Teeth, Sex, and Testosterone: Aging in the World's Smallest Primate
Publication Date
October 29, 2014
Journal
PLOS ONE
Authors
Sarah Zohdy, Brian D. Gerber, Stacey Tecot, Marina B. Blanco, et al
Volume
9
Issue
10
Pages
e109528
DOI
https://dx.plos.org/10.1371/journal.pone.0109528
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0109528
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/25354041
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4212904
Europe PMC
http://europepmc.org/abstract/MED/25354041
Web of Science
000345204200011
Scopus
84908518538
Mendeley
http://www.mendeley.com/research/teeth-sex-testosterone-aging-worlds-smallest-primate
Events
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Mendeley | Further Information

{"title"=>"Teeth, sex, and testosterone: Aging in the world's smallest primate", "type"=>"journal", "authors"=>[{"first_name"=>"Sarah", "last_name"=>"Zohdy", "scopus_author_id"=>"36731932400"}, {"first_name"=>"Brian D.", "last_name"=>"Gerber", "scopus_author_id"=>"36104326900"}, {"first_name"=>"Stacey", "last_name"=>"Tecot", "scopus_author_id"=>"35504290700"}, {"first_name"=>"Marina B.", "last_name"=>"Blanco", "scopus_author_id"=>"23979616000"}, {"first_name"=>"Julia M.", "last_name"=>"Winchester", "scopus_author_id"=>"55223881000"}, {"first_name"=>"Patricia C.", "last_name"=>"Wright", "scopus_author_id"=>"7404315727"}, {"first_name"=>"Jukka", "last_name"=>"Jernvall", "scopus_author_id"=>"6603722003"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84908518538", "pmid"=>"25354041", "doi"=>"10.1371/journal.pone.0109528", "pui"=>"600310351", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84908518538"}, "id"=>"56d35a3b-7b40-39ad-b20d-944239142477", "abstract"=>"Mouse lemurs (Microcebus spp.) are an exciting new primate model for understanding human aging and disease. In captivity, Microcebus murinus develops human-like ailments of old age after five years (e.g., neurodegeneration analogous to Alzheimer's disease) but can live beyond 12 years. It is believed that wild Microcebus follow a similar pattern of senescence observed in captive animals, but that predation limits their lifespan to four years, thus preventing observance of these diseases in the wild. Testing whether this assumption is true is informative about both Microcebus natural history and environmental influences on senescence, leading to interpretation of findings for models of human aging. Additionally, the study of Microcebus longevity provides an opportunity to better understand mechanisms of sex-biased longevity. Longevity is often shorter in males of species with high male-male competition, such as Microcebus, but mouse lemurs are sexually monomorphic, suggesting similar lifespans. We collected individual-based observations of wild brown mouse lemurs (Microcebus rufus) from 2003-2010 to investigate sex-differences in survival and longevity. Fecal testosterone was measured as a potential mechanism of sex-based differences in survival. We used a combination of high-resolution tooth wear techniques, mark-recapture, and hormone enzyme immunoassays. We found no dental or physical signs of senescence in M. rufus as old as eight years (N = 189, ages 1-8, mean = 2.59 ± 1.63 SE), three years older than captive, senescent congeners (M. murinus). Unlike other polygynandrous vertebrates, we found no sex difference in age-dependent survival, nor sex or age differences in testosterone levels. While elevated male testosterone levels have been implicated in shorter lifespans in several species, this is one of the first studies to show equivalent testosterone levels accompanying equivalent lifespans. Future research on captive aged individuals can determine if senescence is partially a condition of their captive environment, and studies controlling for various environmental factors will further our understanding of senescence.", "link"=>"http://www.mendeley.com/research/teeth-sex-testosterone-aging-worlds-smallest-primate", "reader_count"=>31, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>9, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Researcher"=>9, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Environmental Science"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>16, "Medicine and Dentistry"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Social Sciences"=>1, "Earth and Planetary Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>16}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>5}, "Environmental Science"=>{"Environmental Science"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Finland"=>1, "South Africa"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/1771288"], "description"=>"<p>Summary of capture/recaptures and tests of population closure for <i>Microcebus rufus</i> capture history in October 2007–2010.</p>", "links"=>[], "tags"=>["longevity", "survival", "Microcebu", "senescence", "mouse lemurs", "hormone enzyme immunoassays", "testosterone levels", "show equivalent testosterone levels", "lifespan", "se", "Smallest Primate Mouse lemurs"], "article_id"=>1222502, "categories"=>["Biological Sciences"], "users"=>["Sarah Zohdy", "Brian D. Gerber", "Stacey Tecot", "Marina B. Blanco", "Julia M. Winchester", "Patricia C. Wright", "Jukka Jernvall"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0109528.t001", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_capture_recaptures_and_tests_of_population_closure_for_Microcebus_rufus_capture_history_in_October_2007_2010_/1222502", "title"=>"Summary of capture/recaptures and tests of population closure for <i>Microcebus rufus</i> capture history in October 2007–2010.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-10-29 03:31:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/1771286"], "description"=>"<p>A: Obliquely lingual view of tooth rows and dental orientation patch count (OPC) of a one year-old (top) and seven year-old (bottom); p = pre-molar, m = molar. The darker shading indicates wear. B: OPC by age. C: Tooth wear rates of individual males (solid lines) and females (dashed lines) captured four or more consecutive years.</p>", "links"=>[], "tags"=>["longevity", "survival", "Microcebu", "senescence", "mouse lemurs", "hormone enzyme immunoassays", "testosterone levels", "show equivalent testosterone levels", "lifespan", "se", "Smallest Primate Mouse lemurs"], "article_id"=>1222500, "categories"=>["Biological Sciences"], "users"=>["Sarah Zohdy", "Brian D. Gerber", "Stacey Tecot", "Marina B. Blanco", "Julia M. Winchester", "Patricia C. Wright", "Jukka Jernvall"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0109528.g001", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Aging_of_mouse_lemurs_using_high_resolution_tooth_wear_analysis_/1222500", "title"=>"Aging of mouse lemurs using high-resolution tooth wear analysis.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-10-29 03:31:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/1771289"], "description"=>"<div><p>Mouse lemurs (<i>Microcebus</i> spp.) are an exciting new primate model for understanding human aging and disease. In captivity, <i>Microcebus murinus</i> develops human-like ailments of old age after five years (e.g., neurodegeneration analogous to Alzheimer's disease) but can live beyond 12 years. It is believed that wild <i>Microcebus</i> follow a similar pattern of senescence observed in captive animals, but that predation limits their lifespan to four years, thus preventing observance of these diseases in the wild. Testing whether this assumption is true is informative about both <i>Microcebus</i> natural history and environmental influences on senescence, leading to interpretation of findings for models of human aging. Additionally, the study of <i>Microcebus</i> longevity provides an opportunity to better understand mechanisms of sex-biased longevity. Longevity is often shorter in males of species with high male-male competition, such as <i>Microcebus</i>, but mouse lemurs are sexually monomorphic, suggesting similar lifespans. We collected individual-based observations of wild brown mouse lemurs (<i>Microcebus rufus</i>) from 2003–2010 to investigate sex-differences in survival and longevity. Fecal testosterone was measured as a potential mechanism of sex-based differences in survival. We used a combination of high-resolution tooth wear techniques, mark-recapture, and hormone enzyme immunoassays. We found no dental or physical signs of senescence in <i>M. rufus</i> as old as eight years (N = 189, ages 1–8, mean = 2.59±1.63 SE), three years older than captive, senescent congeners (<i>M. murinus</i>). Unlike other polygynandrous vertebrates, we found no sex difference in age-dependent survival, nor sex or age differences in testosterone levels. While elevated male testosterone levels have been implicated in shorter lifespans in several species, this is one of the first studies to show equivalent testosterone levels accompanying equivalent lifespans. Future research on captive aged individuals can determine if senescence is partially a condition of their captive environment, and studies controlling for various environmental factors will further our understanding of senescence.</p></div>", "links"=>[], "tags"=>["longevity", "survival", "Microcebu", "senescence", "mouse lemurs", "hormone enzyme immunoassays", "testosterone levels", "show equivalent testosterone levels", "lifespan", "se", "Smallest Primate Mouse lemurs"], "article_id"=>1222503, "categories"=>["Biological Sciences"], "users"=>["Sarah Zohdy", "Brian D. Gerber", "Stacey Tecot", "Marina B. Blanco", "Julia M. Winchester", "Patricia C. Wright", "Jukka Jernvall"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0109528", "stats"=>{"downloads"=>4, "page_views"=>19, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Teeth_Sex_and_Testosterone_Aging_in_the_World_s_Smallest_Primate_/1222503", "title"=>"Teeth, Sex, and Testosterone: Aging in the World's Smallest Primate", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-10-29 03:31:36"}

PMC Usage Stats | Further Information

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Relative Metric

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