Reactivation of Multiple Viruses in Patients with Sepsis
Publication Date
June 11, 2014
Journal
PLOS ONE
Authors
Andrew H. Walton, Jared T. Muenzer, David Rasche, Jonathan S. Boomer, et al
Volume
9
Issue
6
Pages
e98819
DOI
https://dx.plos.org/10.1371/journal.pone.0098819
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0098819
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/24919177
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053360
Europe PMC
http://europepmc.org/abstract/MED/24919177
Web of Science
000338631000028
Scopus
84903384937
Mendeley
http://www.mendeley.com/research/reactivation-multiple-viruses-patients-sepsis
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Reactivation of multiple viruses in patients with sepsis", "type"=>"journal", "authors"=>[{"first_name"=>"Andrew H.", "last_name"=>"Walton", "scopus_author_id"=>"24077174000"}, {"first_name"=>"Jared T.", "last_name"=>"Muenzer", "scopus_author_id"=>"15071135400"}, {"first_name"=>"David", "last_name"=>"Rasche", "scopus_author_id"=>"55681093600"}, {"first_name"=>"Jonathan S.", "last_name"=>"Boomer", "scopus_author_id"=>"6602255844"}, {"first_name"=>"Bryan", "last_name"=>"Sato", "scopus_author_id"=>"55983210600"}, {"first_name"=>"Bernard H.", "last_name"=>"Brownstein", "scopus_author_id"=>"55666823200"}, {"first_name"=>"Alexandre", "last_name"=>"Pachot", "scopus_author_id"=>"6506724932"}, {"first_name"=>"Terrence L.", "last_name"=>"Brooks", "scopus_author_id"=>"56233700100"}, {"first_name"=>"Elena", "last_name"=>"Deych", "scopus_author_id"=>"22952770900"}, {"first_name"=>"William D.", "last_name"=>"Shannon", "scopus_author_id"=>"7005685366"}, {"first_name"=>"Jonathan M.", "last_name"=>"Green", "scopus_author_id"=>"24461794800"}, {"first_name"=>"Gregory A.", "last_name"=>"Storch", "scopus_author_id"=>"7006444717"}, {"first_name"=>"Richard S.", "last_name"=>"Hotchkiss", "scopus_author_id"=>"26643579500"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"373399015", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0098819", "scopus"=>"2-s2.0-84903384937", "pmid"=>"24919177", "sgr"=>"84903384937"}, "id"=>"c53483c9-997f-3af5-b99d-2d7612329a80", "abstract"=>"A current controversy is whether patients with sepsis progress to an immunosuppressed state. We hypothesized that reactivation of latent viruses occurred with prolonged sepsis thereby providing evidence of clinically-relevant immunosuppression and potentially providing a means to serially-monitor patients' immune status. Secondly, if viral loads are markedly elevated, they may contribute to morbidity and mortality. This study determined if reactivation of herpesviruses, polyomaviruses, and the anellovirus TTV occurred in sepsis and correlated with severity. Serial whole blood and plasma samples from 560 critically-ill septic, 161 critically-ill non-septic, and 164 healthy age-matched patients were analyzed by quantitative-polymerase-chain-reaction for cytomegalovirus (CMV), Epstein-Barr (EBV), herpes-simplex (HSV), human herpes virus-6 (HHV-6), and TTV. Polyomaviruses BK and JC were quantitated in urine. Detectable virus was analyzed with respect to secondary fungal and opportunistic bacterial infections, ICU duration, severity of illness, and survival. Patients with protracted sepsis had markedly increased frequency of detectable virus. Cumulative viral DNA detection rates in blood were: CMV (24.2%), EBV (53.2%), HSV (14.1%), HHV-6 (10.4%), and TTV (77.5%). 42.7% of septic patients had presence of two or more viruses. The 50% detection rate for herpesviruses was 5-8 days after sepsis onset. A small subgroup of septic patients had markedly elevated viral loads (>104-106 DNA copies/ml blood) for CMV, EBV, and HSV. Excluding TTV, DNAemia was uncommon in critically-ill non-septic patients and in age-matched healthy controls. Compared to septic patients without DNAemia, septic patients with viremia had increased fungal and opportunistic bacterial infections. Patients with detectable CMV in plasma had higher 90-day mortality compared to CMV-negative patients; p<0.05. Reactivation of latent viruses is common with prolonged sepsis, with frequencies similar to those occurring in transplant patients on immunosuppressive therapy and consistent with development of an immunosuppressive state. Whether reactivated latent viruses contribute to morbidity and mortality in sepsis remains unknown.", "link"=>"http://www.mendeley.com/research/reactivation-multiple-viruses-patients-sepsis", "reader_count"=>90, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>8, "Researcher"=>22, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>5, "Other"=>9, "Student > Master"=>11, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>2, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>8, "Researcher"=>22, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>5, "Other"=>9, "Student > Master"=>11, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>2, "Professor"=>5}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Unspecified"=>7, "Biochemistry, Genetics and Molecular Biology"=>7, "Medicine and Dentistry"=>54, "Agricultural and Biological Sciences"=>11, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>1, "Social Sciences"=>2, "Immunology and Microbiology"=>5}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>54}, "Social Sciences"=>{"Social Sciences"=>2}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Unspecified"=>{"Unspecified"=>7}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Brazil"=>1, "South Africa"=>2, "Russia"=>1}, "group_count"=>1}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84903384937"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84903384937?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84903384937&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84903384937&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84903384937", "dc:identifier"=>"SCOPUS_ID:84903384937", "eid"=>"2-s2.0-84903384937", "dc:title"=>"Reactivation of multiple viruses in patients with sepsis", "dc:creator"=>"Walton A.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"9", "prism:issueIdentifier"=>"6", "prism:pageRange"=>nil, "prism:coverDate"=>"2014-06-11", "prism:coverDisplayDate"=>"11 June 2014", "prism:doi"=>"10.1371/journal.pone.0098819", "citedby-count"=>"160", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Washington University School of Medicine in St. Louis", "affiliation-city"=>"St. Louis", "affiliation-country"=>"United States"}], "pubmed-id"=>"24919177", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e98819", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true, "freetoread"=>{"value"=>[{"$"=>"all"}, {"$"=>"publisherfullgold"}, {"$"=>"repository"}, {"$"=>"repositoryvor"}]}, "freetoreadLabel"=>{"value"=>[{"$"=>"All Open Access"}, {"$"=>"Gold"}, {"$"=>"Green"}]}}

Article Coverage Curated

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0098819", "share_count"=>2, "like_count"=>2, "comment_count"=>1, "click_count"=>0, "total_count"=>5}

Twitter

Counter

  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"598", "xml_views"=>"26", "html_views"=>"3518"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"129", "xml_views"=>"4", "html_views"=>"372"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"51", "xml_views"=>"2", "html_views"=>"163"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"64", "xml_views"=>"1", "html_views"=>"457"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"41", "xml_views"=>"1", "html_views"=>"230"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"38", "xml_views"=>"1", "html_views"=>"186"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"39", "xml_views"=>"1", "html_views"=>"197"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"46", "xml_views"=>"0", "html_views"=>"202"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"164"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"34", "xml_views"=>"1", "html_views"=>"144"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"37", "xml_views"=>"1", "html_views"=>"136"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"123"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"207"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"124"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"93"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"131"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"123"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"96"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"110"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"90"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"96"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"106"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"113"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"32", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"87"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"160"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"400"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"438"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"38", "xml_views"=>"1", "html_views"=>"447"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"531"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"35", "xml_views"=>"1", "html_views"=>"485"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"26", "xml_views"=>"2", "html_views"=>"412"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"477"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"605"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"25", "xml_views"=>"1", "html_views"=>"534"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"575"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"41", "xml_views"=>"1", "html_views"=>"734"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"629"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"21", "xml_views"=>"4", "html_views"=>"202"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"25", "xml_views"=>"4", "html_views"=>"235"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"3", "html_views"=>"173"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"38", "xml_views"=>"2", "html_views"=>"139"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"33", "xml_views"=>"1", "html_views"=>"100"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"36", "xml_views"=>"1", "html_views"=>"95"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"56"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"52", "xml_views"=>"2", "html_views"=>"64"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"22", "xml_views"=>"2", "html_views"=>"52"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"3", "html_views"=>"30"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"2", "html_views"=>"48"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"90"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"46", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"61", "xml_views"=>"0", "html_views"=>"152"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"77"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"2", "html_views"=>"56"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"30", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"2", "html_views"=>"25"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"48", "xml_views"=>"3", "html_views"=>"59"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"26"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"35", "xml_views"=>"2", "html_views"=>"44"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"11", "year"=>"2020", "pdf_views"=>"49", "xml_views"=>"5", "html_views"=>"99"}
  • {"month"=>"12", "year"=>"2020", "pdf_views"=>"25", "xml_views"=>"6", "html_views"=>"22"}
  • {"month"=>"1", "year"=>"2021", "pdf_views"=>"29", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"2", "year"=>"2021", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"21"}
  • {"month"=>"3", "year"=>"2021", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"1"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1531073"], "description"=>"<p>The average number of days spent in the ICU for septic patients with versus without viremia was determined. Septic patients who were positive for CVM, EBV, TTV, HSV, and HHV-6 had longer ICU stays compared to comparable patients who were viral negative. There was no impact of urine JC or BK positivity on ICU length of stay. Values were compared by student's <i>t</i> test.</p>", "links"=>[], "tags"=>["immunology", "Critical care and emergency medicine", "Infectious diseases", "Inflammatory diseases", "viral", "reactivation", "icu"], "article_id"=>1054273, "categories"=>["Biological Sciences"], "users"=>["Andrew H. Walton", "Jared T. Muenzer", "David Rasche", "Jonathan S. Boomer", "Bryan Sato", "Bernard H. Brownstein", "Alexandre Pachot", "Terrence L. Brooks", "Elena Deych", "William D. Shannon", "Jonathan M. Green", "Gregory A. Storch", "Richard S. Hotchkiss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098819.g005", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patients_with_viral_reactivation_have_increased_ICU_length_of_stays_/1054273", "title"=>"Patients with viral reactivation have increased ICU length of stays.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-11 03:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1531075"], "description"=>"<p>Septic patients who were CMV positive in plasma had increased 90 day mortality compared to CMV negative patients, <i>p</i><0.05. Surprisingly, patients who were EBV positive in whole blood (but not plasma) had decreased 90 day mortality compared to EBV negative patients, <i>p</i><0.001. Data analyzed by Kaplan Meier.</p>", "links"=>[], "tags"=>["immunology", "Critical care and emergency medicine", "Infectious diseases", "Inflammatory diseases", "cmv", "ebv", "sepsis"], "article_id"=>1054275, "categories"=>["Biological Sciences"], "users"=>["Andrew H. Walton", "Jared T. Muenzer", "David Rasche", "Jonathan S. Boomer", "Bryan Sato", "Bernard H. Brownstein", "Alexandre Pachot", "Terrence L. Brooks", "Elena Deych", "William D. Shannon", "Jonathan M. Green", "Gregory A. Storch", "Richard S. Hotchkiss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098819.g006", "stats"=>{"downloads"=>2, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Impact_of_CMV_and_EBV_on_sepsis_mortality_/1054275", "title"=>"Impact of CMV and EBV on sepsis mortality.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-11 03:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1531076"], "description"=>"<p>The relationship between CMV and TTV viral load in blood and 90 day mortality is displayed. There was a non-statistically significant increase in mortality due to sepsis with increasing CMV viral levels in blood. (Note that septic patients who were CMV positive in plasma did have increased mortality compared to CMV negative patients - see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098819#pone-0098819-g006\" target=\"_blank\">Figure 6</a>). Compared to septic patients who were TTV negative, patients with the highest quartile viral load for TTV (Q4) had a trend toward increased 90 day mortality (<i>p</i> = 0.06).</p>", "links"=>[], "tags"=>["immunology", "Critical care and emergency medicine", "Infectious diseases", "Inflammatory diseases", "cmv", "ttv", "viral", "loads", "sepsis"], "article_id"=>1054276, "categories"=>["Biological Sciences"], "users"=>["Andrew H. Walton", "Jared T. Muenzer", "David Rasche", "Jonathan S. Boomer", "Bryan Sato", "Bernard H. Brownstein", "Alexandre Pachot", "Terrence L. Brooks", "Elena Deych", "William D. Shannon", "Jonathan M. Green", "Gregory A. Storch", "Richard S. Hotchkiss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098819.g007", "stats"=>{"downloads"=>1, "page_views"=>36, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Impact_of_CMV_and_TTV_viral_loads_on_sepsis_mortality_/1054276", "title"=>"Impact of CMV and TTV viral loads on sepsis mortality.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-11 03:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1531077"], "description"=>"<p>EBV in whole blood (but not plasma) was associated with a decrease in sepsis mortality. This protective effect of EBV DNAemia tended to lessen with increased viral burden although the effect was not statistically significant.</p>", "links"=>[], "tags"=>["immunology", "Critical care and emergency medicine", "Infectious diseases", "Inflammatory diseases", "ebv"], "article_id"=>1054277, "categories"=>["Biological Sciences"], "users"=>["Andrew H. Walton", "Jared T. Muenzer", "David Rasche", "Jonathan S. Boomer", "Bryan Sato", "Bernard H. Brownstein", "Alexandre Pachot", "Terrence L. Brooks", "Elena Deych", "William D. Shannon", "Jonathan M. Green", "Gregory A. Storch", "Richard S. Hotchkiss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098819.g008", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_EBV_load_on_survival_/1054277", "title"=>"Effect of EBV load on survival.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-11 03:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1531078"], "description"=>"<p>Microbiology and Blood Cell Counts.</p>", "links"=>[], "tags"=>["immunology", "Critical care and emergency medicine", "Infectious diseases", "Inflammatory diseases"], "article_id"=>1054278, "categories"=>["Biological Sciences"], "users"=>["Andrew H. Walton", "Jared T. Muenzer", "David Rasche", "Jonathan S. Boomer", "Bryan Sato", "Bernard H. Brownstein", "Alexandre Pachot", "Terrence L. Brooks", "Elena Deych", "William D. Shannon", "Jonathan M. Green", "Gregory A. Storch", "Richard S. Hotchkiss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098819.t005", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Microbiology_and_Blood_Cell_Counts_/1054278", "title"=>"Microbiology and Blood Cell Counts.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-11 03:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1531080"], "description"=>"<p>Viral Loads in Blood, Plasma, and Urine.</p>", "links"=>[], "tags"=>["immunology", "Critical care and emergency medicine", "Infectious diseases", "Inflammatory diseases", "loads"], "article_id"=>1054280, "categories"=>["Biological Sciences"], "users"=>["Andrew H. Walton", "Jared T. Muenzer", "David Rasche", "Jonathan S. Boomer", "Bryan Sato", "Bernard H. Brownstein", "Alexandre Pachot", "Terrence L. Brooks", "Elena Deych", "William D. Shannon", "Jonathan M. Green", "Gregory A. Storch", "Richard S. Hotchkiss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098819.t004", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Viral_Loads_in_Blood_Plasma_and_Urine_/1054280", "title"=>"Viral Loads in Blood, Plasma, and Urine.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-11 03:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1531081"], "description"=>"†<p>Mean value represents mean of all patients' average APACHE II or SOFA score for the duration of their ICU stay.</p><p>*Represents CMV seropositive patients only.</p>", "links"=>[], "tags"=>["immunology", "Critical care and emergency medicine", "Infectious diseases", "Inflammatory diseases", "viral", "positivity", "severity"], "article_id"=>1054281, "categories"=>["Biological Sciences"], "users"=>["Andrew H. Walton", "Jared T. Muenzer", "David Rasche", "Jonathan S. Boomer", "Bryan Sato", "Bernard H. Brownstein", "Alexandre Pachot", "Terrence L. Brooks", "Elena Deych", "William D. Shannon", "Jonathan M. Green", "Gregory A. Storch", "Richard S. Hotchkiss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098819.t006", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_of_Viral_Positivity_and_Severity_of_Illness_/1054281", "title"=>"Correlation of Viral Positivity and Severity of Illness.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-11 03:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1531082"], "description"=>"<p>*Apache II, “Acute Physiology and Chronic Health Evaluation II” at ICU admission.</p><p>**SOFA, “Sequential Organ Failure Assessment” at ICU admission.</p>", "links"=>[], "tags"=>["immunology", "Critical care and emergency medicine", "Infectious diseases", "Inflammatory diseases"], "article_id"=>1054282, "categories"=>["Biological Sciences"], "users"=>["Andrew H. Walton", "Jared T. Muenzer", "David Rasche", "Jonathan S. Boomer", "Bryan Sato", "Bernard H. Brownstein", "Alexandre Pachot", "Terrence L. Brooks", "Elena Deych", "William D. Shannon", "Jonathan M. Green", "Gregory A. Storch", "Richard S. Hotchkiss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098819.t001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Patient_Characteristics_/1054282", "title"=>"Patient Characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-11 03:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1531083"], "description"=>"<p>*Results are from CMV seropositive patients only. No. positive represents the number of patients who tested positive in Blood or in Plasma separately. No. tested represents the total number of patients tested.</p>", "links"=>[], "tags"=>["immunology", "Critical care and emergency medicine", "Infectious diseases", "Inflammatory diseases", "viral", "dna", "plasma"], "article_id"=>1054283, "categories"=>["Biological Sciences"], "users"=>["Andrew H. Walton", "Jared T. Muenzer", "David Rasche", "Jonathan S. Boomer", "Bryan Sato", "Bernard H. Brownstein", "Alexandre Pachot", "Terrence L. Brooks", "Elena Deych", "William D. Shannon", "Jonathan M. Green", "Gregory A. Storch", "Richard S. Hotchkiss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098819.t003", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Frequency_of_Viral_DNA_in_Blood_and_Plasma_Individually_/1054283", "title"=>"Frequency of Viral DNA in Blood and Plasma Individually.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-11 03:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1531084"], "description"=>"†<p>Except where indicated, No. positive reflects the number of patients who tested positive in either whole blood or plasma or both. No. tested represents the total number of patients tested.</p><p>*Results are from CMV seropositive patients only.</p>‡<p>Tested in plasma only.</p><p>**Tested in urine.</p>", "links"=>[], "tags"=>["immunology", "Critical care and emergency medicine", "Infectious diseases", "Inflammatory diseases", "viral", "dna", "septic"], "article_id"=>1054284, "categories"=>["Biological Sciences"], "users"=>["Andrew H. Walton", "Jared T. Muenzer", "David Rasche", "Jonathan S. Boomer", "Bryan Sato", "Bernard H. Brownstein", "Alexandre Pachot", "Terrence L. Brooks", "Elena Deych", "William D. Shannon", "Jonathan M. Green", "Gregory A. Storch", "Richard S. Hotchkiss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098819.t002", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Frequency_of_Viral_DNA_in_Septic_and_Control_Patients_/1054284", "title"=>"Frequency of Viral DNA in Septic and Control Patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-11 03:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1531110", "https://ndownloader.figshare.com/files/1531111", "https://ndownloader.figshare.com/files/1531112", "https://ndownloader.figshare.com/files/1531113", "https://ndownloader.figshare.com/files/1531114"], "description"=>"<div><p>A current controversy is whether patients with sepsis progress to an immunosuppressed state. We hypothesized that reactivation of latent viruses occurred with prolonged sepsis thereby providing evidence of clinically-relevant immunosuppression and potentially providing a means to serially-monitor patients' immune status. Secondly, if viral loads are markedly elevated, they may contribute to morbidity and mortality. This study determined if reactivation of herpesviruses, polyomaviruses, and the anellovirus TTV occurred in sepsis and correlated with severity. Serial whole blood and plasma samples from 560 critically-ill septic, 161 critically-ill non-septic, and 164 healthy age-matched patients were analyzed by quantitative-polymerase-chain-reaction for cytomegalovirus (CMV), Epstein-Barr (EBV), herpes-simplex (HSV), human herpes virus-6 (HHV-6), and TTV. Polyomaviruses BK and JC were quantitated in urine. Detectable virus was analyzed with respect to secondary fungal and opportunistic bacterial infections, ICU duration, severity of illness, and survival. Patients with protracted sepsis had markedly increased frequency of detectable virus. Cumulative viral DNA detection rates in blood were: CMV (24.2%), EBV (53.2%), HSV (14.1%), HHV-6 (10.4%), and TTV (77.5%). 42.7% of septic patients had presence of two or more viruses. The 50% detection rate for herpesviruses was 5–8 days after sepsis onset. A small subgroup of septic patients had markedly elevated viral loads (>10<sup>4</sup>–10<sup>6</sup> DNA copies/ml blood) for CMV, EBV, and HSV. Excluding TTV, DNAemia was uncommon in critically-ill non-septic patients and in age-matched healthy controls. Compared to septic patients without DNAemia, septic patients with viremia had increased fungal and opportunistic bacterial infections. Patients with detectable CMV in plasma had higher 90-day mortality compared to CMV-negative patients; <i>p</i><0.05. Reactivation of latent viruses is common with prolonged sepsis, with frequencies similar to those occurring in transplant patients on immunosuppressive therapy and consistent with development of an immunosuppressive state. Whether reactivated latent viruses contribute to morbidity and mortality in sepsis remains unknown.</p></div>", "links"=>[], "tags"=>["immunology", "Critical care and emergency medicine", "Infectious diseases", "Inflammatory diseases", "viruses", "patients"], "article_id"=>1054310, "categories"=>["Biological Sciences"], "users"=>["Andrew H. Walton", "Jared T. Muenzer", "David Rasche", "Jonathan S. Boomer", "Bryan Sato", "Bernard H. Brownstein", "Alexandre Pachot", "Terrence L. Brooks", "Elena Deych", "William D. Shannon", "Jonathan M. Green", "Gregory A. Storch", "Richard S. Hotchkiss"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0098819.s001", "https://dx.doi.org/10.1371/journal.pone.0098819.s002", "https://dx.doi.org/10.1371/journal.pone.0098819.s003", "https://dx.doi.org/10.1371/journal.pone.0098819.s004", "https://dx.doi.org/10.1371/journal.pone.0098819.s005"], "stats"=>{"downloads"=>12, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Reactivation_of_Multiple_Viruses_in_Patients_with_Sepsis_/1054310", "title"=>"Reactivation of Multiple Viruses in Patients with Sepsis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-06-11 03:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1531061"], "description"=>"<p>The maximum viral load for each patient is displayed. (Figure 1A) Only data from septic patients are displayed for CMV, EBV, HSV, and HHV-6 because viral levels in control patients for these viruses were at or below the limit of quantitation. (<i>Figure 1B</i>) For JC and BK, data are from urine samples of septic and critically-ill non-septic (CINS) patients. (<i>Figure 1C</i>) The maximum viral load for TTV is displayed for septic, CINS, and healthy control pre-operative elective-surgery (HC) patients. The horizontal line in each graph represents the geometric mean for the virus level.</p>", "links"=>[], "tags"=>["immunology", "Critical care and emergency medicine", "Infectious diseases", "Inflammatory diseases", "septic"], "article_id"=>1054261, "categories"=>["Biological Sciences"], "users"=>["Andrew H. Walton", "Jared T. Muenzer", "David Rasche", "Jonathan S. Boomer", "Bryan Sato", "Bernard H. Brownstein", "Alexandre Pachot", "Terrence L. Brooks", "Elena Deych", "William D. Shannon", "Jonathan M. Green", "Gregory A. Storch", "Richard S. Hotchkiss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098819.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Viral_levels_in_septic_and_control_patients_/1054261", "title"=>"Viral levels in septic and control patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-11 03:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1531063"], "description"=>"<p>Populations were established based upon viral DNA loads; each of these populations was examined for presence or absence of other viruses. The number of patients in each of the groups is defined as the following: <i>Negative</i>  =  no detectable virus, <i>Low</i>  =  less than lower limit of quantitation (lloq), and <i>High</i>  =  greater than lloq. The negative, low, and high values for CMV are N = 274, 34, and 37 septic patients, respectively. Negative, low, and high values for EBV are N = 247, 213, and 61 septic patients, respectively; for HSV comparable values are N = 465, 38, 18, septic patients, respectively). For HHV-6, Negative = no detectable virus (n = 485 patients), Positive = detectable virus (n = 36 patients); *p<0.05, **p<0.01, ***p<0.001. These results show that as the blood viral load of one particular virus increases, there is a corresponding increase in the prevalence of the other herpes family members.</p>", "links"=>[], "tags"=>["immunology", "Critical care and emergency medicine", "Infectious diseases", "Inflammatory diseases", "viral", "loads"], "article_id"=>1054263, "categories"=>["Biological Sciences"], "users"=>["Andrew H. Walton", "Jared T. Muenzer", "David Rasche", "Jonathan S. Boomer", "Bryan Sato", "Bernard H. Brownstein", "Alexandre Pachot", "Terrence L. Brooks", "Elena Deych", "William D. Shannon", "Jonathan M. Green", "Gregory A. Storch", "Richard S. Hotchkiss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098819.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_of_viral_loads_among_the_individual_viruses_/1054263", "title"=>"Correlation of viral loads among the individual viruses.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-11 03:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1531068"], "description"=>"<p>The percentage of patients who tested positive in blood for particular viruses during the course of sepsis (limited to 30 days) is displayed in two formats. Day 0 represents the day that the patient fulfilled sepsis criteria <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098819#pone.0098819-Bland1\" target=\"_blank\">[32]</a>. <i>Figure 3A</i> represents all septic patients positive for viral reactivation divided by the total number of septic patients who were tested on or before the same day. <i>Figure 3B</i> represents only those septic patients who were negative for the particular viruses and who ultimately became positive during their septic course. The % represents the increase in the number of septic patients who convert from virus negative to virus positive status. *TTV was tested only in plasma (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098819#pone.0098819.s005\" target=\"_blank\">Methods S1</a>).</p>", "links"=>[], "tags"=>["immunology", "Critical care and emergency medicine", "Infectious diseases", "Inflammatory diseases", "viral", "detection"], "article_id"=>1054268, "categories"=>["Biological Sciences"], "users"=>["Andrew H. Walton", "Jared T. Muenzer", "David Rasche", "Jonathan S. Boomer", "Bryan Sato", "Bernard H. Brownstein", "Alexandre Pachot", "Terrence L. Brooks", "Elena Deych", "William D. Shannon", "Jonathan M. Green", "Gregory A. Storch", "Richard S. Hotchkiss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098819.g003", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Peak_viral_detection_rate_and_time_course_of_viral_detection_/1054268", "title"=>"Peak viral detection rate and time course of viral detection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-11 03:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/1531071"], "description"=>"<p>Septic patients with CMV detected in either blood or plasma had increased fungal infections compared to CMV negative patients; only results for plasma are shown and are significant, <i>p</i><0.001. Similarly, patients who had EBV detected in blood had increased fungal infections compared to viral negative patients, <i>p</i> = 0.05. Patients who were HSV positive in blood had increased opportunistic bacterial infections due to <i>Stenotrophomonas</i>, <i>Acinetobacter</i>, or <i>Enterococcus</i> compared to viral negative patients, <i>p</i><0.05. Censored subject (vertical hash marks) represent patients who were either discharged from the ICU or who died without events. Analysis was performed using all events but plot was truncated at 60 days for clarity. N = 35 patients with fungal infections, n = 86 patients with <i>Stenotrophomonas</i>, <i>Acinetobacter</i>, or <i>Enterococcus</i> infections.</p>", "links"=>[], "tags"=>["immunology", "Critical care and emergency medicine", "Infectious diseases", "Inflammatory diseases", "viral", "reactivation", "fungal", "opportunistic", "bacterial"], "article_id"=>1054271, "categories"=>["Biological Sciences"], "users"=>["Andrew H. Walton", "Jared T. Muenzer", "David Rasche", "Jonathan S. Boomer", "Bryan Sato", "Bernard H. Brownstein", "Alexandre Pachot", "Terrence L. Brooks", "Elena Deych", "William D. Shannon", "Jonathan M. Green", "Gregory A. Storch", "Richard S. Hotchkiss"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0098819.g004", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Impact_of_viral_reactivation_on_fungal_and_opportunistic_bacterial_infections_/1054271", "title"=>"Impact of viral reactivation on fungal and opportunistic bacterial infections.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-11 03:07:04"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"27", "full-text"=>"25", "pdf"=>"27", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"48", "full-text"=>"44", "pdf"=>"28", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"43", "full-text"=>"43", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"50", "full-text"=>"59", "pdf"=>"27", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"24", "full-text"=>"24", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"40", "full-text"=>"43", "pdf"=>"27", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"30", "full-text"=>"26", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"22", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"37", "full-text"=>"34", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"34", "full-text"=>"32", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"56", "full-text"=>"57", "pdf"=>"34", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"99", "full-text"=>"98", "pdf"=>"71", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"12", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"68", "full-text"=>"79", "pdf"=>"52", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"49", "full-text"=>"59", "pdf"=>"34", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"58", "full-text"=>"54", "pdf"=>"35", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"30", "full-text"=>"29", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"37", "full-text"=>"33", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"34", "full-text"=>"28", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"23", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"40", "full-text"=>"40", "pdf"=>"26", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"51", "full-text"=>"49", "pdf"=>"30", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"35", "full-text"=>"29", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"35", "full-text"=>"37", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"37", "full-text"=>"40", "pdf"=>"31", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"35", "full-text"=>"36", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"27", "full-text"=>"28", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"32", "full-text"=>"30", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"28", "full-text"=>"26", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"27", "full-text"=>"38", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"32", "full-text"=>"32", "pdf"=>"25", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"34", "full-text"=>"41", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"29", "full-text"=>"24", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"38", "full-text"=>"39", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"26", "full-text"=>"30", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"26", "full-text"=>"28", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"18", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"19", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"22", "full-text"=>"20", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"29", "full-text"=>"31", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"23", "full-text"=>"27", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"31", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"29", "full-text"=>"29", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"23", "full-text"=>"15", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"27", "full-text"=>"29", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"22", "full-text"=>"20", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"28", "full-text"=>"30", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"13", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"30", "full-text"=>"34", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"24", "full-text"=>"21", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"46", "full-text"=>"38", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"45", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"26", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"34", "full-text"=>"29", "pdf"=>"38", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"118", "full-text"=>"119", "pdf"=>"111", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"34", "full-text"=>"42", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"5", "cited-by"=>"2", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"39", "full-text"=>"39", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"36", "full-text"=>"43", "pdf"=>"32", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"33", "full-text"=>"40", "pdf"=>"17", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"30", "full-text"=>"30", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"23", "full-text"=>"21", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"56", "full-text"=>"23", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"26", "supp-data"=>"8", "cited-by"=>"1", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"35", "full-text"=>"39", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"26", "full-text"=>"24", "pdf"=>"10", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"28", "full-text"=>"32", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"32", "full-text"=>"32", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"5", "cited-by"=>"1", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"53", "full-text"=>"49", "pdf"=>"27", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"20", "full-text"=>"30", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"19", "full-text"=>"37", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"20", "full-text"=>"26", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"14", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
  • {"unique-ip"=>"25", "full-text"=>"28", "pdf"=>"16", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
  • {"unique-ip"=>"22", "full-text"=>"20", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2021", "month"=>"1"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[280]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[285]}, {"subject_area"=>"/Medicine and health sciences/Hematology", "average_usage"=>[256]}, {"subject_area"=>"/Medicine and health sciences/Infectious diseases", "average_usage"=>[319]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[287]}, {"subject_area"=>"/People and places", "average_usage"=>[302]}]}
Loading … Spinner
There are currently no alerts