Head-to-Head Comparison of Sirolimus-Eluting Stents versus Paclitaxel-Eluting Stents in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis of 76 Studies
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{"title"=>"Head-to-head comparison of sirolimus-eluting stents versus paclitaxel-eluting stents in patients undergoing percutaneous coronary intervention: A meta-analysis of 76 studies", "type"=>"journal", "authors"=>[{"first_name"=>"Xinlin", "last_name"=>"Zhang", "scopus_author_id"=>"54881149300"}, {"first_name"=>"Jun", "last_name"=>"Xie", "scopus_author_id"=>"57043834600"}, {"first_name"=>"Guannan", "last_name"=>"Li", "scopus_author_id"=>"56010317700"}, {"first_name"=>"Qinhua", "last_name"=>"Chen", "scopus_author_id"=>"56009538100"}, {"first_name"=>"Biao", "last_name"=>"Xu", "scopus_author_id"=>"35085585600"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"24844284", "doi"=>"10.1371/journal.pone.0097934", "pui"=>"373160871", "issn"=>"19326203", "sgr"=>"84901295862", "scopus"=>"2-s2.0-84901295862"}, "id"=>"0c85abdd-e2e7-3bed-85f8-c3808141166b", "abstract"=>"BACKGROUND: The relative short-, long- and overall-term efficacy and safety of sirolimus-eluting stents (SES, Cypher) compared with paclitaxel-eluting stents (PES, Taxus) in large head-to-head comparisons still remain to be defined.\\n\\nMETHODS: We searched Pubmed, EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL) for articles comparing outcomes of interest between SES and PES without language restriction. Short- (≤ 1 year), long- (>1 year), and overall-term (the longest follow-up of each study) outcomes were evaluated. The primary endpoint was target lesion revascularization (TLR). Other outcomes of interest were target vessel revascularization (TVR), myocardial infarction, all-cause death, cardiac death, stent thrombosis, major adverse cardiac events (MACEs), restenosis and late lumen loss.\\n\\nRESULTS: Seventy-six studies including more than 15000 patients in randomized controlled trials and over 70000 patients in adjusted observational studies were included. At overall-term follow-up, SES significantly reduced TLR (relative risk [RR]: 0.61; 95% confidence interval [CI]: 0.49-0.76), TVR (RR: 0.67; 95% CI: 0.54-0.83), MACE (RR: 0.79; 95% CI: 0.72-0.87), myocardial infarction (RR: 0.85; 95% CI: 0.73-0.99), in-segment restenosis (RR: 0.50; 95% CI: 0.38-0.65), and in-segment late lumen loss (weighted mean difference [WMD]: -0.19; 95% CI: -0.24--0.14) in randomized controlled trials compared with PES. In addition, lower rates of death (RR: 0.91; 95% CI: 0.83-1.00), any stent thrombosis (RR: 0.62; 95% CI: 0.45-0.86), definite stent thrombosis (RR: 0.59; 95% CI: 0.45-0.77) were found in patients receiving SES in adjusted observational studies. Largely similar results were found at short- and long-term follow-up, and in patients with diabetes, acute myocardial infarction or long lesions.\\n\\nCONCLUSIONS: SES significantly reduced the short-, long- and overall-term risk of TLR/TVR, MACE, and restenosis, and overall-term risk of myocardial infarction in randomized controlled trials, as compared with PES. Lower rates of death and stent thrombosis were also observed in observational studies in SES-treated patients.", "link"=>"http://www.mendeley.com/research/headtohead-comparison-sirolimuseluting-stents-versus-paclitaxeleluting-stents-patients-undergoing-pe", "reader_count"=>17, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>5, "Student > Postgraduate"=>2, "Student > Master"=>3, "Student > Bachelor"=>3, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>5, "Student > Postgraduate"=>2, "Student > Master"=>3, "Student > Bachelor"=>3, "Professor"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Engineering"=>1, "Environmental Science"=>1, "Medicine and Dentistry"=>7, "Pharmacology, Toxicology and Pharmaceutical Science"=>3, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>3}}, "reader_count_by_country"=>{"Japan"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1505079"], "description"=>"<p>Short-term (≤1 year), long-term (>1 year), and overall-term TLR and TVR in patients treated with SES versus PES were evaluated. Adj-OS  =  adjusted observational study; CI  =  confidence interval; No.  =  number of the studies; Non-adj OS  =  non-adjusted observational study; PES  =  paclitaxel-eluting stents; RCT  =  randomized controlled trial; RR  =  relative risk; SES  =  sirolimus-eluting stent; TLR  =  target lesion revascularization; TVR  =  target vessel revascularization.</p>", "links"=>[], "tags"=>["anatomy", "Cardiovascular anatomy", "biotechnology", "Medical devices and equipment", "cardiology", "Acute cardiovascular problems", "Cardiovascular pharmacology", "Interventional cardiology", "Myocardial infarction", "Clinical medicine", "Vascular medicine", "angina", "atherosclerosis", "Coronary artery disease", "mathematics", "Statistics (mathematics)", "Statistical methods", "meta-analysis", "research design", "Clinical research design", "cis", "tlr", "tvr", "ses"], "article_id"=>1032525, "categories"=>["Biological Sciences"], "users"=>["Xinlin Zhang", "Jun Xie", "Guannan Li", "Qinhua Chen", "Biao Xu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0097934.g002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RRs_and_95_CIs_of_TLR_A_and_TVR_B_associated_with_SES_versus_PES_/1032525", "title"=>"RRs and 95% CIs of TLR (A) and TVR (B) associated with SES versus PES.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-20 03:46:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1505101", "https://ndownloader.figshare.com/files/1505102", "https://ndownloader.figshare.com/files/1505103", "https://ndownloader.figshare.com/files/1505104", "https://ndownloader.figshare.com/files/1505105", "https://ndownloader.figshare.com/files/1505106", "https://ndownloader.figshare.com/files/1505107", "https://ndownloader.figshare.com/files/1505108"], "description"=>"<div><p>Background</p><p>The relative short-, long- and overall-term efficacy and safety of sirolimus-eluting stents (SES, Cypher) compared with paclitaxel-eluting stents (PES, Taxus) in large head-to-head comparisons still remain to be defined.</p><p>Methods</p><p>We searched Pubmed, EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL) for articles comparing outcomes of interest between SES and PES without language restriction. Short- (≤1 year), long- (>1 year), and overall-term (the longest follow-up of each study) outcomes were evaluated. The primary endpoint was target lesion revascularization (TLR). Other outcomes of interest were target vessel revascularization (TVR), myocardial infarction, all-cause death, cardiac death, stent thrombosis, major adverse cardiac events (MACEs), restenosis and late lumen loss.</p><p>Results</p><p>Seventy-six studies including more than 15000 patients in randomized controlled trials and over 70000 patients in adjusted observational studies were included. At overall-term follow-up, SES significantly reduced TLR (relative risk [RR]: 0.61; 95% confidence interval [CI]: 0.49–0.76), TVR (RR: 0.67; 95% CI: 0.54–0.83), MACE (RR: 0.79; 95% CI: 0.72–0.87), myocardial infarction (RR: 0.85; 95% CI: 0.73–0.99), in-segment restenosis (RR: 0.50; 95% CI: 0.38–0.65), and in-segment late lumen loss (weighted mean difference [WMD]: −0.19; 95% CI: −0.24–−0.14) in randomized controlled trials compared with PES. In addition, lower rates of death (RR: 0.91; 95% CI: 0.83–1.00), any stent thrombosis (RR: 0.62; 95% CI: 0.45–0.86), definite stent thrombosis (RR: 0.59; 95% CI: 0.45–0.77) were found in patients receiving SES in adjusted observational studies. Largely similar results were found at short- and long-term follow-up, and in patients with diabetes, acute myocardial infarction or long lesions.</p><p>Conclusions</p><p>SES significantly reduced the short-, long- and overall-term risk of TLR/TVR, MACE, and restenosis, and overall-term risk of myocardial infarction in randomized controlled trials, as compared with PES. Lower rates of death and stent thrombosis were also observed in observational studies in SES-treated patients.</p></div>", "links"=>[], "tags"=>["anatomy", "Cardiovascular anatomy", "biotechnology", "Medical devices and equipment", "cardiology", "Acute cardiovascular problems", "Cardiovascular pharmacology", "Interventional cardiology", "Myocardial infarction", "Clinical medicine", "Vascular medicine", "angina", "atherosclerosis", "Coronary artery disease", "mathematics", "Statistics (mathematics)", "Statistical methods", "meta-analysis", "research design", "Clinical research design", "sirolimus-eluting", "stents", "paclitaxel-eluting", "patients", "undergoing", "percutaneous", "coronary", "76"], "article_id"=>1032547, "categories"=>["Biological Sciences"], "users"=>["Xinlin Zhang", "Jun Xie", "Guannan Li", "Qinhua Chen", "Biao Xu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0097934.s001", "https://dx.doi.org/10.1371/journal.pone.0097934.s002", "https://dx.doi.org/10.1371/journal.pone.0097934.s003", "https://dx.doi.org/10.1371/journal.pone.0097934.s004", "https://dx.doi.org/10.1371/journal.pone.0097934.s005", "https://dx.doi.org/10.1371/journal.pone.0097934.s006", "https://dx.doi.org/10.1371/journal.pone.0097934.s007", "https://dx.doi.org/10.1371/journal.pone.0097934.s008"], "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Head_to_Head_Comparison_of_Sirolimus_Eluting_Stents_versus_Paclitaxel_Eluting_Stents_in_Patients_Undergoing_Percutaneous_Coronary_Intervention_A_Meta_Analysis_of_76_Studies_/1032547", "title"=>"Head-to-Head Comparison of Sirolimus-Eluting Stents versus Paclitaxel-Eluting Stents in Patients Undergoing Percutaneous Coronary Intervention: A Meta-Analysis of 76 Studies", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-05-20 03:46:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1505086"], "description"=>"<p>Adj-OS  =  adjusted observational study; AMI  =  acute myocardial infarction; CD  =  cardiac death; CI  =  confidence interval; MACE  =  major adverse cardiac event; MI  =  myocardial infarction; No.  =  number of the studies; Non-adj OS  =  non-adjusted observational study; PES  =  paclitaxel-eluting stents; RCT  =  randomized controlled trial; RR  =  relative risk; SES  =  sirolimus-eluting stent; ST  =  stent thrombosis; TLR  =  target lesion revascularization; TVR  =  target vessel revascularization.</p>", "links"=>[], "tags"=>["anatomy", "Cardiovascular anatomy", "biotechnology", "Medical devices and equipment", "cardiology", "Acute cardiovascular problems", "Cardiovascular pharmacology", "Interventional cardiology", "Myocardial infarction", "Clinical medicine", "Vascular medicine", "angina", "atherosclerosis", "Coronary artery disease", "mathematics", "Statistics (mathematics)", "Statistical methods", "meta-analysis", "research design", "Clinical research design", "cis", "endpoints", "ses", "pes", "ami"], "article_id"=>1032532, "categories"=>["Biological Sciences"], "users"=>["Xinlin Zhang", "Jun Xie", "Guannan Li", "Qinhua Chen", "Biao Xu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0097934.g007", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RRs_and_95_CIs_of_clinical_endpoints_associated_with_SES_versus_PES_in_patient_with_AMI_and_long_lesions_/1032532", "title"=>"RRs and 95% CIs of clinical endpoints associated with SES versus PES in patient with AMI and long-lesions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-20 03:46:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1505082"], "description"=>"<p>Short-term (≤1 year), long-term (>1 year), and overall-term stent thrombosis in patients treated with SES versus PES were evaluated. Short-term stent thrombosis was divided into early (≤30 days) and late (30 days-1 year) stages. Adj-OS  =  adjusted observational study; CI  =  confidence interval; No.  =  number of the studies; Non-adj OS  =  non-adjusted observational study; PES  =  paclitaxel-eluting stents; RCT  =  randomized controlled trial; RR  =  relative risk; SES  =  sirolimus-eluting stent; ST  =  stent thrombosis.</p>", "links"=>[], "tags"=>["anatomy", "Cardiovascular anatomy", "biotechnology", "Medical devices and equipment", "cardiology", "Acute cardiovascular problems", "Cardiovascular pharmacology", "Interventional cardiology", "Myocardial infarction", "Clinical medicine", "Vascular medicine", "angina", "atherosclerosis", "Coronary artery disease", "mathematics", "Statistics (mathematics)", "Statistical methods", "meta-analysis", "research design", "Clinical research design", "cis", "stent", "thrombosis", "ses"], "article_id"=>1032528, "categories"=>["Biological Sciences"], "users"=>["Xinlin Zhang", "Jun Xie", "Guannan Li", "Qinhua Chen", "Biao Xu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0097934.g004", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RRs_and_95_CIs_of_stent_thrombosis_associated_with_SES_versus_PES_/1032528", "title"=>"RRs and 95% CIs of stent thrombosis associated with SES versus PES.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-20 03:46:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1505080"], "description"=>"<p>MACE (A), MI (B), all-cause death (C), cardiac death (D), death/MI (E) were evaluated in Short-term (≤1 year), long-term (>1 year), and overall-term follow-up. Adj-OS  =  adjusted observational study; CD  =  cardiac death; CI  =  confidence interval; Death + MI  =  the composite of death and myocardial infarction; MACE  =  major adverse cardiac event; MI  =  myocardial infarction; No.  =  number of the studies; Non-adj OS  =  non-adjusted observational study; PES  =  paclitaxel-eluting stents; RCT  =  randomized controlled trial; RR  =  relative risk; SES  =  sirolimus-eluting stent.</p>", "links"=>[], "tags"=>["anatomy", "Cardiovascular anatomy", "biotechnology", "Medical devices and equipment", "cardiology", "Acute cardiovascular problems", "Cardiovascular pharmacology", "Interventional cardiology", "Myocardial infarction", "Clinical medicine", "Vascular medicine", "angina", "atherosclerosis", "Coronary artery disease", "mathematics", "Statistics (mathematics)", "Statistical methods", "meta-analysis", "research design", "Clinical research design", "cis", "endpoints", "ses"], "article_id"=>1032526, "categories"=>["Biological Sciences"], "users"=>["Xinlin Zhang", "Jun Xie", "Guannan Li", "Qinhua Chen", "Biao Xu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0097934.g003", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RRs_and_95_CIs_of_other_clinical_endpoints_associated_with_SES_versus_PES_/1032526", "title"=>"RRs and 95% CIs of other clinical endpoints associated with SES versus PES.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-20 03:46:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1505076"], "description"=>"<p>Flow Diagram of Meta-Analysis.</p>", "links"=>[], "tags"=>["anatomy", "Cardiovascular anatomy", "biotechnology", "Medical devices and equipment", "cardiology", "Acute cardiovascular problems", "Cardiovascular pharmacology", "Interventional cardiology", "Myocardial infarction", "Clinical medicine", "Vascular medicine", "angina", "atherosclerosis", "Coronary artery disease", "mathematics", "Statistics (mathematics)", "Statistical methods", "meta-analysis", "research design", "Clinical research design", "diagram"], "article_id"=>1032522, "categories"=>["Biological Sciences"], "users"=>["Xinlin Zhang", "Jun Xie", "Guannan Li", "Qinhua Chen", "Biao Xu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0097934.g001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_Diagram_of_Meta_Analysis_/1032522", "title"=>"Flow Diagram of Meta-Analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-20 03:46:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1505085"], "description"=>"<p>Adj-OS  =  adjusted observational study; CD  =  cardiac death; CI  =  confidence interval; Death + MI  =  the composite of death and myocardial infarction; DM  =  diabetes mellitus; MACE  =  major adverse cardiac event; MI  =  myocardial infarction; No.  =  number of the studies; Non-adj OS  =  non-adjusted observational study; PES  =  paclitaxel-eluting stents; RCT  =  randomized controlled trial; RR  =  relative risk; SES  =  sirolimus-eluting stent; ST  =  stent thrombosis; TLR  =  target lesion revascularization; TVR  =  target vessel revascularization.</p>", "links"=>[], "tags"=>["anatomy", "Cardiovascular anatomy", "biotechnology", "Medical devices and equipment", "cardiology", "Acute cardiovascular problems", "Cardiovascular pharmacology", "Interventional cardiology", "Myocardial infarction", "Clinical medicine", "Vascular medicine", "angina", "atherosclerosis", "Coronary artery disease", "mathematics", "Statistics (mathematics)", "Statistical methods", "meta-analysis", "research design", "Clinical research design", "cis", "endpoints", "ses", "pes"], "article_id"=>1032531, "categories"=>["Biological Sciences"], "users"=>["Xinlin Zhang", "Jun Xie", "Guannan Li", "Qinhua Chen", "Biao Xu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0097934.g006", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RRs_and_95_CIs_of_clinical_endpoints_associated_with_SES_versus_PES_in_diabetes_population_/1032531", "title"=>"RRs and 95% CIs of clinical endpoints associated with SES versus PES in diabetes population.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-20 03:46:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/1505084"], "description"=>"<p>Angiographic outcomes were in-segment restenosis (A), in-stent restenosis (A), and in-segment late lumen loss (B), in-stent late lumen loss (B). Short-term (≤1 year), long-term (>1 year), and overall-term angiographic endpoints in patients treated with SES versus PES were evaluated. The overall population and subgroups of diabetes mellitus, acute myocardial infarction, and long lesion were included. Adj-OS  =  adjusted observational study; CI  =  confidence interval; No.  =  number of the studies; Non-adj OS  =  non-adjusted observational study; PES  =  paclitaxel-eluting stents; RCT  =  randomized controlled trial; RR  =  relative risk; SES  =  sirolimus-eluting stent; WMD  =  weighted mean difference.</p>", "links"=>[], "tags"=>["anatomy", "Cardiovascular anatomy", "biotechnology", "Medical devices and equipment", "cardiology", "Acute cardiovascular problems", "Cardiovascular pharmacology", "Interventional cardiology", "Myocardial infarction", "Clinical medicine", "Vascular medicine", "angina", "atherosclerosis", "Coronary artery disease", "mathematics", "Statistics (mathematics)", "Statistical methods", "meta-analysis", "research design", "Clinical research design", "cis", "angiographic", "endpoints", "ses"], "article_id"=>1032530, "categories"=>["Biological Sciences"], "users"=>["Xinlin Zhang", "Jun Xie", "Guannan Li", "Qinhua Chen", "Biao Xu"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0097934.g005", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RRs_WMDs_and_95_CIs_of_angiographic_endpoints_associated_with_SES_versus_PES_/1032530", "title"=>"RRs/WMDs and 95% CIs of angiographic endpoints associated with SES versus PES.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-20 03:46:21"}

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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Medicine and health sciences/Vascular medicine", "average_usage"=>[248]}, {"subject_area"=>"/People and places/Demography", "average_usage"=>[309]}, {"subject_area"=>"/Physical sciences/Mathematics", "average_usage"=>[286]}]}
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