A New Approach to Homeostatic Regulation: Towards a Unified View of Physiological and Ecological Concepts
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{"title"=>"A new approach to homeostatic regulation: Towards a unified view of physiological and ecological concepts", "type"=>"journal", "authors"=>[{"first_name"=>"Cédric L.", "last_name"=>"Meunier", "scopus_author_id"=>"35097632200"}, {"first_name"=>"Arne M.", "last_name"=>"Malzahn", "scopus_author_id"=>"7801326398"}, {"first_name"=>"Maarten", "last_name"=>"Boersma", "scopus_author_id"=>"7005849520"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84907572499", "sgr"=>"84907572499", "pui"=>"600067716", "isbn"=>"1932-6203", "pmid"=>"25247989", "doi"=>"10.1371/journal.pone.0107737"}, "id"=>"b8928b2a-1ad4-3e13-b63f-2289cdf6d230", "abstract"=>"Stoichiometric homeostasis is the ability of an organism to keep its body chemical composition constant, despite varying inputs. Stoichiometric homeostasis therefore constrains the metabolic needs of consumers which in turn often feed on resources not matching these requirements. In a broader context, homeostasis also relates to the capacity of an organism to maintain other biological parameters (e.g. body temperature) at a constant level over ambient environmental variations. Unfortunately, there are discrepancies in the literature and ecological and physiological definitions of homeostasis are disparate and partly contradictory. Here, we address this matter by reviewing the existing knowledge considering two distinct groups, regulators and conformers and, based on examples of thermo- and osmoregulation, we propose a new approach to stoichiometric homeostasis, unifying ecological and physiological concepts. We suggest a simple and precise graphical way to identify regulators and conformers: for any given biological parameter (e.g. nutrient stoichiometry, temperature), a sigmoidal relation between internal and external conditions can be observed for conformers while an inverse sigmoidal response is characteristic of regulators. This new definition and method, based on well-studied physiological mechanisms, unifies ecological and physiological approaches and is a useful tool for understanding how organisms are affected by and affect their environment.", "link"=>"http://www.mendeley.com/research/new-approach-homeostatic-regulation-towards-unified-view-physiological-ecological-concepts-5", "reader_count"=>39, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Student > Doctoral Student"=>4, "Researcher"=>11, "Student > Ph. D. Student"=>13, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Student > Doctoral Student"=>4, "Researcher"=>11, "Student > Ph. D. Student"=>13, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Environmental Science"=>11, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>17, "Medicine and Dentistry"=>1, "Immunology and Microbiology"=>1, "Earth and Planetary Sciences"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>17}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>5}, "Environmental Science"=>{"Environmental Science"=>11}}, "reader_count_by_country"=>{"Sweden"=>1, "Romania"=>1, "United States"=>2, "Poland"=>1, "France"=>1, "Germany"=>2}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1687092"], "description"=>"<p>(A) Klausmeier et al. <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0107737#pone.0107737-Klausmeier1\" target=\"_blank\">[15]</a> model predicted phytoplankton N: P under three dilution (growth) rates. The solid line represents Rhee's <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0107737#pone.0107737-Rhee1\" target=\"_blank\">[36]</a> experimental setup, with dilution (growth) rate α = 0.59 d<sup>−1</sup>. The dashed and dotted lines represent higher dilution rates, α = 0.9 and α = 1.05 d<sup>−1</sup>, respectively. (B) Dependencies of the molar ratios of N:P of <i>Rhinomonas reticulata</i> cells at a range of inflow N:P ratios under high light (open symbols) and low light (filled symbols). The dashed-line represent the 1∶1 line and error bars represent standard deviation <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0107737#pone.0107737-Leonardos1\" target=\"_blank\">[17]</a>. Since this example is a clear case but there are only very few data points, the solid line is fitted by eye to the data.</p>", "links"=>[], "tags"=>["Unified View", "Homeostatic Regulation", "body chemical composition", "approach", "conformer", "parameter", "definition", "Stoichiometric homeostasis", "New Approach", "body temperature", "Ecological Concepts Stoichiometric homeostasis", "e.g", "sigmoidal response", "regulator", "sigmoidal relation", "organism"], "article_id"=>1179052, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Cédric L. Meunier", "Arne M. Malzahn", "Maarten Boersma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0107737.g003", "stats"=>{"downloads"=>1, "page_views"=>33, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Equilibrium_phytoplankton_stoichiometry_as_a_function_of_nutrient_supply_stoichiometry_in_chemostats_/1179052", "title"=>"Equilibrium phytoplankton stoichiometry as a function of nutrient supply stoichiometry in chemostats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-23 03:17:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/1687100"], "description"=>"<p>(A) Relationship of body temperature of the toad <i>Odontophrynus occidentalis</i> and substrate temperature in the dry season <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0107737#pone.0107737-Sanabria1\" target=\"_blank\">[21]</a>. (B) Relationship between torpid subcutaneous temperature in the pichi <i>Zaedyus pichiy</i> and burrow temperature, estimated as the average temperature measured 1 m aboveground for the previous 10 days <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0107737#pone.0107737-Superina1\" target=\"_blank\">[23]</a>. Dashed lines represent 1∶1 lines and solid lines represent threesegments piecewise regressions applied to the data. R-square and p-values are shown on the plot. The ΔAIC (16.68 and 16.58) indicated that piecewise regressions fit better the data than a straight line.</p>", "links"=>[], "tags"=>["Unified View", "Homeostatic Regulation", "body chemical composition", "approach", "conformer", "parameter", "definition", "Stoichiometric homeostasis", "New Approach", "body temperature", "Ecological Concepts Stoichiometric homeostasis", "e.g", "sigmoidal response", "regulator", "sigmoidal relation", "organism"], "article_id"=>1179061, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Cédric L. Meunier", "Arne M. Malzahn", "Maarten Boersma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0107737.g006", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relationship_between_organismal_temperature_and_external_temperature_/1179061", "title"=>"Relationship between organismal temperature and external temperature.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-23 03:17:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/1687087"], "description"=>"<p>Horizontal and vertical axes are any single stoichiometric measure, such as N:P ratio. Dashed lines represent no homeostasis, i.e. a constant change of consumer's stoichiometry proportional to the resource stoichiometry. Continuous lines represent strict homeostasis. Sterner and Elser <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0107737#pone.0107737-Sterner1\" target=\"_blank\">[2]</a> defined that for an arbitrary point x, y in a plot of consumer versus resource stoichiometry, homeostatic regulation of nutrient content x, y can be diagnosed as a slope less than x/y, down to an expected lower limit of zero.</p>", "links"=>[], "tags"=>["Unified View", "Homeostatic Regulation", "body chemical composition", "approach", "conformer", "parameter", "definition", "Stoichiometric homeostasis", "New Approach", "body temperature", "Ecological Concepts Stoichiometric homeostasis", "e.g", "sigmoidal response", "regulator", "sigmoidal relation", "organism"], "article_id"=>1179046, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Cédric L. Meunier", "Arne M. Malzahn", "Maarten Boersma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0107737.g001", "stats"=>{"downloads"=>0, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Generalized_stoichiometric_patterns_relating_consumer_stoichiometry_to_resource_stoichiometry_2_modified_/1179046", "title"=>"Generalized stoichiometric patterns relating consumer stoichiometry to resource stoichiometry ([2], modified).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-23 03:17:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/1687096"], "description"=>"<p>Data represent means and error bars represent standard deviation of five observations <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0107737#pone.0107737-apucki1\" target=\"_blank\">[20]</a>. The dashed line represents the 1∶1 isosmotic line. The solid line represents the three segments piecewise regression applied to the data. R-square and p-value are shown on the plot. Although the ΔAIC (−10.20) indicated that a straight linear regression fits better the data than a piecewise regression, the residuals are not distributed homogenously around the line. We therefore plotted the piecewise regression.</p>", "links"=>[], "tags"=>["Unified View", "Homeostatic Regulation", "body chemical composition", "approach", "conformer", "parameter", "definition", "Stoichiometric homeostasis", "New Approach", "body temperature", "Ecological Concepts Stoichiometric homeostasis", "e.g", "sigmoidal response", "regulator", "sigmoidal relation", "organism"], "article_id"=>1179056, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Cédric L. Meunier", "Arne M. Malzahn", "Maarten Boersma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0107737.g005", "stats"=>{"downloads"=>0, "page_views"=>35, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Haemolymph_osmolality_of_the_isopod_Idotea_chelipes_in_relation_to_the_medium_osmolality_/1179056", "title"=>"Haemolymph osmolality of the isopod <i>Idotea chelipes</i> in relation to the medium osmolality.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-23 03:17:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/1687094"], "description"=>"<p>The dashed line represents the 1∶1 line. The dashed-dotted line represents the linear regression (the equation is indicated in the graph) used by Sterner and Elser <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0107737#pone.0107737-Sterner1\" target=\"_blank\">[2]</a>. The solid line represents the three segments piecewise regression applied to the data. R-square and p-value are shown on the plot. Although the ΔAIC (−2.27) indicated that a straight linear regression fits better the data than a piecewise regression, the residuals are not distributed homogenously around the line. We therefore plotted the piecewise regression.</p>", "links"=>[], "tags"=>["Unified View", "Homeostatic Regulation", "body chemical composition", "approach", "conformer", "parameter", "definition", "Stoichiometric homeostasis", "New Approach", "body temperature", "Ecological Concepts Stoichiometric homeostasis", "e.g", "sigmoidal response", "regulator", "sigmoidal relation", "organism"], "article_id"=>1179054, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Cédric L. Meunier", "Arne M. Malzahn", "Maarten Boersma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0107737.g004", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_N_C_of_the_fungus_Polyporus_versicolor_as_a_function_of_medium_N_C_data_from_Levi_and_Cowling_19_/1179054", "title"=>"N:C of the fungus <i>Polyporus versicolor</i> as a function of medium N:C, data from Levi and Cowling [19].", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-23 03:17:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/1687091"], "description"=>"<p>Regulators maintain their internal composition stable for a certain range of environmental conditions. The homeostasis strength of an organism is defined by the magnitude of the range of environmental conditions over which the internal milieu of the consumer remains stable. Conformers allow the environment to determine their internal composition for a certain range of environmental conditions.</p>", "links"=>[], "tags"=>["Unified View", "Homeostatic Regulation", "body chemical composition", "approach", "conformer", "parameter", "definition", "Stoichiometric homeostasis", "New Approach", "body temperature", "Ecological Concepts Stoichiometric homeostasis", "e.g", "sigmoidal response", "regulator", "sigmoidal relation", "organism"], "article_id"=>1179051, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Cédric L. Meunier", "Arne M. Malzahn", "Maarten Boersma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0107737.g002", "stats"=>{"downloads"=>0, "page_views"=>28, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Generalized_homeostasis_patterns_relating_organisms_internal_conditions_to_external_conditions_/1179051", "title"=>"Generalized homeostasis patterns relating organisms internal conditions to external conditions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-23 03:17:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/1687103"], "description"=>"<p>(A) Zinc content in zooplankton and tripton in lakes <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0107737#pone.0107737-Zauke1\" target=\"_blank\">[29]</a>. The dashed line represents the 1∶1 line and the black line is fitted by eye to the data due to the very low number of data points. (B) C:N of the dinoflagellate <i>Oxyrrhis marina</i> as a function of its prey <i>Rhodomonas salina</i> C:N (unpublished data from Meunier et al.). The dashed line represents the 1∶1 line. Solid lines represent the three segments piecewise regression applied to the data. R-square and p-value are shown on the plot. The ΔAIC (23.97) indicated that a piecewise regression fits better the data than a straight line.</p>", "links"=>[], "tags"=>["Unified View", "Homeostatic Regulation", "body chemical composition", "approach", "conformer", "parameter", "definition", "Stoichiometric homeostasis", "New Approach", "body temperature", "Ecological Concepts Stoichiometric homeostasis", "e.g", "sigmoidal response", "regulator", "sigmoidal relation", "organism"], "article_id"=>1179064, "categories"=>["Biological Sciences", "Ecology"], "users"=>["Cédric L. Meunier", "Arne M. Malzahn", "Maarten Boersma"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0107737.g007", "stats"=>{"downloads"=>3, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relationship_between_consumer_and_resource_nutrient_content_/1179064", "title"=>"Relationship between consumer and resource nutrient content.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-23 03:17:17"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Nutrition", "average_usage"=>[289]}, {"subject_area"=>"/Biology and life sciences/Organisms", "average_usage"=>[310]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[280]}, {"subject_area"=>"/Medicine and health sciences/Nutrition", "average_usage"=>[285]}, {"subject_area"=>"/Physical sciences", "average_usage"=>[271]}]}
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