Fatty Acid Amide Hydrolase (FAAH) Inhibitors Exert Pharmacological Effects, but Lack Antinociceptive Efficacy in Rats with Neuropathic Spinal Cord Injury Pain
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{"title"=>"Fatty acid amide hydrolase (FAAH) inhibitors exert pharmacological effects, but lack antinociceptive efficacy in rats with neuropathic spinal cord injury pain", "type"=>"journal", "authors"=>[{"first_name"=>"Aldric T.", "last_name"=>"Hama", "scopus_author_id"=>"7004243858"}, {"first_name"=>"Peter", "last_name"=>"Germano", "scopus_author_id"=>"56157078900"}, {"first_name"=>"Matthew S.", "last_name"=>"Varghese", "scopus_author_id"=>"54886339000"}, {"first_name"=>"Benjamin F.", "last_name"=>"Cravatt", "scopus_author_id"=>"35474391200"}, {"first_name"=>"G. Todd", "last_name"=>"Milne", "scopus_author_id"=>"56212149800"}, {"first_name"=>"James P.", "last_name"=>"Pearson", "scopus_author_id"=>"37038316100"}, {"first_name"=>"Jacqueline", "last_name"=>"Sagen", "scopus_author_id"=>"7005695783"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84900406775", "doi"=>"10.1371/journal.pone.0096396", "pui"=>"373071828", "issn"=>"19326203", "pmid"=>"24788435", "isbn"=>"1932-6203", "sgr"=>"84900406775"}, "id"=>"368dd601-a787-3e3f-983d-37a4c136eb85", "abstract"=>"Amelioration of neuropathic spinal cord injury (SCI) pain is a clinical challenge. Increasing the endocannabinoid anandamide and other fatty acid amides (FAA) by blocking fatty acid amide hydrolase (FAAH) has been shown to be antinociceptive in a number of animal models of chronic pain. However, an antinociceptive effect of blocking FAAH has yet to be demonstrated in a rat model of neuropathic SCI pain. Four weeks following a SCI, rats developed significantly decreased hind paw withdrawal thresholds, indicative of below-level cutaneous hypersensitivity. A group of SCI rats were systemically treated (i.p.) with either the selective FAAH inhibitor URB597 or vehicle twice daily for seven days. A separate group of SCI rats received a single dose (p.o.) of either the selective FAAH inhibitor PF-3845 or vehicle. Following behavioral testing, levels of the FAA N-arachidonoylethanolamide, N-oleoyl ethanolamide and N-palmitoyl ethanolamide were quantified in brain and spinal cord from SCI rats. Four weeks following SCI, FAA levels were markedly reduced in spinal cord tissue. Although systemic treatment with URB597 significantly increased CNS FAA levels, no antinociceptive effect was observed. A significant elevation of CNS FAA levels was also observed following oral PF-3845 treatment, but only a modest antinociceptive effect was observed. Increasing CNS FAA levels alone does not lead to robust amelioration of below-level neuropathic SCI pain. Perhaps utilizing FAAH inhibition in conjunction with other analgesic mechanisms could be an effective analgesic therapy.", "link"=>"http://www.mendeley.com/research/fatty-acid-amide-hydrolase-faah-inhibitors-exert-pharmacological-effects-lack-antinociceptive-effica", "reader_count"=>21, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Librarian"=>1, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Master"=>3, "Other"=>2, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Librarian"=>1, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Master"=>3, "Other"=>2, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Nursing and Health Professions"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>4, "Neuroscience"=>5, "Chemistry"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Neuroscience"=>{"Neuroscience"=>5}, "Chemistry"=>{"Chemistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Hungary"=>1, "Spain"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1482854"], "description"=>"<p>Changes in fatty acid amides (AEA, <i>N</i>-arachidonoylethanolamide; OEA, <i>N</i>-oleoyl ethanolamide; PEA, <i>N</i>-palmitoyl ethanolamide) four weeks following spinal cord injury compared to that of uninjured rats.</p><p>↓, decrease; n.c., no change; n.s., not statistically significant; *<i>p</i><0.05 (Student's t-test).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "endocannabinoids", "Neurochemistry", "Neurochemicals", "neuroscience", "Cognitive neuroscience", "Critical care and emergency medicine", "Trauma medicine", "Spinal cord injury", "neurology", "Spinal cord diseases", "Pain management", "pain", "fatty", "amides", "weeks", "spinal"], "article_id"=>1014528, "categories"=>["Biological Sciences"], "users"=>["Aldric T. Hama", "Peter Germano", "Matthew S. Varghese", "Benjamin F. Cravatt", "G. Todd Milne", "James P. Pearson", "Jacqueline Sagen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096396.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_Changes_in_Fatty_Acid_Amides_Four_Weeks_Following_a_Spinal_Cord_Injury_in_Rats_/1014528", "title"=>"Summary of Changes in Fatty Acid Amides Four Weeks Following a Spinal Cord Injury in Rats.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-05-02 02:57:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1482852"], "description"=>"<p>Values are fold-changes compared to vehicle treatment levels in spinal cord injured (SCI) and non-injured (N.I) rats. Tissues were collected 4 hours post-oral administration of either PF-3845 (3, 10 mg/kg) or vehicle.</p><p>“Epicenter” refers to thoracic spinal cord tissue either from the site of injury from SCI rats or comparable spinal cord tissue from non-injured rats.</p><p>*<i>p</i><0.05, **<i>p</i><0.01, ***<i>p</i><0.001 vs. vehicle-treated (Student's t-test).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "endocannabinoids", "Neurochemistry", "Neurochemicals", "neuroscience", "Cognitive neuroscience", "Critical care and emergency medicine", "Trauma medicine", "Spinal cord injury", "neurology", "Spinal cord diseases", "Pain management", "pain", "fatty", "amide", "pf-3845", "compared"], "article_id"=>1014526, "categories"=>["Biological Sciences"], "users"=>["Aldric T. Hama", "Peter Germano", "Matthew S. Varghese", "Benjamin F. Cravatt", "G. Todd Milne", "James P. Pearson", "Jacqueline Sagen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096396.t003", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fold_change_of_tissue_fatty_acid_amide_levels_following_a_single_oral_treatment_with_PF_3845_compared_to_oral_vehicle_treatment_/1014526", "title"=>"Fold-change of tissue fatty acid amide levels following a single oral treatment with PF-3845 compared to oral vehicle treatment.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-05-02 02:57:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1482849"], "description"=>"<p>Following baseline hind paw withdrawal threshold measurement, SCI rats were treated with either PF-3845 (3, 10 mg/kg, p.o.) or vehicle (Veh; 5 ml/kg, p.o.). An antinociceptive effect was observed 1 and 3 hours following administration of 10 mg/kg, but not 3 mg/kg. Data presented as mean ± S.E.M. n = 8–9/group. * <i>p</i><0.05 vs. vehicle (Two-way repeated measures ANOVA, Student-Newman-Keuls test).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "endocannabinoids", "Neurochemistry", "Neurochemicals", "neuroscience", "Cognitive neuroscience", "Critical care and emergency medicine", "Trauma medicine", "Spinal cord injury", "neurology", "Spinal cord diseases", "Pain management", "pain", "pf-3845", "below-level", "cutaneous", "hypersensitivity", "rats", "neuropathic", "sci"], "article_id"=>1014523, "categories"=>["Biological Sciences"], "users"=>["Aldric T. Hama", "Peter Germano", "Matthew S. Varghese", "Benjamin F. Cravatt", "G. Todd Milne", "James P. Pearson", "Jacqueline Sagen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096396.g007", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_PF_3845_treatment_on_below_level_cutaneous_hypersensitivity_in_rats_with_neuropathic_SCI_pain_/1014523", "title"=>"Effect of PF-3845 treatment on below-level cutaneous hypersensitivity in rats with neuropathic SCI pain.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-02 02:57:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1482848"], "description"=>"<p>Baseline hind paw withdrawal thresholds were measured prior to treatment with either URB597 (3 mg/kg, i.p.), WIN 55,212-2 (3 mg/kg, s.c.) or vehicle (Veh, 1.5 ml/kg, i.p.). Rats were treated twice daily and tested following the first daily injection. On the first day of testing, a robust antinociception was observed beginning 30 min post-injection of WIN 55,212-2, which was observed also observed on days 3 and 7. By contrast, no antinociceptive effects were observed following treatment with either URB597 or vehicle. Data presented as mean ± S.E.M. n = 8–10/group. * <i>p</i><0.05 vs. vehicle (Two-way repeated measures ANOVA, Student-Newman-Keuls test).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "endocannabinoids", "Neurochemistry", "Neurochemicals", "neuroscience", "Cognitive neuroscience", "Critical care and emergency medicine", "Trauma medicine", "Spinal cord injury", "neurology", "Spinal cord diseases", "Pain management", "pain", "urb597", "days", "below-level", "cutaneous", "hypersensitivity", "rats", "neuropathic", "sci"], "article_id"=>1014522, "categories"=>["Biological Sciences"], "users"=>["Aldric T. Hama", "Peter Germano", "Matthew S. Varghese", "Benjamin F. Cravatt", "G. Todd Milne", "James P. Pearson", "Jacqueline Sagen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096396.g006", "stats"=>{"downloads"=>2, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_URB597_and_WIN_55_212_2_treatment_over_seven_days_on_below_level_cutaneous_hypersensitivity_in_rats_with_neuropathic_SCI_pain_/1014522", "title"=>"Effects of URB597 and WIN 55,212-2 treatment over seven days on below-level cutaneous hypersensitivity in rats with neuropathic SCI pain.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-02 02:57:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1482842"], "description"=>"<p>Both SCI and uninjured rats were treated with either URB597 (URB; 3 mg/kg, i.p.), WIN 55,212-2 (WIN; 3 mg/kg, s.c.) or vehicle (Veh; 1.5 ml/kg, i.p.) for seven days and euthanized four hours following the last treatment. Rats that received PF-3845 (PF3, PF10) were treated once (3, 10 mg/kg, p.o.) and euthanized four hours following dosing. One group of uninjured rats was treated once with URB597 and euthanized two hours (2 h) following treatment. The FAA levels of thoracic spinal cord of uninjured rats from this figure are repeated for <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0096396#pone-0096396-g003\" target=\"_blank\">Figures 3</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0096396#pone-0096396-g004\" target=\"_blank\">4</a>. Levels of AEA, OEA and PEA from each rat are shown, the thick horizontal line is the mean and the thin horizontal lines are the S.E.M. n = 4–10/group. * <i>p</i><0.05, **<i>p</i><0.01, ***<i>p</i><0.001 vs. vehicle (Student's t-test).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "endocannabinoids", "Neurochemistry", "Neurochemicals", "neuroscience", "Cognitive neuroscience", "Critical care and emergency medicine", "Trauma medicine", "Spinal cord injury", "neurology", "Spinal cord diseases", "Pain management", "pain", "amide", "concentrations", "thoracic", "spinal", "segments", "rostral", "sci", "rats", "uninjured", "faah"], "article_id"=>1014516, "categories"=>["Biological Sciences"], "users"=>["Aldric T. Hama", "Peter Germano", "Matthew S. Varghese", "Benjamin F. Cravatt", "G. Todd Milne", "James P. Pearson", "Jacqueline Sagen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096396.g002", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fatty_acid_amide_concentrations_in_thoracic_spinal_cord_segments_rostral_to_the_spinal_injury_from_SCI_rats_or_comparable_thoracic_spinal_cord_segments_from_uninjured_rats_following_treatment_with_FAAH_inhibitors_WIN_55_212_2_and_vehicle_/1014516", "title"=>"Fatty acid amide concentrations in thoracic spinal cord segments rostral to the spinal injury from SCI rats or comparable thoracic spinal cord segments from uninjured rats following treatment with FAAH inhibitors, WIN 55,212-2 and vehicle.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-02 02:57:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1482851"], "description"=>"<p>Prior to spinal compression surgery (“Baseline”), BBB Locomotor Scores were 21, indicating normal hind limb function. (A Score of “0” indicates no hind limb function.) The mean BBB Locomotor Score obtained the day before initiation of the seven-day treatment procedure (“4 wks” post-SCI) was 9.8±0.4. Spinal cord-injured rats were evaluated again on the sixth day of treatment (“5 wks” post-SCI) and there were no significant changes in BBB Scores. Data presented as mean ± S.E.M. n = 8–10/group. *<i>p</i><0.05 vs. pre-SCI (Two-way repeated measures ANOVA, Student-Newman-Keuls test).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "endocannabinoids", "Neurochemistry", "Neurochemicals", "neuroscience", "Cognitive neuroscience", "Critical care and emergency medicine", "Trauma medicine", "Spinal cord injury", "neurology", "Spinal cord diseases", "Pain management", "pain", "urb597", "bbb", "locomotor", "scores", "sci"], "article_id"=>1014525, "categories"=>["Biological Sciences"], "users"=>["Aldric T. Hama", "Peter Germano", "Matthew S. Varghese", "Benjamin F. Cravatt", "G. Todd Milne", "James P. Pearson", "Jacqueline Sagen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096396.g008", "stats"=>{"downloads"=>0, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_URB597_and_WIN_55_212_2_on_BBB_Locomotor_Scores_in_SCI_rats_/1014525", "title"=>"Effects of URB597 and WIN 55,212-2 on BBB Locomotor Scores in SCI rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-02 02:57:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1482845"], "description"=>"<p>Rats were treated with either URB597 (URB; 3 mg/kg, i.p.), WIN 55,212-2 (WIN; 3 mg/kg, s.c.) or vehicle (Veh; 1 ml/kg, i.p.) for seven days and euthanized four hours following the last treatment. One group of uninjured rats was treated once with URB597 and euthanized two hours (2 h) following treatment. Rats that received PF-3845 (PF3, PF10) were treated once (3, 10 mg/kg, p.o.) and euthanized four hours following dosing. Levels of AEA, OEA and PEA from each rat are shown, the dark horizontal line is the mean and the light horizontal lines are the S.E.M. n = 4–10/group. * <i>p</i><0.05, **<i>p</i><0.01, ***<i>p</i><0.001 vs. vehicle (Student's t-test).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "endocannabinoids", "Neurochemistry", "Neurochemicals", "neuroscience", "Cognitive neuroscience", "Critical care and emergency medicine", "Trauma medicine", "Spinal cord injury", "neurology", "Spinal cord diseases", "Pain management", "pain", "amide", "concentrations", "thoracic", "spinal", "segments", "caudal", "sci", "rats", "uninjured", "faah"], "article_id"=>1014519, "categories"=>["Biological Sciences"], "users"=>["Aldric T. Hama", "Peter Germano", "Matthew S. Varghese", "Benjamin F. Cravatt", "G. Todd Milne", "James P. Pearson", "Jacqueline Sagen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096396.g004", "stats"=>{"downloads"=>2, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fatty_acid_amide_concentrations_in_thoracic_spinal_cord_segments_caudal_to_the_spinal_injury_from_SCI_rats_or_comparable_spinal_cord_segments_from_uninjured_rats_following_treatment_with_FAAH_inhibitors_WIN_55_212_2_and_vehicle_/1014519", "title"=>"Fatty acid amide concentrations in thoracic spinal cord segments caudal to the spinal injury from SCI rats or comparable spinal cord segments from uninjured rats following treatment with FAAH inhibitors, WIN 55,212-2 and vehicle.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-02 02:57:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1482847"], "description"=>"<p>Rats were treated with either URB597 (URB; 3 mg/kg, i.p.), WIN 55,212-2 (WIN; 3 mg/kg, s.c.) or vehicle (Veh; 1.5 ml/kg, i.p.) for seven days and euthanized four hours following the last treatment. One group of uninjured rats was treated once with URB597 and euthanized two hours (2 h) following treatment. Rats that received PF-3845 (PF3, PF10) were treated once (3, 10 mg/kg, p.o.) and euthanized four hours following dosing. Levels of AEA, OEA and PEA from each rat are shown, the thick horizontal line is the mean and the thin horizontal lines are the S.E.M. n = 4–10/group. * <i>p</i><0.05, **<i>p</i><0.01, ***<i>p</i><0.001 vs. vehicle (Student's t-test).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "endocannabinoids", "Neurochemistry", "Neurochemicals", "neuroscience", "Cognitive neuroscience", "Critical care and emergency medicine", "Trauma medicine", "Spinal cord injury", "neurology", "Spinal cord diseases", "Pain management", "pain", "amide", "concentrations", "lumbar", "spinal", "sci", "rats", "uninjured", "faah"], "article_id"=>1014520, "categories"=>["Biological Sciences"], "users"=>["Aldric T. Hama", "Peter Germano", "Matthew S. Varghese", "Benjamin F. Cravatt", "G. Todd Milne", "James P. Pearson", "Jacqueline Sagen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096396.g005", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fatty_acid_amide_concentrations_in_lumbar_spinal_cord_from_SCI_rats_or_uninjured_rats_following_treatment_with_FAAH_inhibitors_WIN_55_212_2_and_vehicle_/1014520", "title"=>"Fatty acid amide concentrations in lumbar spinal cord from SCI rats or uninjured rats following treatment with FAAH inhibitors, WIN 55,212-2 and vehicle.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-02 02:57:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1482844"], "description"=>"<p>Both SCI and uninjured rats were treated with either URB597 (URB; 3 mg/kg, i.p.), WIN 55,212-2 (WIN; 3 mg/kg, s.c.) or vehicle (Veh; 1 ml/kg, i.p.) for seven days and euthanized four hours following the last treatment. One group of uninjured rats was treated once with URB597 and euthanized two hours (2 hr) following treatment. Rats that received PF-3845 (PF3, PF10) were treated once (3, 10 mg/kg, p.o.) and euthanized four hours following dosing. Levels of AEA, OEA and PEA from each rat are shown, the thick horizontal line is the mean and the thin horizontal lines are the S.E.M. n = 4–10/group. * <i>p</i><0.05, **<i>p</i><0.01, ***<i>p</i><0.001 vs. vehicle (Student's t-test).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "endocannabinoids", "Neurochemistry", "Neurochemicals", "neuroscience", "Cognitive neuroscience", "Critical care and emergency medicine", "Trauma medicine", "Spinal cord injury", "neurology", "Spinal cord diseases", "Pain management", "pain", "amide", "concentrations", "thoracic", "spinal", "segments", "epicenter", "sci", "rats", "uninjured", "faah"], "article_id"=>1014518, "categories"=>["Biological Sciences"], "users"=>["Aldric T. Hama", "Peter Germano", "Matthew S. Varghese", "Benjamin F. Cravatt", "G. Todd Milne", "James P. Pearson", "Jacqueline Sagen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096396.g003", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fatty_acid_amide_concentrations_in_thoracic_spinal_cord_segments_from_the_epicenter_of_injury_from_SCI_rats_or_comparable_spinal_cord_segments_from_uninjured_rats_following_treatment_with_FAAH_inhibitors_WIN_55_212_2_and_vehicle_/1014518", "title"=>"Fatty acid amide concentrations in thoracic spinal cord segments from the epicenter of injury from SCI rats or comparable spinal cord segments from uninjured rats following treatment with FAAH inhibitors, WIN 55,212-2 and vehicle.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-02 02:57:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1482841"], "description"=>"<p>Rats were treated with either URB597 (URB; 3 mg/kg, i.p.), WIN 55,212-2 (WIN; 3 mg/kg, s.c.) or vehicle (Veh; 1.5 ml/kg, i.p.) for seven days and euthanized four hours following the last treatment. One group of URB597 rats were euthanized two hours (2 h) following a single treatment. Rats that received PF-3845 (PF3, PF10; 3, 10 mg/kg, p.o) or vehicle (Veh, p.o.) were treated once and euthanized four hours following dosing. Levels of AEA, OEA and PEA from each rat are shown, the thick horizontal line is the mean and the thin horizontal lines are the S.E.M. n = 4–10/group. * <i>p</i><0.05, **<i>p</i><0.01, ***<i>p</i><0.001 vs. vehicle (Student's t-test).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "endocannabinoids", "Neurochemistry", "Neurochemicals", "neuroscience", "Cognitive neuroscience", "Critical care and emergency medicine", "Trauma medicine", "Spinal cord injury", "neurology", "Spinal cord diseases", "Pain management", "pain", "amide", "concentrations", "faah", "sci", "uninjured"], "article_id"=>1014515, "categories"=>["Biological Sciences"], "users"=>["Aldric T. Hama", "Peter Germano", "Matthew S. Varghese", "Benjamin F. Cravatt", "G. Todd Milne", "James P. Pearson", "Jacqueline Sagen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096396.g001", "stats"=>{"downloads"=>3, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fatty_acid_amide_concentrations_in_brain_following_treatment_with_FAAH_inhibitors_WIN_55_212_2_and_vehicle_in_SCI_and_uninjured_rats_/1014515", "title"=>"Fatty acid amide concentrations in brain following treatment with FAAH inhibitors, WIN 55,212-2 and vehicle in SCI and uninjured rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-02 02:57:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1482853"], "description"=>"<p>Values are fold-changes compared to vehicle treatment levels in spinal cord injured (SCI) and non-injured (N.I.) rats. On the seventh day of treatment, tissues were collected 4 hours post-administration with either vehicle, URB597 (URB, 3 mg/kg, i.p.) or WIN 55,212-2 (WIN, 3 mg/kg, s.c.) from SCI rats. Non-injured rats were treated once and tissues collected four hours post-treatment. In one set of non-injured rats (n = 5), tissues were collected two hours (2 h) post-treatment with URB597.</p><p>“Epicenter” refers to thoracic spinal cord tissue either from the site of injury from SCI rats or comparable spinal cord tissue from non-injured rats.</p><p>n.s., not significant.</p><p>*<i>p</i><0.05, **<i>p</i><0.01, ***<i>p</i><0.001 vs. vehicle-treated (Student's t-test).</p>", "links"=>[], "tags"=>["Biochemistry", "lipids", "endocannabinoids", "Neurochemistry", "Neurochemicals", "neuroscience", "Cognitive neuroscience", "Critical care and emergency medicine", "Trauma medicine", "Spinal cord injury", "neurology", "Spinal cord diseases", "Pain management", "pain", "fatty", "amide", "urb597"], "article_id"=>1014527, "categories"=>["Biological Sciences"], "users"=>["Aldric T. Hama", "Peter Germano", "Matthew S. Varghese", "Benjamin F. Cravatt", "G. Todd Milne", "James P. Pearson", "Jacqueline Sagen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096396.t002", "stats"=>{"downloads"=>1, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fold_change_of_tissue_fatty_acid_amide_levels_following_treatment_with_URB597_or_WIN_55_212_2_relative_to_vehicle_treatment_/1014527", "title"=>"Fold-change of tissue fatty acid amide levels following treatment with URB597 or WIN 55,212-2 relative to vehicle treatment.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-05-02 02:57:54"}

PMC Usage Stats | Further Information

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