Chronic Artificial Blue-Enriched White Light Is an Effective Countermeasure to Delayed Circadian Phase and Neurobehavioral Decrements
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{"title"=>"Chronic artificial blue-enriched white light is an effective countermeasure to delayed circadian phase and neurobehavioral decrements", "type"=>"journal", "authors"=>[{"first_name"=>"Raymond P.", "last_name"=>"Najjar", "scopus_author_id"=>"55376172800"}, {"first_name"=>"Luzian", "last_name"=>"Wolf", "scopus_author_id"=>"56298025200"}, {"first_name"=>"Jacques", "last_name"=>"Taillard", "scopus_author_id"=>"6701746180"}, {"first_name"=>"Luc J M", "last_name"=>"Schlangen", "scopus_author_id"=>"6602823027"}, {"first_name"=>"Alex", "last_name"=>"Salam", "scopus_author_id"=>"56298032300"}, {"first_name"=>"Christian", "last_name"=>"Cajochen", "scopus_author_id"=>"7003530216"}, {"first_name"=>"Claude", "last_name"=>"Gronfier", "scopus_author_id"=>"56150474600"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84904965480", "pui"=>"373644996", "doi"=>"10.1371/journal.pone.0102827", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84904965480", "pmid"=>"25072880"}, "id"=>"5faa2cc4-2083-3c02-83e8-274365319147", "abstract"=>"Studies in Polar Base stations, where personnel have no access to sunlight during winter, have reported circadian misalignment, free-running of the sleep-wake rhythm, and sleep problems. Here we tested light as a countermeasure to circadian misalignment in personnel of the Concordia Polar Base station during the polar winter. We hypothesized that entrainment of the circadian pacemaker to a 24-h light-dark schedule would not occur in all crew members (n = 10) exposed to 100-300 lux of standard fluorescent white (SW) light during the daytime, and that chronic non-time restricted daytime exposure to melanopsin-optimized blue-enriched white (BE) light would establish an a stable circadian phase, in participants, together with increased cognitive performance and mood levels. The lighting schedule consisted of an alternation between SW lighting (2 weeks), followed by a BE lighting (2 weeks) for a total of 9 weeks. Rest-activity cycles assessed by actigraphy showed a stable rest-activity pattern under both SW and BE light. No difference was found between light conditions on the intra-daily stability, variability and amplitude of activity, as assessed by non-parametric circadian analysis. As hypothesized, a significant delay of about 30 minutes in the onset of melatonin secretion occurred with SW, but not with BE light. BE light significantly enhanced well being and alertness compared to SW light. We propose that the superior efficacy of blue-enriched white light versus standard white light involves melanopsin-based mechanisms in the activation of the non-visual functions studied, and that their responses do not dampen with time (over 9-weeks). This work could lead to practical applications of light exposure in working environment where background light intensity is chronically low to moderate (polar base stations, power plants, space missions, etc.), and may help design lighting strategies to maintain health, productivity, and personnel safety.", "link"=>"http://www.mendeley.com/research/chronic-artificial-blueenriched-white-light-effective-countermeasure-delayed-circadian-phase-neurobe", "reader_count"=>81, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>6, "Researcher"=>10, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>3, "Student > Master"=>12, "Other"=>6, "Student > Bachelor"=>14, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>6, "Researcher"=>10, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>3, "Student > Master"=>12, "Other"=>6, "Student > Bachelor"=>14, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>9, "Agricultural and Biological Sciences"=>23, "Chemistry"=>1, "Computer Science"=>1, "Engineering"=>5, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>13, "Design"=>3, "Neuroscience"=>7, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Physics and Astronomy"=>2, "Psychology"=>7, "Social Sciences"=>3, "Nursing and Health Professions"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Social Sciences"=>{"Social Sciences"=>3}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Psychology"=>{"Psychology"=>7}, "Unspecified"=>{"Unspecified"=>9}, "Environmental Science"=>{"Environmental Science"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Design"=>{"Design"=>3}, "Engineering"=>{"Engineering"=>5}, "Chemistry"=>{"Chemistry"=>1}, "Neuroscience"=>{"Neuroscience"=>7}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>23}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"Canada"=>1, "Netherlands"=>1, "United States"=>1, "Brazil"=>1, "Malaysia"=>1, "France"=>1, "Spain"=>1}, "group_count"=>3}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1613750"], "description"=>"<p><b>A</b>. Spectra of ambient lightings used in the study. In a black straight line the spectrum of the control SW light used in weeks 1, 4, 5, 8 and 9 of the study. In a blue straight line the spectrum of the BE light used in weeks 2, 3, 6, and 7 of the study. <b>B</b>. Intensity (irradiance) and spectral composition of the lighting environments as measured in different locations of the Polar Station. BE light contained significantly more energy in the blue (p<0.001) and green (p<0.01) range of the light spectrum, and less red (p<0.001) compared to SW light. <b>C</b>. Intensity (irradiance) and spectral composition of the lighting environments as measured by the Lightwatcher device worn by the participants. The light spectra measured by the polar station workers under BE light contained significantly more short wavelength blue light (p<0.001) and less long wavelength red light (p<0.05) compared to SW light. Intensity of middle wavelength green light and IR light detected by the participants were not significantly different. See <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0102827#pone.0102827.s011\" target=\"_blank\">Table S1</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0102827#pone.0102827.s002\" target=\"_blank\">Figures S2</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0102827#pone.0102827.s003\" target=\"_blank\">S3</a> for more details.</p>", "links"=>[], "tags"=>["Chronobiology", "physiology", "Physiological processes", "sleep", "Astronomical sciences", "Space exploration", "Spaceflight", "physics", "Electromagnetic radiation", "light", "Visible light"], "article_id"=>1121344, "categories"=>["Biological Sciences"], "users"=>["Raymond P. Najjar", "Luzian Wolf", "Jacques Taillard", "Luc J. M. Schlangen", "Alex Salam", "Christian Cajochen", "Claude Gronfier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0102827.g001", "stats"=>{"downloads"=>5, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_the_lighting_environments_/1121344", "title"=>"Characteristics of the lighting environments.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-29 03:14:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1613763"], "description"=>"<p>Average lights off time (<b>A</b>) and bed time (<b>B</b>) were significantly earlier under BE light weeks (24.9±0.3 h and 25.4±0.3 h, respectively) in comparison SW light weeks (25.3±0.3 h and 25.7±0.3 h, respectively) (p<0.05). Wake up time was not significantly different between lighting conditions, 9.0±0.6 h and 8.6±0.4 h under BE and SW light respectively (p = 0.4).</p>", "links"=>[], "tags"=>["Chronobiology", "physiology", "Physiological processes", "sleep", "Astronomical sciences", "Space exploration", "Spaceflight", "physics", "Electromagnetic radiation", "light", "Visible light", "sw", "lights", "sleeping"], "article_id"=>1121357, "categories"=>["Biological Sciences"], "users"=>["Raymond P. Najjar", "Luzian Wolf", "Jacques Taillard", "Luc J. M. Schlangen", "Alex Salam", "Christian Cajochen", "Claude Gronfier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0102827.g003", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Impact_of_SW_and_BE_light_on_the_participants_lights_off_time_and_sleeping_pattern_/1121357", "title"=>"Impact of SW and BE light on the participants' lights off time and sleeping pattern.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-29 03:14:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1613762"], "description"=>"<p>Subject (S7) had a relatively regular sleep wake cycle across the studyCircadian phase, assessed by DLMO (<b>*</b>), shows a phase delay under SW light condition (SW 8–9), but not under BE light condition (BE 6–7), compared to W1.</p>", "links"=>[], "tags"=>["Chronobiology", "physiology", "Physiological processes", "sleep", "Astronomical sciences", "Space exploration", "Spaceflight", "physics", "Electromagnetic radiation", "light", "Visible light", "raster", "actigraphy", "circadian"], "article_id"=>1121356, "categories"=>["Biological Sciences"], "users"=>["Raymond P. Najjar", "Luzian Wolf", "Jacques Taillard", "Luc J. M. Schlangen", "Alex Salam", "Christian Cajochen", "Claude Gronfier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0102827.g002", "stats"=>{"downloads"=>2, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_raster_plot_of_continuous_actigraphy_over_9_weeks_and_circadian_phase_/1121356", "title"=>"Representative raster plot of continuous actigraphy over 9 weeks, and circadian phase.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-29 03:14:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1613772"], "description"=>"<p>Values are averages±SEM.</p>#<p>Statistics computed using the Wilcoxon matched pairs test.</p><p>*Phase angle  =  Sleep onset time - DLMO time.</p><p>All times are given in hh:mm.</p><p>In coherence with a significantly later circadian phase, lights off time, bed time were significantly delayed under SW light weeks in comparison to BE light weeks. On the other hand wake up time was not significantly different between lighting conditions, this leading to a significant decrease in sleep duration under SW light weeks. Sleep efficiency was not different between lighting conditions. Phase angle between DLMO and lights off was not different between lighting conditions.</p>", "links"=>[], "tags"=>["Chronobiology", "physiology", "Physiological processes", "sleep", "Astronomical sciences", "Space exploration", "Spaceflight", "physics", "Electromagnetic radiation", "light", "Visible light"], "article_id"=>1121364, "categories"=>["Biological Sciences"], "users"=>["Raymond P. Najjar", "Luzian Wolf", "Jacques Taillard", "Luc J. M. Schlangen", "Alex Salam", "Christian Cajochen", "Claude Gronfier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0102827.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_sleep_and_phase_shift_results_/1121364", "title"=>"Summary of sleep and phase shift results.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-07-29 03:14:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1613767"], "description"=>"<p>Results were normalized to baseline SW1. <b>A</b>. Circadian phase was assessed using salivary DLMO. A delay in circadian phase of −0.64±0.21 h and −0.45±0.34 h was observed during weeks W5 and W9 respectively under SW light (p<0.05). The circadian phase delay observed on week W5 appears to be corrected during BE light on week BE7, and is observed again on week SW9 under SW light. <b>B</b>. Well being was increased by BE light (+9.7±12.8% and +14.5±14.9% on BE3 and BE7 respectively) compared to SW light (−2.9±12.8% and +3.2±11.2% during SW5 and SW9 respectively) (p<0.05). <b>C</b>. Subjective alertness was marginally increased on weeks BE3 and BE7 under BE light (p = 0.08) compared to SW light weeks SW5 and SW9.</p>", "links"=>[], "tags"=>["Chronobiology", "physiology", "Physiological processes", "sleep", "Astronomical sciences", "Space exploration", "Spaceflight", "physics", "Electromagnetic radiation", "light", "Visible light", "neurobehavioral", "sw"], "article_id"=>1121360, "categories"=>["Biological Sciences"], "users"=>["Raymond P. Najjar", "Luzian Wolf", "Jacques Taillard", "Luc J. M. Schlangen", "Alex Salam", "Christian Cajochen", "Claude Gronfier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0102827.g004", "stats"=>{"downloads"=>2, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Circadian_and_neurobehavioral_changes_under_SW_and_BE_light_condition_over_9_weeks_/1121360", "title"=>"Circadian and neurobehavioral changes under SW and BE light condition over 9 weeks.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-29 03:14:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1613877", "https://ndownloader.figshare.com/files/1613878", "https://ndownloader.figshare.com/files/1613880", "https://ndownloader.figshare.com/files/1613881", "https://ndownloader.figshare.com/files/1613882", "https://ndownloader.figshare.com/files/1613883", "https://ndownloader.figshare.com/files/1613884", "https://ndownloader.figshare.com/files/1613885", "https://ndownloader.figshare.com/files/1613887", "https://ndownloader.figshare.com/files/1613888", "https://ndownloader.figshare.com/files/1613889"], "description"=>"<div><p>Studies in Polar Base stations, where personnel have no access to sunlight during winter, have reported circadian misalignment, free-running of the sleep-wake rhythm, and sleep problems. Here we tested light as a countermeasure to circadian misalignment in personnel of the Concordia Polar Base station during the polar winter. We hypothesized that entrainment of the circadian pacemaker to a 24-h light-dark schedule would not occur in all crew members (n = 10) exposed to 100–300 lux of standard fluorescent white (SW) light during the daytime, and that chronic non-time restricted daytime exposure to melanopsin-optimized blue-enriched white (BE) light would establish an a stable circadian phase, in participants, together with increased cognitive performance and mood levels. The lighting schedule consisted of an alternation between SW lighting (2 weeks), followed by a BE lighting (2 weeks) for a total of 9 weeks. Rest-activity cycles assessed by actigraphy showed a stable rest-activity pattern under both SW and BE light. No difference was found between light conditions on the intra-daily stability, variability and amplitude of activity, as assessed by non-parametric circadian analysis. As hypothesized, a significant delay of about 30 minutes in the onset of melatonin secretion occurred with SW, but not with BE light. BE light significantly enhanced well being and alertness compared to SW light. We propose that the superior efficacy of blue-enriched white light versus standard white light involves melanopsin-based mechanisms in the activation of the non-visual functions studied, and that their responses do not dampen with time (over 9-weeks). This work could lead to practical applications of light exposure in working environment where background light intensity is chronically low to moderate (polar base stations, power plants, space missions, etc.), and may help design lighting strategies to maintain health, productivity, and personnel safety.</p></div>", "links"=>[], "tags"=>["Chronobiology", "physiology", "Physiological processes", "sleep", "Astronomical sciences", "Space exploration", "Spaceflight", "physics", "Electromagnetic radiation", "light", "Visible light", "blue-enriched", "countermeasure", "delayed", "circadian", "neurobehavioral"], "article_id"=>1121437, "categories"=>["Biological Sciences"], "users"=>["Raymond P. Najjar", "Luzian Wolf", "Jacques Taillard", "Luc J. M. Schlangen", "Alex Salam", "Christian Cajochen", "Claude Gronfier"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0102827.s001", "https://dx.doi.org/10.1371/journal.pone.0102827.s002", "https://dx.doi.org/10.1371/journal.pone.0102827.s003", "https://dx.doi.org/10.1371/journal.pone.0102827.s004", "https://dx.doi.org/10.1371/journal.pone.0102827.s005", "https://dx.doi.org/10.1371/journal.pone.0102827.s006", "https://dx.doi.org/10.1371/journal.pone.0102827.s007", "https://dx.doi.org/10.1371/journal.pone.0102827.s008", "https://dx.doi.org/10.1371/journal.pone.0102827.s009", "https://dx.doi.org/10.1371/journal.pone.0102827.s010", "https://dx.doi.org/10.1371/journal.pone.0102827.s011"], "stats"=>{"downloads"=>26, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Chronic_Artificial_Blue_Enriched_White_Light_Is_an_Effective_Countermeasure_to_Delayed_Circadian_Phase_and_Neurobehavioral_Decrements_/1121437", "title"=>"Chronic Artificial Blue-Enriched White Light Is an Effective Countermeasure to Delayed Circadian Phase and Neurobehavioral Decrements", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-07-29 03:14:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1613770"], "description"=>"<p>+: monitoring.</p><p>-: not monitoring.</p><p>After one baseline week (SW1), lighting conditions were modified every 2 weeks for 9 weeks. Participant's sleep-wake rhythm and personal light environment were continuously monitored throughout the study via actigraphy and light sensors, respectively. Eight saliva samples were collected on one day every week (6 samples before bedtime and 2 samples after wake time) and a neurobehavioral test battery was performed at the end of each lighting block.</p>", "links"=>[], "tags"=>["Chronobiology", "physiology", "Physiological processes", "sleep", "Astronomical sciences", "Space exploration", "Spaceflight", "physics", "Electromagnetic radiation", "light", "Visible light"], "article_id"=>1121363, "categories"=>["Biological Sciences"], "users"=>["Raymond P. Najjar", "Luzian Wolf", "Jacques Taillard", "Luc J. M. Schlangen", "Alex Salam", "Christian Cajochen", "Claude Gronfier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0102827.t001", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Protocol_of_the_study_/1121363", "title"=>"Protocol of the study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-07-29 03:14:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1613769"], "description"=>"<p>Results were normalized to week SW1. Circadian phase advances (positive phase shifts) and delays (negative phase shifts) and increases and decreases in well being and alertness were averaged over the weeks of the same light condition (SW versus BE). <b>A</b>. On average DLMOs were significantly delayed during SW light weeks compared to BE light weeks (p<0.05). Average subjective well being (<b>B</b>) and alertness (<b>C</b>) were significantly increased under BE light weeks compared to SW light weeks (p<0.05).</p>", "links"=>[], "tags"=>["Chronobiology", "physiology", "Physiological processes", "sleep", "Astronomical sciences", "Space exploration", "Spaceflight", "physics", "Electromagnetic radiation", "light", "Visible light", "sw", "subjective"], "article_id"=>1121362, "categories"=>["Biological Sciences"], "users"=>["Raymond P. Najjar", "Luzian Wolf", "Jacques Taillard", "Luc J. M. Schlangen", "Alex Salam", "Christian Cajochen", "Claude Gronfier"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0102827.g005", "stats"=>{"downloads"=>3, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Impact_of_BE_versus_SW_light_on_each_participant_s_phase_shift_subjective_well_being_and_alertness_/1121362", "title"=>"Impact of BE versus SW light on each participant's phase shift, subjective well being and alertness.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-07-29 03:14:38"}

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  • {"unique-ip"=>"34", "full-text"=>"63", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"18", "full-text"=>"23", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"24", "full-text"=>"26", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"23", "full-text"=>"19", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"28", "full-text"=>"33", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"30", "full-text"=>"51", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Biology and life sciences/Chronobiology", "average_usage"=>[389, 584]}]}
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