Outcomes of Influenza A(H1N1)pdm09 Virus Infection: Results from Two International Cohort Studies
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{"title"=>"Outcomes of influenza A(H1N1)pdm09 virus infection: Results from two international cohort studies", "type"=>"journal", "authors"=>[{"first_name"=>"Ruth", "last_name"=>"Lynfield", "scopus_author_id"=>"6603555307"}, {"first_name"=>"Richard", "last_name"=>"Davey", "scopus_author_id"=>"7202083492"}, {"first_name"=>"Dominic E.", "last_name"=>"Dwyer", "scopus_author_id"=>"7201791996"}, {"first_name"=>"Marcelo H.", "last_name"=>"Losso", "scopus_author_id"=>"6601973486"}, {"first_name"=>"Deborah", "last_name"=>"Wentworth", "scopus_author_id"=>"35453414600"}, {"first_name"=>"Alessandro", "last_name"=>"Cozzi-Lepri", "scopus_author_id"=>"55134188900"}, {"first_name"=>"Kathy", "last_name"=>"Herman-Lamin", "scopus_author_id"=>"56256248600"}, {"first_name"=>"Grazyna", "last_name"=>"Cholewinska", "scopus_author_id"=>"35607192700"}, {"first_name"=>"Daniel", "last_name"=>"David", "scopus_author_id"=>"7202770374"}, {"first_name"=>"Stefan", "last_name"=>"Kuetter", "scopus_author_id"=>"56256333600"}, {"first_name"=>"Zelalem", "last_name"=>"Ternesgen", "scopus_author_id"=>"56256539100"}, {"first_name"=>"Timothy M.", "last_name"=>"Uyeki", "scopus_author_id"=>"6603544967"}, {"first_name"=>"H. Clifford", "last_name"=>"Lane", "scopus_author_id"=>"35418453700"}, {"first_name"=>"Jens", "last_name"=>"Lundgren", "scopus_author_id"=>"35307337700"}, {"first_name"=>"James D.", "last_name"=>"Neaton", "scopus_author_id"=>"7006720136"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84903885738", "sgr"=>"84903885738", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0101785", "pmid"=>"25004134", "isbn"=>"1932-6203", "pui"=>"373472060"}, "id"=>"3fa1d676-9665-338f-8ffa-68fc20889b00", "abstract"=>"BACKGROUND: Data from prospectively planned cohort studies on risk of major clinical outcomes and prognostic factors for patients with influenza A(H1N1)pdm09 virus are limited. In 2009, in order to assess outcomes and evaluate risk factors for progression of illness, two cohort studies were initiated: FLU 002 in outpatients and FLU 003 in hospitalized patients. METHODS AND FINDINGS: Between October 2009 and December 2012, adults with influenza-like illness (ILI) were enrolled; outpatients were followed for 14 days and inpatients for 60 days. Disease progression was defined as hospitalization and/or death for outpatients, and hospitalization for >28 days, transfer to intensive care unit (ICU) if enrolled from general ward, and/or death for inpatients. Infection was confirmed by RT-PCR. 590 FLU 002 and 392 FLU 003 patients with influenza A (H1N1)pdm09 were enrolled from 81 sites in 17 countries at 2 days (IQR 1-3) and 6 days (IQR 4-10) following ILI onset, respectively. Disease progression was experienced by 29 (1 death) outpatients (5.1%; 95% CI: 3.4-7.2%) and 80 inpatients [death (32), hospitalization >28 days (43) or ICU transfer (20)] (21.6%; 95% CI: 17.5-26.2%). Disease progression (death) for hospitalized patients was 53.1% (26.6%) and 12.8% (3.8%), respectively, for those enrolled in the ICU and general ward. In pooled analyses for both studies, predictors of disease progression were age, longer duration of symptoms at enrollment and immunosuppression. Patients hospitalized during the pandemic period had a poorer prognosis than in subsequent seasons. CONCLUSIONS: Patients with influenza A(H1N1)pdm09, particularly when requiring hospital admission, are at high risk for disease progression, especially if they are older, immunodeficient, or admitted late in infection. These data reinforce the need for international trials of novel treatment strategies for influenza infection and serve as a reminder of the need to monitor the severity of seasonal and pandemic influenza epidemics globally. TRIAL REGISTRATION: ClinicalTrials.gov Identifiers: FLU 002--NCT01056354, FLU 003--NCT01056185.", "link"=>"http://www.mendeley.com/research/outcomes-influenza-ah1n1pdm09-virus-infection-results-two-international-cohort-studies", "reader_count"=>12, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>3, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Other"=>2, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>3, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Master"=>1, "Other"=>2, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>1, "Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>5, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1584480"], "description"=>"<p>The number of patients at risk at each timepoint are given below the graph.</p>", "links"=>[], "tags"=>["Infectious diseases", "Viral diseases", "influenza", "h1n1", "patients", "flu", "003"], "article_id"=>1096844, "categories"=>["Biological Sciences"], "users"=>["Ruth Lynfield", "Richard Davey", "Dominic E. Dwyer", "Marcelo H. Losso", "Deborah Wentworth", "Alessandro Cozzi-Lepri", "Kathy Herman-Lamin", "Grazyna Cholewinska", "Daniel David", "Stefan Kuetter", "Zelalem Ternesgen", "Timothy M. Uyeki", "H. Clifford Lane", "Jens Lundgren", "James D. Neaton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101785.g003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cumulative_percentage_of_patients_with_death_from_any_cause_in_FLU_003_according_to_location_of_enrollment_/1096844", "title"=>"Cumulative percentage of patients with death from any cause in FLU 003 according to location of enrollment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-08 03:08:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1584476"], "description"=>"<p>FLU 002 flow diagram.</p>", "links"=>[], "tags"=>["Infectious diseases", "Viral diseases", "influenza", "h1n1", "002"], "article_id"=>1096841, "categories"=>["Biological Sciences"], "users"=>["Ruth Lynfield", "Richard Davey", "Dominic E. Dwyer", "Marcelo H. Losso", "Deborah Wentworth", "Alessandro Cozzi-Lepri", "Kathy Herman-Lamin", "Grazyna Cholewinska", "Daniel David", "Stefan Kuetter", "Zelalem Ternesgen", "Timothy M. Uyeki", "H. Clifford Lane", "Jens Lundgren", "James D. Neaton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101785.g001", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_FLU_002_flow_diagram_/1096841", "title"=>"FLU 002 flow diagram.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-08 03:08:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1584488"], "description"=>"<p>*Univariate odds ratio for death. OR for age is for 10 years older.</p><p>**Multivariate model using imputed data with adjustment for all variables listed.</p><p>***P-value for linear trend from multivariate model = 0.07</p><p>****P-value for linear trend from multivariate model = 0.35</p>", "links"=>[], "tags"=>["Infectious diseases", "Viral diseases", "influenza", "h1n1"], "article_id"=>1096853, "categories"=>["Biological Sciences"], "users"=>["Ruth Lynfield", "Richard Davey", "Dominic E. Dwyer", "Marcelo H. Losso", "Deborah Wentworth", "Alessandro Cozzi-Lepri", "Kathy Herman-Lamin", "Grazyna Cholewinska", "Daniel David", "Stefan Kuetter", "Zelalem Ternesgen", "Timothy M. Uyeki", "H. Clifford Lane", "Jens Lundgren", "James D. Neaton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101785.t007", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_associated_with_death_in_FLU003_/1096853", "title"=>"Baseline characteristics associated with death in FLU003.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-07-08 03:08:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1584487"], "description"=>"<p>*Univariate odds ratio for disease progression. OR for age is for 10 years older.</p><p>**Multivariate model using imputed data with adjustment for all variables listed.</p><p>***P-value for linear trend from multivariate model = 0.16</p><p>****P-value for linear trend from multivariate model = 0.10</p>", "links"=>[], "tags"=>["Infectious diseases", "Viral diseases", "influenza", "h1n1", "flu002", "flu003"], "article_id"=>1096852, "categories"=>["Biological Sciences"], "users"=>["Ruth Lynfield", "Richard Davey", "Dominic E. Dwyer", "Marcelo H. Losso", "Deborah Wentworth", "Alessandro Cozzi-Lepri", "Kathy Herman-Lamin", "Grazyna Cholewinska", "Daniel David", "Stefan Kuetter", "Zelalem Ternesgen", "Timothy M. Uyeki", "H. Clifford Lane", "Jens Lundgren", "James D. Neaton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101785.t006", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_associated_with_disease_progression_FLU002_and_FLU003_pooled_/1096852", "title"=>"Baseline characteristics associated with disease progression: FLU002 and FLU003 pooled.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-07-08 03:08:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1584484"], "description"=>"<p>*Currently or within previous 2 weeks, percent of women ≤45 years.</p><p>**Receipt of influenza vaccine during current season.</p>", "links"=>[], "tags"=>["Infectious diseases", "Viral diseases", "influenza", "h1n1", "enrolled"], "article_id"=>1096849, "categories"=>["Biological Sciences"], "users"=>["Ruth Lynfield", "Richard Davey", "Dominic E. Dwyer", "Marcelo H. Losso", "Deborah Wentworth", "Alessandro Cozzi-Lepri", "Kathy Herman-Lamin", "Grazyna Cholewinska", "Daniel David", "Stefan Kuetter", "Zelalem Ternesgen", "Timothy M. Uyeki", "H. Clifford Lane", "Jens Lundgren", "James D. Neaton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101785.t003", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_of_A_H1N1_pdm09_infected_participants_enrolled_in_FLU003_/1096849", "title"=>"Baseline characteristics of A(H1N1)pdm09-infected participants enrolled in FLU003.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-07-08 03:08:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1584482"], "description"=>"<p>Frequency distribution of number of days between onset of ILI symptoms and enrollment for patients in FLU 002 and FLU 003.</p>", "links"=>[], "tags"=>["Infectious diseases", "Viral diseases", "influenza", "h1n1", "days", "onset", "ili", "symptoms", "enrollment", "patients", "flu", "002"], "article_id"=>1096847, "categories"=>["Biological Sciences"], "users"=>["Ruth Lynfield", "Richard Davey", "Dominic E. Dwyer", "Marcelo H. Losso", "Deborah Wentworth", "Alessandro Cozzi-Lepri", "Kathy Herman-Lamin", "Grazyna Cholewinska", "Daniel David", "Stefan Kuetter", "Zelalem Ternesgen", "Timothy M. Uyeki", "H. Clifford Lane", "Jens Lundgren", "James D. Neaton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101785.g004", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Frequency_distribution_of_number_of_days_between_onset_of_ILI_symptoms_and_enrollment_for_patients_in_FLU_002_and_FLU_003_/1096847", "title"=>"Frequency distribution of number of days between onset of ILI symptoms and enrollment for patients in FLU 002 and FLU 003.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-08 03:08:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1584483"], "description"=>"<p>Outcomes through 14 days of follow-up for A(H1N1)pdm09-infected patients enrolled in FLU002.</p>", "links"=>[], "tags"=>["Infectious diseases", "Viral diseases", "influenza", "h1n1", "14", "days", "follow-up", "patients", "enrolled"], "article_id"=>1096848, "categories"=>["Biological Sciences"], "users"=>["Ruth Lynfield", "Richard Davey", "Dominic E. Dwyer", "Marcelo H. Losso", "Deborah Wentworth", "Alessandro Cozzi-Lepri", "Kathy Herman-Lamin", "Grazyna Cholewinska", "Daniel David", "Stefan Kuetter", "Zelalem Ternesgen", "Timothy M. Uyeki", "H. Clifford Lane", "Jens Lundgren", "James D. Neaton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101785.t002", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Outcomes_through_14_days_of_follow_up_for_A_H1N1_pdm09_infected_patients_enrolled_in_FLU002_/1096848", "title"=>"Outcomes through 14 days of follow-up for A(H1N1)pdm09-infected patients enrolled in FLU002.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-07-08 03:08:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1584478"], "description"=>"<p>FLU 003 flow diagram.</p>", "links"=>[], "tags"=>["Infectious diseases", "Viral diseases", "influenza", "h1n1", "003"], "article_id"=>1096843, "categories"=>["Biological Sciences"], "users"=>["Ruth Lynfield", "Richard Davey", "Dominic E. Dwyer", "Marcelo H. Losso", "Deborah Wentworth", "Alessandro Cozzi-Lepri", "Kathy Herman-Lamin", "Grazyna Cholewinska", "Daniel David", "Stefan Kuetter", "Zelalem Ternesgen", "Timothy M. Uyeki", "H. Clifford Lane", "Jens Lundgren", "James D. Neaton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101785.g002", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_FLU_003_flow_diagram_/1096843", "title"=>"FLU 003 flow diagram.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-08 03:08:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1584495", "https://ndownloader.figshare.com/files/1584496", "https://ndownloader.figshare.com/files/1584497", "https://ndownloader.figshare.com/files/1584498"], "description"=>"<div><p>Background</p><p>Data from prospectively planned cohort studies on risk of major clinical outcomes and prognostic factors for patients with influenza A(H1N1)pdm09 virus are limited. In 2009, in order to assess outcomes and evaluate risk factors for progression of illness, two cohort studies were initiated: FLU 002 in outpatients and FLU 003 in hospitalized patients.</p><p>Methods and Findings</p><p>Between October 2009 and December 2012, adults with influenza-like illness (ILI) were enrolled; outpatients were followed for 14 days and inpatients for 60 days. Disease progression was defined as hospitalization and/or death for outpatients, and hospitalization for >28 days, transfer to intensive care unit (ICU) if enrolled from general ward, and/or death for inpatients. Infection was confirmed by RT-PCR. 590 FLU 002 and 392 FLU 003 patients with influenza A (H1N1)pdm09 were enrolled from 81 sites in 17 countries at 2 days (IQR 1–3) and 6 days (IQR 4–10) following ILI onset, respectively. Disease progression was experienced by 29 (1 death) outpatients (5.1%; 95% CI: 3.4–7.2%) and 80 inpatients [death (32), hospitalization >28 days (43) or ICU transfer (20)] (21.6%; 95% CI: 17.5–26.2%). Disease progression (death) for hospitalized patients was 53.1% (26.6%) and 12.8% (3.8%), respectively, for those enrolled in the ICU and general ward. In pooled analyses for both studies, predictors of disease progression were age, longer duration of symptoms at enrollment and immunosuppression. Patients hospitalized during the pandemic period had a poorer prognosis than in subsequent seasons.</p><p>Conclusions</p><p>Patients with influenza A(H1N1)pdm09, particularly when requiring hospital admission, are at high risk for disease progression, especially if they are older, immunodeficient, or admitted late in infection. These data reinforce the need for international trials of novel treatment strategies for influenza infection and serve as a reminder of the need to monitor the severity of seasonal and pandemic influenza epidemics globally.</p><p>Trial Registration</p><p>ClinicalTrials.gov Identifiers: FLU 002- <a href=\"http://clinicaltrials.gov/ct2/show/NCT01056354\" target=\"_blank\">NCT01056354</a>, FLU 003- <a href=\"http://clinicaltrials.gov/ct2/show/NCT01056185\" target=\"_blank\">NCT01056185</a>.</p></div>", "links"=>[], "tags"=>["Infectious diseases", "Viral diseases", "influenza", "h1n1", "cohort"], "article_id"=>1096860, "categories"=>["Biological Sciences"], "users"=>["Ruth Lynfield", "Richard Davey", "Dominic E. Dwyer", "Marcelo H. Losso", "Deborah Wentworth", "Alessandro Cozzi-Lepri", "Kathy Herman-Lamin", "Grazyna Cholewinska", "Daniel David", "Stefan Kuetter", "Zelalem Ternesgen", "Timothy M. Uyeki", "H. Clifford Lane", "Jens Lundgren", "James D. Neaton"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0101785.s001", "https://dx.doi.org/10.1371/journal.pone.0101785.s002", "https://dx.doi.org/10.1371/journal.pone.0101785.s003", "https://dx.doi.org/10.1371/journal.pone.0101785.s004"], "stats"=>{"downloads"=>34, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Outcomes_of_Influenza_A_H1N1_pdm09_Virus_Infection_Results_from_Two_International_Cohort_Studies_/1096860", "title"=>"Outcomes of Influenza A(H1N1)pdm09 Virus Infection: Results from Two International Cohort Studies", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-07-08 03:08:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1584491"], "description"=>"<p>*Odds ratio for FLU003 vs. FLU002. OR for age is for 10 years older.</p><p>**Multivariate model using imputed data with adjustment for all variables listed except coinfections.</p><p>***P-value for linear trend from multivariate model = .0010</p><p>****P-value for linear trend from multivariate model = .0000</p><p>*****As above for a subset of patients (n = 333) analyzed for co-infections.</p>", "links"=>[], "tags"=>["Infectious diseases", "Viral diseases", "influenza", "h1n1", "severity", "flu002"], "article_id"=>1096856, "categories"=>["Biological Sciences"], "users"=>["Ruth Lynfield", "Richard Davey", "Dominic E. Dwyer", "Marcelo H. Losso", "Deborah Wentworth", "Alessandro Cozzi-Lepri", "Kathy Herman-Lamin", "Grazyna Cholewinska", "Daniel David", "Stefan Kuetter", "Zelalem Ternesgen", "Timothy M. Uyeki", "H. Clifford Lane", "Jens Lundgren", "James D. Neaton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101785.t005", "stats"=>{"downloads"=>6, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_associated_with_disease_severity_at_entry_FLU002_versus_FLU003_/1096856", "title"=>"Baseline characteristics associated with disease severity at entry: FLU002 versus FLU003.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-07-08 03:08:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1584489"], "description"=>"<p>Major outcomes through 60 days of follow-up for A(H1N1)pdm09-infected patients enrolled in FLU003.</p>", "links"=>[], "tags"=>["Infectious diseases", "Viral diseases", "influenza", "h1n1", "outcomes", "60", "days", "follow-up", "patients", "enrolled"], "article_id"=>1096854, "categories"=>["Biological Sciences"], "users"=>["Ruth Lynfield", "Richard Davey", "Dominic E. Dwyer", "Marcelo H. Losso", "Deborah Wentworth", "Alessandro Cozzi-Lepri", "Kathy Herman-Lamin", "Grazyna Cholewinska", "Daniel David", "Stefan Kuetter", "Zelalem Ternesgen", "Timothy M. Uyeki", "H. Clifford Lane", "Jens Lundgren", "James D. Neaton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101785.t004", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Major_outcomes_through_60_days_of_follow_up_for_A_H1N1_pdm09_infected_patients_enrolled_in_FLU003_/1096854", "title"=>"Major outcomes through 60 days of follow-up for A(H1N1)pdm09-infected patients enrolled in FLU003.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-07-08 03:08:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1584485"], "description"=>"<p>*Currently or within previous 2 weeks, percent of women ≤45 years.</p><p>**Receipt of influenza vaccine during current season.</p>", "links"=>[], "tags"=>["Infectious diseases", "Viral diseases", "influenza", "h1n1", "enrolled"], "article_id"=>1096850, "categories"=>["Biological Sciences"], "users"=>["Ruth Lynfield", "Richard Davey", "Dominic E. Dwyer", "Marcelo H. Losso", "Deborah Wentworth", "Alessandro Cozzi-Lepri", "Kathy Herman-Lamin", "Grazyna Cholewinska", "Daniel David", "Stefan Kuetter", "Zelalem Ternesgen", "Timothy M. Uyeki", "H. Clifford Lane", "Jens Lundgren", "James D. Neaton"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101785.t001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_characteristics_of_A_H1N1_pdm09_infected_participants_enrolled_in_FLU002_/1096850", "title"=>"Baseline characteristics of A(H1N1)pdm09-infected participants enrolled in FLU002.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-07-08 03:08:39"}

PMC Usage Stats | Further Information

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Relative Metric

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