Differential Response to α-Oxoaldehydes in Tamoxifen Resistant MCF-7 Breast Cancer Cells
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{"title"=>"Differential response to α-axoaldehydes in tamoxifen resistant MCF-7 breast cancer cells", "type"=>"journal", "authors"=>[{"first_name"=>"Norbert", "last_name"=>"Nass", "scopus_author_id"=>"6603291987"}, {"first_name"=>"Hans Jürgen", "last_name"=>"Brömme", "scopus_author_id"=>"6701518414"}, {"first_name"=>"Roland", "last_name"=>"Hartig", "scopus_author_id"=>"6602837981"}, {"first_name"=>"Sevil", "last_name"=>"Korkmaz", "scopus_author_id"=>"25947512000"}, {"first_name"=>"Saadettin", "last_name"=>"Sel", "scopus_author_id"=>"22635848900"}, {"first_name"=>"Frank", "last_name"=>"Hirche", "scopus_author_id"=>"6603391110"}, {"first_name"=>"Aoife", "last_name"=>"Ward", "scopus_author_id"=>"54966123900"}, {"first_name"=>"Andreas", "last_name"=>"Simm", "scopus_author_id"=>"7005669140"}, {"first_name"=>"Stefan", "last_name"=>"Wiemann", "scopus_author_id"=>"7004272878"}, {"first_name"=>"Anne E.", "last_name"=>"Lykkesfeldt", "scopus_author_id"=>"7004192205"}, {"first_name"=>"Albert", "last_name"=>"Roessner", "scopus_author_id"=>"7102176417"}, {"first_name"=>"Thomas", "last_name"=>"Kalinski", "scopus_author_id"=>"6602722980"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"373434857", "doi"=>"10.1371/journal.pone.0101473", "issn"=>"19326203", "scopus"=>"2-s2.0-84903594884", "sgr"=>"84903594884"}, "id"=>"e1199b83-7701-3783-9a1b-b17da58248b6", "abstract"=>"Tamoxifen is the standard adjuvant endocrine therapy for estrogen-receptor positive premenopausal breast cancer patients. However, tamoxifen resistance is frequently observed under therapy. A tamoxifen resistant cell line has been generated from the estrogen receptor positive mamma carcinoma cell line MCF-7 and was analyzed for putative differences in the aldehyde defence system and accumulation of advanced glycation end products (AGE). In comparison to wt MCF-7 cells, these tamoxifen resistant cells were more sensitive to the dicarbonyl compounds glyoxal and methylglyoxal and displayed increased caspase activity, p38-MAPK- and IκBα-phosphorylation. However, mRNA accumulation of the aldehyde- and AGE-defence enzymes glyoxalase-1 and -2 (GLO1, GLO2) as well as fructosamine-3-kinase (FN3K) was not significantly altered. Tamoxifen resistant cells contained less free sulfhydryl-groups (glutathione) suggesting that the increased sensitivity towards the dicarbonyls was due to a higher sensitivity towards reactive oxygen species which are associated with dicarbonyl stress. To further analyse, if these data are of more general importance, key experiments were replicated with tamoxifen resistant MCF-7 cell lines from two independent sources. These cell lines were also more sensitive to aldehydes, especially glyoxal, but were different in their cellular signalling responses to the aldehydes. In conclusion, glyoxalases and other aldehyde defence enzymes might represent a promising target for the therapy of tamoxifen resistant breast cancers. © 2014 Nass et al.", "link"=>"http://www.mendeley.com/research/differential-response-%CE%B1axoaldehydes-tamoxifen-resistant-mcf7-breast-cancer-cells", "reader_count"=>5, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1576740"], "description"=>"<p>Cells were cultivated with the indicated concentrations of the aldehydes for 3 days in full medium before proliferation and vitality was assessed by the resazurin assay. Signals form control cultures without added aldehydes were set to 1.0.</p>", "links"=>[], "tags"=>["Biochemistry", "Oxidative damage", "cell biology", "Signal transduction", "cell signaling", "Signaling cascades", "Akt signaling cascade", "Apoptotic signaling cascade", "ERK signaling cascade", "MAPK signaling cascades", "Molecular cell biology", "Computational biology", "genetics", "gene expression", "Molecular genetics", "oncology", "Cancers and neoplasms", "Breast tumors", "breast cancer", "Basic cancer research", "Cancer treatment", "women's health", "Obstetrics and gynecology", "proliferation", "mcf-7", "tamr", "cells", "methylglyoxal"], "article_id"=>1090555, "categories"=>["Biological Sciences"], "users"=>["Norbert Nass", "Hans-Jürgen Brömme", "Roland Hartig", "Sevil Korkmaz", "Saadettin Sel", "Frank Hirche", "Aoife Ward", "Andreas Simm", "Stefan Wiemann", "Anne E. Lykkesfeldt", "Albert Roessner", "Thomas Kalinski"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101473.g001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Vitality_proliferation_of_MCF_7_and_TamR_cells_in_response_to_treatment_with_methylglyoxal_and_glyoxal_/1090555", "title"=>"Vitality / proliferation of MCF-7 and TamR cells in response to treatment with methylglyoxal and glyoxal.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-01 03:36:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1576758"], "description"=>"<p>Confluent and serum starved cells were incubated with different concentrations of dicarbonyls for 10 minutes before proteins were extracted and subjected to Western blot analysis. Experiments were repeated three times in duplicate. A representative Western blot and the quantification of the signals of all experiments are shown. Band intensity was expressed relative to the β-actin signal and control treatments were set to 1 for each cell-line.</p>", "links"=>[], "tags"=>["Biochemistry", "Oxidative damage", "cell biology", "Signal transduction", "cell signaling", "Signaling cascades", "Akt signaling cascade", "Apoptotic signaling cascade", "ERK signaling cascade", "MAPK signaling cascades", "Molecular cell biology", "Computational biology", "genetics", "gene expression", "Molecular genetics", "oncology", "Cancers and neoplasms", "Breast tumors", "breast cancer", "Basic cancer research", "Cancer treatment", "women's health", "Obstetrics and gynecology", "phosphorylation", "mcf-7-md", "tamr-md", "cells", "glyoxal"], "article_id"=>1090568, "categories"=>["Biological Sciences"], "users"=>["Norbert Nass", "Hans-Jürgen Brömme", "Roland Hartig", "Sevil Korkmaz", "Saadettin Sel", "Frank Hirche", "Aoife Ward", "Andreas Simm", "Stefan Wiemann", "Anne E. Lykkesfeldt", "Albert Roessner", "Thomas Kalinski"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101473.g005", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Kinase_phosphorylation_in_MCF_7_Md_and_TamR_Md_cells_in_response_to_glyoxal_and_methylglyoxal_/1090568", "title"=>"Kinase phosphorylation in MCF-7-Md and TamR-Md cells in response to glyoxal and methylglyoxal.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-01 03:36:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1576770"], "description"=>"<p>Primers and amplification conditions used for RT-PCR.</p>", "links"=>[], "tags"=>["Biochemistry", "Oxidative damage", "cell biology", "Signal transduction", "cell signaling", "Signaling cascades", "Akt signaling cascade", "Apoptotic signaling cascade", "ERK signaling cascade", "MAPK signaling cascades", "Molecular cell biology", "Computational biology", "genetics", "gene expression", "Molecular genetics", "oncology", "Cancers and neoplasms", "Breast tumors", "breast cancer", "Basic cancer research", "Cancer treatment", "women's health", "Obstetrics and gynecology", "amplification"], "article_id"=>1090580, "categories"=>["Biological Sciences"], "users"=>["Norbert Nass", "Hans-Jürgen Brömme", "Roland Hartig", "Sevil Korkmaz", "Saadettin Sel", "Frank Hirche", "Aoife Ward", "Andreas Simm", "Stefan Wiemann", "Anne E. Lykkesfeldt", "Albert Roessner", "Thomas Kalinski"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101473.t001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Primers_and_amplification_conditions_used_for_RT_PCR_/1090580", "title"=>"Primers and amplification conditions used for RT-PCR.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-07-01 03:36:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1576767"], "description"=>"<p>7A: MCF-7-Hd and TamR-Hd cell lines 7B: MCF-7-Dk and TamR-HDk cell lines. Cells were treated as described for <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0101473#pone-0101473-g005\" target=\"_blank\">figure 5</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0101473#pone-0101473-g006\" target=\"_blank\">6</a>. Experiments were performed at least three times in duplicate and the result of one representative experiment is shown.</p>", "links"=>[], "tags"=>["Biochemistry", "Oxidative damage", "cell biology", "Signal transduction", "cell signaling", "Signaling cascades", "Akt signaling cascade", "Apoptotic signaling cascade", "ERK signaling cascade", "MAPK signaling cascades", "Molecular cell biology", "Computational biology", "genetics", "gene expression", "Molecular genetics", "oncology", "Cancers and neoplasms", "Breast tumors", "breast cancer", "Basic cancer research", "Cancer treatment", "women's health", "Obstetrics and gynecology", "kinases", "mcf-7-hd", "tamr-hd", "-dk", "lines"], "article_id"=>1090577, "categories"=>["Biological Sciences"], "users"=>["Norbert Nass", "Hans-Jürgen Brömme", "Roland Hartig", "Sevil Korkmaz", "Saadettin Sel", "Frank Hirche", "Aoife Ward", "Andreas Simm", "Stefan Wiemann", "Anne E. Lykkesfeldt", "Albert Roessner", "Thomas Kalinski"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101473.g007", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phosphorylation_of_kinases_in_MCF_7_Hd_and_8211_Dk_and_TamR_Hd_and_Dk_cell_lines_in_response_to_dicarbonyls_/1090577", "title"=>"Phosphorylation of kinases in MCF-7-Hd and –Dk and TamR-Hd and -Dk cell lines in response to dicarbonyls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-01 03:36:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1576760"], "description"=>"<p>Cells were incubated with different concentrations of dicarbonyls and with Il-1β (10 ng/mL) as positive control treatment for 10 minutes. IκBα phosphorylation was detected by Western blotting. Experiment has been performed three times with duplicates for each treatment, one representative blot is shown.</p>", "links"=>[], "tags"=>["Biochemistry", "Oxidative damage", "cell biology", "Signal transduction", "cell signaling", "Signaling cascades", "Akt signaling cascade", "Apoptotic signaling cascade", "ERK signaling cascade", "MAPK signaling cascades", "Molecular cell biology", "Computational biology", "genetics", "gene expression", "Molecular genetics", "oncology", "Cancers and neoplasms", "Breast tumors", "breast cancer", "Basic cancer research", "Cancer treatment", "women's health", "Obstetrics and gynecology", "dicarbonyl"], "article_id"=>1090570, "categories"=>["Biological Sciences"], "users"=>["Norbert Nass", "Hans-Jürgen Brömme", "Roland Hartig", "Sevil Korkmaz", "Saadettin Sel", "Frank Hirche", "Aoife Ward", "Andreas Simm", "Stefan Wiemann", "Anne E. Lykkesfeldt", "Albert Roessner", "Thomas Kalinski"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101473.g006", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phosphorylation_of_I_954_B_945_in_response_dicarbonyl_stress_/1090570", "title"=>"Phosphorylation of IκBα in response dicarbonyl stress.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-01 03:36:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1576755"], "description"=>"<p>4A: Assessment of nuclear morphology. MCF-7-Md and TamR-Md cells were incubated for 48 h with dicarbonyls at the indicated concentrations and nuclei visualised by DNA staining with DAPI and fluorescence microscopy. <b>4B: Determination of caspase activity.</b> MCF-7-Md and TamR-Md cells were incubated with the dicarbonyls for 6 h at the indicated concentrations. Executer caspases 3/7 were determined by a specific luminescent enzyme activity assay. Activity in control treatments of the respective cell line was set to 1. 4C: <b>Determination of necrosis and apoptosis by flow cytometry.</b> MCF-7-Md cells were treated for 6 h with 2 mM aldehydes before annexin V and propidium iodide double staining and flow cytometric analysis was performed. Representative results of the flow cytometry are shown on top and quantitative analysis of data from 7 experiments performed in triplicate is shown below. Percentage of cells in each quadrant in the control treatments was set to one. Annexin staining is shown on the y-axis and propidium iodide staining on the x-axis.</p>", "links"=>[], "tags"=>["Biochemistry", "Oxidative damage", "cell biology", "Signal transduction", "cell signaling", "Signaling cascades", "Akt signaling cascade", "Apoptotic signaling cascade", "ERK signaling cascade", "MAPK signaling cascades", "Molecular cell biology", "Computational biology", "genetics", "gene expression", "Molecular genetics", "oncology", "Cancers and neoplasms", "Breast tumors", "breast cancer", "Basic cancer research", "Cancer treatment", "women's health", "Obstetrics and gynecology", "caused", "condensation", "caspase", "activation", "resulted", "necrotic"], "article_id"=>1090565, "categories"=>["Biological Sciences"], "users"=>["Norbert Nass", "Hans-Jürgen Brömme", "Roland Hartig", "Sevil Korkmaz", "Saadettin Sel", "Frank Hirche", "Aoife Ward", "Andreas Simm", "Stefan Wiemann", "Anne E. Lykkesfeldt", "Albert Roessner", "Thomas Kalinski"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101473.g004", "stats"=>{"downloads"=>2, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dicarbonyl_treatment_caused_nuclear_condensation_and_caspase_3_7_activation_but_resulted_mainly_in_necrotic_cell_death_/1090565", "title"=>"Dicarbonyl treatment caused nuclear condensation and caspase 3/7 activation but resulted mainly in necrotic cell death.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-01 03:36:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/2253883"], "description"=>"<p>A: AGE accumulation (CML (left) and MG-AGE (right)) in MCF-7-Md (lower panel) and TamR-Md cells (upper panel) after cultivation for three days with different concentrations of methylglyoxal and glyoxal as shown by Western blotting. Strongly enhanced AGE accumulation became visible when cell number was significantly reduced due to toxic effects, as represented by the decreasing β-actin signal. Glyoxal resulted in accumulation of CML whereas methylglyoxal treatment caused MG-AGE modification. Cells were treated as described for the determination of vitality/proliferation. Proteins were extracted per well and not corrected for protein amount. Therefore, the blots represent adherent cells only. B) AGE accumulation shown by immunofluorescence. Composite images of dual exposures are shown. MCF-7-Md cells were stained for CML and MG-AGE (red) by specific antibodies as indicated and nuclear staining was achieved with DAPI (blue) of cells treated for 24 h with 1 mM methylglyoxal or glyoxal.</p>", "links"=>[], "tags"=>["aldehyde defence enzymes", "therapy", "Cell lines", "cell line", "estrogen receptor", "dicarbonyl compounds glyoxal", "Differential response", "mRNA accumulation", "tamoxifen", "Reactive oxygen species", "glo", "FN 3K", "premenopausal breast cancer patients", "dicarbonyl stress", "aldehyde defence system", "breast cancers", "caspase activity", "glycation end products", "mcf", "tamoxifen resistance"], "article_id"=>1536182, "categories"=>["Biological Sciences"], "users"=>["Norbert Nass", "Hans-Jürgen Brömme", "Roland Hartig", "Sevil Korkmaz", "Saadettin Sel", "Frank Hirche", "Aoife Ward", "Andreas Simm", "Stefan Wiemann", "Anne E. Lykkesfeldt", "Albert Roessner", "Thomas Kalinski"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101473.g003", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_AGE_accumulation_under_exogenous_aldehyde_stress_/1536182", "title"=>"AGE accumulation under exogenous aldehyde stress.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-01 14:21:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/1576769"], "description"=>"<p>Free SH-groups as a measure for glutathione in MCF-7 and TamR cells as determined by electron spin resonance spectroscopy.</p>", "links"=>[], "tags"=>["Biochemistry", "Oxidative damage", "cell biology", "Signal transduction", "cell signaling", "Signaling cascades", "Akt signaling cascade", "Apoptotic signaling cascade", "ERK signaling cascade", "MAPK signaling cascades", "Molecular cell biology", "Computational biology", "genetics", "gene expression", "Molecular genetics", "oncology", "Cancers and neoplasms", "Breast tumors", "breast cancer", "Basic cancer research", "Cancer treatment", "women's health", "Obstetrics and gynecology", "SH-groups", "glutathione", "mcf-7", "tamr", "cells", "electron", "resonance"], "article_id"=>1090579, "categories"=>["Biological Sciences"], "users"=>["Norbert Nass", "Hans-Jürgen Brömme", "Roland Hartig", "Sevil Korkmaz", "Saadettin Sel", "Frank Hirche", "Aoife Ward", "Andreas Simm", "Stefan Wiemann", "Anne E. Lykkesfeldt", "Albert Roessner", "Thomas Kalinski"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101473.t003", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Free_SH_groups_as_a_measure_for_glutathione_in_MCF_7_and_TamR_cells_as_determined_by_electron_spin_resonance_spectroscopy_/1090579", "title"=>"Free SH-groups as a measure for glutathione in MCF-7 and TamR cells as determined by electron spin resonance spectroscopy.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-07-01 03:36:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1576768"], "description"=>"<p>Relative mRNA accumulation of genes involved in dicarbonyl defence and hypoxia.</p>", "links"=>[], "tags"=>["Biochemistry", "Oxidative damage", "cell biology", "Signal transduction", "cell signaling", "Signaling cascades", "Akt signaling cascade", "Apoptotic signaling cascade", "ERK signaling cascade", "MAPK signaling cascades", "Molecular cell biology", "Computational biology", "genetics", "gene expression", "Molecular genetics", "oncology", "Cancers and neoplasms", "Breast tumors", "breast cancer", "Basic cancer research", "Cancer treatment", "women's health", "Obstetrics and gynecology", "mrna", "accumulation", "genes", "dicarbonyl", "defence"], "article_id"=>1090578, "categories"=>["Biological Sciences"], "users"=>["Norbert Nass", "Hans-Jürgen Brömme", "Roland Hartig", "Sevil Korkmaz", "Saadettin Sel", "Frank Hirche", "Aoife Ward", "Andreas Simm", "Stefan Wiemann", "Anne E. Lykkesfeldt", "Albert Roessner", "Thomas Kalinski"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101473.t002", "stats"=>{"downloads"=>2, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relative_mRNA_accumulation_of_genes_involved_in_dicarbonyl_defence_and_hypoxia_/1090578", "title"=>"Relative mRNA accumulation of genes involved in dicarbonyl defence and hypoxia.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-07-01 03:36:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1576744"], "description"=>"<p>MCF-7-Md and TamR-Md cells were grown under standard conditions and harvested in the logarithmic phase. Cells were fractionated by a detergent based protocol and AGEs detected by Western blotting. Based on protein determination and Coomassie staining (A), equal amounts of protein were loaded for both cell lines and the AGEs MG-AGE (B) and CML (C) detected by Western analysis. Differences in the pattern of AGE-modified proteins are indicated by arrows.</p>", "links"=>[], "tags"=>["Biochemistry", "Oxidative damage", "cell biology", "Signal transduction", "cell signaling", "Signaling cascades", "Akt signaling cascade", "Apoptotic signaling cascade", "ERK signaling cascade", "MAPK signaling cascades", "Molecular cell biology", "Computational biology", "genetics", "gene expression", "Molecular genetics", "oncology", "Cancers and neoplasms", "Breast tumors", "breast cancer", "Basic cancer research", "Cancer treatment", "women's health", "Obstetrics and gynecology", "accumulation", "mcf-7", "tamr"], "article_id"=>1090559, "categories"=>["Biological Sciences"], "users"=>["Norbert Nass", "Hans-Jürgen Brömme", "Roland Hartig", "Sevil Korkmaz", "Saadettin Sel", "Frank Hirche", "Aoife Ward", "Andreas Simm", "Stefan Wiemann", "Anne E. Lykkesfeldt", "Albert Roessner", "Thomas Kalinski"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101473.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_AGE_accumulation_in_MCF_7_and_TamR_cells_/1090559", "title"=>"AGE accumulation in MCF-7 and TamR cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-01 03:36:10"}

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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Medicine and health sciences/Oncology", "average_usage"=>[266]}, {"subject_area"=>"/Physical sciences/Chemistry", "average_usage"=>[262]}]}
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