Null Genotypes of GSTM1 and GSTT1 and Endometriosis Risk: A Meta-Analysis of 25 Case-Control Studies
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{"title"=>"Null genotypes of GSTM1 and GSTT1 and endometriosis risk: A meta-analysis of 25 case-control studies", "type"=>"journal", "authors"=>[{"first_name"=>"Haili", "last_name"=>"Zhu", "scopus_author_id"=>"56094887300"}, {"first_name"=>"Jiming", "last_name"=>"Bao", "scopus_author_id"=>"7201398454"}, {"first_name"=>"Shuguang", "last_name"=>"Liu", "scopus_author_id"=>"37000005800"}, {"first_name"=>"Qing", "last_name"=>"Chen", "scopus_author_id"=>"35602829700"}, {"first_name"=>"Hong Shen", "last_name"=>"Shen", "scopus_author_id"=>"57188632413"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"25208225", "isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0106761", "issn"=>"19326203", "scopus"=>"2-s2.0-84921412958", "pui"=>"608993989", "sgr"=>"84921412958"}, "id"=>"0d431c1b-abc2-34d0-8058-13b6ef4a5826", "abstract"=>"Endometriosis is one of the most frequent benign gynecological disorders. Numerous studies have shown an association between GSTM1 and/or GSTT1 polymorphisms and endometriosis susceptibility. However, these associations remain inconclusive. To derive a more precise estimation, we conducted a comprehensive search to identify all existing studies and then performed a meta-analysis. Electronic literature searches of the PubMed, Chinese Biomedical, and China National Knowledge Infrastructure databases were performed up to December 2013. GSTM1-, GSTT1-, and dual-null genotypes were analyzed independently, and pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated by comparing the null genotype with other genotypes using the random-effects or fixed-effects model. Twenty-five and 16 independent studies on GSTM1 and GSTT1 polymorphisms, respectively, and five GSTM1-GSTT1 interaction analyses were identified and included in this meta-analysis. Both GSTM1- and GSTT1-null genotypes increased risk of endometriosis (OR = 1.54, 95% CI: 1.30-1.83, P<0.001; OR = 1.41, 95% CI: 1.10-1.82, P = 0.007; respectively). Moreover, we found a significant positive association between the dual null genotype GSTM1-GSTT1 and endometriosis susceptibility (OR = 1.33, 95% CI: 1.03-1.72, P = 0.027). This meta-analysis provides evidence that null genotypes of GSTM1 and/or GSTT1 contribute to risk of endometriosis. Further investigations are required to confirm these findings.", "link"=>"http://www.mendeley.com/research/null-genotypes-gstm1-gstt1-endometriosis-risk-metaanalysis-25-casecontrol-studies", "reader_count"=>8, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Bachelor"=>2, "Student > Postgraduate"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Bachelor"=>2, "Student > Postgraduate"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>2, "Social Sciences"=>1, "Computer Science"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Computer Science"=>{"Computer Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1669115"], "description"=>"<p>Abbreviations: PB, population-based; HB, hospital-based.</p><p>Characteristics of studies included in the meta-analysis.</p>", "links"=>[], "tags"=>["GSTT 1 polymorphisms", "association", "or", "endometriosis susceptibility", "Electronic literature searches", "genotype", "ci", "GSTM 1", "China National Knowledge Infrastructure databases"], "article_id"=>1166839, "categories"=>["Biological Sciences"], "users"=>["Haili Zhu", "Jiming Bao", "Shuguang Liu", "Qing Chen", "Hong Shen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0106761.t001", "stats"=>{"downloads"=>4, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_studies_included_in_the_meta_analysis_/1166839", "title"=>"Characteristics of studies included in the meta-analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-09-10 02:52:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1669116"], "description"=>"<p>Abbreviations: OR, odds ratio; CI, confidence interval; BS, based on score (studies with quality scores <7 were excluded); PB, population-based; HB, hospital-based; F, fixed-effects model; R, random-effects model.</p><p>Meta-analysis of associations between <i>GSTM1</i>, <i>GSTT1,</i> and <i>GSTM1-GSTT1</i> polymorphisms and endometriosis.</p>", "links"=>[], "tags"=>["GSTT 1 polymorphisms", "association", "or", "endometriosis susceptibility", "Electronic literature searches", "genotype", "ci", "GSTM 1", "China National Knowledge Infrastructure databases"], "article_id"=>1166840, "categories"=>["Biological Sciences"], "users"=>["Haili Zhu", "Jiming Bao", "Shuguang Liu", "Qing Chen", "Hong Shen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0106761.t002", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Meta_analysis_of_associations_between_GSTM1_GSTT1_and_GSTM1_GSTT1_polymorphisms_and_endometriosis_/1166840", "title"=>"Meta-analysis of associations between <i>GSTM1</i>, <i>GSTT1,</i> and <i>GSTM1-GSTT1</i> polymorphisms and endometriosis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-09-10 02:52:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/1669117"], "description"=>"<div><p>Endometriosis is one of the most frequent benign gynecological disorders. Numerous studies have shown an association between <i>GSTM1</i> and/or <i>GSTT1</i> polymorphisms and endometriosis susceptibility. However, these associations remain inconclusive. To derive a more precise estimation, we conducted a comprehensive search to identify all existing studies and then performed a meta-analysis. Electronic literature searches of the PubMed, Chinese Biomedical, and China National Knowledge Infrastructure databases were performed up to December 2013. <i>GSTM1-</i>, <i>GSTT1-</i>, and dual-null genotypes were analyzed independently, and pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated by comparing the null genotype with other genotypes using the random-effects or fixed-effects model. Twenty-five and 16 independent studies on <i>GSTM1</i> and <i>GSTT1</i> polymorphisms, respectively, and five <i>GSTM1-GSTT1</i> interaction analyses were identified and included in this meta-analysis. Both <i>GSTM1-</i> and <i>GSTT1-</i>null genotypes increased risk of endometriosis (OR = 1.54, 95% CI: 1.30–1.83, <i>P</i><0.001; OR = 1.41, 95% CI: 1.10–1.82, <i>P</i> = 0.007; respectively). Moreover, we found a significant positive association between the dual null genotype <i>GSTM1-GSTT1</i> and endometriosis susceptibility (OR = 1.33, 95% CI: 1.03–1.72, <i>P</i> = 0.027). This meta-analysis provides evidence that null genotypes of <i>GSTM1</i> and/or <i>GSTT1</i> contribute to risk of endometriosis. Further investigations are required to confirm these findings.</p></div>", "links"=>[], "tags"=>["GSTT 1 polymorphisms", "association", "or", "endometriosis susceptibility", "Electronic literature searches", "genotype", "ci", "GSTM 1", "China National Knowledge Infrastructure databases"], "article_id"=>1166841, "categories"=>["Biological Sciences"], "users"=>["Haili Zhu", "Jiming Bao", "Shuguang Liu", "Qing Chen", "Hong Shen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0106761", "stats"=>{"downloads"=>6, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Null_Genotypes_of_GSTM1_and_GSTT1_and_Endometriosis_Risk_A_Meta_Analysis_of_25_Case_Control_Studies/1166841", "title"=>"Null Genotypes of <i>GSTM1</i> and <i>GSTT1</i> and Endometriosis Risk: A Meta-Analysis of 25 Case-Control Studies", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-09-10 02:52:13"}

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