Market Assessment of Tuberculosis Diagnostics in Brazil in 2012
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{"title"=>"Market assessment of tuberculosis diagnostics in Brazil in 2012", "type"=>"journal", "authors"=>[{"first_name"=>"Anete", "last_name"=>"Trajman", "scopus_author_id"=>"6603637651"}, {"first_name"=>"Marcia", "last_name"=>"Pinto", "scopus_author_id"=>"36188572600"}, {"first_name"=>"Ruy", "last_name"=>"De Souza", "scopus_author_id"=>"56309892800"}, {"first_name"=>"Marianna", "last_name"=>"Freitas", "scopus_author_id"=>"56310641200"}, {"first_name"=>"Ana", "last_name"=>"Torrens", "scopus_author_id"=>"16067410100"}, {"first_name"=>"Josué", "last_name"=>"Lima", "scopus_author_id"=>"56050241200"}, {"first_name"=>"Dráurio", "last_name"=>"Barreira", "scopus_author_id"=>"6506475666"}, {"first_name"=>"Mark D.", "last_name"=>"Perkins", "scopus_author_id"=>"56265334700"}, {"first_name"=>"Catharina C.", "last_name"=>"Boehme", "scopus_author_id"=>"7005563544"}, {"first_name"=>"Janet", "last_name"=>"Ginnard", "scopus_author_id"=>"56310815000"}, {"first_name"=>"Carole", "last_name"=>"Jefferson", "scopus_author_id"=>"56311252700"}, {"first_name"=>"Andrea", "last_name"=>"Pantoja", "scopus_author_id"=>"16304674100"}, {"first_name"=>"Sandra V.", "last_name"=>"Kik", "scopus_author_id"=>"24449263400"}, {"first_name"=>"Pamela", "last_name"=>"Chedore", "scopus_author_id"=>"6602346215"}, {"first_name"=>"Claudia M.", "last_name"=>"Denkinger", "scopus_author_id"=>"23977479300"}, {"first_name"=>"Madhukar", "last_name"=>"Pai", "scopus_author_id"=>"14054425400"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"373700866", "sgr"=>"84905457108", "pmid"=>"25099237", "scopus"=>"2-s2.0-84905457108", "isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0104105", "issn"=>"19326203"}, "id"=>"b52a8b7b-99b9-39b7-8b69-ed8600f7f8c2", "abstract"=>"BACKGROUND Improved diagnostics for the diagnosis of tuberculosis (TB) are urgently needed. However, test developers and investors require market size data to support new product development. This study assessed the served available market for TB diagnostics in Brazil in 2012 and the market segmentation in the public and private sectors. METHODS Data were collected on test volumes done in the public and private sectors for the diagnosis of latent and active TB, drug susceptibility testing and treatment follow-up. Tests included were tuberculin skin tests, interferon-gamma releases assays, smear microscopy, solid and liquid cultures, nucleic acid amplification tests and phenotypic drug susceptibility tests. The data were collected by means of an electronic survey via the Brazilian State laboratories and from sales information provided by manufacturers. Test costs for the public sector were calculated using a components approach, while costs for the private sector were based on prices paid by patients. The overall market value (expenditure) for the entire country was calculated using the public sector test costs. RESULTS During 2012, an estimated total of 2.4 million TB diagnostic tests were done in Brazil, resulting in an estimated overall market value of USD 17.2 million. The public sector accounted for 91% of the test volumes and 88% of the market value. Smear microscopy was the most commonly test (n = 1.3 million; 55% of total) at an estimated value of USD 3.7 million. Culture overall (n = 302,761) represented 13% of test volumes and 40% (USD 6.9 million) of the market value. On average, USD 208 was spent on TB diagnostics for every notified TB patient in Brazil, in 2012. CONCLUSION The TB diagnostics market value in Brazil in 2012 was over USD 17 million. These study results will help test developers to understand the current and potential market for replacement or add-on diagnostic technologies.", "link"=>"http://www.mendeley.com/research/market-assessment-tuberculosis-diagnostics-brazil-2012", "reader_count"=>31, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>9, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>4, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>9, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>4, "Student > Bachelor"=>1, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>12, "Agricultural and Biological Sciences"=>11}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Brazil"=>1, "India"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["http://files.figshare.com/1623572/Table_2.xls"], "pos_in_sequence"=>0, "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "users"=>[], "links"=>[], "tags"=>["epidemiology", "Economic epidemiology", "tuberculosis", "diagnostic", "Clinical research design", "research design", "Infectious diseases", "costs", "tb", "Diagnostic medicine", "Cross-sectional studies", "breakdown", "Bacterial diseases"], "title"=>"<p>Calculated costs for TB diagnostic tests for the public sector, breakdown by components.</p>", "figshare_url"=>"http://figshare.com/articles/_Calculated_costs_for_TB_diagnostic_tests_for_the_public_sector_breakdown_by_components_/1129344", "defined_type"=>3, "doi"=>["http://dx.doi.org/10.1371/journal.pone.0104105.t002"], "published_date"=>"2014-08-06 03:11:06", "article_id"=>1129344, "categories"=>["Biological Sciences"], "description"=>"<p >TST&#8202;=&#8202;tuberculin skin test; ZN&#8202;=&#8202;Ziehl-Neelsen; PCR&#8202;=&#8202;polymerase chain reaction; DST&#8202;=&#8202;drug susceptibility test; SIRE&#8202;=&#8202;Streptomycin, Isoniazid, Rifampin, Ethambutol; SIREP&#8202;=&#8202;Streptomycin, Isoniazid, Rifampin, Ethambuthol, Pyrazinamid; USD&#8202;=&#8202;United States Dollars.</p><span class=\"pl_xls_label\">#</span><p >Costing is based on Xpert implementation study.</p><span class=\"pl_xls_label\">‡</span><p >Costing done by one of the laboratories (no breakdown known).</p>"}
  • {"files"=>["http://files.figshare.com/1623573/Table_4.xls"], "pos_in_sequence"=>0, "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "users"=>[], "links"=>[], "tags"=>["epidemiology", "Bacterial diseases", "sectors", "Economic epidemiology", "research design", "diagnostic", "Clinical research design", "tuberculosis", "Infectious diseases", "tb", "Diagnostic medicine", "Cross-sectional studies", "brazil"], "title"=>"<p>Total value of the overall TB diagnostic market, public and private sectors combined, using public sector costs, in Brazil in 2012, in USD.</p>", "figshare_url"=>"http://figshare.com/articles/_Total_value_of_the_overall_TB_diagnostic_market_public_and_private_sectors_combined_using_public_sector_costs_in_Brazil_in_2012_in_USD_/1129345", "defined_type"=>3, "doi"=>["http://dx.doi.org/10.1371/journal.pone.0104105.t004"], "published_date"=>"2014-08-06 03:11:06", "article_id"=>1129345, "categories"=>["Biological Sciences"], "description"=>"<p >TST&#8202;=&#8202;tuberculin skin test; IGRA&#8202;=&#8202;Interferon gamma release assay; ZN&#8202;=&#8202;Ziehl-Neelsen; LPA&#8202;=&#8202;line probe assay; PCR&#8202;=&#8202;polymerase chain reaction; DST&#8202;=&#8202;drug susceptibility test; SIRE&#8202;=&#8202;Streptomycin, Isoniazid, Rifampin, Ethambutol; SIREP&#8202;=&#8202;Streptomycin, Isoniazid, Rifampin, Ethambuthol, Pyrazinamid; USD&#8202;=&#8202;United States Dollars.</p><span class=\"pl_xls_label\">1</span><p >Range in sputum smear microcopy volume and corresponding market value show the uncertainty range around the true number of smears done in the country. The lower estimate is the total number of smears reported as reported by the States in the survey. The upper estimate is the total number of smears reported in the Brazilian Ministry of Health database (DATASUS).</p>"}
  • {"files"=>["http://files.figshare.com/1623574/File_S1.docx"], "pos_in_sequence"=>0, "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "users"=>[], "links"=>[], "tags"=>["epidemiology", "Bacterial diseases", "Diagnostic medicine", "Economic epidemiology", "research design", "Clinical research design", "tuberculosis", "Infectious diseases", "diagnostics", "Cross-sectional studies", "brazil"], "title"=>"<p>Market Assessment of Tuberculosis Diagnostics in Brazil in 2012</p>", "figshare_url"=>"http://figshare.com/articles/_Market_Assessment_of_Tuberculosis_Diagnostics_in_Brazil_in_2012_/1129346", "defined_type"=>3, "doi"=>["http://dx.doi.org/10.1371/journal.pone.0104105.s001"], "published_date"=>"2014-08-06 03:11:06", "article_id"=>1129346, "categories"=>["Biological Sciences"], "description"=>"<div><section><p>Background</p><p>Improved diagnostics for the diagnosis of tuberculosis (TB) are urgently needed. However, test developers and investors require market size data to support new product development. This study assessed the served available market for TB diagnostics in Brazil in 2012 and the market segmentation in the public and private sectors.</p></section><section><p>Methods</p><p>Data were collected on test volumes done in the public and private sectors for the diagnosis of latent and active TB, drug susceptibility testing and treatment follow-up. Tests included were tuberculin skin tests, interferon-gamma releases assays, smear microscopy, solid and liquid cultures, nucleic acid amplification tests and phenotypic drug susceptibility tests. The data were collected by means of an electronic survey via the Brazilian State laboratories and from sales information provided by manufacturers. Test costs for the public sector were calculated using a components approach, while costs for the private sector were based on prices paid by patients. The overall market value (expenditure) for the entire country was calculated using the public sector test costs.</p></section><section><p>Results</p><p>During 2012, an estimated total of 2.4 million TB diagnostic tests were done in Brazil, resulting in an estimated overall market value of USD 17.2 million. The public sector accounted for 91% of the test volumes and 88% of the market value. Smear microscopy was the most commonly test (n&#8202;=&#8202;1.3 million; 55% of total) at an estimated value of USD 3.7 million. Culture overall (n&#8202;=&#8202;302,761) represented 13% of test volumes and 40% (USD 6.9 million) of the market value. On average, USD 208 was spent on TB diagnostics for every notified TB patient in Brazil, in 2012.</p></section><section><p>Conclusion</p><p>The TB diagnostics market value in Brazil in 2012 was over USD 17 million. These study results will help test developers to understand the current and potential market for replacement or add-on diagnostic technologies.</p></section></div>"}
  • {"files"=>["http://files.figshare.com/1623569/Figure_1.tif"], "pos_in_sequence"=>0, "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "users"=>[], "links"=>[], "tags"=>["epidemiology", "Economic epidemiology", "tuberculosis", "segmented", "Clinical research design", "research design", "Infectious diseases", "Diagnostic medicine", "Cross-sectional studies", "Bacterial diseases"], "title"=>"<p>Served available market (volumes and costs), segmented by testing category and health sector.</p>", "figshare_url"=>"http://figshare.com/articles/_Served_available_market_volumes_and_costs_segmented_by_testing_category_and_health_sector_/1129341", "defined_type"=>1, "doi"=>["http://dx.doi.org/10.1371/journal.pone.0104105.g001"], "published_date"=>"2014-08-06 03:11:06", "article_id"=>1129341, "categories"=>["Biological Sciences"], "description"=>"<p >Individual tests were categorized into tests that detect LTBI (tuberculin skin test), those that detect active TB (sputum smear microscopy, liquid and solid culture and polymerase chain reaction tests), those that detect active TB as well as drug resistance (Xpert MTB/RIF), those that solely detect drug resistance once the presence of active TB is already demonstrated (phenotypic liquid and solid media DST). Test volumes and market values are given respectively for the public sector (panels A and D), the private sector (panels B and E) and the public and private sectors combined (panels C and F). Percentages were rounded to the nearest integer. LTBI&#8202;=&#8202;latent tuberculosis infection: TB&#8202;=&#8202;tuberculosis; DST&#8202;=&#8202;drug susceptibility tests.</p>"}
  • {"files"=>["http://files.figshare.com/1623570/Table_1.xls"], "pos_in_sequence"=>0, "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "users"=>[], "links"=>[], "tags"=>["epidemiology", "Economic epidemiology", "tuberculosis", "diagnostic", "Clinical research design", "research design", "Infectious diseases", "tb", "Diagnostic medicine", "Cross-sectional studies", "costs", "Bacterial diseases"], "title"=>"<p>Total costs of TB diagnostic tests and market value in the public sector in Brazil, 2012, in USD.</p>", "figshare_url"=>"http://figshare.com/articles/_Total_costs_of_TB_diagnostic_tests_and_market_value_in_the_public_sector_in_Brazil_2012_in_USD_/1129342", "defined_type"=>3, "doi"=>["http://dx.doi.org/10.1371/journal.pone.0104105.t001"], "published_date"=>"2014-08-06 03:11:06", "article_id"=>1129342, "categories"=>["Biological Sciences"], "description"=>"<p >TST&#8202;=&#8202;tuberculin skin test; IGRA&#8202;=&#8202;Interferon gamma release assay; ZN&#8202;=&#8202;Ziehl-Neelsen; LPA&#8202;=&#8202;line probe assay; PCR&#8202;=&#8202;polymerase chain reaction; DST&#8202;=&#8202;drug susceptibility test; SIRE&#8202;=&#8202;Streptomycin, Isoniazid, Rifampin, Ethambutol; SIREP&#8202;=&#8202;Streptomycin, Isoniazid, Rifampin, Ethambutol, Pyrazinamide; USD&#8202;=&#8202;United States Dollars.</p>"}
  • {"files"=>["http://files.figshare.com/1623571/Table_3.xls"], "pos_in_sequence"=>0, "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "users"=>[], "links"=>[], "tags"=>["epidemiology", "Bacterial diseases", "Economic epidemiology", "research design", "diagnostic", "Clinical research design", "prices", "tuberculosis", "Infectious diseases", "tb", "Diagnostic medicine", "Cross-sectional studies", "brazil"], "title"=>"<p>Total prices for TB diagnostic tests in the private sector and market value in Brazil in 2012, in USD.</p>", "figshare_url"=>"http://figshare.com/articles/_Total_prices_for_TB_diagnostic_tests_in_the_private_sector_and_market_value_in_Brazil_in_2012_in_USD_/1129343", "defined_type"=>3, "doi"=>["http://dx.doi.org/10.1371/journal.pone.0104105.t003"], "published_date"=>"2014-08-06 03:11:06", "article_id"=>1129343, "categories"=>["Biological Sciences"], "description"=>"<p >TST&#8202;=&#8202;tuberculin skin test; IGRA&#8202;=&#8202;Interferon gamma release assay; ZN&#8202;=&#8202;Ziehl-Neelsen; LPA&#8202;=&#8202;line probe assay; PCR&#8202;=&#8202;polymerase chain reaction; DST&#8202;=&#8202;drug susceptibility test; SIRE&#8202;=&#8202;Streptomycin, Isoniazid, Rifampin, Ethambutol; SIREP&#8202;=&#8202;Streptomycin, Isoniazid, Rifampin, Ethambuthol, Pyrazinamid; USD&#8202;=&#8202;United States Dollars.</p><p >Note: Private sector market value estimate using the price charged to the patient per test, as the test cost.</p><span class=\"pl_xls_label\">#</span><p >No distinction could be made between prices charged for liquid or solid culture by private laboratories; therefore all the same value was used for liquid and solid culture.</p>"}

PMC Usage Stats | Further Information

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Relative Metric

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