Moxibustion Treatment for Knee Osteoarthritis: A Multi-Centre, Non-Blinded, Randomised Controlled Trial on the Effectiveness and Safety of the Moxibustion Treatment versus Usual Care in Knee Osteoarthritis Patients
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{"title"=>"Moxibustion Treatment for Knee Osteoarthritis: A Multi-Centre, Non-Blinded, Randomised Controlled Trial on the Effectiveness and Safety of the Moxibustion Treatment versus Usual Care in Knee Osteoarthritis Patients", "type"=>"journal", "authors"=>[{"first_name"=>"Tae-Hun", "last_name"=>"Kim"}, {"first_name"=>"Kun Hyung", "last_name"=>"Kim"}, {"first_name"=>"Jung Won", "last_name"=>"Kang"}, {"first_name"=>"MinHee", "last_name"=>"Lee"}, {"first_name"=>"Kyung-Won", "last_name"=>"Kang"}, {"first_name"=>"Jung Eun", "last_name"=>"Kim"}, {"first_name"=>"Joo-Hee", "last_name"=>"Kim"}, {"first_name"=>"Seunghoon", "last_name"=>"Lee"}, {"first_name"=>"Mi-Suk", "last_name"=>"Shin"}, {"first_name"=>"So-Young", "last_name"=>"Jung"}, {"first_name"=>"Ae-Ran", "last_name"=>"Kim"}, {"first_name"=>"Hyo-Ju", "last_name"=>"Park"}, {"first_name"=>"Hee-Jung", "last_name"=>"Jung"}, {"first_name"=>"Ho Sueb", "last_name"=>"Song"}, {"first_name"=>"Hyeong Jun", "last_name"=>"Kim"}, {"first_name"=>"Jin-Bong", "last_name"=>"Choi"}, {"first_name"=>"Kwon Eui", "last_name"=>"Hong"}, {"first_name"=>"Sun-Mi", "last_name"=>"Choi"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"373631581", "issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0101973", "pmid"=>"25061882", "sgr"=>"84904880491"}, "id"=>"3c481776-539e-32c9-9672-8f898bac67ea", "abstract"=>"This study tested the effectiveness of moxibustion on pain and function in chronic knee osteoarthritis (KOA) and evaluated safety. Methods: for Ethics statement, Participants were informed about the written informed consent was obtained from each participant. For Interventions, 212 South Korean patients aged 40–70 were stratified by mild (Kellgren/Lawrence scale grades 0/1) and moderate-severe KOA (grades 2/3/4), and randomly allocated to moxibustion or UC for four weeks. The outcomes of pain to numeric rating scale (NRS) and adverse events were evaluated at 5 and 13 weeks. Results: A total of 251 participants were recruited, and 212 KOA patients met the inclusion criteria. 102 patients (73 mild, 29 moderate-severe) were improved by moxibustion at 5 weeks. The primary outcome improved for mild but not moderate-severe KOA. Conclusions: Moxibustion may improve pain, function and quality of life in KOA patients, but adverse events are common.", "link"=>"http://www.mendeley.com/research/moxibustion-treatment-knee-osteoarthritis-multicentre-nonblinded-randomised-controlled-trial-effecti-2", "reader_count"=>40, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>6, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>16}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>6, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>16}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>1, "Environmental Science"=>1, "Nursing and Health Professions"=>8, "Medicine and Dentistry"=>22, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>1, "Sports and Recreations"=>1, "Psychology"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>22}, "Neuroscience"=>{"Neuroscience"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>8}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"Mexico"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1609511"], "description"=>"<p>Study flow chart.</p>", "links"=>[], "tags"=>["anatomy", "Musculoskeletal system", "Clinical medicine", "clinical trials", "Complementary and alternative medicine", "health care", "Health care policy", "Quality of life", "neurology", "Pain management", "pharmacology", "Adverse reactions", "rheumatology", "arthritis", "osteoarthritis", "research design", "Clinical research design"], "article_id"=>1118024, "categories"=>["Biological Sciences"], "users"=>["Tae-Hun Kim", "Kun Hyung Kim", "Jung Won Kang", "MinHee Lee", "Kyung-Won Kang", "Jung Eun Kim", "Joo-Hee Kim", "Seunghoon Lee", "Mi-Suk Shin", "So-Young Jung", "Ae-Ran Kim", "Hyo-Ju Park", "Hee-Jung Jung", "Ho Sueb Song", "Hyeong Jun Kim", "Jin-Bong Choi", "Kwon Eui Hong", "Sun-Mi Choi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101973.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_flow_chart_/1118024", "title"=>"Study flow chart.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-25 02:43:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1609520", "https://ndownloader.figshare.com/files/1609522", "https://ndownloader.figshare.com/files/1609523"], "description"=>"<div><p>Introduction</p><p>This study tested the effectiveness of moxibustion on pain and function in chronic knee osteoarthritis (KOA) and evaluated safety.</p><p>Methods</p><p>A multi-centre, non-blinded, parallel-group, randomised controlled trial compared moxibustion with usual care (UC) in KOA. 212 South Korean patients aged 40–70 were recruited from 2011–12, stratified by mild (Kellgren/Lawrence scale grades 0/1) and moderate-severe KOA (grades 2/3/4), and randomly allocated to moxibustion or UC for four weeks. Moxibustion involved burning mugwort devices over acupuncture and Ashi points in affected knee(s). UC was allowed. Korean Western Ontario and McMaster Universities Questionnaire (K-WOMAC), Short Form 36 Health Survey (SF-36v2), Beck Depression Inventory (BDI), physical performance test, pain numeric rating scale (NRS) and adverse events were evaluated at 5 and 13 weeks. K-WOMAC global score at 5 weeks was the primary outcome.</p><p>Results</p><p>102 patients (73 mild, 29 moderate-severe) were allocated to moxibustion, 110 (77 mild, 33 moderate-severe) to UC. K-WOMAC global score (moxibustion 25.42+/−SD 19.26, UC 33.60+/−17.91, p<0.01, effect size  = 0.0477), NRS (moxibustion 44.77+/−22.73, UC 56.23+/−17.71, p<0.01, effect size  = 0.0073) and timed-stand test (moxibustion 24.79+/−9.76, UC 25.24+/−8.84, p = 0.0486, effect size  = 0.0021) were improved by moxibustion at 5 weeks. The primary outcome improved for mild but not moderate-severe KOA. At 13 weeks, moxibustion significantly improved the K-WOMAC global score and NRS. Moxibustion improved SF-36 physical component summary (p = 0.0299), bodily pain (p = 0.0003), physical functioning (p = 0.0025) and social functioning (p = 0.0418) at 5 weeks, with no difference in mental component summary at 5 and 13 weeks. BDI showed no difference (p = 0.34) at 5 weeks. After 1158 moxibustion treatments, 121 adverse events included first (n = 6) and second degree (n = 113) burns, pruritus and fatigue (n = 2).</p><p>Conclusions</p><p>Moxibustion may improve pain, function and quality of life in KOA patients, but adverse events are common. Limitations included no sham control or blinding.</p><p>Trial Registration</p><p>Clinical Research Information Service (CRIS) <a href=\"https://cris.nih.go.kr/cris/en/\" target=\"_blank\">KCT0000130</a></p></div>", "links"=>[], "tags"=>["anatomy", "Musculoskeletal system", "Clinical medicine", "clinical trials", "Complementary and alternative medicine", "health care", "Health care policy", "Quality of life", "neurology", "Pain management", "pharmacology", "Adverse reactions", "rheumatology", "arthritis", "osteoarthritis", "research design", "Clinical research design", "randomised", "controlled", "moxibustion"], "article_id"=>1118029, "categories"=>["Biological Sciences"], "users"=>["Tae-Hun Kim", "Kun Hyung Kim", "Jung Won Kang", "MinHee Lee", "Kyung-Won Kang", "Jung Eun Kim", "Joo-Hee Kim", "Seunghoon Lee", "Mi-Suk Shin", "So-Young Jung", "Ae-Ran Kim", "Hyo-Ju Park", "Hee-Jung Jung", "Ho Sueb Song", "Hyeong Jun Kim", "Jin-Bong Choi", "Kwon Eui Hong", "Sun-Mi Choi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0101973.s001", "https://dx.doi.org/10.1371/journal.pone.0101973.s002", "https://dx.doi.org/10.1371/journal.pone.0101973.s003"], "stats"=>{"downloads"=>23, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Moxibustion_Treatment_for_Knee_Osteoarthritis_A_Multi_Centre_Non_Blinded_Randomised_Controlled_Trial_on_the_Effectiveness_and_Safety_of_the_Moxibustion_Treatment_versus_Usual_Care_in_Knee_Osteoarthritis_Patients_/1118029", "title"=>"Moxibustion Treatment for Knee Osteoarthritis: A Multi-Centre, Non-Blinded, Randomised Controlled Trial on the Effectiveness and Safety of the Moxibustion Treatment versus Usual Care in Knee Osteoarthritis Patients", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-07-25 02:43:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1609514"], "description"=>"<p>*ANCOVA was used for the statistical analysis of changes from baseline between two groups on each outcome at 5 weeks and 13 weeks (covariate: baseline value and participating research centre).</p><p>**Grades were evaluated by Kellgren/Lawrence scale.</p><p>***Eta-squared (η2) was calculated as an effect-size estimate in the ANCOVA statistic model. K-WOMAC: Korean version of Western Ontario and McMaster Universities Questionnaire; NRS: numeric rating scale; BDI: Beck Depression Inventory.</p>", "links"=>[], "tags"=>["anatomy", "Musculoskeletal system", "Clinical medicine", "clinical trials", "Complementary and alternative medicine", "health care", "Health care policy", "Quality of life", "neurology", "Pain management", "pharmacology", "Adverse reactions", "rheumatology", "arthritis", "osteoarthritis", "research design", "Clinical research design", "outcomes"], "article_id"=>1118027, "categories"=>["Biological Sciences"], "users"=>["Tae-Hun Kim", "Kun Hyung Kim", "Jung Won Kang", "MinHee Lee", "Kyung-Won Kang", "Jung Eun Kim", "Joo-Hee Kim", "Seunghoon Lee", "Mi-Suk Shin", "So-Young Jung", "Ae-Ran Kim", "Hyo-Ju Park", "Hee-Jung Jung", "Ho Sueb Song", "Hyeong Jun Kim", "Jin-Bong Choi", "Kwon Eui Hong", "Sun-Mi Choi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101973.t002", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Primary_and_secondary_outcomes_at_each_visit_/1118027", "title"=>"Primary and secondary outcomes at each visit.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-07-25 02:43:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1609512"], "description"=>"<p>*The Wilcoxon rank sum test was used for statistical analysis.</p>†<p>The Chi-squared test was used for statistical analysis.</p>‡<p>The t-test was used for statistical analysis.</p>§<p>Fisher's exact test was used for statistical analysis. IQR: interquartile range.</p>", "links"=>[], "tags"=>["anatomy", "Musculoskeletal system", "Clinical medicine", "clinical trials", "Complementary and alternative medicine", "health care", "Health care policy", "Quality of life", "neurology", "Pain management", "pharmacology", "Adverse reactions", "rheumatology", "arthritis", "osteoarthritis", "research design", "Clinical research design", "moxibustion"], "article_id"=>1118025, "categories"=>["Biological Sciences"], "users"=>["Tae-Hun Kim", "Kun Hyung Kim", "Jung Won Kang", "MinHee Lee", "Kyung-Won Kang", "Jung Eun Kim", "Joo-Hee Kim", "Seunghoon Lee", "Mi-Suk Shin", "So-Young Jung", "Ae-Ran Kim", "Hyo-Ju Park", "Hee-Jung Jung", "Ho Sueb Song", "Hyeong Jun Kim", "Jin-Bong Choi", "Kwon Eui Hong", "Sun-Mi Choi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101973.t001", "stats"=>{"downloads"=>4, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_Data_in_the_moxibustion_and_usual_care_Groups_/1118025", "title"=>"Demographic Data in the moxibustion and usual care Groups.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-07-25 02:43:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/1609513"], "description"=>"<p>ANCOVA was used for the statistical analysis of changes from baseline between two groups on each outcome at 5 weeks and 13 weeks (covariate: baseline value and participating research centre).</p><p>*Eta-squared (η2) was calculated as an effect-size estimate in the ANCOVA statistic model.</p>", "links"=>[], "tags"=>["anatomy", "Musculoskeletal system", "Clinical medicine", "clinical trials", "Complementary and alternative medicine", "health care", "Health care policy", "Quality of life", "neurology", "Pain management", "pharmacology", "Adverse reactions", "rheumatology", "arthritis", "osteoarthritis", "research design", "Clinical research design", "short-form", "36"], "article_id"=>1118026, "categories"=>["Biological Sciences"], "users"=>["Tae-Hun Kim", "Kun Hyung Kim", "Jung Won Kang", "MinHee Lee", "Kyung-Won Kang", "Jung Eun Kim", "Joo-Hee Kim", "Seunghoon Lee", "Mi-Suk Shin", "So-Young Jung", "Ae-Ran Kim", "Hyo-Ju Park", "Hee-Jung Jung", "Ho Sueb Song", "Hyeong Jun Kim", "Jin-Bong Choi", "Kwon Eui Hong", "Sun-Mi Choi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0101973.t003", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_short_form_36_health_survey_SF_36v2_results_at_each_visit_/1118026", "title"=>"The short-form 36 health survey (SF-36v2) results at each visit.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-07-25 02:43:37"}

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