Worldwide Occurrence of Integrative Conjugative Element Encoding Multidrug Resistance Determinants in Epidemic Vibrio cholerae O1
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{"title"=>"Worldwide occurrence of integrative conjugative element encoding multidrug resistance determinants in epidemic vibrio cholerae O1", "type"=>"journal", "authors"=>[{"first_name"=>"Michel A.", "last_name"=>"Marin", "scopus_author_id"=>"50161970000"}, {"first_name"=>"Erica L.", "last_name"=>"Fonseca", "scopus_author_id"=>"8413092300"}, {"first_name"=>"Bruno N.", "last_name"=>"Andrade", "scopus_author_id"=>"56872631700"}, {"first_name"=>"Adriana C.", "last_name"=>"Cabral", "scopus_author_id"=>"56819291200"}, {"first_name"=>"Ana Carolina P.", "last_name"=>"Vicente", "scopus_author_id"=>"56570781300"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84942465718", "pui"=>"608758767", "doi"=>"10.1371/journal.pone.0108728", "pmid"=>"25265418", "scopus"=>"2-s2.0-84942465718", "issn"=>"19326203", "isbn"=>"1932-6203"}, "id"=>"3567d6a8-0c7c-33c5-a7bc-5bade843057a", "abstract"=>"In the last decades, there has been an increase of cholera epidemics caused by multidrug resistant strains. Particularly, the integrative and conjugative element (ICE) seems to play a major role in the emergence of multidrug resistant Vibrio cholerae. This study fully characterized, by whole genome sequencing, new ICEs carried by multidrug resistant V. cholerae O1 strains from Nigeria (2010) (ICEVchNig1) and Nepal (1994) (ICEVchNep1). The gene content and gene order of these two ICEs are the same, and identical to ICEVchInd5, ICEVchBan5 and ICEVchHai1 previously identified in multidrug resistant V. cholerae O1. This ICE is characterized by dfrA1, sul2, strAB and floR antimicrobial resistance genes, and by unique gene content in HS4 and HS5 ICE regions. Screening for ICEs, in publicly available V. cholerae genomes, revealed the occurrence and widespread distribution of this ICE among V. cholerae O1. Metagenomic analysis found segments of this ICE in marine environments far from the direct influence of the cholera epidemic. Therefore, this study revealed the epidemiology of a spatio-temporal prevalent ICE in V. cholerae O1. Its occurrence and dispersion in V. cholerae O1 strains from different continents throughout more than two decades can be indicative of its role in the fitness of the current pandemic lineage.", "link"=>"http://www.mendeley.com/research/worldwide-occurrence-integrative-conjugative-element-encoding-multidrug-resistance-determinants-epid", "reader_count"=>21, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>3, "Student > Master"=>7, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>3, "Student > Master"=>7, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Environmental Science"=>2, "Nursing and Health Professions"=>2, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>9, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Environmental Science"=>{"Environmental Science"=>2}}, "reader_count_by_country"=>{"Brazil"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1695001"], "description"=>"a<p>AAM, Antatic Aquatic Metagenome.</p>b<p>GOS, Global Ocean Sampling Expedition.</p><p>BLAST search results using HS4 and HS5 ORFs from the group 1 ICE in metagenomic datasets.</p>", "links"=>[], "tags"=>["cholerae O 1.", "floR antimicrobial resistance genes", "cholerae O 1. Metagenomic analysis", "gene content", "multidrug", "Integrative Conjugative Element Encoding Multidrug Resistance Determinants", "cholerae O 1 strains", "Epidemic Vibrio cholerae O 1", "HS 5 ICE regions"], "article_id"=>1185864, "categories"=>["Biological Sciences"], "users"=>["Michel A. Marin", "Erica L. Fonseca", "Bruno N. Andrade", "Adriana C. Cabral", "Ana Carolina P. Vicente"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0108728.t002", "stats"=>{"downloads"=>2, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_BLAST_search_results_using_HS4_and_HS5_ORFs_from_the_group_1_ICE_in_metagenomic_datasets_/1185864", "title"=>"BLAST search results using HS4 and HS5 ORFs from the group 1 ICE in metagenomic datasets.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-09-29 02:47:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1694999"], "description"=>"<p>(A) The upper line represents the genetic organization of the 2010 Nigeria <i>V. cholerae</i> O1 ICE (Group 1). Regions of variability among previously sequenced ICEs (variable regions), and previously identified hotspots of homologous recombination (HS1–HS5) are indicated in light green shading. The core and dispensable genes are indicated by gray and cream arrows, respectively. Unique genes of type 1, 2 and 3 groups are indicated in red, blue and green arrows, respectively. Genes associated with antimicrobial drug resistance <i>floR</i> (chloramphenicol), <i>strAB</i> (streptomycin), <i>sul2</i> (sulfamethoxazole), and <i>dfrA1</i>/<i>dhfR18</i> (trimethoprim) are written in red. The ICE group 1 have the same structure and gene content in ICE<i>Vch</i>Ind5, ICE<i>Vch</i>Ban5, ICE<i>Vch</i>Nig1 and ICE<i>Vch</i>Nep1; similar occurs with group 2 (including ICE<i>Vch</i>Ban9 and ICE<i>Vch</i>Moz10), and group 3 (including ICE<i>Vch</i>Ind4 and SXT<sup>MO10</sup>) have the same gene content and structure. (B) Spatial distribution of ICEs siblings found in epidemic <i>V. cholerae</i>. The circles are proportional to abundance found in epidemic <i>V. cholerae</i> genomes and the colors are accord to ICE group. The metagenome sites where were obtained BLAST hits are depicted.</p>", "links"=>[], "tags"=>["cholerae O 1.", "floR antimicrobial resistance genes", "cholerae O 1. Metagenomic analysis", "gene content", "multidrug", "Integrative Conjugative Element Encoding Multidrug Resistance Determinants", "cholerae O 1 strains", "Epidemic Vibrio cholerae O 1", "HS 5 ICE regions"], "article_id"=>1185862, "categories"=>["Biological Sciences"], "users"=>["Michel A. Marin", "Erica L. Fonseca", "Bruno N. Andrade", "Adriana C. Cabral", "Ana Carolina P. Vicente"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0108728.g001", "stats"=>{"downloads"=>1, "page_views"=>31, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Structure_and_worldwide_distribution_of_Integrative_and_Conjugative_Elements_ICEs_in_epidemic_V_cholerae_strains_/1185862", "title"=>"Structure and worldwide distribution of Integrative and Conjugative Elements (ICEs) in epidemic <i>V. cholerae</i> strains.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-09-29 02:47:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1695009", "https://ndownloader.figshare.com/files/1695010"], "description"=>"<div><p>In the last decades, there has been an increase of cholera epidemics caused by multidrug resistant strains. Particularly, the integrative and conjugative element (ICE) seems to play a major role in the emergence of multidrug resistant <i>Vibrio cholerae</i>. This study fully characterized, by whole genome sequencing, new ICEs carried by multidrug resistant <i>V. cholerae</i> O1 strains from Nigeria (2010) (ICE<i>Vch</i>Nig1) and Nepal (1994) (ICE<i>Vch</i>Nep1). The gene content and gene order of these two ICEs are the same, and identical to ICE<i>Vch</i>Ind5, ICE<i>Vch</i>Ban5 and ICE<i>Vch</i>Hai1 previously identified in multidrug resistant <i>V. cholerae</i> O1. This ICE is characterized by <i>dfrA1</i>, <i>sul2</i>, <i>strAB</i> and <i>floR</i> antimicrobial resistance genes, and by unique gene content in HS4 and HS5 ICE regions. Screening for ICEs, in publicly available <i>V. cholerae</i> genomes, revealed the occurrence and widespread distribution of this ICE among <i>V. cholerae</i> O1. Metagenomic analysis found segments of this ICE in marine environments far from the direct influence of the cholera epidemic. Therefore, this study revealed the epidemiology of a spatio-temporal prevalent ICE in <i>V. cholerae</i> O1. Its occurrence and dispersion in <i>V. cholerae</i> O1 strains from different continents throughout more than two decades can be indicative of its role in the fitness of the current pandemic lineage.</p></div>", "links"=>[], "tags"=>["cholerae O 1.", "floR antimicrobial resistance genes", "cholerae O 1. Metagenomic analysis", "gene content", "multidrug", "Integrative Conjugative Element Encoding Multidrug Resistance Determinants", "cholerae O 1 strains", "Epidemic Vibrio cholerae O 1", "HS 5 ICE regions"], "article_id"=>1185866, "categories"=>["Biological Sciences"], "users"=>["Michel A. Marin", "Erica L. Fonseca", "Bruno N. Andrade", "Adriana C. Cabral", "Ana Carolina P. Vicente"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0108728.s001", "https://dx.doi.org/10.1371/journal.pone.0108728.s002"], "stats"=>{"downloads"=>9, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Worldwide_Occurrence_of_Integrative_Conjugative_Element_Encoding_Multidrug_Resistance_Determinants_in_Epidemic_Vibrio_cholerae_O1/1185866", "title"=>"Worldwide Occurrence of Integrative Conjugative Element Encoding Multidrug Resistance Determinants in Epidemic <i>Vibrio cholerae</i> O1", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-09-29 02:47:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/1695000"], "description"=>"a<p><i>dfrA1</i> is absent in ICE<i>Vch</i>Moz10;</p>b<p><i>dfrA18</i> is absent in ICE<i>Vch</i>Ind4;</p><p>NA, not available.</p><p>Groups of integrative and conjugative elements with similar gene content found in epidemic <i>V. cholerae</i> O1.</p>", "links"=>[], "tags"=>["cholerae O 1.", "floR antimicrobial resistance genes", "cholerae O 1. Metagenomic analysis", "gene content", "multidrug", "Integrative Conjugative Element Encoding Multidrug Resistance Determinants", "cholerae O 1 strains", "Epidemic Vibrio cholerae O 1", "HS 5 ICE regions"], "article_id"=>1185863, "categories"=>["Biological Sciences"], "users"=>["Michel A. Marin", "Erica L. Fonseca", "Bruno N. Andrade", "Adriana C. Cabral", "Ana Carolina P. Vicente"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0108728.t001", "stats"=>{"downloads"=>5, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Groups_of_integrative_and_conjugative_elements_with_similar_gene_content_found_in_epidemic_V_cholerae_O1_/1185863", "title"=>"Groups of integrative and conjugative elements with similar gene content found in epidemic <i>V. cholerae</i> O1.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-09-29 02:47:01"}

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Relative Metric

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