Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Prostate-Like Epithelial Cells In Vivo
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{"title"=>"Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Prostate-Like Epithelial Cells In Vivo", "type"=>"journal", "authors"=>[{"first_name"=>"Wang", "last_name"=>"Li"}, {"first_name"=>"Bo", "last_name"=>"Ye"}, {"first_name"=>"Xiao-Yan", "last_name"=>"Cai"}, {"first_name"=>"Jian-Hua", "last_name"=>"Lin"}, {"first_name"=>"Wei-Qiang", "last_name"=>"Gao"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0102657", "pmid"=>"25054276", "issn"=>"1932-6203"}, "id"=>"b2da8616-4bce-31bc-8e26-c23aba872c2c", "abstract"=>"Although human umbilical cord mesenchymal stem cells (hUC-MSCs) have been identified as a new source of MSCs for potential application in regenerative medicine, their full potential of differentiation has not been determined. In particular, whether they have the capability to differentiate into epithelial cells of endodermal origin such as the prostate epithelial cells is unknown. Here we report that when hUC-MSCs were combined with rat urogenital sinus stromal cells (rUGSSs) and transplanted into the renal capsule in vivo, they could differentiate into prostate epithelial-like cells that could be verified by prostate epithelial cell-specific markers including the prostate specific antigen. The prostatic glandular structures formed in vivo displayed similar cellular architecture with lumens and branching features as seen for a normal prostate. In addition, the human origin of the hUC-MSCs was confirmed by immunocytochemistry for human nuclear antigen. These findings together indicate that hUC-MSCs have the capability to differentiate into epithelial-like cells that are normally derived from the endoderm, implicating their potential applications in tissue repair and regeneration of many endoderm-derived internal organs.", "link"=>"http://www.mendeley.com/research/differentiation-human-umbilical-cord-mesenchymal-stem-cells-prostatelike-epithelial-cells-vivo-1", "reader_count"=>7, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>5, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>5, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Agricultural and Biological Sciences"=>4, "Neuroscience"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Neuroscience"=>{"Neuroscience"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1606797"], "description"=>"<p>Cells were from P0-P8 hUC-MSCs and stained with CD29, CD105, CD34, CD45, and CD31 antibodies. The upper half of the figure is the flow histogram of single antibody staining. The shaded area shows the profile of the negative control. The lower half of the figure is CD29-FITC and CD105-PE expression of P0-P8 hUC-MSCs. (A) hUC-MSCs exhibit positive surface expression of integrin marker (CD29), (B) MSC marker (CD105), (C-E) but are negative for hematopoietic lineage markers (CD34, CD45) nor the platelet/endothelial cell adhesion molecule (CD31). The CD29+CD105+ hUC-MSC population accounts for 85%∼99.9% of all cells.</p>", "links"=>[], "tags"=>["anatomy", "biological tissue", "epithelium", "Epithelial cells", "Biochemistry", "cytochemistry", "immunocytochemistry", "cell biology", "Cellular types", "Animal cells", "stem cells", "mesenchymal stem cells", "Molecular cell biology", "developmental biology", "morphogenesis", "regeneration", "Cell differentiation", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Prostate cancer", "urology", "Prostate diseases", "p0-p8", "huc-mscs"], "article_id"=>1115848, "categories"=>["Biological Sciences"], "users"=>["Wang Li", "Bo Ye", "Xiao-Yan Cai", "Jian-Hua Lin", "Wei-Qiang Gao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0102657.g002", "stats"=>{"downloads"=>0, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunophenotype_analysis_of_P0_P8_hUC_MSCs_by_FACS_/1115848", "title"=>"Immunophenotype analysis of P0-P8 hUC-MSCs by FACS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-23 04:28:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/1606800"], "description"=>"<p>The field of prostate epithelial regeneration can be seen within the graft transplanted with hUC-MSCs and rUGSSs. (A, B) Immunofluorescent staining for CK8 in the new graft. (C, D) Detection of human cells in the new graft (green). (E, F) Note that the human nuclear antigen+ cells (green) in the graft can be co-stained with CK8. (G, H) The grafts express the prostate specific antigen (PSA). Scale bar 50 µm.</p>", "links"=>[], "tags"=>["anatomy", "biological tissue", "epithelium", "Epithelial cells", "Biochemistry", "cytochemistry", "immunocytochemistry", "cell biology", "Cellular types", "Animal cells", "stem cells", "mesenchymal stem cells", "Molecular cell biology", "developmental biology", "morphogenesis", "regeneration", "Cell differentiation", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Prostate cancer", "urology", "Prostate diseases", "cells"], "article_id"=>1115851, "categories"=>["Biological Sciences"], "users"=>["Wang Li", "Bo Ye", "Xiao-Yan Cai", "Jian-Hua Lin", "Wei-Qiang Gao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0102657.g005", "stats"=>{"downloads"=>2, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Detection_of_human_cells_in_the_regeneration_of_prostate_/1115851", "title"=>"Detection of human cells in the regeneration of prostate.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-23 04:28:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/1606798"], "description"=>"<p>Mice were sacrificed 2 months after co-transplantation surgery, and the kidneys from the cell implanted nude mice were collected. (A) Graft initiated with hUC-MSCs alone and (B) rUGSSs alone were used as negative control, respectively. (C) Graft derived with hUC-MSCs and rUGSSs. (D–F) Histological analyses of the sections of the graft stained for haematoxylin and eosin (H&E). (D) Note that while hUC-MSCs alone and (E) rUGSSs single cell type transplantation fail to regenerate prostate glandular structures. (F) co-transplantation of hUC-MSCs and rUGSSs gives rise to prostate glandular structures. Scale bar 50 µm.</p>", "links"=>[], "tags"=>["anatomy", "biological tissue", "epithelium", "Epithelial cells", "Biochemistry", "cytochemistry", "immunocytochemistry", "cell biology", "Cellular types", "Animal cells", "stem cells", "mesenchymal stem cells", "Molecular cell biology", "developmental biology", "morphogenesis", "regeneration", "Cell differentiation", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Prostate cancer", "urology", "Prostate diseases", "uc-mscs", "rugsss", "prostate"], "article_id"=>1115849, "categories"=>["Biological Sciences"], "users"=>["Wang Li", "Bo Ye", "Xiao-Yan Cai", "Jian-Hua Lin", "Wei-Qiang Gao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0102657.g003", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Human_UC_MSCs_combined_with_rUGSSs_can_generate_prostate_glands_/1115849", "title"=>"Human UC-MSCs combined with rUGSSs can generate prostate glands.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-23 04:28:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/1606799"], "description"=>"<p>(A, C, E, G) Immunofluorescence analysis of the expression of CK8, p63, CK5 and androgen receptor (AR) in regenerated prostate tissue. (F) shows triple-staining for the basal cell marker CK5 (green), luminal marker CK8 (red) and DAPI counter staining (blue). (B, D, F, H) The tissue sections were counterstained with 4, 6-diamidino-2-phenylindole (DAPI; blue). Scale bar 50 µm.</p>", "links"=>[], "tags"=>["anatomy", "biological tissue", "epithelium", "Epithelial cells", "Biochemistry", "cytochemistry", "immunocytochemistry", "cell biology", "Cellular types", "Animal cells", "stem cells", "mesenchymal stem cells", "Molecular cell biology", "developmental biology", "morphogenesis", "regeneration", "Cell differentiation", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Prostate cancer", "urology", "Prostate diseases", "prostates", "phenotypes"], "article_id"=>1115850, "categories"=>["Biological Sciences"], "users"=>["Wang Li", "Bo Ye", "Xiao-Yan Cai", "Jian-Hua Lin", "Wei-Qiang Gao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0102657.g004", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regenerated_prostates_resemble_the_phenotypes_of_normal_prostates_/1115850", "title"=>"Regenerated prostates resemble the phenotypes of normal prostates.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-23 04:28:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/1606796"], "description"=>"<p>(A), Seven days after the initial plating, adherent cells derived from hUC displayed a fibroblastic morphology. (B), rUGSSs were small and fibrous in appearance. (C), hUC-MSCs were immunostained by an anti-human nuclei monoclonal antibody (green). (D), rUGSSs were immunostained by vimentin antibody (red). Scale bar: 50 µm.</p>", "links"=>[], "tags"=>["anatomy", "biological tissue", "epithelium", "Epithelial cells", "Biochemistry", "cytochemistry", "immunocytochemistry", "cell biology", "Cellular types", "Animal cells", "stem cells", "mesenchymal stem cells", "Molecular cell biology", "developmental biology", "morphogenesis", "regeneration", "Cell differentiation", "oncology", "Cancers and neoplasms", "Genitourinary tract tumors", "Prostate cancer", "urology", "Prostate diseases", "morphology", "characterization", "huc-mscs"], "article_id"=>1115847, "categories"=>["Biological Sciences"], "users"=>["Wang Li", "Bo Ye", "Xiao-Yan Cai", "Jian-Hua Lin", "Wei-Qiang Gao"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0102657.g001", "stats"=>{"downloads"=>5, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_morphology_and_characterization_of_hUC_MSCs_and_rUGSSs_/1115847", "title"=>"The morphology and characterization of hUC-MSCs and rUGSSs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-23 04:28:45"}

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Relative Metric

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