Glycyrol Suppresses Collagen-Induced Arthritis by Regulating Autoimmune and Inflammatory Responses
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{"title"=>"Glycyrol suppresses collagen-induced arthritis by regulating autoimmune and inflammatory responses", "type"=>"journal", "authors"=>[{"first_name"=>"Yanxia", "last_name"=>"Fu", "scopus_author_id"=>"55766257300"}, {"first_name"=>"Hailing", "last_name"=>"Zhou", "scopus_author_id"=>"55765809500"}, {"first_name"=>"Shuangyan", "last_name"=>"Wang", "scopus_author_id"=>"57196155561"}, {"first_name"=>"Qun", "last_name"=>"Wei", "scopus_author_id"=>"7201693023"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0098137", "pui"=>"373567615", "sgr"=>"84904479802", "pmid"=>"25036817", "scopus"=>"2-s2.0-84904479802"}, "id"=>"4c9fe702-2f7e-3514-9f4d-656da3f15227", "abstract"=>"Glycyrol is a natural compound extracted from Glycyrrhiza uralensis, first reported by us to be a new immunosuppressant. Here, we demonstrate its beneficial effect in collagen-induced arthritis (CIA) in mice, a model for rheumatoid arthritis (RA) in man, and we document the underlying mechanisms. Peroral administration of glycyrol significantly reduced clinical scores, alleviated cartilage and bone erosion and reduced levels of serum inflammatory cytokines. Glycyrol also decreased delayed-type hypersensitivity, improved carbon clearance and reduced acetic acid-induced capillary permeability. Furthermore, glycyrol decreased NF-kappaB and NFAT transcriptional activities and inhibited IL-2 expression. The therapeutic effect of glycyrol was associated with down-regulation of both autoimmune and inflammatory reactions. In addition, we demonstrated that glycyrol has minimal acute toxicity in mice. Therefore, we propose that glycyrol may hold promise for future treatment of RA.", "link"=>"http://www.mendeley.com/research/glycyrol-suppresses-collageninduced-arthritis-regulating-autoimmune-inflammatory-responses", "reader_count"=>10, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Other"=>1, "Student > Master"=>3, "Student > Bachelor"=>1, "Lecturer"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Other"=>1, "Student > Master"=>3, "Student > Bachelor"=>1, "Lecturer"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>4, "Sports and Recreations"=>1, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Chemistry"=>{"Chemistry"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1600391"], "description"=>"<p>Acetic acid-induced capillary permeability test. Mice were given 150 mg/kg glycyrol perorally for 5 consecutive days before the acute inflammatory test. 0.5% Evan's blue was injected into the tail vein 30 min after the last peroral administration. Permeability scored by Evans Blue concentration in peritoneal fluid (light absorbance at 590 nm). Columns represent means ±SD from 8 mice. Differences between groups were tested by Student's t-test. *P<0.05 for comparison with Model group.</p>", "links"=>[], "tags"=>["immunology", "Clinical immunology", "Autoimmune diseases", "rheumatoid arthritis", "allergies", "Immune response", "inflammation", "Clinical medicine", "pharmacology", "Drug research and development", "rheumatology", "Model organisms", "Animal models", "Mouse models", "glycyrol", "acute"], "article_id"=>1110229, "categories"=>["Biological Sciences"], "users"=>["Yanxia Fu", "Hailing Zhou", "Shuangyan Wang", "Qun Wei"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098137.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_action_of_glycyrol_on_acute_inflammation_in_vivo_/1110229", "title"=>"The action of glycyrol on acute inflammation <i>in vivo.</i>", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-18 02:45:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1600390"], "description"=>"<p>Biochemistry in serum of mice treated with CsA or glycyrol. Dosage schedule: 500 mg/kg on day 0, 100 mg/kg on days 1 and 2; blood sampling on day 4. A: Glutamic-pyruvic transaminase; B: Glutamic-oxaloacetic transaminase; C: Total bilirubin; D: Urea nitrogen; E: Serum creatinine. Bars represent means ±SD from 7 mice. *P<0.05, **P<0.01 and ***P<0.001 for comparison with Vehicle group.</p>", "links"=>[], "tags"=>["immunology", "Clinical immunology", "Autoimmune diseases", "rheumatoid arthritis", "allergies", "Immune response", "inflammation", "Clinical medicine", "pharmacology", "Drug research and development", "rheumatology", "Model organisms", "Animal models", "Mouse models", "toxicity", "glycyrol"], "article_id"=>1110228, "categories"=>["Biological Sciences"], "users"=>["Yanxia Fu", "Hailing Zhou", "Shuangyan Wang", "Qun Wei"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098137.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Acute_toxicity_of_glycyrol_in_mice_/1110228", "title"=>"Acute toxicity of glycyrol in mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-18 02:45:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1600387"], "description"=>"<p>CIA was induced by intradermal injection collagen II in Freund's adjuvant as described in Materials and Methods. A – C. Glycyrol and CsA were administered perorally every day from days 21 to 42. A: Time-dependent mean clinical scores (±SD) of four paws; B: Body weight changes (mean±SD); C1: TNF-α levels in serum on day 42; C2: IL-1β levels in serum on day 42; C3: IL-17 levels in serum on day 42; C4: IL-6 in serum on day 42. Data points are means ± SD of 7 mice. Differences between groups were tested by Student's t-test. # P<0.05 for comparison with Normal group, *P<0.05 for comparison with CIA group. D. Histopathologic features of representative ankle joints of male DBA/1J mice obtained on day 42 and stained with H&E (100x original magnification). “A” represents non-immunized mice showing normal articular cartilage, absence of infiltrate in the synovium and open joint space, “B” indicates CIA mice showing marked infiltration of inflammatory cells, narrow joint space with synovial hyperplasia, and “C” and “D” represent CIA mice treated with CsA or glycyrol, respectively, showing less inflammatory cell infiltration, well-preserved joint spaces, and minimal synovial hyperplasia. “b” denotes bone tissue, whereas “c”, “s”, and “js” indicate cartilage, synovium, and joint space, respectively. E. Quantification of histological changes. Data represent means ±SD from 7 mice. *P<0.05 for comparison with CIA group.</p>", "links"=>[], "tags"=>["immunology", "Clinical immunology", "Autoimmune diseases", "rheumatoid arthritis", "allergies", "Immune response", "inflammation", "Clinical medicine", "pharmacology", "Drug research and development", "rheumatology", "Model organisms", "Animal models", "Mouse models", "attenuates", "collagen-induced"], "article_id"=>1110225, "categories"=>["Biological Sciences"], "users"=>["Yanxia Fu", "Hailing Zhou", "Shuangyan Wang", "Qun Wei"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098137.g001", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Glycyrol_attenuates_collagen_induced_arthritis_/1110225", "title"=>"Glycyrol attenuates collagen-induced arthritis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-18 02:45:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1600393"], "description"=>"<p>A & B: Jurkat cells were stimulated with PMA plus Ion or a combination of indicated concentrations glycyrol or CsA and PMA plus Ion for 24 h to induce IκB-α expression. A: Western blot picture of p-IκB-α; B: Quantification of Western blot. C: RAW 264.7 cells were induced with PMA plus Ion or a combination of indicated concentrations glycyrol or CsA and PMA plus Ion for 24 h to induce NF-κB expression, and measured by dual-reporter gene assay system. Assays were performed in triplicate. Data represent means ±SD over three independent experiments. # P<0.05 for comparison with naïve group, *P<0.05 for comparison with PMA plus Ion-stimulated group.</p>", "links"=>[], "tags"=>["immunology", "Clinical immunology", "Autoimmune diseases", "rheumatoid arthritis", "allergies", "Immune response", "inflammation", "Clinical medicine", "pharmacology", "Drug research and development", "rheumatology", "Model organisms", "Animal models", "Mouse models", "inhibits"], "article_id"=>1110231, "categories"=>["Biological Sciences"], "users"=>["Yanxia Fu", "Hailing Zhou", "Shuangyan Wang", "Qun Wei"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098137.g005", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Glycyrol_inhibits_expression_of_p_I_954_B_and_NF_954_B_/1110231", "title"=>"Glycyrol inhibits expression of p-IκB and NF-κB.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-18 02:45:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1600394"], "description"=>"<p>RAW 264.7 cells were stimulated with PMA plus Ion or a combination of indicated concentrations glycyrol or CsA and PMA plus Ion for 24-2 gene transcription. Panel A: NFAT transcription was measured using the dual-reporter gene assay system; Panel B: IL-2 gene transcription was detected by Real-time quantitative PCR. Assays were performed in triplicate. Data represent means ± SD over three independent experiments. Statistical significance was calculated using one-way analysis of variance (ANOVA) and Bonferroni post-test. # P<0.05 for comparison with naïve group, *P<0.05 for comparison with PMA plus Ion-stimulated group.</p>", "links"=>[], "tags"=>["immunology", "Clinical immunology", "Autoimmune diseases", "rheumatoid arthritis", "allergies", "Immune response", "inflammation", "Clinical medicine", "pharmacology", "Drug research and development", "rheumatology", "Model organisms", "Animal models", "Mouse models", "inhibits", "transcription", "nfat"], "article_id"=>1110232, "categories"=>["Biological Sciences"], "users"=>["Yanxia Fu", "Hailing Zhou", "Shuangyan Wang", "Qun Wei"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098137.g006", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Glycyrol_inhibits_transcription_of_NFAT_and_IL_2genes_/1110232", "title"=>"Glycyrol inhibits transcription of NFAT and IL-2genes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-18 02:45:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1600389"], "description"=>"<p>DNFB-induced DTH reaction (panel A) and carbon particle clearance test (panel B) conducted on mice given glycyrol (50 or 100 mg/kg) or CsA (50 mg/kg). The mice were initially sensitized by 50 µL of 1% DNFB on abdomens 30 min after drug administration on days 1 and 2. On day 5, 30 min after drug administration, mice were treated with 10 µL of 1% DNFB on both sides of their right ear. The mice were killed by cervical dislocation 24 h after the third sensitization. A1: ear swelling; A2: thymus; A3: spleen; B: phagocytic index. Data are shown as means ±SD from 8 mice. Differences between groups were tested by Student's t-test. # P<0.05 for comparison with Vehicle group, *P<0.05 for comparison with Model group.</p>", "links"=>[], "tags"=>["immunology", "Clinical immunology", "Autoimmune diseases", "rheumatoid arthritis", "allergies", "Immune response", "inflammation", "Clinical medicine", "pharmacology", "Drug research and development", "rheumatology", "Model organisms", "Animal models", "Mouse models", "peroral", "glycyrol", "immunoregulation"], "article_id"=>1110227, "categories"=>["Biological Sciences"], "users"=>["Yanxia Fu", "Hailing Zhou", "Shuangyan Wang", "Qun Wei"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098137.g002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_the_peroral_administration_of_glycyrol_on_immunoregulation_in_vivo_/1110227", "title"=>"Effect of the peroral administration of glycyrol on immunoregulation <i>in vivo.</i>", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-18 02:45:49"}

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