Behavioral and Cardiorespiratory Responses to Bilateral Microinjections of Oxytocin into the Central Nucleus of Amygdala of Wistar Rats, an Experimental Model of Compulsion
Publication Date
July 18, 2014
Journal
PLOS ONE
Authors
Érica Maria Granjeiro, Simone Saldanha Marroni, Daniel Penteado Martins Dias, Leni Gomes Heck Bonagamba, et al
Volume
9
Issue
7
Pages
e99284
DOI
https://dx.plos.org/10.1371/journal.pone.0099284
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0099284
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/25036025
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103777
Europe PMC
http://europepmc.org/abstract/MED/25036025
Web of Science
000339615200003
Scopus
84904578352
Mendeley
http://www.mendeley.com/research/behavioral-cardiorespiratory-responses-bilateral-microinjections-oxytocin-central-nucleus-amygdala-w
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Mendeley | Further Information

{"title"=>"Behavioral and cardiorespiratory responses to bilateral microinjections of oxytocin into the central nucleus of amygdala of wistar rats, an experimental model of compulsion", "type"=>"journal", "authors"=>[{"first_name"=>"Érica Maria", "last_name"=>"Granjeiro", "scopus_author_id"=>"26658486300"}, {"first_name"=>"Simone Saldanha", "last_name"=>"Marroni", "scopus_author_id"=>"23019325200"}, {"first_name"=>"Daniel Penteado Martins", "last_name"=>"Dias", "scopus_author_id"=>"35409093900"}, {"first_name"=>"Leni Gomes Heck", "last_name"=>"Bonagamba", "scopus_author_id"=>"6603666219"}, {"first_name"=>"Kauê Machado", "last_name"=>"Costa", "scopus_author_id"=>"36149977900"}, {"first_name"=>"Jéssica Cristina", "last_name"=>"Dos Santos", "scopus_author_id"=>"56285363400"}, {"first_name"=>"José Antônio Cortes", "last_name"=>"Oliveira", "scopus_author_id"=>"7202452411"}, {"first_name"=>"Benedito H.", "last_name"=>"Machado", "scopus_author_id"=>"7005886476"}, {"first_name"=>"Norberto", "last_name"=>"Garcia-Cairasco", "scopus_author_id"=>"7003476789"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84904578352", "pui"=>"373577909", "pmid"=>"25036025", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0099284", "sgr"=>"84904578352"}, "id"=>"21b294c9-da24-36c0-bd85-8c1674b3f547", "abstract"=>"INTRODUCTION: The central nucleus of amygdala plays an important role mediating fear and anxiety responses. It is known that oxytocin microinjections into the central nucleus of amygdala induce hypergrooming, an experimental model of compulsive behavior. We evaluated the behavioral and cardiorespiratory responses of conscious rats microinjected with oxytocin into the central nucleus of amygdala.\\n\\nMETHODS: Male Wistar rats were implanted with guide cannulae into the central nucleus of amygdala and microinjected with oxytocin (0.5 µg, 1 µg) or saline. After 24 h, rats had a catheter implanted into the femoral artery for pulsatile arterial pressure measurement. The pulsatile arterial pressure was recorded at baseline conditions and data used for cardiovascular variability and baroreflex sensitivity analysis. Respiratory and behavioral parameters were assessed during this data collection session.\\n\\nRESULTS: Microinjections of oxytocin (0.5 µg) into the central nucleus of amygdala produced hypergrooming behavior but did not change cardiorespiratory parameters. However, hypergrooming evoked by microinjections of oxytocin (1 µg) into the central nucleus of amygdala was accompanied by increase in arterial pressure, heart rate and ventilation and augmented the power of low and high (respiratory-related) frequency bands of the systolic arterial pressure spectrum. No changes were observed in power of the low and high frequency bands of the pulse interval spectrum. Baroreflex sensitivity was found lower after oxytocin microinjections, demonstrating that the oxytocin-induced pressor response may involve an inhibition of baroreflex pathways and a consequent facilitation of sympathetic outflow to the cardiovascular system.\\n\\nCONCLUSIONS: The microinjection of oxytocin (1 µg) into the central nucleus of amygdala not only induces hypergrooming but also changes cardiorespiratory parameters. Moreover, specific oxytocin receptor antagonism attenuated hypergrooming but did not affect pressor, tachycardic and ventilatory responses to oxytocin, suggesting the involvement of distinct neural pathways.", "link"=>"http://www.mendeley.com/research/behavioral-cardiorespiratory-responses-bilateral-microinjections-oxytocin-central-nucleus-amygdala-w", "reader_count"=>32, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>7, "Researcher"=>3, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>4, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>7, "Researcher"=>3, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>4, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>10, "Neuroscience"=>4, "Business, Management and Accounting"=>1, "Psychology"=>7}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Neuroscience"=>{"Neuroscience"=>4}, "Psychology"=>{"Psychology"=>7}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Unspecified"=>{"Unspecified"=>4}}, "reader_count_by_country"=>{"Brazil"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1600823"], "description"=>"<p>(A) Time-course of respiratory frequency (Δf<sub>R</sub>, cpm), (C) tidal volume (ΔV<sub>T</sub>, mL.Kg<sup>−1</sup>) and (E) minute ventilation (ΔV<sub>E</sub>, mL.Kg<sup>−1</sup>.min<sup>−1</sup>) changes for 60 min after bilateral microinjections of oxytocin (OT) 0.5 µg, OT 1 µg or saline (SAL) into the central nucleus of amygdala (CeA) group and OT 1 µg outside CeA group. Maximum responses in (B) respiratory frequency (Δf<sub>R</sub>, cpm), (D) tidal volume (ΔV<sub>T</sub>, mL.Kg<sup>−1</sup>) and (F) minute ventilation (ΔV<sub>E</sub>, mL.Kg<sup>−1</sup>.min<sup>−1</sup>) 5 min after bilateral microinjections of OT 0.5 µg (black-white bar), OT 1 µg (black bar) or SAL (open bar) inside CeA group and OT 1 µg outside CeA group (striped bar). The arrow indicates the moment of microinjections. Data shown represent the means ± standard error of mean. (*) SAL inside CeA group <i>vs</i> OT 1 µg inside CeA group; p<0.05, Two-way ANOVA followed by Bonferroni's <i>post hoc</i> test.</p>", "links"=>[], "tags"=>["anatomy", "nervous system", "Autonomic nervous system", "neurology", "Neurodegenerative diseases", "Movement disorders", "responses", "oxytocin", "microinjection", "nucleus"], "article_id"=>1110592, "categories"=>["Biological Sciences"], "users"=>["Érica Maria Granjeiro", "Simone Saldanha Marroni", "Daniel Penteado Martins Dias", "Leni Gomes Heck Bonagamba", "Kauê Machado Costa", "Jéssica Cristina dos Santos", "José Antônio Cortes Oliveira", "Benedito H. Machado", "Norberto Garcia-Cairasco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0099284.g004", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Respiratory_responses_to_oxytocin_microinjection_into_the_central_nucleus_of_amygdala_/1110592", "title"=>"Respiratory responses to oxytocin microinjection into the central nucleus of amygdala.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-18 03:13:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1600821"], "description"=>"<p>(A–C) Systolic arterial blood pressure (SABP) and (D–F) pulse interval (PI) variability analysis at 10 min after bilateral microinjections of oxytocin (OT) (black-white bar, n = 4), OT 1 µg (black bar, n = 8) or SAL (open bar, n = 8) into the central nucleus of amygdala (CeA) group and OT 1 µg outside CeA group (striped bar, n = 7). A and D: variance (σ<sup>2</sup>); B, C, E and F: power of the low and high frequency (LF; HF) bands. Data shown represent the means ± standard error of mean. (*) SAL inside CeA group <i>vs</i> OT 1 µg inside CeA group; (**) OT 0.5 µg inside CeA group <i>vs</i> OT 1 µg inside CeA group; (‡) OT 1 µg inside CeA group <i>vs</i> OT 1 µg outside CeA group.p<0.05, One-way ANOVA followed by Bonferroni's <i>post hoc</i> test.</p>", "links"=>[], "tags"=>["anatomy", "nervous system", "Autonomic nervous system", "neurology", "Neurodegenerative diseases", "Movement disorders", "arterial", "variability", "oxytocin", "microinjection", "nucleus"], "article_id"=>1110590, "categories"=>["Biological Sciences"], "users"=>["Érica Maria Granjeiro", "Simone Saldanha Marroni", "Daniel Penteado Martins Dias", "Leni Gomes Heck Bonagamba", "Kauê Machado Costa", "Jéssica Cristina dos Santos", "José Antônio Cortes Oliveira", "Benedito H. Machado", "Norberto Garcia-Cairasco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0099284.g003", "stats"=>{"downloads"=>1, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Systolic_arterial_blood_pressure_and_pulse_interval_variability_following_oxytocin_microinjection_into_central_nucleus_of_amygdala_/1110590", "title"=>"Systolic arterial blood pressure and pulse interval variability following oxytocin microinjection into central nucleus of amygdala.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-18 03:13:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1600817"], "description"=>"<p>(A) Time-course of mean arterial blood pressure (ΔMABP, mmHg) and (C) heart rate (ΔHR, bpm) changes for 60 min after bilateral microinjections of oxytocin (OT) 0.5 µg, OT 1 µg or saline (SAL) into the central nucleus of amygdala (CeA) group and OT 1 µg outside CeA group. (B) Maximum responses in mean arterial blood pressure (ΔMABP, mmHg) at 50 min and (D) heart rate (ΔHR, bpm) at 5 min after bilateral microinjections of OT 0.5 µg (black-white bar), OT 1 µg (black bar) or SAL (open bar) inside CeA group and OT 1 µg outside CeA group (striped bar). The arrow indicates the moment of microinjections. Data presented are the means ± standard error of the mean. (*) SAL inside CeA group <i>vs</i> OT 1 µg inside CeA group; (**) OT 0.5 µg inside CeA group <i>vs</i> OT 1 µg inside CeA group; (‡) OT 1 µg inside CeA group <i>vs</i> OT 1 µg outside CeA group. p<0.001, Two-way ANOVA followed by Bonferroni's <i>post hoc</i> test.</p>", "links"=>[], "tags"=>["anatomy", "nervous system", "Autonomic nervous system", "neurology", "Neurodegenerative diseases", "Movement disorders", "responses", "oxytocin", "microinjection", "nucleus"], "article_id"=>1110586, "categories"=>["Biological Sciences"], "users"=>["Érica Maria Granjeiro", "Simone Saldanha Marroni", "Daniel Penteado Martins Dias", "Leni Gomes Heck Bonagamba", "Kauê Machado Costa", "Jéssica Cristina dos Santos", "José Antônio Cortes Oliveira", "Benedito H. Machado", "Norberto Garcia-Cairasco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0099284.g002", "stats"=>{"downloads"=>6, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hemodynamic_responses_to_oxytocin_microinjection_into_the_central_nucleus_of_amygdala_/1110586", "title"=>"Hemodynamic responses to oxytocin microinjection into the central nucleus of amygdala.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-18 03:13:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1600816"], "description"=>"<p>(A) Grooming score average count showing 5-min behavior sampling curve of oxytocin (OT) 0.5 µg, OT 1 µg or saline (SAL) into the central nucleus of amygdala (CeA) group and OT 1 µg outside CeA group. (B) grooming score (sum of grooming behavior over 60 min) of OT 0.5 µg (checkered bar), OT 1 µg (black bar, n = 8) or SAL (open bar) inside CeA group and OT 1 µg outside CeA group (striped bar). The arrow indicates the moment of microinjections. Data shown represent the means. (‡ ‡) SAL inside CeA group <i>vs</i> OT 0.5 µg inside CeA group; (*) SAL inside CeA group <i>vs</i> OT 1 µg inside CeA group; (**) OT 0.5 µg inside CeA group <i>vs</i> OT 1 µg outside CeA group; (‡) OT 1 µg inside CeA group <i>vs</i> OT 1 µg outside CeA group. p<0.05, <i>Poisson</i> model.</p>", "links"=>[], "tags"=>["anatomy", "nervous system", "Autonomic nervous system", "neurology", "Neurodegenerative diseases", "Movement disorders", "oxytocin", "microinjection", "nucleus"], "article_id"=>1110585, "categories"=>["Biological Sciences"], "users"=>["Érica Maria Granjeiro", "Simone Saldanha Marroni", "Daniel Penteado Martins Dias", "Leni Gomes Heck Bonagamba", "Kauê Machado Costa", "Jéssica Cristina dos Santos", "José Antônio Cortes Oliveira", "Benedito H. Machado", "Norberto Garcia-Cairasco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0099284.g001", "stats"=>{"downloads"=>12, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Grooming_score_following_oxytocin_microinjection_into_the_central_nucleus_of_amygdala_/1110585", "title"=>"Grooming score following oxytocin microinjection into the central nucleus of amygdala.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-18 03:13:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1600824"], "description"=>"<p>(A) Grooming score average count of the 5-min behavior sampling window of the saline+oxytocin (SAL+OT) 1 µg and vasotocin+OT (OTA+OT) 1 µg groups. (B) Grooming score (mean of 60 min) of the SAL+OT 1 µg (open bar) and OTA+OT 1 µg (black bar) groups. Time-course of (C) mean arterial blood pressure (ΔMABP, mmHg), (E) heart rate (ΔHR, bpm) and (G) minute ventilation (ΔV<sub>E</sub>, mL.Kg<sup>−1</sup>.min<sup>−1</sup>) changes for 60 min after bilateral microinjections of OT 1 µg into the central nucleus of amygdala (CeA) in the SAL+OT 1 µg and OTA+OT 1 µg groups. Maximum responses in (D) mean arterial blood pressure (ΔMABP, mmHg) at 50 min, (F) heart rate (ΔHR, bpm) at 5 min and (H) minute ventilation (ΔV<sub>E</sub>, mL.Kg<sup>−1</sup>.min<sup>−1</sup>) at 5 min after bilateral microinjections of OT 1 µg into the CeA in the SAL+OT 1 µg (open bars) and OTA+OT 1 µg (black bars) groups. The arrow indicates the moment of microinjections. Data shown represent the means ± standard error of mean. (*) SAL+OT 1 µg group <i>vs</i> VASO+OT 1 µg group; p<0.05, <i>Poisson</i> model.</p>", "links"=>[], "tags"=>["anatomy", "nervous system", "Autonomic nervous system", "neurology", "Neurodegenerative diseases", "Movement disorders", "hemodynamic", "respiratory", "responses", "oxytocin"], "article_id"=>1110593, "categories"=>["Biological Sciences"], "users"=>["Érica Maria Granjeiro", "Simone Saldanha Marroni", "Daniel Penteado Martins Dias", "Leni Gomes Heck Bonagamba", "Kauê Machado Costa", "Jéssica Cristina dos Santos", "José Antônio Cortes Oliveira", "Benedito H. Machado", "Norberto Garcia-Cairasco"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0099284.g005", "stats"=>{"downloads"=>2, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Behavioral_hemodynamic_and_respiratory_responses_to_oxytocin_antagonist_/1110593", "title"=>"Behavioral, hemodynamic and respiratory responses to oxytocin antagonist.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-18 03:13:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/1600843", "https://ndownloader.figshare.com/files/1600844", "https://ndownloader.figshare.com/files/1600845", "https://ndownloader.figshare.com/files/1600846", "https://ndownloader.figshare.com/files/1600847"], "description"=>"<div><p>Introduction</p><p>The central nucleus of amygdala plays an important role mediating fear and anxiety responses. It is known that oxytocin microinjections into the central nucleus of amygdala induce hypergrooming, an experimental model of compulsive behavior. We evaluated the behavioral and cardiorespiratory responses of conscious rats microinjected with oxytocin into the central nucleus of amygdala.</p><p>Methods</p><p>Male Wistar rats were implanted with guide cannulae into the central nucleus of amygdala and microinjected with oxytocin (0.5 µg, 1 µg) or saline. After 24 h, rats had a catheter implanted into the femoral artery for pulsatile arterial pressure measurement. The pulsatile arterial pressure was recorded at baseline conditions and data used for cardiovascular variability and baroreflex sensitivity analysis. Respiratory and behavioral parameters were assessed during this data collection session.</p><p>Results</p><p>Microinjections of oxytocin (0.5 µg) into the central nucleus of amygdala produced hypergrooming behavior but did not change cardiorespiratory parameters. However, hypergrooming evoked by microinjections of oxytocin (1 µg) into the central nucleus of amygdala was accompanied by increase in arterial pressure, heart rate and ventilation and augmented the power of low and high (respiratory-related) frequency bands of the systolic arterial pressure spectrum. No changes were observed in power of the low and high frequency bands of the pulse interval spectrum. Baroreflex sensitivity was found lower after oxytocin microinjections, demonstrating that the oxytocin-induced pressor response may involve an inhibition of baroreflex pathways and a consequent facilitation of sympathetic outflow to the cardiovascular system.</p><p>Conclusions</p><p>The microinjection of oxytocin (1 µg) into the central nucleus of amygdala not only induces hypergrooming but also changes cardiorespiratory parameters. Moreover, specific oxytocin receptor antagonism attenuated hypergrooming but did not affect pressor, tachycardic and ventilatory responses to oxytocin, suggesting the involvement of distinct neural pathways.</p></div>", "links"=>[], "tags"=>["anatomy", "nervous system", "Autonomic nervous system", "neurology", "Neurodegenerative diseases", "Movement disorders", "cardiorespiratory", "responses", "bilateral", "microinjections", "oxytocin", "nucleus", "amygdala", "wistar"], "article_id"=>1110610, "categories"=>["Biological Sciences"], "users"=>["Érica Maria Granjeiro", "Simone Saldanha Marroni", "Daniel Penteado Martins Dias", "Leni Gomes Heck Bonagamba", "Kauê Machado Costa", "Jéssica Cristina dos Santos", "José Antônio Cortes Oliveira", "Benedito H. Machado", "Norberto Garcia-Cairasco"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0099284.s001", "https://dx.doi.org/10.1371/journal.pone.0099284.s002", "https://dx.doi.org/10.1371/journal.pone.0099284.s003", "https://dx.doi.org/10.1371/journal.pone.0099284.s004", "https://dx.doi.org/10.1371/journal.pone.0099284.s005"], "stats"=>{"downloads"=>8, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Behavioral_and_Cardiorespiratory_Responses_to_Bilateral_Microinjections_of_Oxytocin_into_the_Central_Nucleus_of_Amygdala_of_Wistar_Rats_an_Experimental_Model_of_Compulsion_/1110610", "title"=>"Behavioral and Cardiorespiratory Responses to Bilateral Microinjections of Oxytocin into the Central Nucleus of Amygdala of Wistar Rats, an Experimental Model of Compulsion", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-07-18 03:13:16"}

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