Cheburator Software for Automatically Calculating Drug Inhibitory Concentrations from In Vitro Screening Assays
- Publication Date
- September 03, 2014
- Journal
- PLOS ONE
- Author
- Dmitry Nevozhay
- Volume
- 9
- Issue
- 9
- Pages
- e106186
- DOI
- https://dx.plos.org/10.1371/journal.pone.0106186
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0106186
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/25184280
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153570
- Europe PMC
- http://europepmc.org/abstract/MED/25184280
- Web of Science
- 000341257700034
- Scopus
- 84906998215
- Mendeley
- http://www.mendeley.com/research/cheburator-software-automatically-calculating-drug-inhibitory-concentrations-vitroscreening-assays
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Mendeley | Further Information
{"title"=>"Cheburator software for automatically calculating drug inhibitory concentrations from in vitroscreening assays", "type"=>"journal", "authors"=>[{"first_name"=>"Dmitry", "last_name"=>"Nevozhay", "scopus_author_id"=>"8561272000"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84906998215", "pui"=>"600017515", "doi"=>"10.1371/journal.pone.0106186", "sgr"=>"84906998215", "pmid"=>"25184280"}, "id"=>"746338be-81d8-36a6-925e-84341277c805", "abstract"=>"In the process of new cancer drug development, as the first step of their assessment, their activities are usually studied in vitro against a panel of cancer cell lines. The results of these in vitro drug screening assays are commonly expressed as inhibitory concentration 50% (IC50): the concentration of the tested agent that inhibits the proliferation of the cancer cell population to 50% of the theoretically possible effect (absolute IC50) or maximum effect practically achieved by the drug (relative IC50). The currently available software for calculating IC50 values requires manual data entry, is time consuming, and is prone to calculation errors. Thus, we have developed open source, free, easy-to-use software for performing standardized data evaluations and automatically calculating the IC50. This software eliminates the laborious and error-prone manual entry of data, substantially reduces the amount of time spent for data analysis. It has been extensively used in our department as the main tool for in vitro data processing during the past several years and can be useful for other research groups working in the area of anticancer drug discovery, either alone or combined with other software packages. The current version of our program, Cheburator, together with sample data, source code, and documentation, is freely available at the following URL: http://www.cheburator.nevozhay.com (it is free for academic use, but a license is required for commercial use).", "link"=>"http://www.mendeley.com/research/cheburator-software-automatically-calculating-drug-inhibitory-concentrations-vitroscreening-assays", "reader_count"=>20, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Researcher"=>2, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>1, "Student > Master"=>4, "Student > Bachelor"=>1, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Researcher"=>2, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>1, "Student > Master"=>4, "Student > Bachelor"=>1, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>1, "Chemistry"=>3, "Computer Science"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Chemistry"=>{"Chemistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"India"=>1}, "group_count"=>0}CrossRef
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Scopus | Further Information
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Relative Metric
{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Computer and information sciences/Information technology", "average_usage"=>[314, 484]}, {"subject_area"=>"/Engineering and technology/Software engineering", "average_usage"=>[348, 519]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[285]}]}Loading … 

Net::HTTPInternalServerError
Source
ScopusTime
2020-10-24 15:06:17 UTCTarget URL
https://api.elsevier.com/content/search/index:SCOPUS?query=DOI(10.1371%2Fjournal.pone.0106186)Trace
/app/models/concerns/networkable.rb:21:in `get_result'
/app/models/source.rb:165:in `get_data'
/app/models/retrieval_status.rb:47:in `perform_get_data'
/app/jobs/source_job.rb:52:in `block (2 levels) in perform'
/app/jobs/source_job.rb:51:in `block in perform'
/app/jobs/source_job.rb:35:in `each'
/app/jobs/source_job.rb:35:in `perform'