Alterations to the Frequency and Function of Peripheral Blood Monocytes and Associations with Chronic Disease in the Advanced-Age, Frail Elderly
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{"title"=>"Alterations to the frequency and function of peripheral blood monocytes and associations with chronic disease in the advanced-age, frail elderly", "type"=>"journal", "authors"=>[{"first_name"=>"Chris P.", "last_name"=>"Verschoor", "scopus_author_id"=>"24435901500"}, {"first_name"=>"Jennie", "last_name"=>"Johnstone", "scopus_author_id"=>"22934100500"}, {"first_name"=>"Jamie", "last_name"=>"Millar", "scopus_author_id"=>"7203077069"}, {"first_name"=>"Robin", "last_name"=>"Parsons", "scopus_author_id"=>"10540400600"}, {"first_name"=>"Alina", "last_name"=>"Lelic", "scopus_author_id"=>"24169077400"}, {"first_name"=>"Mark", "last_name"=>"Loeb", "scopus_author_id"=>"13310215300"}, {"first_name"=>"Jonathan L.", "last_name"=>"Bramson", "scopus_author_id"=>"7003883470"}, {"first_name"=>"Dawn M E", "last_name"=>"Bowdish", "scopus_author_id"=>"8852759100"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84905649973", "pmid"=>"25105870", "sgr"=>"84905649973", "doi"=>"10.1371/journal.pone.0104522", "issn"=>"19326203", "pui"=>"373717028"}, "id"=>"3c70c88f-5caf-389b-a8f1-49e750da3225", "abstract"=>"<sec> <title>Background</title> <p>Circulating myeloid cells are important mediators of the inflammatory response, acting as a major source of resident tissue antigen presenting cells and serum cytokines. They represent a number of distinct subpopulations whose functional capacity and relative concentrations are known to change with age. Little is known of these changes in the very old and physically frail, a rapidly increasing proportion of the North American population.</p> </sec><sec> <title>Design</title> <p>In the following study the frequency and receptor expression of blood monocytes and dendritic cells (DCs) were characterized in a sample of advanced-age, frail elderly (81–100 yrs), and compared against that of adults (19–59 yrs), and community-dwelling seniors (61–76 yrs). Cytokine responses following TLR stimulation were also investigated, as well as associations between immunophenotyping parameters and chronic diseases.</p> </sec><sec> <title>Results</title> <p>The advanced-age, frail elderly had significantly fewer CD14(++) and CD14(+)CD16(+), but not CD14(++)CD16(+) monocytes, fewer plasmacytoid and myeloid DCs, and a lower frequency of monocytes expressing the chemokine receptors CCR2 and CX<sub>3</sub>CR1. At baseline and following stimulation with TLR-2 and -4 agonists, monocytes from the advanced-age, frail elderly produced more TNF than adults, although the overall induction was significantly lower. Finally, monocyte subset frequency and CX<sub>3</sub>CR1 expression was positively associated with dementia, while negatively associated with anemia and diabetes in the advanced-age, frail elderly.</p> </sec><sec> <title>Conclusions</title> <p>These data demonstrate that blood monocyte frequency and phenotype are altered in the advanced-age, frail elderly and that these changes correlate with certain chronic diseases. Whether these changes contribute to or are caused by these conditions warrants further investigation.</p> </sec>", "link"=>"http://www.mendeley.com/research/alterations-frequency-function-peripheral-blood-monocytes-associations-chronic-disease-advancedage-f", "reader_count"=>25, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Student > Master"=>4, "Student > Bachelor"=>5, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Student > Master"=>4, "Student > Bachelor"=>5, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>9, "Neuroscience"=>2, "Sports and Recreations"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Neuroscience"=>{"Neuroscience"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"Netherlands"=>1, "United States"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1628726"], "description"=>"<p>PBMCs were stimulated with mock (PBS), and TLR-2 (Pam3CSK4, Pam) and TLR-4 (LPS) agonists, and the production of A) IL-1β, B) IL-6, C) IL-8 and D) TNF in classical (CLS), intermediate (INT) and non-classical (NON) monocytes was measured by flow cytometry. Relative to mock, the induction of E) TNF was significantly lower in the advanced-age, frail elderly. n = 5–8 per group, per treatment. Comparison-wise p-value, ***p<0.001, **p<0.01, *p<0.05.</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Immune system proteins", "Immune receptors", "Toll-like receptors", "cell biology", "Cellular types", "Animal cells", "Blood cells", "White blood cells", "monocytes", "Immune cells", "immunology", "epidemiology", "Clinical epidemiology", "geriatrics", "Spectrum analysis techniques", "spectrophotometry", "Cytophotometry", "flow cytometry", "elevated", "frail", "compared"], "article_id"=>1133248, "categories"=>["Biological Sciences"], "users"=>["Chris P. Verschoor", "Jennie Johnstone", "Jamie Millar", "Robin Parsons", "Alina Lelic", "Mark Loeb", "Jonathan L. Bramson", "Dawn M. E. Bowdish"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104522.g002", "stats"=>{"downloads"=>3, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cytokine_production_but_not_induction_is_elevated_in_monocytes_from_the_advanced_age_frail_elderly_as_compared_to_young_adults_/1133248", "title"=>"Cytokine production, but not induction, is elevated in monocytes from the advanced-age, frail elderly as compared to young adults.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-08 03:19:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1628729"], "description"=>"<p>Comparison-wise p-value, **p<0.01, *p<0.05.</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Immune system proteins", "Immune receptors", "Toll-like receptors", "cell biology", "Cellular types", "Animal cells", "Blood cells", "White blood cells", "monocytes", "Immune cells", "immunology", "epidemiology", "Clinical epidemiology", "geriatrics", "Spectrum analysis techniques", "spectrophotometry", "Cytophotometry", "flow cytometry", "differences", "intermediate", "non-classical", "monocyte", "subsets", "cases", "controls", "mellitus"], "article_id"=>1133251, "categories"=>["Biological Sciences"], "users"=>["Chris P. Verschoor", "Jennie Johnstone", "Jamie Millar", "Robin Parsons", "Alina Lelic", "Mark Loeb", "Jonathan L. Bramson", "Dawn M. E. Bowdish"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104522.g003", "stats"=>{"downloads"=>5, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representation_of_the_differences_in_A_the_expression_of_CX_3_CR1_on_the_classical_CLS_intermediate_INT_and_non_classical_NON_monocyte_subsets_and_B_the_classical_to_intermediate_monocyte_ratio_between_cases_grey_and_controls_white_for_dementia_diabetes_/1133251", "title"=>"Representation of the differences in A) the expression of CX<sub>3</sub>CR1 on the classical (CLS), intermediate (INT) and non-classical (NON) monocyte subsets and B) the classical to intermediate monocyte ratio, between cases (grey) and controls (white) for dementia, diabetes mellitus and anemia.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-08 03:19:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1628730"], "description"=>"<p>Mean and standard error presented. Only values with comparison-wise (Wilcoxon rank-sum test) significance at p<0.25 shown; Bolded values indicated experimental-wise (Benjamin-Hochberg FDR) significance at p<0.05. Cells/µL, cells per microliter of blood (absolute count); Rel. PBMCs, relative to PBMCs.</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Immune system proteins", "Immune receptors", "Toll-like receptors", "cell biology", "Cellular types", "Animal cells", "Blood cells", "White blood cells", "monocytes", "Immune cells", "immunology", "epidemiology", "Clinical epidemiology", "geriatrics", "Spectrum analysis techniques", "spectrophotometry", "Cytophotometry", "flow cytometry", "peripheral", "mononuclear", "cells", "community-dwelling", "frail"], "article_id"=>1133252, "categories"=>["Biological Sciences"], "users"=>["Chris P. Verschoor", "Jennie Johnstone", "Jamie Millar", "Robin Parsons", "Alina Lelic", "Mark Loeb", "Jonathan L. Bramson", "Dawn M. E. Bowdish"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104522.t002", "stats"=>{"downloads"=>11, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunophenotyping_of_peripheral_blood_mononuclear_cells_PBMCs_from_young_adults_community_dwelling_seniors_and_advanced_age_frail_elderly_/1133252", "title"=>"Immunophenotyping of peripheral blood mononuclear cells (PBMCs) from young adults, community-dwelling seniors, and advanced-age, frail elderly.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-08-08 03:19:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1628731"], "description"=>"<p>Odds ratios and 95% confidence intervals presented. Only comparison-wise (logistic regression) significance at p<0.25 shown;</p><p>*p<0.05,</p><p>**p<0.01. Bolded observations indicate experimental-wise (Benjamini-Hochberg FDR) significance at p<0.15. CD45%, percentage of cells relative to CD45+ PBMCs; MFI, mean fluorescent intensity.</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Immune system proteins", "Immune receptors", "Toll-like receptors", "cell biology", "Cellular types", "Animal cells", "Blood cells", "White blood cells", "monocytes", "Immune cells", "immunology", "epidemiology", "Clinical epidemiology", "geriatrics", "Spectrum analysis techniques", "spectrophotometry", "Cytophotometry", "flow cytometry", "monocyte", "dc", "markers", "frail"], "article_id"=>1133253, "categories"=>["Biological Sciences"], "users"=>["Chris P. Verschoor", "Jennie Johnstone", "Jamie Millar", "Robin Parsons", "Alina Lelic", "Mark Loeb", "Jonathan L. Bramson", "Dawn M. E. Bowdish"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104522.t003", "stats"=>{"downloads"=>4, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Associations_between_blood_monocyte_and_DC_markers_and_disease_in_the_advanced_age_frail_elderly_/1133253", "title"=>"Associations between blood monocyte and DC markers and disease in the advanced-age, frail elderly.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-08-08 03:19:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1628733"], "description"=>"<p>M:F, Male:Female.</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Immune system proteins", "Immune receptors", "Toll-like receptors", "cell biology", "Cellular types", "Animal cells", "Blood cells", "White blood cells", "monocytes", "Immune cells", "immunology", "epidemiology", "Clinical epidemiology", "geriatrics", "Spectrum analysis techniques", "spectrophotometry", "Cytophotometry", "flow cytometry", "frail", "regards"], "article_id"=>1133255, "categories"=>["Biological Sciences"], "users"=>["Chris P. Verschoor", "Jennie Johnstone", "Jamie Millar", "Robin Parsons", "Alina Lelic", "Mark Loeb", "Jonathan L. Bramson", "Dawn M. E. Bowdish"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104522.t001", "stats"=>{"downloads"=>2, "page_views"=>36, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_advanced_age_frail_elderly_with_regards_to_disease_/1133255", "title"=>"Distribution of advanced-age, frail elderly with regards to disease.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-08-08 03:19:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/1628723"], "description"=>"<p>Monocytes were defined as CD45 and HLA-DR expressing and lineage (CD2, CD3, CD15, CD19, CD56, NKp46) negative. Dendritic cell subsets were defined as CD45 and HLA-DR expressing, lineage (CD3, CD15, CD19, CD56) negative, and CD123 bright plasmacytoid dendritic cells (pDCs) or CD123 low, and CD1c or CD141 expressing myeloid dendritic cells (mDCs).</p>", "links"=>[], "tags"=>["Biochemistry", "proteins", "Immune system proteins", "Immune receptors", "Toll-like receptors", "cell biology", "Cellular types", "Animal cells", "Blood cells", "White blood cells", "monocytes", "Immune cells", "immunology", "epidemiology", "Clinical epidemiology", "geriatrics", "Spectrum analysis techniques", "spectrophotometry", "Cytophotometry", "flow cytometry", "gating", "monocyte", "dendritic"], "article_id"=>1133245, "categories"=>["Biological Sciences"], "users"=>["Chris P. Verschoor", "Jennie Johnstone", "Jamie Millar", "Robin Parsons", "Alina Lelic", "Mark Loeb", "Jonathan L. Bramson", "Dawn M. E. Bowdish"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104522.g001", "stats"=>{"downloads"=>42, "page_views"=>621, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_the_gating_strategy_to_define_blood_monocyte_upper_panel_and_dendritic_cell_lower_panel_subsets_/1133245", "title"=>"Summary of the gating strategy to define blood monocyte (upper panel) and dendritic cell (lower panel) subsets.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-08 03:19:27"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[291]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[286]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[285]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[293]}, {"subject_area"=>"/Medicine and health sciences/Hematology", "average_usage"=>[256]}, {"subject_area"=>"/People and places", "average_usage"=>[302]}, {"subject_area"=>"/People and places/Population groupings", "average_usage"=>[300]}]}
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