BMI Modulates Calorie-Dependent Dopamine Changes in Accumbens from Glucose Intake
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{"title"=>"BMI modulates calorie-dependent dopamine changes in accumbens from glucose intake", "type"=>"journal", "authors"=>[{"first_name"=>"Gene Jack", "last_name"=>"Wang", "scopus_author_id"=>"7407143813"}, {"first_name"=>"Dardo", "last_name"=>"Tomasi", "scopus_author_id"=>"6701594153"}, {"first_name"=>"Antonio", "last_name"=>"Convit", "scopus_author_id"=>"7003659386"}, {"first_name"=>"Jean", "last_name"=>"Logan", "scopus_author_id"=>"7202175370"}, {"first_name"=>"Christopher T.", "last_name"=>"Wong", "scopus_author_id"=>"7404954089"}, {"first_name"=>"Elena", "last_name"=>"Shumay", "scopus_author_id"=>"6603627502"}, {"first_name"=>"Joanna S.", "last_name"=>"Fowler", "scopus_author_id"=>"35398051200"}, {"first_name"=>"Nora D.", "last_name"=>"Volkow", "scopus_author_id"=>"36048418300"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"373550457", "sgr"=>"84904382765", "issn"=>"19326203", "pmid"=>"25000285", "scopus"=>"2-s2.0-84904382765", "doi"=>"10.1371/journal.pone.0101585", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"ad6760e1-4174-3b49-8820-7194d6a9bcee", "abstract"=>"OBJECTIVE: Dopamine mediates the rewarding effects of food that can lead to overeating and obesity, which then trigger metabolic neuroadaptations that further perpetuate excessive food consumption. We tested the hypothesis that the dopamine response to calorie intake (independent of palatability) in striatal brain regions is attenuated with increases in weight. METHOD: We used positron emission tomography with [11C]raclopride to measure dopamine changes triggered by calorie intake by contrasting the effects of an artificial sweetener (sucralose) devoid of calories to that of glucose to assess their association with body mass index (BMI) in nineteen healthy participants (BMI range 21-35). RESULTS: Neither the measured blood glucose concentrations prior to the sucralose and the glucose challenge days, nor the glucose concentrations following the glucose challenge vary as a function of BMI. In contrast the dopamine changes in ventral striatum (assessed as changes in non-displaceable binding potential of [11C]raclopride) triggered by calorie intake (contrast glucose - sucralose) were significantly correlated with BMI (r = 0.68) indicating opposite responses in lean than in obese individuals. Specifically whereas in normal weight individuals (BMI <25) consumption of calories was associated with increases in dopamine in the ventral striatum in obese individuals it was associated with decreases in dopamine. CONCLUSION: These findings show reduced dopamine release in ventral striatum with calorie consumption in obese subjects, which might contribute to their excessive food intake to compensate for the deficit between the expected and the actual response to food consumption.", "link"=>"http://www.mendeley.com/research/bmi-modulates-caloriedependent-dopamine-changes-accumbens-glucose-intake", "reader_count"=>60, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>10, "Student > Doctoral Student"=>11, "Student > Ph. D. Student"=>16, "Student > Master"=>7, "Other"=>1, "Student > Bachelor"=>9, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>10, "Student > Doctoral Student"=>11, "Student > Ph. D. Student"=>16, "Student > Master"=>7, "Other"=>1, "Student > Bachelor"=>9, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>8, "Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>13, "Medicine and Dentistry"=>11, "Neuroscience"=>6, "Arts and Humanities"=>1, "Sports and Recreations"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>16}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Neuroscience"=>{"Neuroscience"=>6}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>16}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>8}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "reader_count_by_country"=>{"Mexico"=>1, "Germany"=>3}, "group_count"=>1}

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  • {"files"=>["https://ndownloader.figshare.com/files/1581967"], "description"=>"<p>Significant activated clusters show dopamine (DA) changes in nucleus accumbens for the contrast glucose > sucralose intake (<b>Δ</b>BP<sub>ND</sub>). Note that increases in BP<sub>ND</sub> reflect DA decreases (less competition from DA for [<sup>11</sup>C]raclopride to bind to D2/D3 receptors) whereas decreases in BP<sub>ND</sub> reflect DA increases with glucose (as compared to sucralose) The SPM images were superimposed onto T2 weighted MR images in sagittal (left upper), coronal (right upper) and transverse (lower) views. The color bar indicates <i>t</i>-score values. <b>b: Correlation between BMI and brain DA changes.</b> The differences between DRD2 availability after the glucose and the sucralose intake (<b>Δ</b>BP<sub>ND</sub>) were compared with BMI (kg/m<sup>2</sup>). The leaner subjects showed the largest DRD2 decreases with glucose in nucleus accumbens (consistent with DA increases) whereas the heavier subjects showed DRD2 increases (consistent with DA decreases). <b>Δ</b>BP*: corrected for changes in blood glucose levels (glucose – sucralose) within PET acquisition (0–60min).</p>", "links"=>[], "tags"=>["neuroscience", "Neurochemistry", "neurotransmitters", "Biogenic amines", "catecholamines", "dopamine", "neuroimaging", "neurotransmission", "nutrition", "nutrients", "Mental health and psychiatry", "Eating disorders", "Overeating", "Radiology and imaging", "Diagnostic radiology", "Radionuclide imaging", "spm", "images"], "article_id"=>1094943, "categories"=>["Biological Sciences"], "users"=>["Gene-Jack Wang", "Dardo Tomasi", "Antonio Convit", "Jean Logan", "Christopher T. Wong", "Elena Shumay", "Joanna S. Fowler", "Nora D. Volkow"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101585.g001", "stats"=>{"downloads"=>1, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_a_SPM_images_of_brain_dopamine_changes_/1094943", "title"=>"a: SPM images of brain dopamine changes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-07 02:45:50"}

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