Three Months of High-Fructose Feeding Fails to Induce Excessive Weight Gain or Leptin Resistance in Mice
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{"title"=>"Three months of high-fructose feeding fails to induce excessive weight gain or leptin resistance in mice", "type"=>"journal", "authors"=>[{"first_name"=>"Erik J.", "last_name"=>"Tillman", "scopus_author_id"=>"13607247500"}, {"first_name"=>"Donald A.", "last_name"=>"Morgan", "scopus_author_id"=>"7403986084"}, {"first_name"=>"Kamal", "last_name"=>"Rahmouni", "scopus_author_id"=>"7003780122"}, {"first_name"=>"Steven J.", "last_name"=>"Swoap", "scopus_author_id"=>"6701588808"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"608759167", "sgr"=>"84924172288", "issn"=>"19326203", "pmid"=>"25211467", "scopus"=>"2-s2.0-84924172288", "doi"=>"10.1371/journal.pone.0107206", "isbn"=>"1932-6203"}, "id"=>"e1858c34-b98e-3788-ba1b-b84632b6db63", "abstract"=>"High-fructose diets have been implicated in obesity via impairment of leptin signaling in humans and rodents. We investigated whether fructose-induced leptin resistance in mice could be used to study the metabolic consequences of fructose consumption in humans, particularly in children and adolescents. Male C57Bl/6 mice were weaned to a randomly assigned diet: high fructose, high sucrose, high fat, or control (sugar-free, low-fat). Mice were maintained on their diets for at least 14 weeks. While fructose-fed mice regularly consumed more kcal and expended more energy, there was no difference in body weight compared to control by the end of the study. Additionally, after 14 weeks, both fructose-fed and control mice displayed similar leptin sensitivity. Fructose-feeding also did not change circulating glucose, triglycerides, or free fatty acids. Though fructose has been linked to obesity in several animal models, our data fail to support a role for fructose intake through food lasting 3 months in altering of body weight and leptin signaling in mice. The lack of impact of fructose in the food of growing mice on either body weight or leptin sensitivity over this time frame was surprising, and important information for researchers interested in fructose and body weight regulation.", "link"=>"http://www.mendeley.com/research/three-months-highfructose-feeding-fails-induce-excessive-weight-gain-leptin-resistance-mice", "reader_count"=>50, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>9, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>3, "Student > Master"=>7, "Other"=>5, "Student > Bachelor"=>12, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>9, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>3, "Student > Master"=>7, "Other"=>5, "Student > Bachelor"=>12, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>5, "Nursing and Health Professions"=>2, "Materials Science"=>1, "Agricultural and Biological Sciences"=>21, "Medicine and Dentistry"=>12, "Neuroscience"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Business, Management and Accounting"=>2, "Chemistry"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Neuroscience"=>{"Neuroscience"=>3}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>21}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Austria"=>1, "Netherlands"=>1, "Romania"=>1, "Cyprus"=>1, "United States"=>1, "Mexico"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1672261"], "description"=>"<p>Male C57Bl/6J mice were fed a high fat (n = 56), high sucrose (n = 82), high fructose (n = 64), or control (n = 48) diet. The body weight of only the high-fat fed mice was significantly different from control-fed mice throughout the duration of the experiment (*p<0.05 vs. control diet and vs. high fructose diet and vs. high sucrose diet; #p<0.05 vs. control diet and vs. high sucrose diet).</p>", "links"=>[], "tags"=>["Body weight", "leptin sensitivity", "Induce Excessive Weight Gain", "Body Weight Regulation", "14 weeks", "diet", "fructose", "Male C 57Bl mice"], "article_id"=>1167689, "categories"=>["Uncategorised"], "users"=>["Erik J. Tillman", "Donald A. Morgan", "Kamal Rahmouni", "Steven J. Swoap"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0107206.g004", "stats"=>{"downloads"=>5, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_High_fat_feeding_but_not_high_fructose_feeding_increases_body_weight_in_C57Bl_6J_mice_/1167689", "title"=>"High-fat-feeding, but not high-fructose-feeding, increases body weight in C57Bl/6J mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-11 02:43:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1672262"], "description"=>"<p>Fed plasma glucose, triglyceride, and free fatty acid concentrations.</p>", "links"=>[], "tags"=>["Body weight", "leptin sensitivity", "Induce Excessive Weight Gain", "Body Weight Regulation", "14 weeks", "diet", "fructose", "Male C 57Bl mice"], "article_id"=>1167690, "categories"=>["Uncategorised"], "users"=>["Erik J. Tillman", "Donald A. Morgan", "Kamal Rahmouni", "Steven J. Swoap"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0107206.t001", "stats"=>{"downloads"=>5, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fed_plasma_glucose_triglyceride_and_free_fatty_acid_concentrations_/1167690", "title"=>"Fed plasma glucose, triglyceride, and free fatty acid concentrations.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-09-11 02:43:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1672259"], "description"=>"<p>Leptin injection leads to decreased food intake in both control-fed and fructose-fed mice compared to injection of vehicle over 6 and 24 hours, and returns to normal after 24 hours (*p<0.05 vs. the same diet and same time point with injection of vehicle; ◊p = 0.053 vs. 60% fructose). The first time point is a 24-hour average of the two days prior to the injection. Later time points are total caloric intake over indicated time interval after injection.</p>", "links"=>[], "tags"=>["Body weight", "leptin sensitivity", "Induce Excessive Weight Gain", "Body Weight Regulation", "14 weeks", "diet", "fructose", "Male C 57Bl mice"], "article_id"=>1167687, "categories"=>["Uncategorised"], "users"=>["Erik J. Tillman", "Donald A. Morgan", "Kamal Rahmouni", "Steven J. Swoap"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0107206.g003", "stats"=>{"downloads"=>2, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Persistence_of_leptin_sensitivity_in_fructose_fed_mice_/1167687", "title"=>"Persistence of leptin sensitivity in fructose-fed mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-11 02:43:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1672256"], "description"=>"<p>A) Representative comparison of metabolic rates between high-fructose-fed (n = 7) and control-fed (n = 7) mice, week 9. Each data point represents a condensed 40-minute average for all the mice in that feeding group. The dark (active) phase—denoted by the black bar—spans hours 0–12, and the light (inactive) phase, hours 12–23. B) Average light- and dark-phase metabolic rates throughout the study. In weeks 2 and 9, fructose-fed mice (n = 7) had elevated metabolic rates compared to control-fed mice (n = 7). This difference was not present in week 14 (*- p<0.05 vs. control diet for indicated week).</p>", "links"=>[], "tags"=>["Body weight", "leptin sensitivity", "Induce Excessive Weight Gain", "Body Weight Regulation", "14 weeks", "diet", "fructose", "Male C 57Bl mice"], "article_id"=>1167684, "categories"=>["Uncategorised"], "users"=>["Erik J. Tillman", "Donald A. Morgan", "Kamal Rahmouni", "Steven J. Swoap"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0107206.g002", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Differences_in_metabolic_rate_across_feeding_groups_/1167684", "title"=>"Differences in metabolic rate across feeding groups.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-11 02:43:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/1672251"], "description"=>"<p>A) Transient changes in body weight in response to a high fructose diet. Fructose-fed mice were significantly heavier than control-fed mice from weeks 2–7 (*p<0.05). From 8 weeks to 14 weeks on their respective diets, there was no statistical difference in body weight between control-fed (n = 19) and fructose-fed (n = 19) mice. B) Fructose-fed mice consumed more food on average daily than control-fed mice for all weeks except week 13 (*p<0.05). C) Elevated cumulative caloric intake of fructose-fed mice. Over the course of the 14 weeks, fructose-fed mice consumed more total kcal than control-fed mice (*p<0.05).</p>", "links"=>[], "tags"=>["Body weight", "leptin sensitivity", "Induce Excessive Weight Gain", "Body Weight Regulation", "14 weeks", "diet", "fructose", "Male C 57Bl mice"], "article_id"=>1167679, "categories"=>["Uncategorised"], "users"=>["Erik J. Tillman", "Donald A. Morgan", "Kamal Rahmouni", "Steven J. Swoap"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0107206.g001", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_High_fructose_feeding_does_not_increase_body_weight_despite_increased_caloric_intake_/1167679", "title"=>"High-fructose-feeding does not increase body weight despite increased caloric intake.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-11 02:43:48"}

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Relative Metric

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