No Impairment in Host Defense against Streptococcus pneumoniae in Obese CPEfat/fat Mice
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{"title"=>"No impairment in host defense against Streptococcus pneumoniae in obese CPEfat/fat mice", "type"=>"journal", "authors"=>[{"first_name"=>"Peter", "last_name"=>"Mancuso", "scopus_author_id"=>"7005179936"}, {"first_name"=>"Edmund", "last_name"=>"O'brien", "scopus_author_id"=>"35784957200"}, {"first_name"=>"Joseph", "last_name"=>"Prano", "scopus_author_id"=>"56649376700"}, {"first_name"=>"Deepti", "last_name"=>"Goel", "scopus_author_id"=>"35069523600"}, {"first_name"=>"David M.", "last_name"=>"Aronoff", "scopus_author_id"=>"7004894957"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84929511994", "sgr"=>"84929511994", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0106420", "pmid"=>"25203099", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"606939429"}, "id"=>"f521b241-7d92-3cf2-a299-153cedad4df7", "abstract"=>"In the US and globally, dramatic increases in the prevalence of adult and childhood obesity have been reported during the last 30 years. In addition to cardiovascular disease, type II diabetes, and liver disease, obesity has recently been recognized as an important risk factor for influenza pneumonia. During the influenza pandemic of 2009, obese individuals experienced a greater severity of illness from the H1N1 virus. In addition, obese mice have also been shown to exhibit increased lethality and aberrant pulmonary inflammatory responses following influenza infection. In contrast to influenza, the impact of obesity on bacterial pneumonia in human patients is controversial. In this report, we compared the responses of lean WT and obese CPE(fat/fat) mice following an intratracheal infection with Streptococcus pneumoniae, the leading cause of community-acquired pneumonia. At 16 weeks of age, CPE(fat/fat) mice develop severe obesity, hyperglycemia, elevated serum triglycerides and leptin, and increased blood neutrophil counts. There were no differences between lean WT and obese CPE(fat/fat) mice in survival or lung and spleen bacterial burdens following intratracheal infection with S. pneumoniae. Besides a modest increase in TNF-alpha levels and increased peripheral blood neutrophil counts in CPE(fat/fat) mice, there were not differences in lung or serum cytokines after infection. These results suggest that obesity, accompanied by hyperglycemia and modestly elevated triglycerides, at least in the case of CPE(fat/fat) mice, does not impair innate immunity against pneumococcal pneumonia.", "link"=>"http://www.mendeley.com/research/impairment-host-defense-against-streptococcus-pneumoniae-obese-cpefatfat-mice", "reader_count"=>11, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Postgraduate"=>2, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>1, "Librarian"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Postgraduate"=>2, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>1, "Librarian"=>1}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>1, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>2, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1667842"], "description"=>"<p>Mice were infected with 5×10<sup>4</sup> CFUs of <i>S. pneumoniae</i> via the intratracheal route and bacterial loads in tissue homogenates were determined by enumerating CFUs as described in the <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0106420#s2\" target=\"_blank\"><i>Materials and Methods</i></a> section. Statistical comparisons were performed using the students <i>t</i>-test. n = 5 (24 h) and 15 (48 h) mice per group.</p>", "links"=>[], "tags"=>["influenza", "wt", "obesity", "intratracheal infection", "CPEfat", "streptococcus pneumoniae", "H 1N virus", "type II diabetes", "blood neutrophil counts", "tnf"], "article_id"=>1165784, "categories"=>["Biological Sciences"], "users"=>["Peter Mancuso", "Edmund O′Brien", "Joseph Prano", "Deepti Goel", "David M. Aronoff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0106420.g003", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bacterial_burdens_in_WT_and_CPE_fat_fat_mice_24_A_and_48_h_B_following_S_pneumoniae_challenge_/1165784", "title"=>"Bacterial burdens in WT and CPE<i><sup>fat/fat</sup></i> mice 24 (A) and 48 h (B) following <i>S. pneumoniae</i> challenge.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-09 02:57:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1667839"], "description"=>"<p>*,<0.05 vs WT using student's <i>t</i>-test. N = 4 mice per group (A-D) and N = 10 mice per group (E).</p>", "links"=>[], "tags"=>["influenza", "wt", "obesity", "intratracheal infection", "CPEfat", "streptococcus pneumoniae", "H 1N virus", "type II diabetes", "blood neutrophil counts", "tnf"], "article_id"=>1165781, "categories"=>["Biological Sciences"], "users"=>["Peter Mancuso", "Edmund O′Brien", "Joseph Prano", "Deepti Goel", "David M. Aronoff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0106420.g001", "stats"=>{"downloads"=>2, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Body_weight_A_blood_glucose_B_serum_leptin_C_triglycerides_D_and_white_blood_cell_counts_E_in_16_wk_old_female_wild_type_WT_and_carboxypeptidase_E_fat_fat_CPE_fat_fat_mice_at_baseline_/1165781", "title"=>"Body weight (A), blood glucose (B), serum leptin (C), triglycerides (D), and white blood cell counts (E) in 16-wk-old female wild type (WT) and carboxypeptidase E <i><sup>fat/fat</sup></i> (CPE<i><sup>fat/fat</sup></i>) mice at baseline.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-09 02:57:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1667840"], "description"=>"<p>Mice were infected with 5×10<sup>4</sup> CFUs of <i>S. pneumonia</i> via the intratracheal route and monitored for survival for 10 days. N = 6–9 mice per group from 2 independent experiments. Survival was evaluated using the log-rank test. *, <i>p</i><0.05, total weight loss for WT vs CPE<i><sup>fat/fat</sup></i> mice post-infection using a student's <i>t</i>-test, n = 5 (24 h) and 15 (48 h) mice per group.</p>", "links"=>[], "tags"=>["influenza", "wt", "obesity", "intratracheal infection", "CPEfat", "streptococcus pneumoniae", "H 1N virus", "type II diabetes", "blood neutrophil counts", "tnf"], "article_id"=>1165782, "categories"=>["Biological Sciences"], "users"=>["Peter Mancuso", "Edmund O′Brien", "Joseph Prano", "Deepti Goel", "David M. Aronoff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0106420.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Survival_of_WT_and_CPE_fat_fat_mice_following_S_pneumoniae_infection_A_Body_weight_loss_expressed_as_total_weight_loss_24_and_48_h_post_infection_B_/1165782", "title"=>"Survival of WT and CPE<i><sup>fat/fat</sup></i> mice following <i>S. pneumoniae</i> infection (A). Body weight loss, expressed as total weight loss, 24 and 48 h post-infection (B).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-09 02:57:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1667843"], "description"=>"<p>Mice were challenged with 5×10<sup>4</sup> CFUs of <i>S. pneumoniae</i> via the intratracheal route and BALF was obtained 24 and 48 h post- infection and cytokine levels were determined as described in the <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0106420#s2\" target=\"_blank\"><i>Materials and Methods</i></a> section. n = 5–7 mice per group. *, <i>p<0.05</i> vs WT using a student's <i>t</i>-test.</p>", "links"=>[], "tags"=>["influenza", "wt", "obesity", "intratracheal infection", "CPEfat", "streptococcus pneumoniae", "H 1N virus", "type II diabetes", "blood neutrophil counts", "tnf"], "article_id"=>1165785, "categories"=>["Biological Sciences"], "users"=>["Peter Mancuso", "Edmund O′Brien", "Joseph Prano", "Deepti Goel", "David M. Aronoff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0106420.g004", "stats"=>{"downloads"=>3, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cytokines_in_bronchoalveolar_lavage_fluid_BALF_from_WT_and_CPE_fat_fat_mice_24_A_and_48_h_B_post_infection_/1165785", "title"=>"Cytokines in bronchoalveolar lavage fluid (BALF) from WT and CPE<i><sup>fat/fat</sup></i> mice 24 (A) and 48 h (B) post-infection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-09 02:57:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/1667844"], "description"=>"<p>WT and CPE<i><sup>fat/fat</sup></i> mice were challenged with 10<sup>5</sup> CFUs of <i>S. pneumoniae</i> via the intratracheal route and serum was prepared from blood samples obtained 24 and 48 h post-infection as mentioned in the <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0106420#s2\" target=\"_blank\"><i>Materials and Methods</i></a> section. n = 5–7 mice per group *, <i>p</i><0.05 vs WT using a student's <i>t</i>-test.</p>", "links"=>[], "tags"=>["influenza", "wt", "obesity", "intratracheal infection", "CPEfat", "streptococcus pneumoniae", "H 1N virus", "type II diabetes", "blood neutrophil counts", "tnf"], "article_id"=>1165786, "categories"=>["Biological Sciences"], "users"=>["Peter Mancuso", "Edmund O′Brien", "Joseph Prano", "Deepti Goel", "David M. Aronoff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0106420.g005", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Serum_cytokines_A_and_B_and_peripheral_blood_cell_counts_C_in_WT_and_CPE_fat_fat_mice_following_S_pneumoniae_challenge_/1165786", "title"=>"Serum cytokines (A and B) and peripheral blood cell counts (C) in WT and CPE<i><sup>fat/fat</sup></i> mice following <i>S. pneumoniae</i> challenge.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-09 02:57:28"}

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