Age-Related Decrease of Meiotic Cohesins in Human Oocytes
Publication Date
May 07, 2014
Journal
PLOS ONE
Authors
Makiko Tsutsumi, Reiko Fujiwara, Haruki Nishizawa, Mayuko Ito, et al
Volume
9
Issue
5
Pages
e96710
DOI
https://dx.plos.org/10.1371/journal.pone.0096710
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0096710
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/24806359
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013030
Europe PMC
http://europepmc.org/abstract/MED/24806359
Web of Science
000335728900083
Scopus
84900549740
Mendeley
http://www.mendeley.com/research/agerelated-decrease-meiotic-cohesins-human-oocytes
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Mendeley | Further Information

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CrossRef

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1488156"], "description"=>"<p>(A, B) Relative signal intensity of REC8 or SMC1B. Intensities were determined as indicated in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0096710#pone.0096710.s002\" target=\"_blank\">Figure S2</a>. Three mice were used at each age. Horizontal bars are the mean cohesin levels within each female. (C) Cohesin signal intensity means in each female (mean ± SD). (D) Cohesin signal intensity means in each oocyte (mean ± SD). *<i>P</i><0.05, **<i>P</i><0.01, Student's t-test.</p>", "links"=>[], "tags"=>["cell biology", "Cell processes", "Cell cycle and cell division", "meiosis", "Chromosome biology", "chromatin", "genetics", "Departures from diploidy", "aneuploidy", "Human genetics", "Clinical genetics", "Chromosomal disorders", "Down syndrome", "women's health", "Maternal health", "pregnancy", "Miscarriage and stillbirth", "meiosis-specific", "cohesin", "2-", "10-month-old"], "article_id"=>1019025, "categories"=>["Biological Sciences"], "users"=>["Makiko Tsutsumi", "Reiko Fujiwara", "Haruki Nishizawa", "Mayuko Ito", "Hiroshi Kogo", "Hidehito Inagaki", "Tamae Ohye", "Takema Kato", "Takuma Fujii", "Hiroki Kurahashi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096710.g005", "stats"=>{"downloads"=>2, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Quantitative_results_for_meiosis_specific_cohesin_levels_in_2_and_10_month_old_mouse_oocytes_/1019025", "title"=>"Quantitative results for meiosis-specific cohesin levels in 2- and 10-month-old mouse oocytes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-07 02:54:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1488158"], "description"=>"<p>(A–C) Signal intensities for SMC3, RAD21 or SMC1A determined as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0096710#pone.0096710.s002\" target=\"_blank\">Figure S2</a>. (D) Cohesin signal intensity means in each female (mean ± SD). (E) Cohesin signal intensity means in each oocyte (mean ± SD). **<i>P</i><0.01, Student's <i>t</i>-test.</p>", "links"=>[], "tags"=>["cell biology", "Cell processes", "Cell cycle and cell division", "meiosis", "Chromosome biology", "chromatin", "genetics", "Departures from diploidy", "aneuploidy", "Human genetics", "Clinical genetics", "Chromosomal disorders", "Down syndrome", "women's health", "Maternal health", "pregnancy", "Miscarriage and stillbirth", "mitotic", "cohesin"], "article_id"=>1019026, "categories"=>["Biological Sciences"], "users"=>["Makiko Tsutsumi", "Reiko Fujiwara", "Haruki Nishizawa", "Mayuko Ito", "Hiroshi Kogo", "Hidehito Inagaki", "Tamae Ohye", "Takema Kato", "Takuma Fujii", "Hiroki Kurahashi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096710.g006", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Quantitative_results_for_mitotic_cohesin_levels_in_mouse_oocytes_/1019026", "title"=>"Quantitative results for mitotic cohesin levels in mouse oocytes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-07 02:54:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1488161", "https://ndownloader.figshare.com/files/1488162", "https://ndownloader.figshare.com/files/1488163", "https://ndownloader.figshare.com/files/1488164"], "description"=>"<div><p>Aneuploidy in fetal chromosomes is one of the causes of pregnancy loss and of congenital birth defects. It is known that the frequency of oocyte aneuploidy increases with the human maternal age. Recent data have highlighted the contribution of cohesin complexes in the correct segregation of meiotic chromosomes. In mammalian oocytes, cohesion is established during the fetal stages and meiosis-specific cohesin subunits are not replenished after birth, raising the possibility that the long meiotic arrest of oocytes facilitates a deterioration of cohesion that leads to age-related increases in aneuploidy. We here examined the cohesin levels in dictyate oocytes from different age groups of humans and mice by immunofluorescence analyses of ovarian sections. The meiosis-specific cohesin subunits, REC8 and SMC1B, were found to be decreased in women aged 40 and over compared with those aged around 20 years (P<0.01). Age-related decreases in meiotic cohesins were also evident in mice. Interestingly, SMC1A, the mitotic counterpart of SMC1B, was substantially detectable in human oocytes, but little expressed in mice. Further, the amount of mitotic cohesins of mice slightly increased with age. These results suggest that, mitotic and meiotic cohesins may operate in a coordinated way to maintain cohesions over a sustained period in humans and that age-related decreases in meiotic cohesin subunits impair sister chromatid cohesion leading to increased segregation errors.</p></div>", "links"=>[], "tags"=>["cell biology", "Cell processes", "Cell cycle and cell division", "meiosis", "Chromosome biology", "chromatin", "genetics", "Departures from diploidy", "aneuploidy", "Human genetics", "Clinical genetics", "Chromosomal disorders", "Down syndrome", "women's health", "Maternal health", "pregnancy", "Miscarriage and stillbirth", "meiotic", "cohesins"], "article_id"=>1019030, "categories"=>["Biological Sciences"], "users"=>["Makiko Tsutsumi", "Reiko Fujiwara", "Haruki Nishizawa", "Mayuko Ito", "Hiroshi Kogo", "Hidehito Inagaki", "Tamae Ohye", "Takema Kato", "Takuma Fujii", "Hiroki Kurahashi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0096710.s001", "https://dx.doi.org/10.1371/journal.pone.0096710.s002", "https://dx.doi.org/10.1371/journal.pone.0096710.s003", "https://dx.doi.org/10.1371/journal.pone.0096710.s004"], "stats"=>{"downloads"=>4, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Age_Related_Decrease_of_Meiotic_Cohesins_in_Human_Oocytes_/1019030", "title"=>"Age-Related Decrease of Meiotic Cohesins in Human Oocytes", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-05-07 02:54:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1488151"], "description"=>"<p>(A, B) REC8 or SMC1B (green) proteins co-immunostained with RAD21. (C, D) SMC3 or SMC1A (green) signals counterstained with DAPI. C-KIT (red) was used as a marker of oocytes. Asterisks indicate autofluorescence in the cytoplasmic region of the oocytes. Bar, 10 µm.</p>", "links"=>[], "tags"=>["cell biology", "Cell processes", "Cell cycle and cell division", "meiosis", "Chromosome biology", "chromatin", "genetics", "Departures from diploidy", "aneuploidy", "Human genetics", "Clinical genetics", "Chromosomal disorders", "Down syndrome", "women's health", "Maternal health", "pregnancy", "Miscarriage and stillbirth", "staining", "oocytes", "ovarian", "sections", "19-", "49-year-old"], "article_id"=>1019020, "categories"=>["Biological Sciences"], "users"=>["Makiko Tsutsumi", "Reiko Fujiwara", "Haruki Nishizawa", "Mayuko Ito", "Hiroshi Kogo", "Hidehito Inagaki", "Tamae Ohye", "Takema Kato", "Takuma Fujii", "Hiroki Kurahashi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096710.g001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunofluorescent_staining_of_human_oocytes_in_ovarian_sections_from_19_and_49_year_old_women_/1019020", "title"=>"Immunofluorescent staining of human oocytes in ovarian sections from 19- and 49-year-old women.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-07 02:54:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1488152"], "description"=>"<p>(A, B) Relative signal intensity of REC8 or SMC1B. Intensities were determined as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0096710#pone.0096710.s002\" target=\"_blank\">Figure S2</a>. Specimens were obtained from two 40 year old female subjects (40a and 40b). Horizontal bars indicate the mean cohesin levels for each subject. (C) Regression analyses of the mean cohesin signal intensities shown in (A) and (B) (mean ± SD). The regression lines are indicated by solid lines. The coefficients of determination are indicated in parentheses. (D, E) Comparisons of the signal intensity means between grouped samples. Women were grouped as younger (≤29-year-old) or older (≥40-year-old). (D) The cohesin signal intensity means shown in (A–C) were compared between groups (mean ± SD). (E) The cohesin signal intensity means in single oocytes were compared between groups (mean ± SD). *<i>P</i><0.05, **<i>P</i><0.01, Student's <i>t</i>-test.</p>", "links"=>[], "tags"=>["cell biology", "Cell processes", "Cell cycle and cell division", "meiosis", "Chromosome biology", "chromatin", "genetics", "Departures from diploidy", "aneuploidy", "Human genetics", "Clinical genetics", "Chromosomal disorders", "Down syndrome", "women's health", "Maternal health", "pregnancy", "Miscarriage and stillbirth", "meiosis-specific", "cohesins"], "article_id"=>1019021, "categories"=>["Biological Sciences"], "users"=>["Makiko Tsutsumi", "Reiko Fujiwara", "Haruki Nishizawa", "Mayuko Ito", "Hiroshi Kogo", "Hidehito Inagaki", "Tamae Ohye", "Takema Kato", "Takuma Fujii", "Hiroki Kurahashi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096710.g002", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Quantitative_results_for_meiosis_specific_cohesins_in_human_oocytes_/1019021", "title"=>"Quantitative results for meiosis-specific cohesins in human oocytes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-07 02:54:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1488153"], "description"=>"<p>(A–C) Relative signal intensities for SMC3, RAD21 or SMC1A. (D) Regression analyses of the cohesin signal intensity means shown in (A–C) (mean ± SD). Lines are the regression lines. The coefficients of determination are in parentheses. (E, F) Comparisons of the signal intensity means between grouped samples. Women were grouped as indicated in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0096710#pone-0096710-g002\" target=\"_blank\">Figure 2</a>. (E) The cohesin signal intensity means shown in (A–D) were compared between groups (mean ± SD). (F) The cohesin signal intensity means in single oocytes were compared between groups (mean ± SD). *<i>P</i><0.05, Student's <i>t</i>-test.</p>", "links"=>[], "tags"=>["cell biology", "Cell processes", "Cell cycle and cell division", "meiosis", "Chromosome biology", "chromatin", "genetics", "Departures from diploidy", "aneuploidy", "Human genetics", "Clinical genetics", "Chromosomal disorders", "Down syndrome", "women's health", "Maternal health", "pregnancy", "Miscarriage and stillbirth", "mitotic", "cohesin"], "article_id"=>1019022, "categories"=>["Biological Sciences"], "users"=>["Makiko Tsutsumi", "Reiko Fujiwara", "Haruki Nishizawa", "Mayuko Ito", "Hiroshi Kogo", "Hidehito Inagaki", "Tamae Ohye", "Takema Kato", "Takuma Fujii", "Hiroki Kurahashi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096710.g003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Quantitative_results_for_the_mitotic_cohesin_levels_in_human_oocytes_/1019022", "title"=>"Quantitative results for the mitotic cohesin levels in human oocytes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-07 02:54:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1488154"], "description"=>"<p>(A) Slides were co-immunostained with REC8 (green) and SMC3 (red). (B) Slides were co-immunostained with SMC1B (green) and RAD21 (red). (C) SMC1A (green) signals with DAPI nuclear counterstaining. Asterisks indicate autofluorescence. Bar, 10 µm.</p>", "links"=>[], "tags"=>["cell biology", "Cell processes", "Cell cycle and cell division", "meiosis", "Chromosome biology", "chromatin", "genetics", "Departures from diploidy", "aneuploidy", "Human genetics", "Clinical genetics", "Chromosomal disorders", "Down syndrome", "women's health", "Maternal health", "pregnancy", "Miscarriage and stillbirth", "staining", "oocytes", "ovarian", "sections", "2-", "10-month-old"], "article_id"=>1019023, "categories"=>["Biological Sciences"], "users"=>["Makiko Tsutsumi", "Reiko Fujiwara", "Haruki Nishizawa", "Mayuko Ito", "Hiroshi Kogo", "Hidehito Inagaki", "Tamae Ohye", "Takema Kato", "Takuma Fujii", "Hiroki Kurahashi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0096710.g004", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunofluorescent_staining_of_mouse_oocytes_in_ovarian_sections_from_2_and_10_month_old_female_mice_/1019023", "title"=>"Immunofluorescent staining of mouse oocytes in ovarian sections from 2- and 10-month-old female mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-07 02:54:00"}

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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[286]}]}
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