A Novel Glycated Hemoglobin A1c-Lowering Traditional Chinese Medicinal Formula, Identified by Translational Medicine Study
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"A novel glycated hemoglobin A1c-lowering traditional Chinese medicinal formula, identified by translational medicine study", "type"=>"journal", "authors"=>[{"first_name"=>"Hsin Yi", "last_name"=>"Lo", "scopus_author_id"=>"7202085486"}, {"first_name"=>"Chien Yun", "last_name"=>"Hsiang", "scopus_author_id"=>"26643342000"}, {"first_name"=>"Tsai Chung", "last_name"=>"Li", "scopus_author_id"=>"35196265000"}, {"first_name"=>"Chia Cheng", "last_name"=>"Li", "scopus_author_id"=>"16042782500"}, {"first_name"=>"Hui Chi", "last_name"=>"Huang", "scopus_author_id"=>"55669772500"}, {"first_name"=>"Jaw Chyun", "last_name"=>"Chen", "scopus_author_id"=>"57154865700"}, {"first_name"=>"Tin Yun", "last_name"=>"Ho", "scopus_author_id"=>"56059411900"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84929136433", "doi"=>"10.1371/journal.pone.0104650", "issn"=>"19326203", "pui"=>"373772730", "isbn"=>"1932-6203", "pmid"=>"25133699", "scopus"=>"2-s2.0-84929136433"}, "id"=>"642f21ed-7fa8-3323-aecc-8c416eecb537", "abstract"=>"Diabetes is a chronic metabolic disorder that has a significant impact on the health care system. The reduction of glycated hemoglobin A1c is highly associated with the improvements of glycemic control and diabetic complications. In this study, we identified a traditional Chinese medicinal formula with a HbA1c-lowering potential from clinical evidences. By surveying 9,973 diabetic patients enrolled in Taiwan Diabetic Care Management Program, we found that Chu-Yeh-Shih-Kao-Tang (CYSKT) significantly reduced HbA1c values in diabetic patients. CYSKT reduced the levels of HbA1c and fasting blood glucose, and stimulated the blood glucose clearance in type 2 diabetic mice. CYSKT affected the expressions of genes associated with insulin signaling pathway, increased the amount of phosphorylated insulin receptor in cells and tissues, and stimulated the translocation of glucose transporter 4. Moreover, CYSKT affected the expressions of genes related to diabetic complications, improved the levels of renal function indexes, and increased the survival rate of diabetic mice. In conclusion, this was a translational medicine study that applied a \"bedside-to-bench\" approach to identify a novel HbA1c-lowering formula. Our findings suggested that oral administration of CYSKT affected insulin signaling pathway, decreased HbA1c and blood glucose levels, and consequently reduced mortality rate in type 2 diabetic mice.", "link"=>"http://www.mendeley.com/research/novel-glycated-hemoglobin-a1clowering-traditional-chinese-medicinal-formula-identified-translational", "reader_count"=>5, "reader_count_by_academic_status"=>{"Librarian"=>1, "Student > Doctoral Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>1}, "reader_count_by_user_role"=>{"Librarian"=>1, "Student > Doctoral Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>1, "Other"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>1}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84929136433"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84929136433?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84929136433&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84929136433&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84929136433", "dc:identifier"=>"SCOPUS_ID:84929136433", "eid"=>"2-s2.0-84929136433", "dc:title"=>"A novel glycated hemoglobin A1c-lowering traditional Chinese medicinal formula, identified by translational medicine study", "dc:creator"=>"Lo H.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"9", "prism:issueIdentifier"=>"8", "prism:pageRange"=>nil, "prism:coverDate"=>"2014-08-18", "prism:coverDisplayDate"=>"18 August 2014", "prism:doi"=>"10.1371/journal.pone.0104650", "citedby-count"=>"6", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"China Medical University Taichung", "affiliation-city"=>"Taichung", "affiliation-country"=>"Taiwan"}], "pubmed-id"=>"25133699", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e104650", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0104650", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"27", "xml_views"=>"10", "html_views"=>"197"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"60"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"3", "html_views"=>"59"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"62"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"48"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"58"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"77"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"65"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"81"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"75"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"65"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"22"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"20"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"50"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"2", "html_views"=>"34"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"15"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"3", "html_views"=>"15"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"4"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"6"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1641188", "https://ndownloader.figshare.com/files/1641189", "https://ndownloader.figshare.com/files/1641190", "https://ndownloader.figshare.com/files/1641191", "https://ndownloader.figshare.com/files/1641192", "https://ndownloader.figshare.com/files/1641193"], "description"=>"<div><p>Diabetes is a chronic metabolic disorder that has a significant impact on the health care system. The reduction of glycated hemoglobin A1c is highly associated with the improvements of glycemic control and diabetic complications. In this study, we identified a traditional Chinese medicinal formula with a HbA1c-lowering potential from clinical evidences. By surveying 9,973 diabetic patients enrolled in Taiwan Diabetic Care Management Program, we found that Chu-Yeh-Shih-Kao-Tang (CYSKT) significantly reduced HbA1c values in diabetic patients. CYSKT reduced the levels of HbA1c and fasting blood glucose, and stimulated the blood glucose clearance in type 2 diabetic mice. CYSKT affected the expressions of genes associated with insulin signaling pathway, increased the amount of phosphorylated insulin receptor in cells and tissues, and stimulated the translocation of glucose transporter 4. Moreover, CYSKT affected the expressions of genes related to diabetic complications, improved the levels of renal function indexes, and increased the survival rate of diabetic mice. In conclusion, this was a translational medicine study that applied a “bedside-to-bench” approach to identify a novel HbA1c-lowering formula. Our findings suggested that oral administration of CYSKT affected insulin signaling pathway, decreased HbA1c and blood glucose levels, and consequently reduced mortality rate in type 2 diabetic mice.</p></div>", "links"=>[], "tags"=>["phosphorylated insulin receptor", "blood glucose levels", "HbA 1c values", "CYSKT", "novel HbA 1c formula", "type 2", "glucose transporter 4.", "Chinese Medicinal Formula", "blood glucose clearance", "fasting blood glucose", "Taiwan Diabetic Care Management Program", "Translational Medicine Study Diabetes", "HbA 1c", "translational medicine study", "health care system", "Novel Glycated Hemoglobin"], "article_id"=>1143680, "categories"=>["Biological Sciences"], "users"=>["Hsin-Yi Lo", "Chien-Yun Hsiang", "Tsai-Chung Li", "Chia-Cheng Li", "Hui-Chi Huang", "Jaw-Chyun Chen", "Tin-Yun Ho"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0104650.s001", "https://dx.doi.org/10.1371/journal.pone.0104650.s002", "https://dx.doi.org/10.1371/journal.pone.0104650.s003", "https://dx.doi.org/10.1371/journal.pone.0104650.s004", "https://dx.doi.org/10.1371/journal.pone.0104650.s005", "https://dx.doi.org/10.1371/journal.pone.0104650.s006"], "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_A_Novel_Glycated_Hemoglobin_A1c_Lowering_Traditional_Chinese_Medicinal_Formula_Identified_by_Translational_Medicine_Study_/1143680", "title"=>"A Novel Glycated Hemoglobin A1c-Lowering Traditional Chinese Medicinal Formula, Identified by Translational Medicine Study", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-08-18 04:49:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1641186"], "description"=>"<p>*Type 2 diabetic mice were given orally with 200 mg/kg CYSKT for 30 consecutive days. Total RNAs were extracted from muscle tissues and analyzed by microarray.</p>†<p><i>p</i> values were calculated by geneSetTest function implemented in the limma package.</p>", "links"=>[], "tags"=>["phosphorylated insulin receptor", "blood glucose levels", "HbA 1c values", "CYSKT", "novel HbA 1c formula", "type 2", "glucose transporter 4.", "Chinese Medicinal Formula", "blood glucose clearance", "fasting blood glucose", "Taiwan Diabetic Care Management Program", "Translational Medicine Study Diabetes", "HbA 1c", "translational medicine study", "health care system", "Novel Glycated Hemoglobin"], "article_id"=>1143678, "categories"=>["Biological Sciences"], "users"=>["Hsin-Yi Lo", "Chien-Yun Hsiang", "Tsai-Chung Li", "Chia-Cheng Li", "Hui-Chi Huang", "Jaw-Chyun Chen", "Tin-Yun Ho"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104650.t003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gene_expression_connection_of_CYSKT_treatments_with_disease_states_/1143678", "title"=>"Gene-expression connection of CYSKT treatments with disease states<sup>*</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-08-18 04:49:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1641183"], "description"=>"<p>(A) Phospho-IR ELISA. Left panel: HepG2 cells were treated with 0.5 µM insulin or various amounts of CYSKT. Ten minutes later, cellular proteins were collected and the levels of phosphorylated IR were measured by ELISA. Values are mean ± SD (<i>n</i> = 6). Right panel: BALC/c mice were given orally with various amounts of CYSKT. One hour later, mice were sacrificed, and livers were collected for analysis. Values are mean ± SD (<i>n</i> = 6). *<i>p</i><0.05, ***<i>p</i><0.001, compared with mock. (B) Phospho-IR ELISA. Type 2 diabetic mice were administered orally 200 mg/kg CYSKT for 30 days. Proteins were extracted from intestines and muscles, and the levels of phosphorylated IR were measured by ELISA. Values are mean ± SD (<i>n</i> = 5). *<i>p</i><0.05, **<i>p</i><0.01, ***<i>p</i><0.001, compared with mock. (C) IHC. Type 2 diabetic mice were administered orally 200 mg/kg CYSKT for 30 consecutive days. Muscle tissues were collected and the sections were stained by IHC using antibody against GLUT-4 (100× and 400× magnification). Photos are representative images (<i>n</i> = 5).</p>", "links"=>[], "tags"=>["phosphorylated insulin receptor", "blood glucose levels", "HbA 1c values", "CYSKT", "novel HbA 1c formula", "type 2", "glucose transporter 4.", "Chinese Medicinal Formula", "blood glucose clearance", "fasting blood glucose", "Taiwan Diabetic Care Management Program", "Translational Medicine Study Diabetes", "HbA 1c", "translational medicine study", "health care system", "Novel Glycated Hemoglobin"], "article_id"=>1143675, "categories"=>["Biological Sciences"], "users"=>["Hsin-Yi Lo", "Chien-Yun Hsiang", "Tsai-Chung Li", "Chia-Cheng Li", "Hui-Chi Huang", "Jaw-Chyun Chen", "Tin-Yun Ho"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104650.g003", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_CYSKT_on_IR_phosphorylation_and_GLUT_4_translocation_/1143675", "title"=>"Effects of CYSKT on IR phosphorylation and GLUT-4 translocation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-18 04:49:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1641182"], "description"=>"<p>Normal mice were administered orally various amounts of CYSKT. Glucose (4 g/kg) was injected intraperitoneally 15 min later, blood samples were collected at intervals, and blood glucose levels were measured by a glucometer (A). (B) AUC of glucose tolerance assay. Values are mean ± SD (<i>n</i> = 5). *<i>p</i><0.05, **<i>p</i><0.01, compared with mock.</p>", "links"=>[], "tags"=>["phosphorylated insulin receptor", "blood glucose levels", "HbA 1c values", "CYSKT", "novel HbA 1c formula", "type 2", "glucose transporter 4.", "Chinese Medicinal Formula", "blood glucose clearance", "fasting blood glucose", "Taiwan Diabetic Care Management Program", "Translational Medicine Study Diabetes", "HbA 1c", "translational medicine study", "health care system", "Novel Glycated Hemoglobin"], "article_id"=>1143674, "categories"=>["Biological Sciences"], "users"=>["Hsin-Yi Lo", "Chien-Yun Hsiang", "Tsai-Chung Li", "Chia-Cheng Li", "Hui-Chi Huang", "Jaw-Chyun Chen", "Tin-Yun Ho"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104650.g002", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_CYSKT_on_blood_glucose_levels_in_normal_mice_/1143674", "title"=>"Effect of CYSKT on blood glucose levels in normal mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-18 04:49:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1641185"], "description"=>"<p>*Type 2 diabetic mice were given orally with 200 mg/kg CYSKT for 30 consecutive days. Total RNAs were extracted from muscle tissues and analyzed by microarray.</p>†<p>Pathways associated with glucose and lipid metabolism are shown.</p>‡<p><i>p</i> values were calculated by geneSetTest function implemented in the limma package.</p>", "links"=>[], "tags"=>["phosphorylated insulin receptor", "blood glucose levels", "HbA 1c values", "CYSKT", "novel HbA 1c formula", "type 2", "glucose transporter 4.", "Chinese Medicinal Formula", "blood glucose clearance", "fasting blood glucose", "Taiwan Diabetic Care Management Program", "Translational Medicine Study Diabetes", "HbA 1c", "translational medicine study", "health care system", "Novel Glycated Hemoglobin"], "article_id"=>1143677, "categories"=>["Biological Sciences"], "users"=>["Hsin-Yi Lo", "Chien-Yun Hsiang", "Tsai-Chung Li", "Chia-Cheng Li", "Hui-Chi Huang", "Jaw-Chyun Chen", "Tin-Yun Ho"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104650.t002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pathways_significantly_regulated_by_CYSKT_in_type_2_diabetic_mice_/1143677", "title"=>"Pathways significantly regulated by CYSKT in type 2 diabetic mice<sup>*</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-08-18 04:49:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1641184"], "description"=>"<p>(A) CYSKT (200 mg/kg) was orally given to type 2 diabetic mice for 30 consecutive days. The levels of BUN and creatinine in sera were measured by an autoanalyzer. Values are mean ± SD (<i>n</i> = 5). **<i>p</i><0.01, compared with mock. (B) Long-term survival rate. Type 2 diabetic mice were administered orally with 200 mg/kg CYSKT and/or 20 mg/kg TZD for 120 consecutive days. The number of death was observed daily.</p>", "links"=>[], "tags"=>["phosphorylated insulin receptor", "blood glucose levels", "HbA 1c values", "CYSKT", "novel HbA 1c formula", "type 2", "glucose transporter 4.", "Chinese Medicinal Formula", "blood glucose clearance", "fasting blood glucose", "Taiwan Diabetic Care Management Program", "Translational Medicine Study Diabetes", "HbA 1c", "translational medicine study", "health care system", "Novel Glycated Hemoglobin"], "article_id"=>1143676, "categories"=>["Biological Sciences"], "users"=>["Hsin-Yi Lo", "Chien-Yun Hsiang", "Tsai-Chung Li", "Chia-Cheng Li", "Hui-Chi Huang", "Jaw-Chyun Chen", "Tin-Yun Ho"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104650.g004", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_CYSKT_on_renal_function_indexes_and_survival_rate_in_type_2_diabetic_mice_/1143676", "title"=>"Effects of CYSKT on renal function indexes and survival rate in type 2 diabetic mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-18 04:49:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1641181"], "description"=>"<p>Type 2 diabetic mice were administered orally 200 mg/kg CYSKT for 30 consecutive days. Blood samples were collected every 10 days and measured for HbA1c levels (A) and fasting blood glucose levels (B). Glucose tolerance test was performed on 30th day after CYSKT administration. Mice were fasted for 4 h, glucose (1 g/kg) was injected intraperitoneally, and the blood glucose levels at intervals were measured (C). Values are mean ± SD (<i>n</i> = 5). *<i>p</i><0.05, **<i>p</i><0.01, ***<i>p</i><0.001, compared with mock.</p>", "links"=>[], "tags"=>["phosphorylated insulin receptor", "blood glucose levels", "HbA 1c values", "CYSKT", "novel HbA 1c formula", "type 2", "glucose transporter 4.", "Chinese Medicinal Formula", "blood glucose clearance", "fasting blood glucose", "Taiwan Diabetic Care Management Program", "Translational Medicine Study Diabetes", "HbA 1c", "translational medicine study", "health care system", "Novel Glycated Hemoglobin"], "article_id"=>1143673, "categories"=>["Biological Sciences"], "users"=>["Hsin-Yi Lo", "Chien-Yun Hsiang", "Tsai-Chung Li", "Chia-Cheng Li", "Hui-Chi Huang", "Jaw-Chyun Chen", "Tin-Yun Ho"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104650.g001", "stats"=>{"downloads"=>1, "page_views"=>63, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_CYSKT_on_the_levels_of_HbA1c_and_blood_glucose_in_type_2_diabetic_mice_/1143673", "title"=>"Effects of CYSKT on the levels of HbA1c and blood glucose in type 2 diabetic mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-18 04:49:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1641187"], "description"=>"<p>Demographic information of participants in this study.</p>", "links"=>[], "tags"=>["phosphorylated insulin receptor", "blood glucose levels", "HbA 1c values", "CYSKT", "novel HbA 1c formula", "type 2", "glucose transporter 4.", "Chinese Medicinal Formula", "blood glucose clearance", "fasting blood glucose", "Taiwan Diabetic Care Management Program", "Translational Medicine Study Diabetes", "HbA 1c", "translational medicine study", "health care system", "Novel Glycated Hemoglobin"], "article_id"=>1143679, "categories"=>["Biological Sciences"], "users"=>["Hsin-Yi Lo", "Chien-Yun Hsiang", "Tsai-Chung Li", "Chia-Cheng Li", "Hui-Chi Huang", "Jaw-Chyun Chen", "Tin-Yun Ho"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0104650.t001", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_information_of_participants_in_this_study_/1143679", "title"=>"Demographic information of participants in this study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-08-18 04:49:42"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"22", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"24", "full-text"=>"92", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"24", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"5", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"31", "full-text"=>"26", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"25", "full-text"=>"21", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"9", "pdf"=>"9", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"19", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"24", "full-text"=>"22", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"13", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"18", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"28", "full-text"=>"15", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"22", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"21", "full-text"=>"22", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[267]}, {"subject_area"=>"/Medicine and health sciences/Hematology", "average_usage"=>[256]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[278]}]}
Loading … Spinner
There are currently no alerts