Perinatal Exposure to Bisphenol-A Impairs Spatial Memory through Upregulation of Neurexin1 and Neuroligin3 Expression in Male Mouse Brain
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{"title"=>"Perinatal exposure to bisphenol-A impairs spatial memory through upregulation of neurexin1 and neuroligin3 expression in male mouse brain", "type"=>"journal", "authors"=>[{"first_name"=>"Dhiraj", "last_name"=>"Kumar", "scopus_author_id"=>"57199657552"}, {"first_name"=>"Mahendra", "last_name"=>"Kumar Thakur", "scopus_author_id"=>"56392897200"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"600182973", "sgr"=>"84908133393", "issn"=>"19326203", "pmid"=>"25330104", "scopus"=>"2-s2.0-84908133393", "doi"=>"10.1371/journal.pone.0110482", "isbn"=>"1932-6203 (Electronic)"}, "id"=>"3c507ef7-187f-34fd-b359-b0cb16ea029f", "abstract"=>"Bisphenol-A (BPA), a well known endocrine disruptor, impairs learning and memory in rodents. However, the underlying molecular mechanism of BPA induced impairment in learning and memory is not well known. As synaptic plasticity is the cellular basis of memory, the present study investigated the effect of perinatal exposure to BPA on the expression of synaptic proteins neurexin1 (Nrxn1) and neuroligin3 (Nlgn3), dendritic spine density and spatial memory in postnatal male mice. The pregnant mice were orally administered BPA (50 µg/kgbw/d) from gestation day (GD) 7 to postnatal day (PND) 21 and sesame oil was used as a vehicle control. In Morris water maze (MWM) test, BPA extended the escape latency time to locate the hidden platform in 8 weeks male mice. RT-PCR and Immunoblotting results showed significant upregulation of Nrxn1 and Nlgn3 expression in both cerebral cortex and hippocampus of 3 and 8 weeks male mice. This was further substantiated by in-situ hybridization and immunofluorescence techniques. BPA also significantly increased the density of dendritic spines in both regions, as analyzed by rapid Golgi staining. Thus our data suggest that perinatal exposure to BPA impairs spatial memory through upregulation of expression of synaptic proteins Nrxn1 and Nlgn3 and increased dendritic spine density in cerebral cortex and hippocampus of postnatal male mice.", "link"=>"http://www.mendeley.com/research/perinatal-exposure-bisphenola-impairs-spatial-memory-through-upregulation-neurexin1-neuroligin3-expr", "reader_count"=>31, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Librarian"=>2, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>7, "Student > Master"=>8, "Other"=>2, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Librarian"=>2, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>7, "Student > Master"=>8, "Other"=>2, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>5, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>11, "Medicine and Dentistry"=>3, "Neuroscience"=>4, "Chemistry"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>4}, "Chemistry"=>{"Chemistry"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>3}, "Environmental Science"=>{"Environmental Science"=>2}}, "reader_count_by_country"=>{"Hungary"=>1, "United States"=>1}, "group_count"=>3}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1723075"], "description"=>"<p>Immunoblotting analysis showing protein expression in the cerebral cortex and hippocampus of 3 and 8 weeks male mice (A) Nrxn1 and (B) Nlgn3. Each bar represents the mean ± SEM and * denotes the significant difference (<i>p</i><0.05) between sesame oil and BPA exposed mice.</p>", "links"=>[], "tags"=>["synaptic proteins neurexin 1", "Morris water maze", "Nlgn 3 expression", "gd", "dendritic spine density", "mwm", "Neuroligin 3 Expression", "bpa", "postnatal", "8 weeks", "perinatal exposure", "synaptic proteins Nrxn 1", "pnd"], "article_id"=>1208909, "categories"=>["Biological Sciences"], "users"=>["Dhiraj Kumar", "Mahendra Kumar Thakur"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0110482.g004", "stats"=>{"downloads"=>0, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_perinatal_exposure_to_BPA_on_the_expression_of_Nrxn1_and_Nlgn3_proteins_in_cerebral_cortex_and_hippocampus_of_male_mice_/1208909", "title"=>"Effect of perinatal exposure to BPA on the expression of Nrxn1 and Nlgn3 proteins in cerebral cortex and hippocampus of male mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-10-17 03:41:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1723071"], "description"=>"<p>RT-PCR analysis showing mRNA expression of genes following BPA exposure in the cerebral cortex and hippocampus of 3 and 8 weeks male mice (A) <i>Nrxn1</i> and (B) <i>Nlgn3.</i> Each bar represents the mean ± SEM and * denotes the significant difference (<i>p</i><0.05) between sesame oil and BPA exposed mice.</p>", "links"=>[], "tags"=>["synaptic proteins neurexin 1", "Morris water maze", "Nlgn 3 expression", "gd", "dendritic spine density", "mwm", "Neuroligin 3 Expression", "bpa", "postnatal", "8 weeks", "perinatal exposure", "synaptic proteins Nrxn 1", "pnd"], "article_id"=>1208905, "categories"=>["Biological Sciences"], "users"=>["Dhiraj Kumar", "Mahendra Kumar Thakur"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0110482.g002", "stats"=>{"downloads"=>0, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_perinatal_exposure_to_BPA_on_the_mRNA_expression_of_Nrxn1_and_Nlgn3_in_cerebral_cortex_and_hippocampus_of_male_mice_/1208905", "title"=>"Effect of perinatal exposure to BPA on the mRNA expression of Nrxn1 and Nlgn3 in cerebral cortex and hippocampus of male mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-10-17 03:41:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1723070"], "description"=>"<p>Behavior of mice in Morris water maze test to reach the hidden platform. (A) Escape latency (in seconds), (B) Tracking of path on day 1, 4 and 8, (C) Percentage time spent in the target quadrant during probe trial (without platform) and (D) Tracking of path in probe trial. The results are expressed as the mean ± SEM (n = 15 mice/group) and * denotes the significant difference (<i>p</i><0.05) between sesame oil and BPA exposed mice.</p>", "links"=>[], "tags"=>["synaptic proteins neurexin 1", "Morris water maze", "Nlgn 3 expression", "gd", "dendritic spine density", "mwm", "Neuroligin 3 Expression", "bpa", "postnatal", "8 weeks", "perinatal exposure", "synaptic proteins Nrxn 1", "pnd"], "article_id"=>1208904, "categories"=>["Biological Sciences"], "users"=>["Dhiraj Kumar", "Mahendra Kumar Thakur"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0110482.g001", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_perinatal_exposure_to_BPA_on_spatial_memory_of_male_mice_/1208904", "title"=>"Effect of perinatal exposure to BPA on spatial memory of male mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-10-17 03:41:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1723082"], "description"=>"<p>Rapid Golgi staining of neurons in the cerebral cortex and hippocampus of 3 and 8 weeks male mice. The histograms represent the number of dendritic spines/10 µm length of primary dendrites. Each bar represents the mean ± SEM of 15 neurons from three independent experiments and * denotes the significant difference (<i>p</i><0.05) between sesame oil and BPA exposed mice.</p>", "links"=>[], "tags"=>["synaptic proteins neurexin 1", "Morris water maze", "Nlgn 3 expression", "gd", "dendritic spine density", "mwm", "Neuroligin 3 Expression", "bpa", "postnatal", "8 weeks", "perinatal exposure", "synaptic proteins Nrxn 1", "pnd"], "article_id"=>1208916, "categories"=>["Biological Sciences"], "users"=>["Dhiraj Kumar", "Mahendra Kumar Thakur"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0110482.g006", "stats"=>{"downloads"=>0, "page_views"=>39, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_perinatal_exposure_to_BPA_on_dendritic_spine_density_in_cerebral_cortex_and_hippocampus_of_male_mice_/1208916", "title"=>"Effect of perinatal exposure to BPA on dendritic spine density in cerebral cortex and hippocampus of male mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-10-17 03:41:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1723072"], "description"=>"<p>Photomicrographs of <i>in-situ</i> hybridization in cerebral cortex and dentate gyrus of 3 and 8 weeks male mice (A) <i>Nrxn1</i> and (B) <i>Nlgn3</i>. Histograms represent IDV/Area from three independent experiments. Each bar represents the mean ± SEM and * denotes the significant difference (<i>p</i><0.05) between control and BPA exposed group. Scale bar 50 µm. CC (cerebral cortex) and DG (dentate gyrus).</p>", "links"=>[], "tags"=>["synaptic proteins neurexin 1", "Morris water maze", "Nlgn 3 expression", "gd", "dendritic spine density", "mwm", "Neuroligin 3 Expression", "bpa", "postnatal", "8 weeks", "perinatal exposure", "synaptic proteins Nrxn 1", "pnd"], "article_id"=>1208906, "categories"=>["Biological Sciences"], "users"=>["Dhiraj Kumar", "Mahendra Kumar Thakur"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0110482.g003", "stats"=>{"downloads"=>0, "page_views"=>30, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_situ_hybridization_analysis_of_Nrxn1_and_Nlgn3_mRNA_expression_upon_perinatal_exposure_to_BPA_in_cerebral_cortex_and_hippocampus_of_male_mice_/1208906", "title"=>"<i>In-situ</i> hybridization analysis of Nrxn1 and Nlgn3 mRNA expression upon perinatal exposure to BPA in cerebral cortex and hippocampus of male mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-10-17 03:41:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/1723081"], "description"=>"<p>Photomicrographs of immunofluorescence staining in the cerebral cortex and dentate gyrus of 3 and 8 weeks male mice (A) Nrxn1 (TRITC-labeled) and (B) Nlgn3 (FITC-labeled). Histograms represent IDV/Area from three independent experiments. Each bar represents the mean ± SEM and * denotes the significant difference (<i>p</i><0.05) between sesame oil and BPA exposed mice. Scale bar 100 µm. CC (cerebral cortex) and DG (dentate gyrus).</p>", "links"=>[], "tags"=>["synaptic proteins neurexin 1", "Morris water maze", "Nlgn 3 expression", "gd", "dendritic spine density", "mwm", "Neuroligin 3 Expression", "bpa", "postnatal", "8 weeks", "perinatal exposure", "synaptic proteins Nrxn 1", "pnd"], "article_id"=>1208915, "categories"=>["Biological Sciences"], "users"=>["Dhiraj Kumar", "Mahendra Kumar Thakur"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0110482.g005", "stats"=>{"downloads"=>3, "page_views"=>95, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunofluorescence_analysis_showing_BPA_induced_variation_in_protein_expression_of_Nrxn1_and_Nlgn3_in_cerebral_cortex_and_hippocampus_of_male_mice_/1208915", "title"=>"Immunofluorescence analysis showing BPA induced variation in protein expression of Nrxn1 and Nlgn3 in cerebral cortex and hippocampus of male mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-10-17 03:41:00"}

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