The HIVToolbox 2 Web System Integrates Sequence, Structure, Function and Mutation Analysis
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"The HIVToolbox 2 web system integrates sequence, structure, function and mutation analysis", "type"=>"journal", "authors"=>[{"first_name"=>"David P.", "last_name"=>"Sargeant", "scopus_author_id"=>"36605085500"}, {"first_name"=>"Sandeep", "last_name"=>"Deverasetty", "scopus_author_id"=>"38361386700"}, {"first_name"=>"Christy L.", "last_name"=>"Strong", "scopus_author_id"=>"24492561600"}, {"first_name"=>"Izua J.", "last_name"=>"Alaniz", "scopus_author_id"=>"39061010100"}, {"first_name"=>"Alexandria", "last_name"=>"Bartlett", "scopus_author_id"=>"56150737800"}, {"first_name"=>"Nicholas R.", "last_name"=>"Brandon", "scopus_author_id"=>"56150625500"}, {"first_name"=>"Steven B.", "last_name"=>"Brooks", "scopus_author_id"=>"56149386600"}, {"first_name"=>"Frederick A.", "last_name"=>"Brown", "scopus_author_id"=>"56150378800"}, {"first_name"=>"Flaviona", "last_name"=>"Bufi", "scopus_author_id"=>"56150590200"}, {"first_name"=>"Monika", "last_name"=>"Chakarova", "scopus_author_id"=>"56149977700"}, {"first_name"=>"Roxanne P.", "last_name"=>"David", "scopus_author_id"=>"56149214700"}, {"first_name"=>"Karlyn M.", "last_name"=>"Dobritch", "scopus_author_id"=>"56149034500"}, {"first_name"=>"Horacio P.", "last_name"=>"Guerra", "scopus_author_id"=>"56150024800"}, {"first_name"=>"Michael W.", "last_name"=>"Hedden", "scopus_author_id"=>"56149389000"}, {"first_name"=>"Rma", "last_name"=>"Kumra", "scopus_author_id"=>"56203421400"}, {"first_name"=>"Kelvy S.", "last_name"=>"Levitt", "scopus_author_id"=>"56204178600"}, {"first_name"=>"Kiran R.", "last_name"=>"Mathew", "scopus_author_id"=>"56149523400"}, {"first_name"=>"Ray", "last_name"=>"Matti", "scopus_author_id"=>"56150392200"}, {"first_name"=>"Dorothea Q.", "last_name"=>"Maza", "scopus_author_id"=>"56150825500"}, {"first_name"=>"Sabyasachy", "last_name"=>"Mistry", "scopus_author_id"=>"56149506200"}, {"first_name"=>"Nemanja", "last_name"=>"Novakovic", "scopus_author_id"=>"56149104400"}, {"first_name"=>"Austin", "last_name"=>"Pomerantz", "scopus_author_id"=>"56151043400"}, {"first_name"=>"Josue", "last_name"=>"Portillo", "scopus_author_id"=>"56203708100"}, {"first_name"=>"Timothy F.", "last_name"=>"Rafalski", "scopus_author_id"=>"56149269500"}, {"first_name"=>"Viraj R.", "last_name"=>"Rathnayake", "scopus_author_id"=>"36661456900"}, {"first_name"=>"Noura", "last_name"=>"Rezapour", "scopus_author_id"=>"56150913800"}, {"first_name"=>"Sarah", "last_name"=>"Songao", "scopus_author_id"=>"56149461600"}, {"first_name"=>"Sean L.", "last_name"=>"Tuggle", "scopus_author_id"=>"56149015200"}, {"first_name"=>"Sandy", "last_name"=>"Yousif", "scopus_author_id"=>"56149767700"}, {"first_name"=>"David I.", "last_name"=>"Dorsky", "scopus_author_id"=>"6603744506"}, {"first_name"=>"Martin R.", "last_name"=>"Schiller", "scopus_author_id"=>"7101808538"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84902322300", "isbn"=>"1932-6203", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0098810", "scopus"=>"2-s2.0-84902322300", "pui"=>"373302336", "pmid"=>"24886930"}, "id"=>"5f7b2508-544f-3dab-a420-b048cf9398b8", "abstract"=>"There is enormous interest in studying HIV pathogenesis for improving the treatment of patients with HIV infection. HIV infection has become one of the best-studied systems for understanding how a virus can hijack a cell. To help facilitate discovery, we previously built HIVToolbox, a web system for visual data mining. The original HIVToolbox integrated information for HIV protein sequence, structure, functional sites, and sequence conservation. This web system has been used for almost 40,000 searches. We report improvements to HIVToolbox including new functions and workflows, data updates, and updates for ease of use. HIVToolbox2, is an improvement over HIVToolbox with new functions. HIVToolbox2 has new functionalities focused on HIV pathogenesis including drug-binding sites, drug-resistance mutations, and immune epitopes. The integrated, interactive view enables visual mining to generate hypotheses that are not readily revealed by other approaches. Most HIV proteins form multimers, and there are posttranslational modification and protein-protein interaction sites at many of these multimerization interfaces. Analysis of protease drug binding sites reveals an anatomy of drug resistance with different types of drug-resistance mutations regionally localized on the surface of protease. Some of these drug-resistance mutations have a high prevalence in specific HIV-1 M subtypes. Finally, consolidation of Tat functional sites reveals a hotspot region where there appear to be 30 interactions or posttranslational modifications. A cursory analysis with HIVToolbox2 has helped to identify several global patterns for HIV proteins. An initial analysis with this tool identifies homomultimerization of almost all HIV proteins, functional sites that overlap with multimerization sites, a global drug resistance anatomy for HIV protease, and specific distributions of some DRMs in specific HIV M subtypes. HIVToolbox2 is an open-access web application available at [http://hivtoolbox2.bio-toolkit.com].", "link"=>"http://www.mendeley.com/research/hivtoolbox-2-web-system-integrates-sequence-structure-function-mutation-analysis", "reader_count"=>10, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>4, "Computer Science"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84902322300"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84902322300?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84902322300&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84902322300&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84902322300", "dc:identifier"=>"SCOPUS_ID:84902322300", "eid"=>"2-s2.0-84902322300", "dc:title"=>"The HIVToolbox 2 web system integrates sequence, structure, function and mutation analysis", "dc:creator"=>"Sargeant D.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"9", "prism:issueIdentifier"=>"6", "prism:pageRange"=>nil, "prism:coverDate"=>"2014-06-02", "prism:coverDisplayDate"=>"2 June 2014", "prism:doi"=>"10.1371/journal.pone.0098810", "citedby-count"=>"2", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"University of Nevada, Las Vegas", "affiliation-city"=>"Las Vegas", "affiliation-country"=>"United States"}], "pubmed-id"=>"24886930", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e98810", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0098810", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"36", "xml_views"=>"17", "html_views"=>"153"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"19"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"22"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"93"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"100"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"107"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"85"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"82"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"2", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"3", "html_views"=>"27"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"11"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"19"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"44"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"22"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"3", "html_views"=>"2"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"0"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"0"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1517571"], "description"=>"<p>*The reference sequence for HIV-1 protease is NP_705926.</p>", "links"=>[], "tags"=>["Computational biology", "Biological data management", "Computer software", "Infectious diseases", "Viral diseases", "HIV infections", "mutation", "distributions", "protease", "hiv-1"], "article_id"=>1043259, "categories"=>["Biological Sciences"], "users"=>["David P. Sargeant", "Sandeep Deverasetty", "Christy L. Strong", "Izua J. Alaniz", "Alexandria Bartlett", "Nicholas R. Brandon", "Steven B. Brooks", "Frederick A. Brown", "Flaviona Bufi", "Monika Chakarova", "Roxanne P. David", "Karlyn M. Dobritch", "Horacio P. Guerra", "Michael W. Hedden", "Rma Kumra", "Kelvy S. Levitt", "Kiran R. Mathew", "Ray Matti", "Dorothea Q. Maza", "Sabyasachy Mistry", "Nemanja Novakovic", "Austin Pomerantz", "Josue Portillo", "Timothy F. Rafalski", "Viraj R. Rathnayake", "Noura Rezapour", "Sarah Songao", "Sean L. Tuggle", "Sandy Yousif", "David I. Dorsky", "Martin R. Schiller"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098810.t005", "stats"=>{"downloads"=>0, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HIV_Mutation_distributions_for_protease_in_select_HIV_1_Class_M_subtypes_/1043259", "title"=>"HIV Mutation distributions for protease in select HIV-1 Class M subtypes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-02 05:07:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1517569"], "description"=>"<p>*Bolded residues are known multimerization inhibitors.</p>", "links"=>[], "tags"=>["Computational biology", "Biological data management", "Computer software", "Infectious diseases", "Viral diseases", "HIV infections", "hiv"], "article_id"=>1043258, "categories"=>["Biological Sciences"], "users"=>["David P. Sargeant", "Sandeep Deverasetty", "Christy L. Strong", "Izua J. Alaniz", "Alexandria Bartlett", "Nicholas R. Brandon", "Steven B. Brooks", "Frederick A. Brown", "Flaviona Bufi", "Monika Chakarova", "Roxanne P. David", "Karlyn M. Dobritch", "Horacio P. Guerra", "Michael W. Hedden", "Rma Kumra", "Kelvy S. Levitt", "Kiran R. Mathew", "Ray Matti", "Dorothea Q. Maza", "Sabyasachy Mistry", "Nemanja Novakovic", "Austin Pomerantz", "Josue Portillo", "Timothy F. Rafalski", "Viraj R. Rathnayake", "Noura Rezapour", "Sarah Songao", "Sean L. Tuggle", "Sandy Yousif", "David I. Dorsky", "Martin R. Schiller"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098810.t004", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multimerization_of_HIV_proteins_/1043258", "title"=>"Multimerization of HIV proteins.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-02 05:07:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1517565"], "description"=>"<p>Previously not capable in the original HIVToolbox application.</p><p>Conservation can be examined for all viruses or within subtypes.</p><p>NP_705926 is used as the reference sequence for protease.</p>", "links"=>[], "tags"=>["Computational biology", "Biological data management", "Computer software", "Infectious diseases", "Viral diseases", "HIV infections", "cases", "enabled"], "article_id"=>1043253, "categories"=>["Biological Sciences"], "users"=>["David P. Sargeant", "Sandeep Deverasetty", "Christy L. Strong", "Izua J. Alaniz", "Alexandria Bartlett", "Nicholas R. Brandon", "Steven B. Brooks", "Frederick A. Brown", "Flaviona Bufi", "Monika Chakarova", "Roxanne P. David", "Karlyn M. Dobritch", "Horacio P. Guerra", "Michael W. Hedden", "Rma Kumra", "Kelvy S. Levitt", "Kiran R. Mathew", "Ray Matti", "Dorothea Q. Maza", "Sabyasachy Mistry", "Nemanja Novakovic", "Austin Pomerantz", "Josue Portillo", "Timothy F. Rafalski", "Viraj R. Rathnayake", "Noura Rezapour", "Sarah Songao", "Sean L. Tuggle", "Sandy Yousif", "David I. Dorsky", "Martin R. Schiller"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098810.t003", "stats"=>{"downloads"=>0, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Example_of_use_cases_1_8211_16_enabled_by_HIVToolbox2_/1043253", "title"=>"Example of use cases 1–16 enabled by HIVToolbox2.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-02 05:07:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1517487"], "description"=>"<p><b>A</b>. DRM structure window showing the structure of HIV protease:Saquinavir complex (1C6Z) with DRMs for Saquinavir colored. The coloring scheme for the DRMs is beneficial (green), beneficial set (dark green; not shown), primary (red), primary set (pink), secondary set (purple) <b>B</b>. Information for each DRM is shown in a table that is color coded using the same DRM coloring scheme. DRMs for different drugs can be loaded using the pulldown menu at the bottom of the table. This sortable table also provides the chain:position, mutated amino acid, and links to the abstracts of PubMed papers supporting the DRM. The first column of this table is interactive, where a mouse click identifies the amino acid in the structure of the DRM structure window (<b>A</b>).</p>", "links"=>[], "tags"=>["Computational biology", "Biological data management", "Computer software", "Infectious diseases", "Viral diseases", "HIV infections", "mutations"], "article_id"=>1043174, "categories"=>["Biological Sciences"], "users"=>["David P. Sargeant", "Sandeep Deverasetty", "Christy L. Strong", "Izua J. Alaniz", "Alexandria Bartlett", "Nicholas R. Brandon", "Steven B. Brooks", "Frederick A. Brown", "Flaviona Bufi", "Monika Chakarova", "Roxanne P. David", "Karlyn M. Dobritch", "Horacio P. Guerra", "Michael W. Hedden", "Rma Kumra", "Kelvy S. Levitt", "Kiran R. Mathew", "Ray Matti", "Dorothea Q. Maza", "Sabyasachy Mistry", "Nemanja Novakovic", "Austin Pomerantz", "Josue Portillo", "Timothy F. Rafalski", "Viraj R. Rathnayake", "Noura Rezapour", "Sarah Songao", "Sean L. Tuggle", "Sandy Yousif", "David I. Dorsky", "Martin R. Schiller"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098810.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Drug_Resistance_Mutations_structure_window_and_table_/1043174", "title"=>"Drug Resistance Mutations structure window and table.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-02 05:07:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1517563"], "description"=>"<p>HIVToolbox2 Data Statistics.</p>", "links"=>[], "tags"=>["Computational biology", "Biological data management", "Computer software", "Infectious diseases", "Viral diseases", "HIV infections"], "article_id"=>1043252, "categories"=>["Biological Sciences"], "users"=>["David P. Sargeant", "Sandeep Deverasetty", "Christy L. Strong", "Izua J. Alaniz", "Alexandria Bartlett", "Nicholas R. Brandon", "Steven B. Brooks", "Frederick A. Brown", "Flaviona Bufi", "Monika Chakarova", "Roxanne P. David", "Karlyn M. Dobritch", "Horacio P. Guerra", "Michael W. Hedden", "Rma Kumra", "Kelvy S. Levitt", "Kiran R. Mathew", "Ray Matti", "Dorothea Q. Maza", "Sabyasachy Mistry", "Nemanja Novakovic", "Austin Pomerantz", "Josue Portillo", "Timothy F. Rafalski", "Viraj R. Rathnayake", "Noura Rezapour", "Sarah Songao", "Sean L. Tuggle", "Sandy Yousif", "David I. Dorsky", "Martin R. Schiller"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098810.t002", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HIVToolbox2_Data_Statistics_/1043252", "title"=>"HIVToolbox2 Data Statistics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-02 05:07:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1517562"], "description"=>"<p>A collection of DRM surface plots for HIV protease generated with HIVToolbox2. All plots are for a structure of Amprenavir (ball and stick) bound to one subunit of protease (1HPV, chain A). The top-left panel shows functional sites and the adjacent panel shows all known immune epitopes from the IEDB ids 32326, 40375, 64343, and 71361. All other panels show resistance to different FDA-approved HIV protease inhibitors. The last panel shows a compendium of DRMs identify regions of the protease with different types of DRMs. The coloring of DRMs is as in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098810#pone-0098810-g002\" target=\"_blank\"><b>Fig. 2</b></a>.</p>", "links"=>[], "tags"=>["Computational biology", "Biological data management", "Computer software", "Infectious diseases", "Viral diseases", "HIV infections", "drm"], "article_id"=>1043249, "categories"=>["Biological Sciences"], "users"=>["David P. Sargeant", "Sandeep Deverasetty", "Christy L. Strong", "Izua J. Alaniz", "Alexandria Bartlett", "Nicholas R. Brandon", "Steven B. Brooks", "Frederick A. Brown", "Flaviona Bufi", "Monika Chakarova", "Roxanne P. David", "Karlyn M. Dobritch", "Horacio P. Guerra", "Michael W. Hedden", "Rma Kumra", "Kelvy S. Levitt", "Kiran R. Mathew", "Ray Matti", "Dorothea Q. Maza", "Sabyasachy Mistry", "Nemanja Novakovic", "Austin Pomerantz", "Josue Portillo", "Timothy F. Rafalski", "Viraj R. Rathnayake", "Noura Rezapour", "Sarah Songao", "Sean L. Tuggle", "Sandy Yousif", "David I. Dorsky", "Martin R. Schiller"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098810.g007", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Protease_DRM_landscape_/1043249", "title"=>"Protease DRM landscape.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-02 05:07:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1517527"], "description"=>"<p>Synchronized structure windows of HIV protease:Saquinavir complex (1C6Z; chain A; <b>A</b>–<b>F</b>) and information tables (<b>G</b>–<b>H</b>). The coloring schemes are: <b>A.</b> Domains and motifs are colored in the Domain/Motif window as defined in the Log windows (not shown). <b>B.</b> Functional sites and protein-protein interactions are colored in the Protein Interactions/Sites window <b>C.</b> Conservation of the residues is shown in the Homology window. The conservation slide threshold is set to 99% amino acid identity and yellow residues are conserved among 50,017 viral sequences shown here. <b>D.</b> DRM window with DRMs for Saquinavir colored. The coloring scheme for the DRMs is beneficial (green), beneficial set (light green), primary (red), primary set (pink), secondary set (purple) <b>G.</b> Information for each DRM is shown in a table that is color coded using the same DRM coloring scheme. DRMs for different drugs can be loaded using the pulldown menu at the bottom of the table. This table also provides the original amino acid, position, mutated amino acid, and links to the abstracts of PubMed papers supporting the DRM. The first column of this table is interactive, where a mouse click identifies the amino acid in the structure of the DRM window (<b>D</b>)<b>. </b><b>E.</b> Drug Binding Site window showing the structure of protease with the binding site for Saquinavir colored. The coloring scheme for the DRMs is as in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098810#pone-0098810-g002\" target=\"_blank\"><b>Fig. 2</b></a> with an additional orange color for binding site residues that do not have a known DRM (orange). <b>H.</b> Information for each Drug Binding Site Residue is shown in a table that is color-coded using the same coloring scheme as in <b>E</b>. A distance threshold between atoms of the drug and atoms of the protein (2.5–4.0 Å) can be set using a pulldown menu; 4.0 Å was set in this figure. This table provides the amino acid position, shortest distance to a drug atom, whether it is a DRM, and the type of DRM. The first column of this table is interactive, where a mouse click identifies the amino acid in the structure of the Drug Binding Site window (<b>E</b>)<b>. F.</b> Epitope window showing protease with the immune epitope KMIGGIGGFI colored green. Different positive immune epitopes for the loaded HIV protein from the IEDB can be selected using a pulldown menu on the top of the window that shows the IEDB id number and peptide sequence<sup>4</sup>.</p>", "links"=>[], "tags"=>["Computational biology", "Biological data management", "Computer software", "Infectious diseases", "Viral diseases", "HIV infections", "windows", "hiv"], "article_id"=>1043215, "categories"=>["Biological Sciences"], "users"=>["David P. Sargeant", "Sandeep Deverasetty", "Christy L. Strong", "Izua J. Alaniz", "Alexandria Bartlett", "Nicholas R. Brandon", "Steven B. Brooks", "Frederick A. Brown", "Flaviona Bufi", "Monika Chakarova", "Roxanne P. David", "Karlyn M. Dobritch", "Horacio P. Guerra", "Michael W. Hedden", "Rma Kumra", "Kelvy S. Levitt", "Kiran R. Mathew", "Ray Matti", "Dorothea Q. Maza", "Sabyasachy Mistry", "Nemanja Novakovic", "Austin Pomerantz", "Josue Portillo", "Timothy F. Rafalski", "Viraj R. Rathnayake", "Noura Rezapour", "Sarah Songao", "Sean L. Tuggle", "Sandy Yousif", "David I. Dorsky", "Martin R. Schiller"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098810.g005", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_HIVToolbox2_structure_windows_for_the_HIV_protease_Saquinavir_complex_/1043215", "title"=>"HIVToolbox2 structure windows for the HIV protease:Saquinavir complex.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-02 05:07:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1517541"], "description"=>"<p>Output of HIVToolbox2 for Tat. <b>A.</b> Surface plot of Tat (1TAC) with functional site amino acids colored. Colors are ADP ribosylation sites (blue), proteolysis site (cyan), dimerization site (purple), phosphorylation sites (dark brown, teal), acetylation sites (tan, orange), RNA binding site (brown), methylation sites (red, royal blue), ubiquitination site (gray), and cell attachment site (green). Other sites on the opposite face are not shown. <b>B.</b> Surface Plot showing residues >90% conserved in 2482 Tat sequences (yellow) <b>C.</b> Protein Sequence of Tat. Highlighted colors are as described in <b>A</b>. Mapping of functional site (highlighted fonts) and protein-protein interaction sites (lines underneath sequence). These lines map Tat interaction with Cyclin T1, CDK9, CDK2, Lysine acetyl transferase 2B, 5, Tat interaction protein, Transcription elongation factor 1, p53, p73, Zinc finger and BTB domain containing 7A, Early growth response 1, BCL2-like 11, Protein phosphatase 1, Tubulin α4a, TBP-associated factor 1, several PKCs, and PKD3, Histone cluster 1, Karyopherin β1, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2, DNA directed RNA polymerase II, Eukaryotic translation initiation factor 2α kinase 2 (left to right). The blue shaded box shows residues 15–57.</p>", "links"=>[], "tags"=>["Computational biology", "Biological data management", "Computer software", "Infectious diseases", "Viral diseases", "HIV infections", "sites"], "article_id"=>1043229, "categories"=>["Biological Sciences"], "users"=>["David P. Sargeant", "Sandeep Deverasetty", "Christy L. Strong", "Izua J. Alaniz", "Alexandria Bartlett", "Nicholas R. Brandon", "Steven B. Brooks", "Frederick A. Brown", "Flaviona Bufi", "Monika Chakarova", "Roxanne P. David", "Karlyn M. Dobritch", "Horacio P. Guerra", "Michael W. Hedden", "Rma Kumra", "Kelvy S. Levitt", "Kiran R. Mathew", "Ray Matti", "Dorothea Q. Maza", "Sabyasachy Mistry", "Nemanja Novakovic", "Austin Pomerantz", "Josue Portillo", "Timothy F. Rafalski", "Viraj R. Rathnayake", "Noura Rezapour", "Sarah Songao", "Sean L. Tuggle", "Sandy Yousif", "David I. Dorsky", "Martin R. Schiller"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098810.g006", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Functional_sites_and_their_conservation_in_Tat_/1043229", "title"=>"Functional sites and their conservation in Tat.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-02 05:07:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1517508"], "description"=>"<p>Epitope window showing the structure of protease:Saquinavir complex (1C6Z) with immune epitope KMIGGIGGFI colored green. Different positive immune epitopes for the loaded HIV protein from the IEDB can be selected using a pulldown menu on the top of the window that shows the IEDB id number and peptide sequence or from the sortable Epitopes Log table <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098810#pone.0098810-Vita1\" target=\"_blank\">[25]</a>.</p>", "links"=>[], "tags"=>["Computational biology", "Biological data management", "Computer software", "Infectious diseases", "Viral diseases", "HIV infections"], "article_id"=>1043196, "categories"=>["Biological Sciences"], "users"=>["David P. Sargeant", "Sandeep Deverasetty", "Christy L. Strong", "Izua J. Alaniz", "Alexandria Bartlett", "Nicholas R. Brandon", "Steven B. Brooks", "Frederick A. Brown", "Flaviona Bufi", "Monika Chakarova", "Roxanne P. David", "Karlyn M. Dobritch", "Horacio P. Guerra", "Michael W. Hedden", "Rma Kumra", "Kelvy S. Levitt", "Kiran R. Mathew", "Ray Matti", "Dorothea Q. Maza", "Sabyasachy Mistry", "Nemanja Novakovic", "Austin Pomerantz", "Josue Portillo", "Timothy F. Rafalski", "Viraj R. Rathnayake", "Noura Rezapour", "Sarah Songao", "Sean L. Tuggle", "Sandy Yousif", "David I. Dorsky", "Martin R. Schiller"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098810.g004", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Epitope_structure_window_and_table_/1043196", "title"=>"Epitope structure window and table.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-02 05:07:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1517567"], "description"=>"<p>Definitions for drug resistance mutation classifications.</p>", "links"=>[], "tags"=>["Computational biology", "Biological data management", "Computer software", "Infectious diseases", "Viral diseases", "HIV infections", "mutation"], "article_id"=>1043255, "categories"=>["Biological Sciences"], "users"=>["David P. Sargeant", "Sandeep Deverasetty", "Christy L. Strong", "Izua J. Alaniz", "Alexandria Bartlett", "Nicholas R. Brandon", "Steven B. Brooks", "Frederick A. Brown", "Flaviona Bufi", "Monika Chakarova", "Roxanne P. David", "Karlyn M. Dobritch", "Horacio P. Guerra", "Michael W. Hedden", "Rma Kumra", "Kelvy S. Levitt", "Kiran R. Mathew", "Ray Matti", "Dorothea Q. Maza", "Sabyasachy Mistry", "Nemanja Novakovic", "Austin Pomerantz", "Josue Portillo", "Timothy F. Rafalski", "Viraj R. Rathnayake", "Noura Rezapour", "Sarah Songao", "Sean L. Tuggle", "Sandy Yousif", "David I. Dorsky", "Martin R. Schiller"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098810.t001", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Definitions_for_drug_resistance_mutation_classifications_/1043255", "title"=>"Definitions for drug resistance mutation classifications.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-02 05:07:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1517472"], "description"=>"<p><b>A</b>. The Sequence window shows the sequence of the selected proteins with fonts colored by domain. Highlighted residues are for functional sites shown in the Color Key/Log window (<b>B</b>), which has hyperlinked entries. The PDB structure identifier is also shown here. Colored thick lines above the sequence show the residue mapping of different PDB structures onto the sequence. These can be selected to load different structures. A checkbox at the bottom enables display of individual chains. Figures under the sequence are for predicted or known minimotifs, which can be selected to display in a Structure window. The DxTVxE minimotif is selected and colored purple here. All hyperlinked information about each minimotif is shown in the Motif Key/Log window tab (<b>C</b>).</p>", "links"=>[], "tags"=>["Computational biology", "Biological data management", "Computer software", "Infectious diseases", "Viral diseases", "HIV infections"], "article_id"=>1043160, "categories"=>["Biological Sciences"], "users"=>["David P. Sargeant", "Sandeep Deverasetty", "Christy L. Strong", "Izua J. Alaniz", "Alexandria Bartlett", "Nicholas R. Brandon", "Steven B. Brooks", "Frederick A. Brown", "Flaviona Bufi", "Monika Chakarova", "Roxanne P. David", "Karlyn M. Dobritch", "Horacio P. Guerra", "Michael W. Hedden", "Rma Kumra", "Kelvy S. Levitt", "Kiran R. Mathew", "Ray Matti", "Dorothea Q. Maza", "Sabyasachy Mistry", "Nemanja Novakovic", "Austin Pomerantz", "Josue Portillo", "Timothy F. Rafalski", "Viraj R. Rathnayake", "Noura Rezapour", "Sarah Songao", "Sean L. Tuggle", "Sandy Yousif", "David I. Dorsky", "Martin R. Schiller"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098810.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sequence_display_and_log_windows_/1043160", "title"=>"Sequence display and log windows.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-02 05:07:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/1517499"], "description"=>"<p><b>A</b>. Drug Binding Site structure window showing the structure of HIV protease:Saquinavir complex (1C6Z) with drug binding site for Saquinavir colored. The coloring scheme for the DRMs is as in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098810#pone-0098810-g002\" target=\"_blank\"><b>Fig. 2</b></a> with an additional color for binding site residues that do not have a known DRM (orange). <b>B</b>. Information for each Drug Binding Site Residue is shown in a table that is color-coded using the same coloring scheme. A distance threshold between atoms of the drug and atoms of the protein (2.5–4.0 Å) can be set using a pulldown menu; 4.0 Å was set in this figure. This table provides the chain:position of the amino acid, distance, whether it is a DRM, and the type of DRM. The first column of this sortable table is interactive, where a mouse click identifies the amino acid in the structure of the Drug Binding Site window (<b>A</b>).</p>", "links"=>[], "tags"=>["Computational biology", "Biological data management", "Computer software", "Infectious diseases", "Viral diseases", "HIV infections", "binding"], "article_id"=>1043187, "categories"=>["Biological Sciences"], "users"=>["David P. Sargeant", "Sandeep Deverasetty", "Christy L. Strong", "Izua J. Alaniz", "Alexandria Bartlett", "Nicholas R. Brandon", "Steven B. Brooks", "Frederick A. Brown", "Flaviona Bufi", "Monika Chakarova", "Roxanne P. David", "Karlyn M. Dobritch", "Horacio P. Guerra", "Michael W. Hedden", "Rma Kumra", "Kelvy S. Levitt", "Kiran R. Mathew", "Ray Matti", "Dorothea Q. Maza", "Sabyasachy Mistry", "Nemanja Novakovic", "Austin Pomerantz", "Josue Portillo", "Timothy F. Rafalski", "Viraj R. Rathnayake", "Noura Rezapour", "Sarah Songao", "Sean L. Tuggle", "Sandy Yousif", "David I. Dorsky", "Martin R. Schiller"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098810.g003", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Drug_Binding_Site_structure_window_and_table_/1043187", "title"=>"Drug Binding Site structure window and table.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-02 05:07:49"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"17", "full-text"=>"11", "pdf"=>"11", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"9", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"18", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"3", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"12", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"20", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"11", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"15", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[282]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[306, 482]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[287]}, {"subject_area"=>"/Medicine and health sciences/Pharmacology", "average_usage"=>[286]}]}
Loading … Spinner
There are currently no alerts