Effects of Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036 on Hepatic Steatosis in Zucker Rats
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{"title"=>"Effects of Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036 on hepatic steatosis in Zucker rats", "type"=>"journal", "authors"=>[{"first_name"=>"Julio", "last_name"=>"Plaza-Diaz", "scopus_author_id"=>"55587885300"}, {"first_name"=>"Carolina", "last_name"=>"Gomez-Llorente", "scopus_author_id"=>"6507533760"}, {"first_name"=>"Francisco", "last_name"=>"Abadia-Molina", "scopus_author_id"=>"6602256255"}, {"first_name"=>"Maria Jose", "last_name"=>"Saez-Lara", "scopus_author_id"=>"6507619072"}, {"first_name"=>"Laura", "last_name"=>"Campaña-Martin", "scopus_author_id"=>"55757204000"}, {"first_name"=>"Sergio", "last_name"=>"Muñoz-Quezada", "scopus_author_id"=>"55337575800"}, {"first_name"=>"Fernando", "last_name"=>"Romero", "scopus_author_id"=>"55596506100"}, {"first_name"=>"Angel", "last_name"=>"Gil", "scopus_author_id"=>"56244656400"}, {"first_name"=>"Luis", "last_name"=>"Fontana", "scopus_author_id"=>"7102339506"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84901373547", "pui"=>"373161156", "doi"=>"10.1371/journal.pone.0098401", "sgr"=>"84901373547", "pmid"=>"24852284"}, "id"=>"19e37e38-707a-3aa5-aa9f-74ab37d7d7bb", "abstract"=>"We have previously described the safety and immunomodulatory effects of Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036 in healthy volunteers. The scope of this work was to evaluate the effects of these probiotic strains on the hepatic steatosis of obese rats. We used the Zucker rat as a genetic model of obesity. Zucker-Lepr(fa/fa) rats received one of three probiotic strains, a mixture of L. paracasei CNCM I-4034 and B. breve CNCM I-4035, or a placebo for 30 days. An additional group of Zucker-lean+/fa rats received a placebo for 30 days. No alterations in intestinal histology, in the epithelial, lamina propria, muscular layers of the ileal or colonic mucosa, or the submucosae, were observed in any of the experimental groups. Triacylglycerol content decreased in the liver of Zucker-Lepr(fa/fa) rats that were fed L. rhamnosus, B. breve, or the mixture of B. breve and L. paracasei. Likewise, the area corresponding to neutral lipids was significantly smaller in the liver of all four groups of Zucker-Lepr(fa/fa) rats that received probiotics than in rats fed the placebo. Zucker-Lepr(fa/fa) rats exhibited significantly greater serum LPS levels than Zucker-lean+/fa rats upon administration of placebo for 30 days. In contrast, all four groups of obese Zucker-Lepr(fa/fa) rats that received LAB strains exhibited serum LPS concentrations similar to those of Zucker-lean+/fa rats. Serum TNF-α levels decreased in the Zucker-Lepr(fa/fa) rats that received B. breve, L. rhamnosus, or the mixture, whereas L. paracasei feeding decreased IL-6 levels in the serum of Zucker-Lepr(fa/fa) rats. In conclusion, the probiotic strains reduced hepatic steatosis in part by lowering serum LPS, and had an anti-inflammatory effect in obese Zucker rats.", "link"=>"http://www.mendeley.com/research/effects-lactobacillus-paracasei-cncm-i4034-bifidobacterium-breve-cncm-i4035-lactobacillus-rhamnosus", "reader_count"=>42, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>10, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>1, "Student > Master"=>7, "Other"=>2, "Student > Bachelor"=>7, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>10, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>1, "Student > Master"=>7, "Other"=>2, "Student > Bachelor"=>7, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>16, "Medicine and Dentistry"=>11, "Sports and Recreations"=>2, "Social Sciences"=>3, "Immunology and Microbiology"=>3, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Social Sciences"=>{"Social Sciences"=>3}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Netherlands"=>1, "Norway"=>1, "Spain"=>2}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1508010"], "description"=>"<p>Values are the means ± SEM, n = 8 per group. <sup>#</sup><i>P</i><0.05 (ZL baseline vs. ZO baseline), <sup>†</sup><i>P</i><0.05 (ZL + placebo vs. ZO + placebo), *<i>P</i><0.05 (ZO baseline vs. ZO + placebo). ALT, alanine aminotransferase; AST, aspartate aminotransferase; NEFA, non-esterified fatty acids. HOMA-IR, homeostasis model assessment of insulin resistance. ZL, Zucker-lean<sup>+/<i>fa</i></sup> rats; ZO, Zucker-Lepr<i><sup>fa/fa</sup></i> rats.</p>", "links"=>[], "tags"=>["Biochemistry", "microbiology", "nutrition", "Gastroenterology and hepatology", "biochemical", "rats", "fed", "placebo"], "article_id"=>1034453, "categories"=>["Biological Sciences"], "users"=>["Julio Plaza-Diaz", "Carolina Gomez-Llorente", "Francisco Abadia-Molina", "Maria Jose Saez-Lara", "Laura Campaña-Martin", "Sergio Muñoz-Quezada", "Fernando Romero", "Angel Gil", "Luis Fontana"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098401.t001", "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_biochemical_parameters_of_Zucker_lean_fa_and_Zucker_Lepr_fa_fa_rats_fed_either_a_placebo_or_LAB_strains_/1034453", "title"=>"Serum biochemical parameters of Zucker-lean<sup>+/<i>fa</i></sup> and Zucker-Lepr<i><sup>fa/fa</sup></i> rats fed either a placebo or LAB strains.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-05-22 03:21:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1508009"], "description"=>"<p>Values are the means ± SEM, n = 8 per group. <sup>†</sup><i>P</i><0.05 (ZL + placebo vs. ZO + placebo), and *<i>P</i><0.05 (ZO + placebo vs. ZO + LAB strains). ZL, Zucker-lean<sup>+/<i>fa</i></sup> rats; ZO, Zucker-Lepr<i><sup>fa/fa</sup></i> rats.</p>", "links"=>[], "tags"=>["Biochemistry", "microbiology", "nutrition", "Gastroenterology and hepatology", "serum", "rats", "fed", "placebo", "strains", "30"], "article_id"=>1034452, "categories"=>["Biological Sciences"], "users"=>["Julio Plaza-Diaz", "Carolina Gomez-Llorente", "Francisco Abadia-Molina", "Maria Jose Saez-Lara", "Laura Campaña-Martin", "Sergio Muñoz-Quezada", "Fernando Romero", "Angel Gil", "Luis Fontana"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098401.g006", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_LPS_concentration_in_serum_of_Zucker_lean_fa_and_Zucker_Lepr_fa_fa_rats_that_were_fed_either_a_placebo_or_LAB_strains_for_30_days_/1034452", "title"=>"LPS concentration in serum of Zucker-lean<sup>+/<i>fa</i></sup> and Zucker-Lepr<i><sup>fa/fa</sup></i> rats that were fed either a placebo or LAB strains for 30 days.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-22 03:21:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1508006"], "description"=>"<p>Percentage of the micrograph area corresponding to the lipid staining of liver sections described in panel A was calculated (B). Values are the means ± SEM, n = 2 per group. <sup>†</sup><i>P</i><0.05 (ZL + placebo vs. ZO + placebo), and *<i>P</i><0.05 (ZO + placebo vs. ZO + LAB strains). ZL, Zucker-lean<sup>+/<i>fa</i></sup> rats; ZO, Zucker-Lepr<i><sup>fa/fa</sup></i> rats.</p>", "links"=>[], "tags"=>["Biochemistry", "microbiology", "nutrition", "Gastroenterology and hepatology", "micrographs", "sections", "stained", "isopropanol", "rats", "fed", "placebo", "strains", "30", "days"], "article_id"=>1034449, "categories"=>["Biological Sciences"], "users"=>["Julio Plaza-Diaz", "Carolina Gomez-Llorente", "Francisco Abadia-Molina", "Maria Jose Saez-Lara", "Laura Campaña-Martin", "Sergio Muñoz-Quezada", "Fernando Romero", "Angel Gil", "Luis Fontana"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098401.g003", "stats"=>{"downloads"=>7, "page_views"=>81, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_micrographs_of_7_m_thick_liver_sections_stained_with_0_3_Oil_red_O_in_60_isopropanol_of_Zucker_lean_fa_and_Zucker_Lepr_fa_fa_rats_that_were_fed_either_a_placebo_or_LAB_strains_for_30_days_A_/1034449", "title"=>"Representative micrographs of 7-µm-thick liver sections stained with 0.3% Oil red O in 60% isopropanol of Zucker-lean<sup>+/<i>fa</i></sup> and Zucker-Lepr<i><sup>fa/fa</sup></i> rats that were fed either a placebo or LAB strains for 30 days (A).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-22 03:21:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1508004"], "description"=>"<p>Values are the means ± SEM, n = 8 per group. <sup>†</sup><i>P</i><0.05 (ZL + placebo vs. ZO + placebo), and *<i>P</i><0.05 (ZO + placebo vs. ZO + LAB strains). ZL, Zucker-lean<sup>+/<i>fa</i></sup> rats; ZO, Zucker-Lepr<i><sup>fa/fa</sup></i> rats.</p>", "links"=>[], "tags"=>["Biochemistry", "microbiology", "nutrition", "Gastroenterology and hepatology", "triacylglycerol", "rats", "fed", "placebo", "strains", "30"], "article_id"=>1034447, "categories"=>["Biological Sciences"], "users"=>["Julio Plaza-Diaz", "Carolina Gomez-Llorente", "Francisco Abadia-Molina", "Maria Jose Saez-Lara", "Laura Campaña-Martin", "Sergio Muñoz-Quezada", "Fernando Romero", "Angel Gil", "Luis Fontana"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098401.g001", "stats"=>{"downloads"=>7, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Liver_triacylglycerol_content_of_Zucker_lean_fa_and_Zucker_Lepr_fa_fa_rats_that_were_fed_either_a_placebo_or_LAB_strains_for_30_days_/1034447", "title"=>"Liver triacylglycerol content of Zucker-lean<sup>+/<i>fa</i></sup> and Zucker-Lepr<i><sup>fa/fa</sup></i> rats that were fed either a placebo or LAB strains for 30 days.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-22 03:21:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1508005"], "description"=>"<p>Two rats per group were used for this staining. Three pieces of tissue from each animal were fixed and embedded in the same paraffin block. Four to 8 sections per block were cut, stained and analyzed. Representative micrographs from various groups are shown. A and E: Zucker-lean<sup>+/<i>fa</i></sup> rats at baseline; B and F: Zucker-Lepr<i><sup>fa/fa</sup></i> rats + placebo; C and G: Zucker-Lepr<i><sup>fa/fa</sup></i> rats +<i>L. rhamnosus</i>; and D and H: Zucker-Lepr<i><sup>fa/fa</sup></i> rats + LAB mixture.</p>", "links"=>[], "tags"=>["Biochemistry", "microbiology", "nutrition", "Gastroenterology and hepatology", "sections", "ileal", "colonic", "mucosa", "rats", "fed", "placebo", "strains", "30"], "article_id"=>1034448, "categories"=>["Biological Sciences"], "users"=>["Julio Plaza-Diaz", "Carolina Gomez-Llorente", "Francisco Abadia-Molina", "Maria Jose Saez-Lara", "Laura Campaña-Martin", "Sergio Muñoz-Quezada", "Fernando Romero", "Angel Gil", "Luis Fontana"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098401.g002", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Haematoxylin_eosin_stained_5_m_thick_sections_of_ileal_top_panels_A_D_and_colonic_bottom_panels_E_H_mucosa_of_Zucker_lean_fa_and_Zucker_Lepr_fa_fa_rats_that_were_fed_either_a_placebo_or_LAB_strains_for_30_days_/1034448", "title"=>"Haematoxylin-eosin stained, 5-µm-thick sections of ileal (top panels, A–D) and colonic (bottom panels, E–H) mucosa of Zucker-lean<sup>+/<i>fa</i></sup> and Zucker-Lepr<i><sup>fa/fa</sup></i> rats that were fed either a placebo or LAB strains for 30 days.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-22 03:21:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1508011"], "description"=>"<div><p>We have previously described the safety and immunomodulatory effects of <i>Lactobacillus paracasei</i> CNCM I-4034, <i>Bifidobacterium breve</i> CNCM I-4035 and <i>Lactobacillus rhamnosus</i> CNCM I-4036 in healthy volunteers. The scope of this work was to evaluate the effects of these probiotic strains on the hepatic steatosis of obese rats. We used the Zucker rat as a genetic model of obesity. Zucker-Lepr<i><sup>fa/fa</sup></i> rats received one of three probiotic strains, a mixture of <i>L. paracasei</i> CNCM I-4034 and <i>B. breve</i> CNCM I-4035, or a placebo for 30 days. An additional group of Zucker-lean<sup>+/<i>fa</i></sup> rats received a placebo for 30 days. No alterations in intestinal histology, in the epithelial, lamina propria, muscular layers of the ileal or colonic mucosa, or the submucosae, were observed in any of the experimental groups. Triacylglycerol content decreased in the liver of Zucker-Lepr<i><sup>fa/fa</sup></i> rats that were fed <i>L. rhamnosus</i>, <i>B. breve</i>, or the mixture of <i>B. breve</i> and <i>L. paracasei</i>. Likewise, the area corresponding to neutral lipids was significantly smaller in the liver of all four groups of Zucker-Lepr<i><sup>fa/fa</sup></i> rats that received probiotics than in rats fed the placebo. Zucker-Lepr<i><sup>fa/fa</sup></i> rats exhibited significantly greater serum LPS levels than Zucker-lean<sup>+/<i>fa</i></sup> rats upon administration of placebo for 30 days. In contrast, all four groups of obese Zucker-Lepr<i><sup>fa/fa</sup></i> rats that received LAB strains exhibited serum LPS concentrations similar to those of Zucker-lean<sup>+/<i>fa</i></sup> rats. Serum TNF-α levels decreased in the Zucker-Lepr<i><sup>fa/fa</sup></i> rats that received <i>B. breve</i>, <i>L. rhamnosus</i>, or the mixture, whereas <i>L. paracasei</i> feeding decreased IL-6 levels in the serum of Zucker-Lepr<i><sup>fa/fa</sup></i> rats. In conclusion, the probiotic strains reduced hepatic steatosis in part by lowering serum LPS, and had an anti-inflammatory effect in obese Zucker rats.</p></div>", "links"=>[], "tags"=>["Biochemistry", "microbiology", "nutrition", "Gastroenterology and hepatology", "cncm", "i-4035", "i-4036", "hepatic", "steatosis", "zucker", "rats"], "article_id"=>1034454, "categories"=>["Biological Sciences"], "users"=>["Julio Plaza-Diaz", "Carolina Gomez-Llorente", "Francisco Abadia-Molina", "Maria Jose Saez-Lara", "Laura Campaña-Martin", "Sergio Muñoz-Quezada", "Fernando Romero", "Angel Gil", "Luis Fontana"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098401", "stats"=>{"downloads"=>6, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Effects_of_Lactobacillus_paracasei_CNCM_I_4034_Bifidobacterium_breve_CNCM_I_4035_and_Lactobacillus_rhamnosus_CNCM_I_4036_on_Hepatic_Steatosis_in_Zucker_Rats/1034454", "title"=>"Effects of <i>Lactobacillus paracasei</i> CNCM I-4034, <i>Bifidobacterium breve</i> CNCM I-4035 and <i>Lactobacillus rhamnosus</i> CNCM I-4036 on Hepatic Steatosis in Zucker Rats", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-05-22 03:21:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1508008"], "description"=>"<p>Values are the means ± SEM, n = 8 per group. <sup>†</sup><i>P</i><0.05 (ZL + placebo vs. ZO + placebo), and *<i>P</i><0.05 (ZO + placebo vs. ZO + probiotic strains). ZL, Zucker-lean<sup>+/<i>fa</i></sup> rats; ZO, Zucker-Lepr<i><sup>fa/fa</sup></i> rats.</p>", "links"=>[], "tags"=>["Biochemistry", "microbiology", "nutrition", "Gastroenterology and hepatology", "serum", "il-6", "rats", "fed", "placebo", "strains", "30"], "article_id"=>1034451, "categories"=>["Biological Sciences"], "users"=>["Julio Plaza-Diaz", "Carolina Gomez-Llorente", "Francisco Abadia-Molina", "Maria Jose Saez-Lara", "Laura Campaña-Martin", "Sergio Muñoz-Quezada", "Fernando Romero", "Angel Gil", "Luis Fontana"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098401.g005", "stats"=>{"downloads"=>2, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Concentrations_of_serum_TNF_A_and_IL_6_B_of_Zucker_lean_fa_and_Zucker_Lepr_fa_fa_rats_that_were_fed_either_a_placebo_or_LAB_strains_for_30_days_/1034451", "title"=>"Concentrations of serum TNF-α (A) and IL-6 (B) of Zucker-lean<sup>+/<i>fa</i></sup> and Zucker-Lepr<i><sup>fa/fa</sup></i> rats that were fed either a placebo or LAB strains for 30 days.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-22 03:21:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1508007"], "description"=>"<p>Values are the means ± SEM, n = 8 per group. <sup>#</sup><i>P</i><0.05 (ZL baseline vs. ZO baseline), and <sup>†</sup><i>P</i><0.05 (ZL + placebo vs. ZO + placebo). ZL, Zucker-lean<sup>+/<i>fa</i></sup> rats; ZO, Zucker-Lepr<i><sup>fa/fa</sup></i> rats.</p>", "links"=>[], "tags"=>["Biochemistry", "microbiology", "nutrition", "Gastroenterology and hepatology", "leptin", "adiponectin", "concentrations", "rats", "fed", "placebo", "strains", "30"], "article_id"=>1034450, "categories"=>["Biological Sciences"], "users"=>["Julio Plaza-Diaz", "Carolina Gomez-Llorente", "Francisco Abadia-Molina", "Maria Jose Saez-Lara", "Laura Campaña-Martin", "Sergio Muñoz-Quezada", "Fernando Romero", "Angel Gil", "Luis Fontana"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098401.g004", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_leptin_A_and_adiponectin_B_concentrations_of_Zucker_lean_fa_and_Zucker_Lepr_fa_fa_rats_that_were_fed_either_a_placebo_or_LAB_strains_for_30_days_/1034450", "title"=>"Serum leptin (A) and adiponectin (B) concentrations of Zucker-lean<sup>+/<i>fa</i></sup> and Zucker-Lepr<i><sup>fa/fa</sup></i> rats that were fed either a placebo or LAB strains for 30 days.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-22 03:21:04"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
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  • {"unique-ip"=>"18", "full-text"=>"26", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
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  • {"unique-ip"=>"6", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
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Relative Metric

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