Perinatal Lead (Pb) Exposure Results in Sex-Specific Effects on Food Intake, Fat, Weight, and Insulin Response across the Murine Life-Course
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{"title"=>"Perinatal lead (Pb) exposure results in sex-specific effects on food intake, fat, weight, and insulin response across the murine life-course", "type"=>"journal", "authors"=>[{"first_name"=>"Christopher", "last_name"=>"Faulk", "scopus_author_id"=>"13613910000"}, {"first_name"=>"Amanda", "last_name"=>"Barks", "scopus_author_id"=>"26767541500"}, {"first_name"=>"Brisa N.", "last_name"=>"Sánchez", "scopus_author_id"=>"10039288900"}, {"first_name"=>"Zhenzhen", "last_name"=>"Zhang", "scopus_author_id"=>"55721816100"}, {"first_name"=>"Olivia S.", "last_name"=>"Anderson", "scopus_author_id"=>"52163304500"}, {"first_name"=>"Karen E.", "last_name"=>"Peterson", "scopus_author_id"=>"7201802959"}, {"first_name"=>"Dana C.", "last_name"=>"Dolinoy", "scopus_author_id"=>"6507741630"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"373717010", "sgr"=>"84905659626", "issn"=>"19326203", "pmid"=>"25105421", "scopus"=>"2-s2.0-84905659626", "doi"=>"10.1371/journal.pone.0104273"}, "id"=>"5670d775-b0b5-37e7-bc59-c7d44da82a70", "abstract"=>"Developmental lead (Pb) exposure has been associated with lower body weight in human infants and late onset obesity in mice. We determined the association of perinatal Pb exposure in mice with changes in obesity-related phenotypes into adulthood. Mice underwent exposure via maternal drinking water supplemented with 0 (control), 2.1 (low), 16 (medium), or 32 (high) ppm Pb-acetate two weeks prior to mating through lactation. Offspring were phenotyped at ages 3, 6, and 9 months for energy expenditure, spontaneous activity, food intake, body weight, body composition, and at age 10 months for glucose tolerance. Data analyses were stratified by sex and adjusted for litter effects. Exposed females and males exhibited increased energy expenditure as compared to controls (p<0.0001 for both). In females, horizontal activity differed significantly from controls (p = 0.02) over the life-course. Overall, food intake increased in exposed females and males (p<0.0008 and p<0.0001, respectively) with significant linear trends at 9 months in females (p = 0.01) and 6 months in males (p<0.01). Body weight was significantly increased in males at the medium and high exposures (p = 0.001 and p = 0.006). Total body fat differed among exposed females and males (p<0.0001 and p<0.0001, respectively). Insulin response was significantly increased in medium exposure males (p<0.05). Perinatal Pb exposure at blood lead levels between 4.1 µg/dL and 32 µg/dL is associated with increased food intake, body weight, total body fat, energy expenditure, activity, and insulin response in mice. Physiological effects of developmental Pb exposure persist and vary according to sex and age.", "link"=>"http://www.mendeley.com/research/perinatal-lead-pb-exposure-results-sexspecific-effects-food-intake-fat-weight-insulin-response-acros", "reader_count"=>18, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>4, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>4, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>4, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>4, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>8, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Psychology"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1628259"], "description"=>"<p>Male offspring across all exposure groups (grams) were weighed. Both medium and high exposure groups are significantly increased in weight across the life course as compared to control mice (in green). Arrows indicate weeks when mice were transferred for physiological parameter testing resulting in stress-induced weight loss. Bars represent 95% confidence intervals. P-values were obtained by adjusting for litter, and the autoregressive structure within mice, and adjusting for week using indicator variables for week of measurement.</p>", "links"=>[], "tags"=>["developmental biology", "Organism development", "physiology", "Endocrine physiology", "Insulin tolerance", "Physiological parameters", "Body weight", "obesity", "weight gain", "toxicology", "Toxic agents", "toxins", "Heavy metals", "Model organisms", "Animal models", "Mouse models"], "article_id"=>1132845, "categories"=>["Biological Sciences"], "users"=>["Christopher Faulk", "Amanda Barks", "Brisa N. Sánchez", "Zhenzhen Zhang", "Olivia S. Anderson", "Karen E. Peterson", "Dana C. Dolinoy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104273.g003", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Weekly_Body_Weight_Measurements_/1132845", "title"=>"Weekly Body Weight Measurements.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-08 02:52:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1628258"], "description"=>"<p>Energy expenditure (mL/kg/hr) measured over a 72-hr period by indirect calorimetry. (A) Oxygen consumption and carbon dioxide (CO<sub>2</sub>) production decline with age, across both sexes and all exposure groups. P-values represent differences from control. (B) Food intake across the life-course, stratified by sex. Stars indicate p-values<0.05 as compared to control. Linear trend p-values represent exposure-dependent trend significance.</p>", "links"=>[], "tags"=>["developmental biology", "Organism development", "physiology", "Endocrine physiology", "Insulin tolerance", "Physiological parameters", "Body weight", "obesity", "weight gain", "toxicology", "Toxic agents", "toxins", "Heavy metals", "Model organisms", "Animal models", "Mouse models", "expenditure"], "article_id"=>1132844, "categories"=>["Biological Sciences"], "users"=>["Christopher Faulk", "Amanda Barks", "Brisa N. Sánchez", "Zhenzhen Zhang", "Olivia S. Anderson", "Karen E. Peterson", "Dana C. Dolinoy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104273.g002", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Energy_Expenditure_and_Food_Intake_/1132844", "title"=>"Energy Expenditure and Food Intake.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-08 02:52:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1628263", "https://ndownloader.figshare.com/files/1628264", "https://ndownloader.figshare.com/files/1628265", "https://ndownloader.figshare.com/files/1628266"], "description"=>"<div><p>Developmental lead (Pb) exposure has been associated with lower body weight in human infants and late onset obesity in mice. We determined the association of perinatal Pb exposure in mice with changes in obesity-related phenotypes into adulthood. Mice underwent exposure via maternal drinking water supplemented with 0 (control), 2.1 (low), 16 (medium), or 32 (high) ppm Pb-acetate two weeks prior to mating through lactation. Offspring were phenotyped at ages 3, 6, and 9 months for energy expenditure, spontaneous activity, food intake, body weight, body composition, and at age 10 months for glucose tolerance. Data analyses were stratified by sex and adjusted for litter effects. Exposed females and males exhibited increased energy expenditure as compared to controls (p<0.0001 for both). In females, horizontal activity differed significantly from controls (p = 0.02) over the life-course. Overall, food intake increased in exposed females and males (p<0.0008 and p<0.0001, respectively) with significant linear trends at 9 months in females (p = 0.01) and 6 months in males (p<0.01). Body weight was significantly increased in males at the medium and high exposures (p = 0.001 and p = 0.006). Total body fat differed among exposed females and males (p<0.0001 and p<0.0001, respectively). Insulin response was significantly increased in medium exposure males (p<0.05). Perinatal Pb exposure at blood lead levels between 4.1 µg/dL and 32 µg/dL is associated with increased food intake, body weight, total body fat, energy expenditure, activity, and insulin response in mice. Physiological effects of developmental Pb exposure persist and vary according to sex and age.</p></div>", "links"=>[], "tags"=>["developmental biology", "Organism development", "physiology", "Endocrine physiology", "Insulin tolerance", "Physiological parameters", "Body weight", "obesity", "weight gain", "toxicology", "Toxic agents", "toxins", "Heavy metals", "Model organisms", "Animal models", "Mouse models", "sex-specific", "insulin", "murine"], "article_id"=>1132849, "categories"=>["Biological Sciences"], "users"=>["Christopher Faulk", "Amanda Barks", "Brisa N. Sánchez", "Zhenzhen Zhang", "Olivia S. Anderson", "Karen E. Peterson", "Dana C. Dolinoy"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0104273.s001", "https://dx.doi.org/10.1371/journal.pone.0104273.s002", "https://dx.doi.org/10.1371/journal.pone.0104273.s003", "https://dx.doi.org/10.1371/journal.pone.0104273.s004"], "stats"=>{"downloads"=>6, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Perinatal_Lead_Pb_Exposure_Results_in_Sex_Specific_Effects_on_Food_Intake_Fat_Weight_and_Insulin_Response_across_the_Murine_Life_Course_/1132849", "title"=>"Perinatal Lead (Pb) Exposure Results in Sex-Specific Effects on Food Intake, Fat, Weight, and Insulin Response across the Murine Life-Course", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-08-08 02:52:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1628261"], "description"=>"<p>(A) Glucose (mg/dl) measured by a fasting oral glucose tolerance AUC did not differ in either males or females. (B) Insulin (ng/ml) is increased in males at the medium exposure area under the curve (AUC) and (C) Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). Calculated from baseline blood insulin and glucose levels, indicates an index of insulin resistance. Males at the medium exposure level show a significant increase in HOMA-IR as over control. Single stars indicate p-values<0.05, when compared to controls. Bars represent standard error.</p>", "links"=>[], "tags"=>["developmental biology", "Organism development", "physiology", "Endocrine physiology", "Insulin tolerance", "Physiological parameters", "Body weight", "obesity", "weight gain", "toxicology", "Toxic agents", "toxins", "Heavy metals", "Model organisms", "Animal models", "Mouse models", "insulin", "glucose"], "article_id"=>1132847, "categories"=>["Biological Sciences"], "users"=>["Christopher Faulk", "Amanda Barks", "Brisa N. Sánchez", "Zhenzhen Zhang", "Olivia S. Anderson", "Karen E. Peterson", "Dana C. Dolinoy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104273.g005", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Blood_Insulin_and_Glucose_9_months_/1132847", "title"=>"Blood Insulin and Glucose (9 months).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-08 02:52:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1628262"], "description"=>"<p>Body Weights at 3, 6, and 9 Months.</p>", "links"=>[], "tags"=>["developmental biology", "Organism development", "physiology", "Endocrine physiology", "Insulin tolerance", "Physiological parameters", "Body weight", "obesity", "weight gain", "toxicology", "Toxic agents", "toxins", "Heavy metals", "Model organisms", "Animal models", "Mouse models", "weights"], "article_id"=>1132848, "categories"=>["Biological Sciences"], "users"=>["Christopher Faulk", "Amanda Barks", "Brisa N. Sánchez", "Zhenzhen Zhang", "Olivia S. Anderson", "Karen E. Peterson", "Dana C. Dolinoy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104273.t001", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Body_Weights_at_3_6_and_9_Months_/1132848", "title"=>"Body Weights at 3, 6, and 9 Months.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-08-08 02:52:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/1628260"], "description"=>"<p>Measured by nuclear magnetic imaging. Females show no linear trend with exposure level. Males show a significant trend of increasing body fat with dose at 3 months, and near significance at 6 months. Stars indicate p-values<0.05 as compared to control offspring.</p>", "links"=>[], "tags"=>["developmental biology", "Organism development", "physiology", "Endocrine physiology", "Insulin tolerance", "Physiological parameters", "Body weight", "obesity", "weight gain", "toxicology", "Toxic agents", "toxins", "Heavy metals", "Model organisms", "Animal models", "Mouse models"], "article_id"=>1132846, "categories"=>["Biological Sciences"], "users"=>["Christopher Faulk", "Amanda Barks", "Brisa N. Sánchez", "Zhenzhen Zhang", "Olivia S. Anderson", "Karen E. Peterson", "Dana C. Dolinoy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104273.g004", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Body_Fat_/1132846", "title"=>"Body Fat.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-08 02:52:39"}
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PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[285]}, {"subject_area"=>"/Medicine and health sciences/Diagnostic medicine", "average_usage"=>[257]}, {"subject_area"=>"/Medicine and health sciences/Endocrinology", "average_usage"=>[282, 453]}, {"subject_area"=>"/Medicine and health sciences/Pharmacology", "average_usage"=>[286]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[271]}]}
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