Relationship between Vagal Tone, Cortisol, TNF-Alpha, Epinephrine and Negative Affects in Crohn’s Disease and Irritable Bowel Syndrome
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{"title"=>"Relationship between Vagal Tone, Cortisol, TNF-alpha, epinephrine and negative affects in Crohn's disease and irritable bowel syndrome", "type"=>"journal", "authors"=>[{"first_name"=>"Sonia", "last_name"=>"Pellissier", "scopus_author_id"=>"6603330085"}, {"first_name"=>"Cécile", "last_name"=>"Dantzer", "scopus_author_id"=>"14821792100"}, {"first_name"=>"Laurie", "last_name"=>"Mondillon", "scopus_author_id"=>"8712013700"}, {"first_name"=>"Candice", "last_name"=>"Trocme", "scopus_author_id"=>"6603573869"}, {"first_name"=>"Anne Sophie", "last_name"=>"Gauchez", "scopus_author_id"=>"6603382434"}, {"first_name"=>"Véronique", "last_name"=>"Ducros", "scopus_author_id"=>"7006042912"}, {"first_name"=>"Nicolas", "last_name"=>"Mathieu", "scopus_author_id"=>"35345239700"}, {"first_name"=>"Bertrand", "last_name"=>"Toussaint", "scopus_author_id"=>"55217301100"}, {"first_name"=>"Alicia", "last_name"=>"Fournier", "scopus_author_id"=>"56657127600"}, {"first_name"=>"Frédéric", "last_name"=>"Canini", "scopus_author_id"=>"55892620100"}, {"first_name"=>"Bruno", "last_name"=>"Bonaz", "scopus_author_id"=>"7004197628"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84929941271", "doi"=>"10.1371/journal.pone.0105328", "pui"=>"608759021", "pmid"=>"25207649", "scopus"=>"2-s2.0-84929941271", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"905dd05f-a84c-337f-9557-123b75ba901b", "abstract"=>"Crohn's disease (CD) and irritable bowel syndrome (IBS) involve brain-gut dysfunctions where vagus nerve is an important component. The aim of this work was to study the association between vagal tone and markers of stress and inflammation in patients with CD or IBS compared to healthy subjects (controls). The study was performed in 73 subjects (26 controls, 21 CD in remission and 26 IBS patients). The day prior to the experiment, salivary cortisol was measured at 8:00 AM and 10:00 PM. The day of the experiment, subjects completed questionnaires for anxiety (STAI) and depressive symptoms (CES-D). After 30 min of rest, ECG was recorded for heart rate variability (HRV) analysis. Plasma cortisol, epinephrine, norepinephrine, TNF-alpha and IL-6 were measured in blood samples taken at the end of ECG recording. Compared with controls, CD and IBS patients had higher scores of state-anxiety and depressive symptomatology. A subgroup classification based on HRV-normalized high frequency band (HFnu) as a marker of vagal tone, showed that control subjects with high vagal tone had significantly lower evening salivary cortisol levels than subjects with low vagal tone. Such an effect was not observed in CD and IBS patients. Moreover, an inverse association (r = -0.48; p<0.05) was observed between the vagal tone and TNF-alpha level in CD patients exclusively. In contrast, in IBS patients, vagal tone was inversely correlated with plasma epinephrine (r = -0.39; p<0.05). No relationship was observed between vagal tone and IL-6, norepinephrine or negative affects (anxiety and depressive symptomatology) in any group. In conclusion, these data argue for an imbalance between the hypothalamus-pituitary-adrenal axis and the vagal tone in CD and IBS patients. Furthermore, they highlight the specific homeostatic link between vagal tone and TNF-alpha in CD and epinephrine in IBS and argue for the relevance of vagus nerve reinforcement interventions in those diseases.", "link"=>"http://www.mendeley.com/research/relationship-between-vagal-tone-cortisol-tnfalpha-epinephrine-negative-affects-crohns-disease-irrita", "reader_count"=>105, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Librarian"=>1, "Researcher"=>14, "Student > Doctoral Student"=>12, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>5, "Other"=>10, "Student > Master"=>14, "Student > Bachelor"=>18, "Lecturer"=>2, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>4, "Librarian"=>1, "Researcher"=>14, "Student > Doctoral Student"=>12, "Student > Ph. D. Student"=>17, "Student > Postgraduate"=>5, "Other"=>10, "Student > Master"=>14, "Student > Bachelor"=>18, "Lecturer"=>2, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Agricultural and Biological Sciences"=>17, "Arts and Humanities"=>1, "Computer Science"=>1, "Engineering"=>5, "Biochemistry, Genetics and Molecular Biology"=>4, "Nursing and Health Professions"=>5, "Medicine and Dentistry"=>29, "Neuroscience"=>10, "Sports and Recreations"=>2, "Psychology"=>21, "Social Sciences"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>29}, "Social Sciences"=>{"Social Sciences"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Psychology"=>{"Psychology"=>21}, "Unspecified"=>{"Unspecified"=>7}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Engineering"=>{"Engineering"=>5}, "Neuroscience"=>{"Neuroscience"=>10}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>17}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}}, "reader_count_by_country"=>{"Colombia"=>1, "Belgium"=>1, "United States"=>3, "France"=>1, "Australia"=>1, "Russia"=>1}, "group_count"=>9}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1669359"], "description"=>"<p>A balance was observed between the parasympathetic tone and the evening salivary cortisol in healthy subjects (control group) but not in CD and IBS patients. Data are expressed as mean ± sem. Comparisons are made between the high and low parasympathetic level subgroups using permutations test.</p>", "links"=>[], "tags"=>["vagus nerve reinforcement interventions", "hrv", "IBS patients", "subject", "pm", "vagal tone", "depressive symptomatology", "ecg", "Heart rate variability", "26 IBS patients", "stai", "am", "il"], "article_id"=>1167040, "categories"=>["Uncategorised"], "users"=>["Sonia Pellissier", "Cécile Dantzer", "Laurie Mondillon", "Candice Trocme", "Anne-Sophie Gauchez", "Véronique Ducros", "Nicolas Mathieu", "Bertrand Toussaint", "Alicia Fournier", "Frederic Canini", "Bruno Bonaz"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0105328.g002", "stats"=>{"downloads"=>0, "page_views"=>53, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relationship_between_the_resting_parasympathetic_vagal_tone_and_the_evening_salivary_cortisol_in_controls_Crohn_8217_s_disease_CD_and_Irritable_bowel_syndrome_IBS_patients_/1167040", "title"=>"Relationship between the resting parasympathetic vagal tone and the evening salivary cortisol in controls, Crohn’s disease (CD) and Irritable bowel syndrome (IBS) patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-10 03:10:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1669360"], "description"=>"<p>CD patients with low parasympathetic vagal tone exhibit a higher level of TNF-alpha than those with high parasympathetic vagal tone. This inverse relationship was not observed in controls or IBS patients. Data are expressed as mean ± sem. Comparisons are made between the high and low parasympathetic level subgroups using permutations test.</p>", "links"=>[], "tags"=>["vagus nerve reinforcement interventions", "hrv", "IBS patients", "subject", "pm", "vagal tone", "depressive symptomatology", "ecg", "Heart rate variability", "26 IBS patients", "stai", "am", "il"], "article_id"=>1167042, "categories"=>["Uncategorised"], "users"=>["Sonia Pellissier", "Cécile Dantzer", "Laurie Mondillon", "Candice Trocme", "Anne-Sophie Gauchez", "Véronique Ducros", "Nicolas Mathieu", "Bertrand Toussaint", "Alicia Fournier", "Frederic Canini", "Bruno Bonaz"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0105328.g003", "stats"=>{"downloads"=>0, "page_views"=>35, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Specific_inverse_relationship_between_the_resting_parasympathetic_vagal_tone_and_TNF_alpha_plasma_level_in_CD_patients_/1167042", "title"=>"Specific inverse relationship between the resting parasympathetic vagal tone and TNF-alpha plasma level in CD patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-10 03:10:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/1669362"], "description"=>"<p>IBS patients with low parasympathetic vagal tone exhibit a higher level of plasma epinephrine at rest than those with high parasympathetic vagal tone. This inverse relationship was not observed in controls or CD patients. Data are expressed as mean ± sem. Comparisons are made between the high and low parasympathetic level subgroups using permutations test.</p>", "links"=>[], "tags"=>["vagus nerve reinforcement interventions", "hrv", "IBS patients", "subject", "pm", "vagal tone", "depressive symptomatology", "ecg", "Heart rate variability", "26 IBS patients", "stai", "am", "il"], "article_id"=>1167043, "categories"=>["Uncategorised"], "users"=>["Sonia Pellissier", "Cécile Dantzer", "Laurie Mondillon", "Candice Trocme", "Anne-Sophie Gauchez", "Véronique Ducros", "Nicolas Mathieu", "Bertrand Toussaint", "Alicia Fournier", "Frederic Canini", "Bruno Bonaz"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0105328.g004", "stats"=>{"downloads"=>3, "page_views"=>48, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Specific_inverse_relationship_between_the_resting_parasympathetic_vagal_tone_and_epinephrine_plasma_level_in_IBS_patients_/1167043", "title"=>"Specific inverse relationship between the resting parasympathetic vagal tone and epinephrine plasma level in IBS patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-10 03:10:35"}
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