol to epoxy-amine-resin-based and calcium-hydroxide-based root canal sealers is warranted, but the enhanced cytotoxicity and synergistic effect must be considered.</p></div>", "links"=>[], "tags"=>["biotechnology", "biomaterials", "cell biology", "Molecular cell biology", "immunology", "Immune response", "inflammation", "immunity", "microbiology", "Microbial control", "Clinical medicine", "Complementary and alternative medicine", "Oral medicine", "Oral diseases", "Materials Science", "Materials physics", "antimicrobial", "anti-inflammation", "potentials", "dental", "canal", "sealers", "containing", "hinokitiol"], "article_id"=>1052156, "categories"=>["Biological Sciences"], "users"=>["Yin-Hua Shih", "Dan-Jae Lin", "Kuo-Wei Chang", "Shih-Min Hsia", "Shun-Yao Ko", "Shyh-Yuan Lee", "Shui-Sang Hsue", "Tong-Hong Wang", "Yi-Ling Chen", "Tzong-Ming Shieh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094941", "stats"=>{"downloads"=>3, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Evaluation_Physical_Characteristics_and_Comparison_Antimicrobial_and_Anti_Inflammation_Potentials_of_Dental_Root_Canal_Sealers_Containing_Hinokitiol_In_Vitro_/1052156", "title"=>"Evaluation Physical Characteristics and Comparison Antimicrobial and Anti-Inflammation Potentials of Dental Root Canal Sealers Containing Hinokitiol <i>In Vitro</i>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-10 03:00:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1528612"], "description"=>"<p>Entries are mean values with standard deviations in parentheses, and sample size (Mean (SD)). An unpaired <i>t</i> test was used to determine significant differences of the physical characteristics among the sealers contained various hinokitiol dosages in each group. The sample size of each group were 3 to 8. AP was control (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0094941#pone-0094941-t002\" target=\"_blank\">Table 2</a>). The asterisk indicates <i>P</i><0.05, the double asterisk indicates <i>P</i><0.01, and the triple asterisk indicates <i>P</i><0.001.</p>", "links"=>[], "tags"=>["biotechnology", "biomaterials", "cell biology", "Molecular cell biology", "immunology", "Immune response", "inflammation", "immunity", "microbiology", "Microbial control", "Clinical medicine", "Complementary and alternative medicine", "Oral medicine", "Oral diseases", "Materials Science", "Materials physics", "ap", "contained", "hinokitiol"], "article_id"=>1052153, "categories"=>["Biological Sciences"], "users"=>["Yin-Hua Shih", "Dan-Jae Lin", "Kuo-Wei Chang", "Shih-Min Hsia", "Shun-Yao Ko", "Shyh-Yuan Lee", "Shui-Sang Hsue", "Tong-Hong Wang", "Yi-Ling Chen", "Tzong-Ming Shieh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094941.t003", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Physical_tests_of_the_AP_contained_0_5_8211_2_hinokitiol_Mean_SD_/1052153", "title"=>"Physical tests of the AP contained 0.5%–2% hinokitiol (Mean (SD)).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-10 03:00:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1528610"], "description"=>"<p>(A) Agar diffusion test analysis of anti-MRSA activity of the sealers (AP, AP+0.2%–2%H). Dot line, the diameter of the specimen (5 mm); column, mean of triplicate analysis; bars, SE. (C) Direct contact test analysis of the effect of close contact between test bacteria and the sealers on the kinetics of bacterial outgrowth. A was Group A (with AP+0.2%–2%H in the wells), and B was Group B (transfer 15 µl TSB from Group A and without sealers in the wells). Unpaired <i>t</i> test. **, <i>P</i><0.01; ***, <i>P</i><0.001.</p>", "links"=>[], "tags"=>["biotechnology", "biomaterials", "cell biology", "Molecular cell biology", "immunology", "Immune response", "inflammation", "immunity", "microbiology", "Microbial control", "Clinical medicine", "Complementary and alternative medicine", "Oral medicine", "Oral diseases", "Materials Science", "Materials physics", "apexit", "containing", "hinokitiol"], "article_id"=>1052151, "categories"=>["Biological Sciences"], "users"=>["Yin-Hua Shih", "Dan-Jae Lin", "Kuo-Wei Chang", "Shih-Min Hsia", "Shun-Yao Ko", "Shyh-Yuan Lee", "Shui-Sang Hsue", "Tong-Hong Wang", "Yi-Ling Chen", "Tzong-Ming Shieh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094941.g006", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Anti_MRSA_activity_of_Apexit_Plus_containing_0_2_8211_2_hinokitiol_were_increased_/1052151", "title"=>"Anti-MRSA activity of Apexit Plus containing 0.2%–2% hinokitiol were increased.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-10 03:00:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1528611"], "description"=>"<p>(A) The COX-2, HIF-1α, and LOX mRNA expression in MG-63 and HGF after AP, AP+0.5%H, and AP+1%H conditional medium incubated for 24 h. A normal cell culture conditional medium was used for the control. The COX-2, HIF-1α, LOX, and GAPDH expressions of MG-63 are shown in the left panel and of HGF are shown in the right panel. (B) Semi-quantitative the genes mRNA expression ratio to control in MG-63 and HGF cells. Three independent experiments were performed in triplicate. Column, mean of triplicate analysis; bars, SE. Unpaired <i>t</i> test. *, <i>P</i><0.05; **, <i>P</i><0.01; ***, <i>P</i><0.001.</p>", "links"=>[], "tags"=>["biotechnology", "biomaterials", "cell biology", "Molecular cell biology", "immunology", "Immune response", "inflammation", "immunity", "microbiology", "Microbial control", "Clinical medicine", "Complementary and alternative medicine", "Oral medicine", "Oral diseases", "Materials Science", "Materials physics", "abscess", "apexit", "containing", "hinokitiol"], "article_id"=>1052152, "categories"=>["Biological Sciences"], "users"=>["Yin-Hua Shih", "Dan-Jae Lin", "Kuo-Wei Chang", "Shih-Min Hsia", "Shun-Yao Ko", "Shyh-Yuan Lee", "Shui-Sang Hsue", "Tong-Hong Wang", "Yi-Ling Chen", "Tzong-Ming Shieh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094941.g007", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Anti_inflammation_and_anti_S_aureus_abscess_formation_potential_of_Apexit_Plus_containing_0_5_1_hinokitiol_were_increased_/1052152", "title"=>"Anti-inflammation and anti-<i>S. aureus</i> abscess formation potential of Apexit Plus containing 0.5%–1% hinokitiol were increased.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-10 03:00:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1528606"], "description"=>"<p>(A) MTT test analysis of the cytotoxicity of hinokitiol (H), CaCl<sub>2</sub>, and ZnO treated to MG-63 for 24 h. Vehicle (0.1% DMSO) and test compounds (6.25 µM-400 µM) were tested. Three independent experiments were performed in triplicate. (B) MTT test analysis of the cytotoxicity of combined various dosages of H:CaCl<sub>2</sub>, and H:ZnO to MG-63. Column, mean of more than triplicate analysis; bars, SE. (C) Logarithmic combination index plot for combo of H+CaCl<sub>2</sub>, and H+ZnO. Unpaired <i>t</i> test. *, <i>P</i><0.05; ***, <i>P</i><0.001.</p>", "links"=>[], "tags"=>["biotechnology", "biomaterials", "cell biology", "Molecular cell biology", "immunology", "Immune response", "inflammation", "immunity", "microbiology", "Microbial control", "Clinical medicine", "Complementary and alternative medicine", "Oral medicine", "Oral diseases", "Materials Science", "Materials physics", "hinokitiol", "zno", "created"], "article_id"=>1052147, "categories"=>["Biological Sciences"], "users"=>["Yin-Hua Shih", "Dan-Jae Lin", "Kuo-Wei Chang", "Shih-Min Hsia", "Shun-Yao Ko", "Shyh-Yuan Lee", "Shui-Sang Hsue", "Tong-Hong Wang", "Yi-Ling Chen", "Tzong-Ming Shieh"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0094941.g004", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Combined_hinokitiol_and_ZnO_treatment_created_strong_synergism_/1052147", "title"=>"Combined hinokitiol and ZnO treatment created strong synergism.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-10 03:00:20"}

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