Cortical Bone Mechanical Properties Are Altered in an Animal Model of Progressive Chronic Kidney Disease
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{"title"=>"Cortical bone mechanical properties are altered in an animal model of progressive chronic kidney disease", "type"=>"journal", "authors"=>[{"first_name"=>"Christopher L.", "last_name"=>"Newman", "scopus_author_id"=>"55830701800"}, {"first_name"=>"Sharon M.", "last_name"=>"Moe", "scopus_author_id"=>"7006851442"}, {"first_name"=>"Neal X.", "last_name"=>"Chen", "scopus_author_id"=>"7401911961"}, {"first_name"=>"Max A.", "last_name"=>"Hammond", "scopus_author_id"=>"55971831000"}, {"first_name"=>"Joseph M.", "last_name"=>"Wallace", "scopus_author_id"=>"7402967101"}, {"first_name"=>"Jeffry S.", "last_name"=>"Nyman", "scopus_author_id"=>"7006598811"}, {"first_name"=>"Matthew R.", "last_name"=>"Allen", "scopus_author_id"=>"7404104714"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84902577352", "doi"=>"10.1371/journal.pone.0099262", "pui"=>"373338044", "pmid"=>"24911162", "scopus"=>"2-s2.0-84902577352", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"b220f4cf-88da-3931-9da9-84cf7c412985", "abstract"=>"Chronic kidney disease (CKD), which leads tocortical bone loss and increasedporosity,increases therisk of fracture. Animal models have confirmed that these changes compromise whole bone mechanical properties. Estimates from whole bone testing suggest that material properties are negatively affected, though tissue-level assessmentshavenot been conducted. Therefore, the goal of the present study was to examine changes in cortical bone at different length scales using a rat model with theprogressive development of CKD. At 30 weeks of age (∼75% reduction in kidney function), skeletally mature male Cy/+ rats were compared to their normal littermates. Cortical bone material propertieswere assessed with reference point indentation (RPI), atomic force microscopy (AFM), Raman spectroscopy,and high performance liquid chromatography (HPLC). Bones from animals with CKD had higher (+18%) indentation distance increase and first cycle energy dissipation (+8%) as measured by RPI.AFM indentation revealed a broader distribution of elastic modulus values in CKD animals witha greater proportion of both higher and lower modulus values compared to normal controls. Yet, tissue composition, collagen morphology, and collagen cross-linking fail to account for these differences. Though the specific skeletal tissue alterations responsible for these mechanical differences remain unclear, these results indicate that cortical bone material properties are altered in these animals and may contribute to the increased fracture risk associated with CKD.", "link"=>"http://www.mendeley.com/research/cortical-bone-mechanical-properties-altered-animal-model-progressive-chronic-kidney-disease-4", "reader_count"=>21, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>3}, "reader_count_by_subject_area"=>{"Engineering"=>9, "Unspecified"=>2, "Materials Science"=>1, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>9}, "Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1527604"], "description"=>"<p>These previously published data (Allen <i>et al</i>., 2013) show abnormalities in kidney function and mineral metabolism resulting from hyperparathyroidism in the animals utilized in the current work. Data are presented as a percentage of non-affected normal animals with (*) representing statistical significance.</p>", "links"=>[], "tags"=>["anatomy", "biological tissue", "Connective tissue", "bone", "Bone matrix", "biomechanics", "Bone and joint mechanics", "Nephrology", "Chronic kidney disease", "Materials Science", "Material properties", "kidney"], "article_id"=>1051524, "categories"=>["Biological Sciences"], "users"=>["Christopher L. Newman", "Sharon M. Moe", "Neal X. Chen", "Max A. Hammond", "Joseph M. Wallace", "Jeffry S. Nyman", "Matthew R. Allen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0099262.g001", "stats"=>{"downloads"=>1, "page_views"=>26, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Biochemical_assessment_of_kidney_function_and_mineral_metabolism_/1051524", "title"=>"Biochemical assessment of kidney function and mineral metabolism.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-09 03:46:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1527608"], "description"=>"<p>These previously published data (Allen <i>et al</i>., 2013) show compromised whole bone mechanical properties from femoral 3-point bending and apparent material-level mechanical properties derived from standard beam bending equations in the animals utilized in the current work. Data are presented as a percentage of non-affected normal animals with (*) representing statistical significance.</p>", "links"=>[], "tags"=>["anatomy", "biological tissue", "Connective tissue", "bone", "Bone matrix", "biomechanics", "Bone and joint mechanics", "Nephrology", "Chronic kidney disease", "Materials Science", "Material properties"], "article_id"=>1051527, "categories"=>["Biological Sciences"], "users"=>["Christopher L. Newman", "Sharon M. Moe", "Neal X. Chen", "Max A. Hammond", "Joseph M. Wallace", "Jeffry S. Nyman", "Matthew R. Allen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0099262.g002", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Structural_mechanical_properties_and_estimated_material_properties_/1051527", "title"=>"Structural mechanical properties and estimated material properties.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-09 03:46:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1527609"], "description"=>"<p>Using reference point indentation (RPI), the indentation distance increase (IDI) was found to be significantly higher in CKD animals compared to normal. These data indicate that the mechanical integrity of the bone is less able to resist microscale damage formation and propagation. Data are presented as mean and standard deviation. *p<0.05 versus normal controls.</p>", "links"=>[], "tags"=>["anatomy", "biological tissue", "Connective tissue", "bone", "Bone matrix", "biomechanics", "Bone and joint mechanics", "Nephrology", "Chronic kidney disease", "Materials Science", "Material properties", "reveals", "ckd", "skeletal"], "article_id"=>1051528, "categories"=>["Biological Sciences"], "users"=>["Christopher L. Newman", "Sharon M. Moe", "Neal X. Chen", "Max A. Hammond", "Joseph M. Wallace", "Jeffry S. Nyman", "Matthew R. Allen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0099262.g003", "stats"=>{"downloads"=>4, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Microindentation_reveals_that_CKD_skeletal_tissue_is_less_able_to_resist_damage_/1051528", "title"=>"Microindentation reveals that CKD skeletal tissue is less able to resist damage.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-09 03:46:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1527611"], "description"=>"<p>There was no significant difference in the average elastic modulus (A), but the distribution of elastic modulus values was significantly broader (B), with a greater proportion of both high and low values in CKD relative to normal (p<0.0001).</p>", "links"=>[], "tags"=>["anatomy", "biological tissue", "Connective tissue", "bone", "Bone matrix", "biomechanics", "Bone and joint mechanics", "Nephrology", "Chronic kidney disease", "Materials Science", "Material properties", "reveals", "ckd", "skeletal", "heterogeneity", "elastic", "modulus", "compared"], "article_id"=>1051530, "categories"=>["Biological Sciences"], "users"=>["Christopher L. Newman", "Sharon M. Moe", "Neal X. Chen", "Max A. Hammond", "Joseph M. Wallace", "Jeffry S. Nyman", "Matthew R. Allen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0099262.g004", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Nanoindenation_reveals_that_CKD_skeletal_tissue_has_increased_heterogeneity_in_the_elastic_modulus_compared_to_normal_bone_/1051530", "title"=>"Nanoindenation reveals that CKD skeletal tissue has increased heterogeneity in the elastic modulus compared to normal bone.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-06-09 03:46:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1527612"], "description"=>"<p>Values are presented as mean ± standard deviation.</p><p>*equal variance t-test.</p>#<p>Wilcoxon ranked-sum test.</p><p>p-values less than 0.05 are in bold.</p>", "links"=>[], "tags"=>["anatomy", "biological tissue", "Connective tissue", "bone", "Bone matrix", "biomechanics", "Bone and joint mechanics", "Nephrology", "Chronic kidney disease", "Materials Science", "Material properties", "microindentation"], "article_id"=>1051531, "categories"=>["Biological Sciences"], "users"=>["Christopher L. Newman", "Sharon M. Moe", "Neal X. Chen", "Max A. Hammond", "Joseph M. Wallace", "Jeffry S. Nyman", "Matthew R. Allen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0099262.t001", "stats"=>{"downloads"=>7, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mechanical_properties_from_microindentation_and_nanoindentation_/1051531", "title"=>"Mechanical properties from microindentation and nanoindentation.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-09 03:46:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/1527613"], "description"=>"<p>Values are presented as mean ± standard deviation.</p><p>*equal variances t-test.</p><p>**unequal variances t-test.</p>#<p>Wilcoxon ranked-sum test.</p>", "links"=>[], "tags"=>["anatomy", "biological tissue", "Connective tissue", "bone", "Bone matrix", "biomechanics", "Bone and joint mechanics", "Nephrology", "Chronic kidney disease", "Materials Science", "Material properties", "collagen"], "article_id"=>1051532, "categories"=>["Biological Sciences"], "users"=>["Christopher L. Newman", "Sharon M. Moe", "Neal X. Chen", "Max A. Hammond", "Joseph M. Wallace", "Jeffry S. Nyman", "Matthew R. Allen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0099262.t002", "stats"=>{"downloads"=>1, "page_views"=>28, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tissue_composition_and_collagen_morphology_/1051532", "title"=>"Tissue composition and collagen morphology.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-06-09 03:46:25"}

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Relative Metric

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