Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown
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{"title"=>"Speech sound processing deficits and training-induced neural plasticity in rats with dyslexia gene knockdown", "type"=>"journal", "authors"=>[{"first_name"=>"Tracy M.", "last_name"=>"Centanni", "scopus_author_id"=>"55780561300"}, {"first_name"=>"Fuyi", "last_name"=>"Chen", "scopus_author_id"=>"55810683800"}, {"first_name"=>"Anne M.", "last_name"=>"Booker", "scopus_author_id"=>"6603792730"}, {"first_name"=>"Crystal T.", "last_name"=>"Engineer", "scopus_author_id"=>"24166339900"}, {"first_name"=>"Andrew M.", "last_name"=>"Sloan", "scopus_author_id"=>"7005636503"}, {"first_name"=>"Robert L.", "last_name"=>"Rennaker", "scopus_author_id"=>"7801616439"}, {"first_name"=>"Joseph J.", "last_name"=>"LoTurco", "scopus_author_id"=>"7003693464"}, {"first_name"=>"Michael P.", "last_name"=>"Kilgard", "scopus_author_id"=>"6603889432"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"373194688", "sgr"=>"84901596192", "issn"=>"19326203", "pmid"=>"24871331", "scopus"=>"2-s2.0-84901596192", "doi"=>"10.1371/journal.pone.0098439", "isbn"=>"1932-6203 (Electronic) 1932-6203 (Linking)"}, "id"=>"7a7bbb05-845c-3ddb-979f-88370e38dece", "abstract"=>"In utero RNAi of the dyslexia-associated gene Kiaa0319 in rats (KIA-) degrades cortical responses to speech sounds and increases trial-by-trial variability in onset latency. We tested the hypothesis that KIA- rats would be impaired at speech sound discrimination. KIA- rats needed twice as much training in quiet conditions to perform at control levels and remained impaired at several speech tasks. Focused training using truncated speech sounds was able to normalize speech discrimination in quiet and background noise conditions. Training also normalized trial-by-trial neural variability and temporal phase locking. Cortical activity from speech trained KIA- rats was sufficient to accurately discriminate between similar consonant sounds. These results provide the first direct evidence that assumed reduced expression of the dyslexia-associated gene KIAA0319 can cause phoneme processing impairments similar to those seen in dyslexia and that intensive behavioral therapy can eliminate these impairments.", "link"=>"http://www.mendeley.com/research/speech-sound-processing-deficits-traininginduced-neural-plasticity-rats-dyslexia-gene-knockdown", "reader_count"=>37, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>9, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>7, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Researcher"=>9, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>7, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Engineering"=>4, "Biochemistry, Genetics and Molecular Biology"=>2, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>3, "Neuroscience"=>6, "Psychology"=>5}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>4}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>6}, "Psychology"=>{"Psychology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>7}}, "reader_count_by_country"=>{"United States"=>3, "United Kingdom"=>2}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1512397"], "description"=>"<p><b>A</b>. Performance of KIA- and control rats on the first 5 days of full length speech training. KIA- rats were significantly worse than control rats on the full speech discrimination task on 4 of the days (* = p<0.01). <b>B</b>. On day 5 of testing, KIA- rats hit to the target sound dad at the same rate as control rats (unpaired t-test; p = 0.33), but false alarmed to the distractor sounds significantly more than control rats (* = p = 0.04). <b>C</b>. Break down of lever press rates on day 5 of testing to each of the distractor sounds. KIA- rats responded to every sound significantly more than control rats (unpaired t-tests, * = p<0.01).</p>", "links"=>[], "tags"=>["organisms", "animals", "vertebrates", "mammals", "rodents", "rats", "genetics", "epigenetics", "RNA interference", "gene expression", "Genetics of disease", "neuroscience", "neuropsychology", "psychology", "Model organisms", "Animal models", "neurology", "Developmental and pediatric neurology", "linguistics", "languages", "Natural language", "speech", "Sociology", "communications", "rnai", "impaired"], "article_id"=>1039019, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Tracy M. Centanni", "Fuyi Chen", "Anne M. Booker", "Crystal T. Engineer", "Andrew M. Sloan", "Robert L. Rennaker", "Joseph J. LoTurco", "Michael P. Kilgard"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0098439.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Rats_with_in_utero_RNAi_of_Kiaa0319_are_impaired_at_speech_discrimination_tasks_/1039019", "title"=>"Rats with <i>in utero</i> RNAi of <i>Kiaa0319</i> are impaired at speech discrimination tasks.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-28 03:00:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/1512398"], "description"=>"<p>Horizontal lines in each panel represent chance performance for that task. <b>A</b>. Timeline of performance on the full length speech task. After an additional week of training, 8 KIA- rats were able to perform the full speech task at the same level as 5 control rats (unpaired t-test, p = 0.24). <b>B</b>. Timeline of performance on speech in noise task. KIA- rats remained significantly below control levels at the end of training (* = p<0.05). <b>C</b>. Timeline of performance on sequence task. There were no significant differences between control and KIA- rats during this 40 day training period. Symbols correspond to the first day of training at each new stage (see panel F for symbol key). <b>D</b>. Timeline of performance on truncated speech task. KIA- rats were significantly impaired at this task compared to controls until the final day of training (* = p<0.01). <b>E</b>. Last day performance of rats on the speech in noise task. (* = p<0.01). <b>F</b>. Last day performance of rats on the sequence task. There were no significant differences between control and KIA- rats at any presentation rate tested (2 sps, p = 0.45; 4 sps, p = 0.68; 5 sps, p = 0.27; 6.67 sps, p = 0.65; 10 sps, p = 0.99; 20 sps, p = 0.74).</p>", "links"=>[], "tags"=>["organisms", "animals", "vertebrates", "mammals", "rodents", "rats", "genetics", "epigenetics", "RNA interference", "gene expression", "Genetics of disease", "neuroscience", "neuropsychology", "psychology", "Model organisms", "Animal models", "neurology", "Developmental and pediatric neurology", "linguistics", "languages", "Natural language", "speech", "Sociology", "communications"], "article_id"=>1039020, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Tracy M. Centanni", "Fuyi Chen", "Anne M. Booker", "Crystal T. Engineer", "Andrew M. Sloan", "Robert L. Rennaker", "Joseph J. LoTurco", "Michael P. Kilgard"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0098439.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Extensive_speech_discrimination_training_can_improve_on_clear_speech_tasks_/1039020", "title"=>"Extensive speech discrimination training can improve on clear speech tasks.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-28 03:00:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/1512399"], "description"=>"<p>Correlation line denotes significance. <b>A</b>. The percentage of layer 2/3 pyramidal neurons affected by the transfection was calculated in A1 bilaterally. In KIA- rats, a higher percentage of transfected neurons was strongly correlated with impaired behavioral performance on the last day of full speech training (R = −0.66, p<0.01). <b>B</b>. The percentage of transfected neurons in control animals was not correlated with performance (R = 0.88, p = 0.12).</p>", "links"=>[], "tags"=>["organisms", "animals", "vertebrates", "mammals", "rodents", "rats", "genetics", "epigenetics", "RNA interference", "gene expression", "Genetics of disease", "neuroscience", "neuropsychology", "psychology", "Model organisms", "Animal models", "neurology", "Developmental and pediatric neurology", "linguistics", "languages", "Natural language", "speech", "Sociology", "communications", "transfected", "neurons", "aptitude", "kia-"], "article_id"=>1039021, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Tracy M. Centanni", "Fuyi Chen", "Anne M. Booker", "Crystal T. Engineer", "Andrew M. Sloan", "Robert L. Rennaker", "Joseph J. LoTurco", "Michael P. Kilgard"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0098439.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Percentage_of_transfected_neurons_predicts_behavioral_aptitude_in_KIA_rats_/1039021", "title"=>"Percentage of transfected neurons predicts behavioral aptitude in KIA- rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-28 03:00:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/1512400"], "description"=>"<p>Horizontal lines in each panel represent chance performance for that task. <b>A</b>. Timeline of group 2 rats' performance on truncated speech task. KIA- rats needed slightly longer to reach 80% correct compared to controls (unpaired 1-tailed t-test, p = 0.07). At the end of training, there was no significant difference in performance across groups (unpaired 1-tailed t-test, p = 0.11). <b>B</b>. Timeline of performance on full length speech task. <b>C</b>. Timeline of performance on the speech in noise task. <b>D</b>. Timeline of performance on the sequence task. Performance on this task falls slightly over time due to the addition of increased repetition rates. <b>E</b>. Last day of speech in noise performance by control and KIA- rats. <b>F</b>. Last day of sequence performance.</p>", "links"=>[], "tags"=>["organisms", "animals", "vertebrates", "mammals", "rodents", "rats", "genetics", "epigenetics", "RNA interference", "gene expression", "Genetics of disease", "neuroscience", "neuropsychology", "psychology", "Model organisms", "Animal models", "neurology", "Developmental and pediatric neurology", "linguistics", "languages", "Natural language", "speech", "Sociology", "communications", "truncated", "improves", "kia-"], "article_id"=>1039022, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Tracy M. Centanni", "Fuyi Chen", "Anne M. Booker", "Crystal T. Engineer", "Andrew M. Sloan", "Robert L. Rennaker", "Joseph J. LoTurco", "Michael P. Kilgard"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0098439.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Extensive_truncated_speech_training_improves_full_speech_and_speech_in_noise_performance_in_KIA_rats_/1039022", "title"=>"Extensive truncated speech training improves full speech and speech in noise performance in KIA- rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-28 03:00:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/1512401"], "description"=>"<p><b>A</b>. Training significantly decreased the variability in onset latency in KIA- A1 (* = p<0.01) and KIA- PAF (* = p<0.01). Training also decreased variability in control A1 (* = p = 0.04) and control PAF (* = p<0.01). <b>B</b>. Training significantly increased the number of evoked spikes (* = p<0.04). <b>C</b>. Consonant classifier performance before and after training. (* = p<0.01). <b>D</b>. Vowel classifier performance before and after training.</p>", "links"=>[], "tags"=>["organisms", "animals", "vertebrates", "mammals", "rodents", "rats", "genetics", "epigenetics", "RNA interference", "gene expression", "Genetics of disease", "neuroscience", "neuropsychology", "psychology", "Model organisms", "Animal models", "neurology", "Developmental and pediatric neurology", "linguistics", "languages", "Natural language", "speech", "Sociology", "communications", "improves", "neural", "firing"], "article_id"=>1039023, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Tracy M. Centanni", "Fuyi Chen", "Anne M. Booker", "Crystal T. Engineer", "Andrew M. Sloan", "Robert L. Rennaker", "Joseph J. LoTurco", "Michael P. Kilgard"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0098439.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Extensive_behavioral_training_improves_reliability_of_neural_firing_and_neural_discrimination_performance_/1039023", "title"=>"Extensive behavioral training improves reliability of neural firing and neural discrimination performance.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-28 03:00:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/1512402"], "description"=>"<p>Single site examples of neural responses to the consonant sounds /d/ and /b/ in every field before and after training. Classifier performance for each site is plotted on top of each panel, and trials which the classifier guessed incorrectly are marked by an ‘x’. <b>A–D</b>. Representative examples of single site responses to the consonants /b/ and /d/ in A1 and PAF of untrained control or KIA- rats. <b>E–F</b>. Representative examples of single site responses to the consonants /b/ and /d/ in A1 and PAF of control or KIA- rats after training was complete.</p>", "links"=>[], "tags"=>["organisms", "animals", "vertebrates", "mammals", "rodents", "rats", "genetics", "epigenetics", "RNA interference", "gene expression", "Genetics of disease", "neuroscience", "neuropsychology", "psychology", "Model organisms", "Animal models", "neurology", "Developmental and pediatric neurology", "linguistics", "languages", "Natural language", "speech", "Sociology", "communications", "improves", "firing", "consonant"], "article_id"=>1039024, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Tracy M. Centanni", "Fuyi Chen", "Anne M. Booker", "Crystal T. Engineer", "Andrew M. Sloan", "Robert L. Rennaker", "Joseph J. LoTurco", "Michael P. Kilgard"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0098439.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Training_improves_firing_reliability_in_response_to_consonant_speech_sounds_/1039024", "title"=>"Training improves firing reliability in response to consonant speech sounds.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-28 03:00:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/1512403"], "description"=>"<p><b>A</b>. Untrained KIA- A1 sites are significantly worse at following repetitive stimuli as measured by vector strength (* = p<0.01). <b>B</b>. Vector strength in control and KIA- A1 following auditory training. <b>C</b>. Vector strength in untrained control and KIA- PAF sites. <b>D</b>. Vector strength in control and KIA- PAF following auditory training.</p>", "links"=>[], "tags"=>["organisms", "animals", "vertebrates", "mammals", "rodents", "rats", "genetics", "epigenetics", "RNA interference", "gene expression", "Genetics of disease", "neuroscience", "neuropsychology", "psychology", "Model organisms", "Animal models", "neurology", "Developmental and pediatric neurology", "linguistics", "languages", "Natural language", "speech", "Sociology", "communications", "improves", "kia-", "a1", "paf", "sites", "reliably", "repetitive"], "article_id"=>1039025, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Tracy M. Centanni", "Fuyi Chen", "Anne M. Booker", "Crystal T. Engineer", "Andrew M. Sloan", "Robert L. Rennaker", "Joseph J. LoTurco", "Michael P. Kilgard"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0098439.g007"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Training_improves_the_ability_of_KIA_A1_and_PAF_sites_to_fire_reliably_to_repetitive_stimuli_/1039025", "title"=>"Training improves the ability of KIA- A1 and PAF sites to fire reliably to repetitive stimuli.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-28 03:00:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/1512404"], "description"=>"<p>Responses are plotted with gray markers at −50 and 50 mV to help visualize differences across plots. Significant differences are marked by a black line. <b>A</b>. LFP response to the sound /dad/ in untrained control and KIA- A1. <b>B</b>. Extensive training improves onset latency and amplitude of the LFP response in KIA- A1. <b>C</b>. LFP response to the sound /dad/ in untrained control and KIA- PAF sites. As was seen in A1 recordings, latency and amplitude of KIA- PAF responses were significantly different from control recordings. <b>D</b>. Following training, there were not significant differences in the LFP response to the sound /dad/ between control PAF and KIA- PAF.</p>", "links"=>[], "tags"=>["organisms", "animals", "vertebrates", "mammals", "rodents", "rats", "genetics", "epigenetics", "RNA interference", "gene expression", "Genetics of disease", "neuroscience", "neuropsychology", "psychology", "Model organisms", "Animal models", "neurology", "Developmental and pediatric neurology", "linguistics", "languages", "Natural language", "speech", "Sociology", "communications", "shortens", "latency", "amplitude", "n1", "lfp"], "article_id"=>1039026, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Tracy M. Centanni", "Fuyi Chen", "Anne M. Booker", "Crystal T. Engineer", "Andrew M. Sloan", "Robert L. Rennaker", "Joseph J. LoTurco", "Michael P. Kilgard"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0098439.g008"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Extensive_behavioral_training_shortens_latency_and_increases_amplitude_of_N1_component_of_LFP_response_/1039026", "title"=>"Extensive behavioral training shortens latency and increases amplitude of N1 component of LFP response.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-05-28 03:00:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/1512405", "https://ndownloader.figshare.com/files/1512406", "https://ndownloader.figshare.com/files/1512407", "https://ndownloader.figshare.com/files/1512408", "https://ndownloader.figshare.com/files/1512409", "https://ndownloader.figshare.com/files/1512410"], "description"=>"<div><p><i>In utero</i> RNAi of the dyslexia-associated gene <i>Kiaa0319</i> in rats (KIA-) degrades cortical responses to speech sounds and increases trial-by-trial variability in onset latency. We tested the hypothesis that KIA- rats would be impaired at speech sound discrimination. KIA- rats needed twice as much training in quiet conditions to perform at control levels and remained impaired at several speech tasks. Focused training using truncated speech sounds was able to normalize speech discrimination in quiet and background noise conditions. Training also normalized trial-by-trial neural variability and temporal phase locking. Cortical activity from speech trained KIA- rats was sufficient to accurately discriminate between similar consonant sounds. These results provide the first direct evidence that assumed reduced expression of the dyslexia-associated gene <i>KIAA0319</i> can cause phoneme processing impairments similar to those seen in dyslexia and that intensive behavioral therapy can eliminate these impairments.</p></div>", "links"=>[], "tags"=>["organisms", "animals", "vertebrates", "mammals", "rodents", "rats", "genetics", "epigenetics", "RNA interference", "gene expression", "Genetics of disease", "neuroscience", "neuropsychology", "psychology", "Model organisms", "Animal models", "neurology", "Developmental and pediatric neurology", "linguistics", "languages", "Natural language", "speech", "Sociology", "communications", "deficits", "training-induced", "neural", "plasticity", "dyslexia"], "article_id"=>1039027, "categories"=>["Biological Sciences", "Science Policy"], "users"=>["Tracy M. Centanni", "Fuyi Chen", "Anne M. Booker", "Crystal T. Engineer", "Andrew M. Sloan", "Robert L. Rennaker", "Joseph J. LoTurco", "Michael P. Kilgard"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0098439.s001", "https://dx.doi.org/10.1371/journal.pone.0098439.s002", "https://dx.doi.org/10.1371/journal.pone.0098439.s003", "https://dx.doi.org/10.1371/journal.pone.0098439.s004", "https://dx.doi.org/10.1371/journal.pone.0098439.s005", "https://dx.doi.org/10.1371/journal.pone.0098439.s006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Speech_Sound_Processing_Deficits_and_Training_Induced_Neural_Plasticity_in_Rats_with_Dyslexia_Gene_Knockdown_/1039027", "title"=>"Speech Sound Processing Deficits and Training-Induced Neural Plasticity in Rats with Dyslexia Gene Knockdown", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-05-28 03:00:18"}

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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[267]}, {"subject_area"=>"/Biology and life sciences/Organisms", "average_usage"=>[310]}, {"subject_area"=>"/Social sciences/Linguistics", "average_usage"=>[348, 505]}]}
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