Spontaneous Brain Activity in Type 2 Diabetics Revealed by Amplitude of Low-Frequency Fluctuations and Its Association with Diabetic Vascular Disease: A Resting-State fMRI Study
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{"title"=>"Spontaneous brain activity in type 2 diabetics revealed by amplitude of low-frequency fluctuations and its association with diabetic vascular disease: A resting-state fMRI study", "type"=>"journal", "authors"=>[{"first_name"=>"Chun Xia", "last_name"=>"Wang", "scopus_author_id"=>"55957433500"}, {"first_name"=>"Kai Liang", "last_name"=>"Fu", "scopus_author_id"=>"55206528300"}, {"first_name"=>"Huai Jun", "last_name"=>"Liu", "scopus_author_id"=>"23470196700"}, {"first_name"=>"Fei", "last_name"=>"Xing", "scopus_author_id"=>"56362752400"}, {"first_name"=>"Song Yun", "last_name"=>"Zhang", "scopus_author_id"=>"37073703400"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84907528116", "doi"=>"10.1371/journal.pone.0108883", "pui"=>"600087117", "issn"=>"19326203", "pmid"=>"25272033", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "scopus"=>"2-s2.0-84907528116"}, "id"=>"80279b90-a9a1-346c-b397-e8ff737ef7fd", "abstract"=>"PURPOSE: To investigate correlations between altered spontaneous brain activity, diabetic vascular disease, and cognitive function for patients with type 2 diabetes mellitus (T2DM) using resting-state functional magnetic resonance imaging (rs-fMRI).\\n\\nMETHODS: Rs-fMRI was performed for T2DM patients (n = 26) and age-, gender-, and education-matched non-diabetic control subjects (n = 26). Amplitude of low frequency fluctuations (ALFF) were computed from fMRI signals to measure spontaneous neuronal activity. Differences in the ALFF patterns between patients and controls, as well as their correlations with clinical variables, were evaluated.\\n\\nRESULTS: Compared with healthy controls, T2DM patients exhibited significantly decreased ALFF values mainly in the frontal and parietal lobes, the bilateral thalumi, the posterior lobe of the cerebellum, and increased ALFF values mainly in the visual cortices. Furthermore, lower ALFF values in the left subcallosal gyrus correlated with lower ankle-brachial index values (r = 0.481, p = 0.020), while lower ALFF values in the bilateral medial prefrontal gyri correlated with higher urinary albumin-creatinine ratio (r =  -0.418, p = 0.047). In addition, most of the regions with increased ALFF values in the visual cortices were found to negatively correlate with MoCA scores.\\n\\nCONCLUSIONS: These results confirm that ALFF are altered in many brain regions in T2DM patients, and this is associated with the presence of diabetic vascular disease and poor cognitive performance. These findings may provide additional insight into the neurophysiological mechanisms that mediate T2DM-related cognitive dysfunction, and may also serve as a reference for future research.", "link"=>"http://www.mendeley.com/research/spontaneous-brain-activity-type-2-diabetics-revealed-amplitude-lowfrequency-fluctuations-association-3", "reader_count"=>4, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Other"=>1, "Student > Master"=>2}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Other"=>1, "Student > Master"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>1, "Neuroscience"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>1}, "Psychology"=>{"Psychology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1699806"], "description"=>"<p>ALFF patterns detected in T2DM patients (A) and healthy controls (B). <i>P</i><0.01, AlphaSim correction was applied using a minimum cluster size of 21 voxels. The underlying structure image is <i>Ch2</i> image.</p>", "links"=>[], "tags"=>["Spontaneous Brain Activity", "Type 2 Diabetics Revealed", "T 2DM patients", "medial prefrontal gyri", "type 2 diabetes mellitus", "T 2DM", "ALFF values", "Diabetic Vascular Disease", "MoCA scores.ConclusionsThese results"], "article_id"=>1189659, "categories"=>["Biological Sciences"], "users"=>["Chun-Xia Wang", "Kai-Liang Fu", "Huai-Jun Liu", "Fei Xing", "Song-Yun Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0108883.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Activation_ALFF_maps_using_one_sample_t_test_/1189659", "title"=>"Activation ALFF maps using one sample t-test.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-10-01 02:55:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1699807"], "description"=>"<p>(A) Regions of increased ALFF in T2DM patients. The visual network is indicated with green circles. (B) Regions of decreased ALFF in T2DM patients. The scatter-plot maps below show the correlations calculated between ALFF values for the clusters indicated with red arrows and indices of diabetic vascular disease (e.g., UACR and ABI). Note that the UACRs have been logarithm transformed. <i>P</i><0.05, AlphaSim correction was applied using a minimum cluster size of 46 voxels. The underlying structure image is <i>Ch2</i> image.</p>", "links"=>[], "tags"=>["Spontaneous Brain Activity", "Type 2 Diabetics Revealed", "T 2DM patients", "medial prefrontal gyri", "type 2 diabetes mellitus", "T 2DM", "ALFF values", "Diabetic Vascular Disease", "MoCA scores.ConclusionsThese results"], "article_id"=>1189660, "categories"=>["Biological Sciences"], "users"=>["Chun-Xia Wang", "Kai-Liang Fu", "Huai-Jun Liu", "Fei Xing", "Song-Yun Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0108883.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Altered_ALFF_in_T2DM_patients_compared_to_healthy_controls_/1189660", "title"=>"Altered ALFF in T2DM patients compared to healthy controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-10-01 02:55:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1699809"], "description"=>"<p>(A) Regions that negatively-correlated with MoCA scores in T2DM patients. Note that the visual cortex is indicated with green circles and these regions are highly consistent with the data shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0108883#pone-0108883-g001\" target=\"_blank\">Figure 1A</a>. (B) Regions that positively-correlated with MoCA scores in T2DM patients. <i>P</i><0.05, AlphaSim correction was applied using a minimum cluster size of 46 voxels. The underlying structure image is <i>Ch2</i> image.</p>", "links"=>[], "tags"=>["Spontaneous Brain Activity", "Type 2 Diabetics Revealed", "T 2DM patients", "medial prefrontal gyri", "type 2 diabetes mellitus", "T 2DM", "ALFF values", "Diabetic Vascular Disease", "MoCA scores.ConclusionsThese results"], "article_id"=>1189662, "categories"=>["Biological Sciences"], "users"=>["Chun-Xia Wang", "Kai-Liang Fu", "Huai-Jun Liu", "Fei Xing", "Song-Yun Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0108883.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Regions_of_ALFF_values_that_correlated_with_MoCA_scores_in_T2DM_patients_/1189662", "title"=>"Regions of ALFF values that correlated with MoCA scores in T2DM patients.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-10-01 02:55:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1699810"], "description"=>"<p>*Data are presented as the mean ± SD unless otherwise noted; ** <i>p</i><0.05.</p><p>T2DM, type 2 diabetes mellitus; BMI, body mass index; HbA1c, glycated hemoglobin; HOMA2-S%, homeostasis model assessment for insulin sensitivity; ABI, ankle-brachial index; UACR, urine albumin creatinine ratio; MMSE, Mini Mental State Exam; MoCA, Montreal Cognitive Assessment; CDT, clock drawing test; MRI, magnetic resonance imaging; SVD, small vessel disease; WMLs, white matter lesions (these were assessed in both hemispheres using the Wahlund age-related white matter changes scale <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0108883#pone.0108883-Wahlund1\" target=\"_blank\">[40]</a>).</p><p>Demographic, clinical, and cognitive characteristics of T2DM patients and healthy control subjects.<sup><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0108883#nt101\" target=\"_blank\">*</a></sup></p>", "links"=>[], "tags"=>["Spontaneous Brain Activity", "Type 2 Diabetics Revealed", "T 2DM patients", "medial prefrontal gyri", "type 2 diabetes mellitus", "T 2DM", "ALFF values", "Diabetic Vascular Disease", "MoCA scores.ConclusionsThese results"], "article_id"=>1189663, "categories"=>["Biological Sciences"], "users"=>["Chun-Xia Wang", "Kai-Liang Fu", "Huai-Jun Liu", "Fei Xing", "Song-Yun Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0108883.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_clinical_and_cognitive_characteristics_of_T2DM_patients_and_healthy_control_subjects_/1189663", "title"=>"Demographic, clinical, and cognitive characteristics of T2DM patients and healthy control subjects.<sup>*</sup>", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-10-01 02:55:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1699811"], "description"=>"<p>A corrected threshold of <i>p</i><0.05 was applied according to Monte Carlo simulations.</p><p>BA, Brodmann's area; MNI, Montreal Neurological Institute; L, left; R, right; NA, not applicable; B, bilateral.</p><p>Brain regions that showed significant differences in ALFF values for the T2DM group compared with the healthy control group.</p>", "links"=>[], "tags"=>["Spontaneous Brain Activity", "Type 2 Diabetics Revealed", "T 2DM patients", "medial prefrontal gyri", "type 2 diabetes mellitus", "T 2DM", "ALFF values", "Diabetic Vascular Disease", "MoCA scores.ConclusionsThese results"], "article_id"=>1189664, "categories"=>["Biological Sciences"], "users"=>["Chun-Xia Wang", "Kai-Liang Fu", "Huai-Jun Liu", "Fei Xing", "Song-Yun Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0108883.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Brain_regions_that_showed_significant_differences_in_ALFF_values_for_the_T2DM_group_compared_with_the_healthy_control_group_/1189664", "title"=>"Brain regions that showed significant differences in ALFF values for the T2DM group compared with the healthy control group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-10-01 02:55:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1699812"], "description"=>"<p>These analyses were controlled for patient age, gender, and education level, * <i>p<</i>0.05.</p><p>ABI, ankle-brachial index; UACR, urinary albumin creatinine ratio; MoCA, Montreal Cognitive Assessment; L, left; R, right; B, bilateral.</p><p>Partial correlations between the ALFF values of the survived clusters, the vascular variables evaluated, and the MoCA scores for the T2DM patients.</p>", "links"=>[], "tags"=>["Spontaneous Brain Activity", "Type 2 Diabetics Revealed", "T 2DM patients", "medial prefrontal gyri", "type 2 diabetes mellitus", "T 2DM", "ALFF values", "Diabetic Vascular Disease", "MoCA scores.ConclusionsThese results"], "article_id"=>1189665, "categories"=>["Biological Sciences"], "users"=>["Chun-Xia Wang", "Kai-Liang Fu", "Huai-Jun Liu", "Fei Xing", "Song-Yun Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0108883.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Partial_correlations_between_the_ALFF_values_of_the_survived_clusters_the_vascular_variables_evaluated_and_the_MoCA_scores_for_the_T2DM_patients_/1189665", "title"=>"Partial correlations between the ALFF values of the survived clusters, the vascular variables evaluated, and the MoCA scores for the T2DM patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-10-01 02:55:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/1699813"], "description"=>"<p>These analyses were controlled for patient age, gender, and education level. No significant correlations were observed in these analyses.</p><p>DM, diabetes mellitus; HbA1c, glycated hemoglobin; HOMA2-S%, homeostasis model assessment for insulin sensitivity; L, left; R, right; B, bilateral.</p><p>Partial correlations between the ALFF values of the survived clusters and the diabetic clinical variables examined for the T2DM patients.</p>", "links"=>[], "tags"=>["Spontaneous Brain Activity", "Type 2 Diabetics Revealed", "T 2DM patients", "medial prefrontal gyri", "type 2 diabetes mellitus", "T 2DM", "ALFF values", "Diabetic Vascular Disease", "MoCA scores.ConclusionsThese results"], "article_id"=>1189666, "categories"=>["Biological Sciences"], "users"=>["Chun-Xia Wang", "Kai-Liang Fu", "Huai-Jun Liu", "Fei Xing", "Song-Yun Zhang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0108883.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Partial_correlations_between_the_ALFF_values_of_the_survived_clusters_and_the_diabetic_clinical_variables_examined_for_the_T2DM_patients_/1189666", "title"=>"Partial correlations between the ALFF values of the survived clusters and the diabetic clinical variables examined for the T2DM patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-10-01 02:55:56"}
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