Global Brain Blood-Oxygen Level Responses to Autonomic Challenges in Obstructive Sleep Apnea
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{"title"=>"Global brain blood-oxygen level responses to autonomic challenges in obstructive sleep apnea", "type"=>"journal", "authors"=>[{"first_name"=>"Paul M.", "last_name"=>"Macey", "scopus_author_id"=>"14834343100"}, {"first_name"=>"Rajesh", "last_name"=>"Kumar", "scopus_author_id"=>"7406019218"}, {"first_name"=>"Jennifer A.", "last_name"=>"Ogren", "scopus_author_id"=>"22980994100"}, {"first_name"=>"Mary A.", "last_name"=>"Woo", "scopus_author_id"=>"7201527644"}, {"first_name"=>"Ronald M.", "last_name"=>"Harper", "scopus_author_id"=>"35361154800"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84940303549", "sgr"=>"84940303549", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0105261", "pmid"=>"25166862", "isbn"=>"10.1371/journal.pone.0105261", "pui"=>"373852691"}, "id"=>"c9e46f93-61b8-334f-bb11-58a23e78f994", "abstract"=>"Obstructive sleep apnea (OSA) is accompanied by brain injury, perhaps resulting from apnea-related hypoxia or periods of impaired cerebral perfusion. Perfusion changes can be determined indirectly by evaluation of cerebral blood volume and oxygenation alterations, which can be measured rapidly and non-invasively with the global blood oxygen level dependent (BOLD) signal, a magnetic resonance imaging procedure. We assessed acute BOLD responses in OSA subjects to pressor challenges that elicit cerebral blood flow changes, using a two-group comparative design with healthy subjects as a reference. We separately assessed female and male patterns, since OSA characteristics and brain injury differ between sexes. We studied 94 subjects, 37 with newly-diagnosed, untreated OSA (6 female (age mean ± std: 52.1±8.1 yrs; apnea/hypopnea index [AHI]: 27.7±15.6 events/hr and 31 male 54.3±8.4 yrs; AHI: 37.4±19.6 events/hr), and 20 female (age 50.5±8.1 yrs) and 37 male (age 45.6±9.2 yrs) healthy control subjects. We measured brain BOLD responses every 2 s while subjects underwent cold pressor, hand grip, and Valsalva maneuver challenges. The global BOLD signal rapidly changed after the first 2 s of each challenge, and differed in magnitude between groups to two challenges (cold pressor, hand grip), but not to the Valsalva maneuver (repeated measures ANOVA, p<0.05). OSA females showed greater differences from males in response magnitude and pattern, relative to healthy counterparts. Cold pressor BOLD signal increases (mean ± adjusted standard error) at the 8 s peak were: OSA 0.14±0.08% vs. Control 0.31±0.06%, and hand grip at 6 s were: OSA 0.08±0.03% vs. Control at 0.30±0.02%. These findings, indicative of reduced cerebral blood flow changes to autonomic challenges in OSA, complement earlier reports of altered resting blood flow and reduced cerebral artery responsiveness. Females are more affected than males, an outcome which may contribute to the sex-specific brain injury in the syndrome.", "link"=>"http://www.mendeley.com/research/global-brain-bloodoxygen-level-responses-autonomic-challenges-obstructive-sleep-apnea", "reader_count"=>24, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>6, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>6, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Medicine and Dentistry"=>18, "Agricultural and Biological Sciences"=>1, "Sports and Recreations"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>18}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1653497"], "description"=>"<p>Chi Square statistics and <i>p</i> value are reported for repeated measures ANOVA, implemented as a mixed linear model with group, time and group by time as effects of interest (SAS proc mixed).</p><p>Statistics for mixed models.</p>", "links"=>[], "tags"=>["anova", "Obstructive Sleep Apnea Obstructive", "yr", "ahi", "Valsalva maneuver challenges", "resonance imaging procedure", "subject", "hand grip", "osa", "blood oxygen level", "blood flow changes", "Cold pressor BOLD signal increases", "brain injury", "brain BOLD responses"], "article_id"=>1154336, "categories"=>["Biological Sciences"], "users"=>["Paul M. Macey", "Rajesh Kumar", "Jennifer A. Ogren", "Mary A. Woo", "Ronald M. Harper"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0105261.t002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Statistics_for_mixed_models_/1154336", "title"=>"Statistics for mixed models.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-08-28 03:07:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1653495"], "description"=>"<p>Time courses, separated by sex of heart rate and global BOLD signals over four Valsalva maneuvers (Val; gray rectangles). <b>A:</b> Global BOLD signals in females (6 OSA, 20 control) and males (31 OSA, 37 control) during the complete sequence. For females (<b>B</b>) and males (<b>C</b>), global BOLD signal averages over four challenges of change relative to baseline (group mean ± SE), with time-points of significant increase or decrease relative to baseline within-group, and time-points of between-group differences (RMANOVA, <i>p</i><0.05).</p>", "links"=>[], "tags"=>["anova", "Obstructive Sleep Apnea Obstructive", "yr", "ahi", "Valsalva maneuver challenges", "resonance imaging procedure", "subject", "hand grip", "osa", "blood oxygen level", "blood flow changes", "Cold pressor BOLD signal increases", "brain injury", "brain BOLD responses"], "article_id"=>1154334, "categories"=>["Biological Sciences"], "users"=>["Paul M. Macey", "Rajesh Kumar", "Jennifer A. Ogren", "Mary A. Woo", "Ronald M. Harper"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0105261.g006", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Valsalva_4_group_/1154334", "title"=>"Valsalva, 4 group.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-28 03:07:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1653510", "https://ndownloader.figshare.com/files/1653511", "https://ndownloader.figshare.com/files/1653512"], "description"=>"<div><p>Obstructive sleep apnea (OSA) is accompanied by brain injury, perhaps resulting from apnea-related hypoxia or periods of impaired cerebral perfusion. Perfusion changes can be determined indirectly by evaluation of cerebral blood volume and oxygenation alterations, which can be measured rapidly and non-invasively with the global blood oxygen level dependent (BOLD) signal, a magnetic resonance imaging procedure. We assessed acute BOLD responses in OSA subjects to pressor challenges that elicit cerebral blood flow changes, using a two-group comparative design with healthy subjects as a reference. We separately assessed female and male patterns, since OSA characteristics and brain injury differ between sexes. We studied 94 subjects, 37 with newly-diagnosed, untreated OSA (6 female (age mean ± std: 52.1±8.1 yrs; apnea/hypopnea index [AHI]: 27.7±15.6 events/hr and 31 male 54.3±8.4 yrs; AHI: 37.4±19.6 events/hr), and 20 female (age 50.5±8.1 yrs) and 37 male (age 45.6±9.2 yrs) healthy control subjects. We measured brain BOLD responses every 2 s while subjects underwent cold pressor, hand grip, and Valsalva maneuver challenges. The global BOLD signal rapidly changed after the first 2 s of each challenge, and differed in magnitude between groups to two challenges (cold pressor, hand grip), but not to the Valsalva maneuver (repeated measures ANOVA, <i>p</i><0.05). OSA females showed greater differences from males in response magnitude and pattern, relative to healthy counterparts. Cold pressor BOLD signal increases (mean ± adjusted standard error) at the 8 s peak were: OSA 0.14±0.08% vs. Control 0.31±0.06%, and hand grip at 6 s were: OSA 0.08±0.03% vs. Control at 0.30±0.02%. These findings, indicative of reduced cerebral blood flow changes to autonomic challenges in OSA, complement earlier reports of altered resting blood flow and reduced cerebral artery responsiveness. Females are more affected than males, an outcome which may contribute to the sex-specific brain injury in the syndrome.</p></div>", "links"=>[], "tags"=>["anova", "Obstructive Sleep Apnea Obstructive", "yr", "ahi", "Valsalva maneuver challenges", "resonance imaging procedure", "subject", "hand grip", "osa", "blood oxygen level", "blood flow changes", "Cold pressor BOLD signal increases", "brain injury", "brain BOLD responses"], "article_id"=>1154343, "categories"=>["Biological Sciences"], "users"=>["Paul M. Macey", "Rajesh Kumar", "Jennifer A. Ogren", "Mary A. Woo", "Ronald M. Harper"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0105261.s001", "https://dx.doi.org/10.1371/journal.pone.0105261.s002", "https://dx.doi.org/10.1371/journal.pone.0105261.s003"], "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Global_Brain_Blood_Oxygen_Level_Responses_to_Autonomic_Challenges_in_Obstructive_Sleep_Apnea_/1154343", "title"=>"Global Brain Blood-Oxygen Level Responses to Autonomic Challenges in Obstructive Sleep Apnea", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-08-28 03:07:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1653486"], "description"=>"<p>Time courses, separated by sex, of global BOLD signals over four hand grip challenges (Grip effort; gray rectangles). <b>A:</b> Average global BOLD signal in females (6 OSA, 20 control) and males (31 OSA, 37 control) during the complete sequence. For females (<b>B</b>) and males (<b>C</b>), average over four challenges of change in global BOLD signals relative to baseline (group mean ± SE), with time-points of significant increase or decrease relative to baseline within-group, and time-points of between-group differences (RMANOVA, <i>p</i><0.05).</p>", "links"=>[], "tags"=>["anova", "Obstructive Sleep Apnea Obstructive", "yr", "ahi", "Valsalva maneuver challenges", "resonance imaging procedure", "subject", "hand grip", "osa", "blood oxygen level", "blood flow changes", "Cold pressor BOLD signal increases", "brain injury", "brain BOLD responses"], "article_id"=>1154325, "categories"=>["Biological Sciences"], "users"=>["Paul M. Macey", "Rajesh Kumar", "Jennifer A. Ogren", "Mary A. Woo", "Ronald M. Harper"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0105261.g004", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hand_grip_4_group_/1154325", "title"=>"Hand grip, 4 group.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-28 03:07:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1653462"], "description"=>"<p>Time course of global BOLD signals during a cold pressor challenge (gray shaded rectangles). Change in BOLD signals, relative to baseline (group mean ± SE), with time-points of significant increase or decrease relative to baseline within-group, and time-points of between-group differences (RMANOVA, <i>p</i><0.05).</p>", "links"=>[], "tags"=>["anova", "Obstructive Sleep Apnea Obstructive", "yr", "ahi", "Valsalva maneuver challenges", "resonance imaging procedure", "subject", "hand grip", "osa", "blood oxygen level", "blood flow changes", "Cold pressor BOLD signal increases", "brain injury", "brain BOLD responses"], "article_id"=>1154301, "categories"=>["Biological Sciences"], "users"=>["Paul M. Macey", "Rajesh Kumar", "Jennifer A. Ogren", "Mary A. Woo", "Ronald M. Harper"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0105261.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cold_pressor_2_group_/1154301", "title"=>"Cold pressor, 2 group.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-28 03:07:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1653479"], "description"=>"<p>Time course of global BOLD signals over four hand grip challenges (Grip effort; gray rectangles). <b>A:</b> Global BOLD signal in 37 OSA and 57 control subjects during the complete sequence. <b>B:</b> Average over four challenges of percent change in BOLD signals relative to baseline (group mean ± SE), with time-points of significant increase or decrease relative to baseline within-group, and time-points of between-group differences (RMANOVA, <i>p</i><0.05).</p>", "links"=>[], "tags"=>["anova", "Obstructive Sleep Apnea Obstructive", "yr", "ahi", "Valsalva maneuver challenges", "resonance imaging procedure", "subject", "hand grip", "osa", "blood oxygen level", "blood flow changes", "Cold pressor BOLD signal increases", "brain injury", "brain BOLD responses"], "article_id"=>1154318, "categories"=>["Biological Sciences"], "users"=>["Paul M. Macey", "Rajesh Kumar", "Jennifer A. Ogren", "Mary A. Woo", "Ronald M. Harper"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0105261.g003", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hand_grip_2_group_/1154318", "title"=>"Hand grip, 2 group.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-28 03:07:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1653493"], "description"=>"<p>Time course of global BOLD signals over four Valsalva maneuvers (Val; gray rectangles). <b>A:</b> Global BOLD signal, and <b>B:</b> expiratory pressure in 37 OSA and 57 control subjects during the complete sequence. <b>C:</b> Average over four challenges of change in BOLD signals relative to baseline (group mean ± SE), with time-points of significant increase or decrease relative to baseline within-group, and time-points of between-group differences (RMANOVA, <i>p</i><0.05).</p>", "links"=>[], "tags"=>["anova", "Obstructive Sleep Apnea Obstructive", "yr", "ahi", "Valsalva maneuver challenges", "resonance imaging procedure", "subject", "hand grip", "osa", "blood oxygen level", "blood flow changes", "Cold pressor BOLD signal increases", "brain injury", "brain BOLD responses"], "article_id"=>1154332, "categories"=>["Biological Sciences"], "users"=>["Paul M. Macey", "Rajesh Kumar", "Jennifer A. Ogren", "Mary A. Woo", "Ronald M. Harper"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0105261.g005", "stats"=>{"downloads"=>0, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Valsalva_2_group_/1154332", "title"=>"Valsalva, 2 group.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-28 03:07:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1653470"], "description"=>"<p>Time courses separated by sex of global BOLD signals during a cold pressor challenge (gray rectangles). <b>A:</b> Global BOLD signals in females (6 OSA, 20 control) and males (31 OSA, 37 control) during the complete sequence. For females (<b>B</b>) and males (<b>C</b>), changes in BOLD signals relative to baseline (group mean ± SE), with time-points of significant increase or decrease relative to baseline within-group, and time-points of between-group differences (RMANOVA, <i>p</i><0.05).</p>", "links"=>[], "tags"=>["anova", "Obstructive Sleep Apnea Obstructive", "yr", "ahi", "Valsalva maneuver challenges", "resonance imaging procedure", "subject", "hand grip", "osa", "blood oxygen level", "blood flow changes", "Cold pressor BOLD signal increases", "brain injury", "brain BOLD responses"], "article_id"=>1154309, "categories"=>["Biological Sciences"], "users"=>["Paul M. Macey", "Rajesh Kumar", "Jennifer A. Ogren", "Mary A. Woo", "Ronald M. Harper"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0105261.g002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cold_pressor_4_group_/1154309", "title"=>"Cold pressor, 4 group.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-08-28 03:07:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/1653496"], "description"=>"<p>Group effects were tested with ANOVA (four-way for age and BMI, and two-way for OSA parameters).</p><p>Subject information with group averages and standard deviations (± std).</p>", "links"=>[], "tags"=>["anova", "Obstructive Sleep Apnea Obstructive", "yr", "ahi", "Valsalva maneuver challenges", "resonance imaging procedure", "subject", "hand grip", "osa", "blood oxygen level", "blood flow changes", "Cold pressor BOLD signal increases", "brain injury", "brain BOLD responses"], "article_id"=>1154335, "categories"=>["Biological Sciences"], "users"=>["Paul M. Macey", "Rajesh Kumar", "Jennifer A. Ogren", "Mary A. Woo", "Ronald M. Harper"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0105261.t001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Subject_information_with_group_averages_and_standard_deviations_177_std_/1154335", "title"=>"Subject information with group averages and standard deviations (± std).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-08-28 03:07:38"}

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