Medusa: A Novel Gene Drive System for Confined Suppression of Insect Populations
- Publication Date
- July 23, 2014
- Journal
- PLOS ONE
- Authors
- John M. Marshall & Bruce A. Hay
- Volume
- 9
- Issue
- 7
- Pages
- e102694
- DOI
- https://dx.plos.org/10.1371/journal.pone.0102694
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0102694
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/25054803
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108329
- Europe PMC
- http://europepmc.org/abstract/MED/25054803
- Web of Science
- 000339614100049
- Scopus
- 84904622855
- Mendeley
- http://www.mendeley.com/research/medusa-novel-gene-drive-system-confined-suppression-insect-populations
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Mendeley | Further Information
{"title"=>"Medusa: A novel gene drive system for confined suppression of insect populations", "type"=>"journal", "authors"=>[{"first_name"=>"John M.", "last_name"=>"Marshall", "scopus_author_id"=>"55471919700"}, {"first_name"=>"Bruce A.", "last_name"=>"Hay", "scopus_author_id"=>"7006167912"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"25054803", "sgr"=>"84904622855", "doi"=>"10.1371/journal.pone.0102694", "scopus"=>"2-s2.0-84904622855", "pui"=>"373596272", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "issn"=>"19326203"}, "id"=>"d10b74d2-0a14-3361-87fc-8d0640c43353", "abstract"=>"Gene drive systems provide novel opportunities for insect population suppression by driving genes that confer a fitness cost into pest or disease vector populations; however regulatory issues arise when genes are capable of spreading across international borders. Gene drive systems displaying threshold properties provide a solution since they can be confined to local populations and eliminated through dilution with wild-types. We propose a novel, threshold-dependent gene drive system, Medusa, capable of inducing a local and reversible population crash. Medusa consists of four components--two on the X chromosome, and two on the Y chromosome. A maternally-expressed, X-linked toxin and a zygotically-expressed, Y-linked antidote results in suppression of the female population and selection for the presence of the transgene-bearing Y because only male offspring of Medusa-bearing females are protected from the effects of the toxin. At the same time, the combination of a zygotically-expressed, Y-linked toxin and a zygotically-expressed, X-linked antidote selects for the transgene-bearing X in the presence of the transgene-bearing Y. Together these chromosomes create a balanced lethal system that spreads while selecting against females when present above a certain threshold frequency. Simple population dynamic models show that an all-male release of Medusa males, carried out over six generations, is expected to induce a population crash within 12 generations for modest release sizes on the order of the wild population size. Re-invasion of non-transgenic insects into a suppressed population can result in a population rebound; however this can be prevented through regular releases of modest numbers of Medusa males. Finally, we outline how Medusa could be engineered with currently available molecular tools.", "link"=>"http://www.mendeley.com/research/medusa-novel-gene-drive-system-confined-suppression-insect-populations", "reader_count"=>38, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>12, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>4, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>12, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>4, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>7, "Mathematics"=>1, "Medicine and Dentistry"=>1, "Agricultural and Biological Sciences"=>23, "Veterinary Science and Veterinary Medicine"=>1, "Social Sciences"=>1, "Computer Science"=>1, "Decision Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Decision Sciences"=>{"Decision Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>23}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Environmental Science"=>{"Environmental Science"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"United States"=>1, "United Kingdom"=>3, "Mexico"=>1, "Switzerland"=>1}, "group_count"=>7}CrossRef
- http://doi.org/10.1111/eva.12583
- http://doi.org/10.1038/nrg.2015.34
- http://doi.org/10.1371/journal.pcbi.1006059
- http://doi.org/10.1073/pnas.1805278115
- http://doi.org/10.1021/acssynbio.9b00452
- http://doi.org/10.1111/eva.12827
- http://doi.org/10.1038/nbt.3361
- http://doi.org/10.1038/s41467-020-14960-3
- http://doi.org/10.1111/eva.13180
- http://doi.org/10.1186/s12915-020-0761-2
Scopus | Further Information
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Relative Metric
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