Criteria for Viability Assessment of Discarded Human Donor Livers during Ex Vivo Normothermic Machine Perfusion
Publication Date
November 04, 2014
Journal
PLOS ONE
Authors
Michael E. Sutton, Sanna Op Den Dries, Negin Karimian, Pepijn D. Weeder, et al
Volume
9
Issue
11
Pages
e110642
DOI
https://dx.plos.org/10.1371/journal.pone.0110642
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0110642
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/25369327
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219693
Europe PMC
http://europepmc.org/abstract/MED/25369327
Web of Science
000344402000024
Scopus
84926444533
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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1778736"], "description"=>"<p>Presented are individual values for 12 livers that were declined for transplantation. <i>Ex vivo</i> machine perfusion and viability testing was started after a median cold storage of 6.5 hours. Two distinct patterns of bile flow could be identified: 1) a steadily increasing bile production, resulting in a cumulative bile output of ≥30 g during the 6 h of perfusion (green lines), and 2) an initially increasing bile production during the first 2–3 hours, followed by a diminishing production, resulting in a cumulative bile production in 6 h <20 g (red lines).</p>", "links"=>[], "tags"=>["graft viability", "vivo machine perfusion", "vivo findings need", "Discarded Human Donor Livers", "normothermic machine perfusion", "vivo normothermic machine perfusion", "bile output group", "Ex Vivo Normothermic Machine Perfusion", "bile production", "6 h", "donor livers"], "article_id"=>1228649, "categories"=>["Biological Sciences"], "users"=>["Michael E. Sutton", "Sanna op den Dries", "Negin Karimian", "Pepijn D. Weeder", "Marieke T. de Boer", "Janneke Wiersema-Buist", "Annette S. H. Gouw", "Henri G. D. Leuvenink", "Ton Lisman", "Robert J. Porte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0110642.g001", "stats"=>{"downloads"=>4, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cumulative_bile_production_during_ex_vivo_normothermic_machine_perfusion_of_human_donor_livers_/1228649", "title"=>"Cumulative bile production during <i>ex vivo</i> normothermic machine perfusion of human donor livers.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-04 14:44:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/1778737"], "description"=>"<p>Flow in the portal vein and hepatic artery increased rapidly during the first 30 min and flows remained stable thereafter for the entire 6 h perfusion period. There were no significant differences in portal flow and although median arterial flow was constantly lower in livers with a low bile output, compared to the high bile output group, this did not reach statistical significance.</p>", "links"=>[], "tags"=>["graft viability", "vivo machine perfusion", "vivo findings need", "Discarded Human Donor Livers", "normothermic machine perfusion", "vivo normothermic machine perfusion", "bile output group", "Ex Vivo Normothermic Machine Perfusion", "bile production", "6 h", "donor livers"], "article_id"=>1228650, "categories"=>["Biological Sciences"], "users"=>["Michael E. Sutton", "Sanna op den Dries", "Negin Karimian", "Pepijn D. Weeder", "Marieke T. de Boer", "Janneke Wiersema-Buist", "Annette S. H. Gouw", "Henri G. D. Leuvenink", "Ton Lisman", "Robert J. Porte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0110642.g002", "stats"=>{"downloads"=>1, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Changes_in_portal_flow_panel_A_and_arterial_flow_panel_B_during_ex_vivo_normothermic_machine_perfusion_of_human_donor_livers_using_a_pressure_controlled_device_/1228650", "title"=>"Changes in portal flow (panel A) and arterial flow (panel B) during <i>ex vivo</i> normothermic machine perfusion of human donor livers, using a pressure controlled device.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-04 14:44:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/1778738"], "description"=>"<p>In contrast to livers with low bile output, livers in the high bile output group showed a significantly higher hepatic ATP content during the course of NMP. (AUC p = 0.04).</p>", "links"=>[], "tags"=>["graft viability", "vivo machine perfusion", "vivo findings need", "Discarded Human Donor Livers", "normothermic machine perfusion", "vivo normothermic machine perfusion", "bile output group", "Ex Vivo Normothermic Machine Perfusion", "bile production", "6 h", "donor livers"], "article_id"=>1228651, "categories"=>["Biological Sciences"], "users"=>["Michael E. Sutton", "Sanna op den Dries", "Negin Karimian", "Pepijn D. Weeder", "Marieke T. de Boer", "Janneke Wiersema-Buist", "Annette S. H. Gouw", "Henri G. D. Leuvenink", "Ton Lisman", "Robert J. Porte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0110642.g003", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Changes_in_hepatic_energy_content_as_reflected_by_hepatic_ATP_content_/1228651", "title"=>"Changes in hepatic energy content as reflected by hepatic ATP content.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-04 14:44:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/1778748"], "description"=>"<p>In comparison to livers with high bile output, livers in the low bile output group displayed more signs of hepatic necrosis (panels A and B) and venous congestion (panels C en D). Despite these differences in hepatic parenchymal damage between the two groups, there were no major differences in the degree of biliary damage (panels E and F).</p>", "links"=>[], "tags"=>["graft viability", "vivo machine perfusion", "vivo findings need", "Discarded Human Donor Livers", "normothermic machine perfusion", "vivo normothermic machine perfusion", "bile output group", "Ex Vivo Normothermic Machine Perfusion", "bile production", "6 h", "donor livers"], "article_id"=>1228660, "categories"=>["Biological Sciences"], "users"=>["Michael E. Sutton", "Sanna op den Dries", "Negin Karimian", "Pepijn D. Weeder", "Marieke T. de Boer", "Janneke Wiersema-Buist", "Annette S. H. Gouw", "Henri G. D. Leuvenink", "Ton Lisman", "Robert J. Porte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0110642.g004", "stats"=>{"downloads"=>9, "page_views"=>125, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Histology_of_livers_after_6_hours_of_normothermic_machine_perfusion_/1228660", "title"=>"Histology of livers after 6 hours of normothermic machine perfusion.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-04 14:44:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/1778749"], "description"=>"<p>* To convert values for glucose to mg/dL, multiply by 18.02. To convert values for lactate to mg/dL, multiply by 9.01. To convert values for hemoglobin to g/dL, multiply by 1.650. To convert the value for bilirubin to mg/dL, divide by 17.1.</p><p>Biochemical Composition of Perfusion Fluid Used For Normothermic Machine Perfusion of Donor Livers.</p>", "links"=>[], "tags"=>["graft viability", "vivo machine perfusion", "vivo findings need", "Discarded Human Donor Livers", "normothermic machine perfusion", "vivo normothermic machine perfusion", "bile output group", "Ex Vivo Normothermic Machine Perfusion", "bile production", "6 h", "donor livers"], "article_id"=>1228661, "categories"=>["Biological Sciences"], "users"=>["Michael E. Sutton", "Sanna op den Dries", "Negin Karimian", "Pepijn D. Weeder", "Marieke T. de Boer", "Janneke Wiersema-Buist", "Annette S. H. Gouw", "Henri G. D. Leuvenink", "Ton Lisman", "Robert J. Porte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0110642.t001", "stats"=>{"downloads"=>8, "page_views"=>31, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Biochemical_Composition_of_Perfusion_Fluid_Used_For_Normothermic_Machine_Perfusion_of_Donor_Livers_/1228661", "title"=>"Biochemical Composition of Perfusion Fluid Used For Normothermic Machine Perfusion of Donor Livers.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-04 14:44:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/1778750"], "description"=>"<p>* One DCD donor with history of iv drug abuse (low bile output group) and one donor with prolonged s0<sub>2</sub><30% after withdrawal of life support (high bile output group).</p><p>** defined as macrovesicular steatosis with more than 60% of hepatocytes involved.</p><p>*** last known value before procurement.</p>†<p>Donor warm ischemia times was defined as the time interval between cardiac arrest and start of <i>in situ</i> cold perfusion. Total donor warm ischemia time was defined as the time interval between switch -off and start of <i>in situ</i> cold perfusion.</p><p>Continuous variables are presented as median and interquartile range, categorical variables are presented as numbers and percentage.</p><p>Abbreviations used: DCD, donation after cardiac death; DBD, donation after brain death; ALT, alanine aminotransferase; GGT, gamma glutamate transferase; UW, university of Wisconsin; HTK, Histidine- tryptophan-ketoglutarate.</p><p>Donor Characteristics.</p>", "links"=>[], "tags"=>["graft viability", "vivo machine perfusion", "vivo findings need", "Discarded Human Donor Livers", "normothermic machine perfusion", "vivo normothermic machine perfusion", "bile output group", "Ex Vivo Normothermic Machine Perfusion", "bile production", "6 h", "donor livers"], "article_id"=>1228662, "categories"=>["Biological Sciences"], "users"=>["Michael E. Sutton", "Sanna op den Dries", "Negin Karimian", "Pepijn D. Weeder", "Marieke T. de Boer", "Janneke Wiersema-Buist", "Annette S. H. Gouw", "Henri G. D. Leuvenink", "Ton Lisman", "Robert J. Porte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0110642.t002", "stats"=>{"downloads"=>5, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Donor_Characteristics_/1228662", "title"=>"Donor Characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-04 14:44:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/1778751"], "description"=>"<p>* To convert values for glucose to mg/dL, multiply by 18.02. To convert values for lactate to mg/dL, multiply by 9.01. To convert values for hemoglobin to g/dL, multiply by 1.650. To convert the value for bilirubin to mg/dL, divide by 17.1. To convert kPa to mmHg, multiply by 7.5.</p><p>** Peak values during 6 h of machine perfusion.</p><p>Abbreviations used: ALT, alanine aminotransferase; ALP, alkaline phosphatase; GGT, gamma-glutamate transferase; LDH, lactate dehydrogenase.</p><p>Biochemical Composition of Perfusion Fluid and Bile after 6 hour of <i>Ex Vivo</i> Normothermic Machine Perfusion.</p>", "links"=>[], "tags"=>["graft viability", "vivo machine perfusion", "vivo findings need", "Discarded Human Donor Livers", "normothermic machine perfusion", "vivo normothermic machine perfusion", "bile output group", "Ex Vivo Normothermic Machine Perfusion", "bile production", "6 h", "donor livers"], "article_id"=>1228663, "categories"=>["Biological Sciences"], "users"=>["Michael E. Sutton", "Sanna op den Dries", "Negin Karimian", "Pepijn D. Weeder", "Marieke T. de Boer", "Janneke Wiersema-Buist", "Annette S. H. Gouw", "Henri G. D. Leuvenink", "Ton Lisman", "Robert J. Porte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0110642.t003", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Biochemical_Composition_of_Perfusion_Fluid_and_Bile_after_6_hour_of_Ex_Vivo_Normothermic_Machine_Perfusion_/1228663", "title"=>"Biochemical Composition of Perfusion Fluid and Bile after 6 hour of <i>Ex Vivo</i> Normothermic Machine Perfusion.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-04 14:44:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/1778752"], "description"=>"<p>Criteria are: 1) Cumulative bile production of ≥10 grams after 2.5 h and 2) a bile production of ≥4 grams in the preceding hour (1.5–2.5 h of perfusion).</p><p>Criteria to Assess Bile Production after 2.5 hours of Normothermic Machine Perfusion.</p>", "links"=>[], "tags"=>["graft viability", "vivo machine perfusion", "vivo findings need", "Discarded Human Donor Livers", "normothermic machine perfusion", "vivo normothermic machine perfusion", "bile output group", "Ex Vivo Normothermic Machine Perfusion", "bile production", "6 h", "donor livers"], "article_id"=>1228664, "categories"=>["Biological Sciences"], "users"=>["Michael E. Sutton", "Sanna op den Dries", "Negin Karimian", "Pepijn D. Weeder", "Marieke T. de Boer", "Janneke Wiersema-Buist", "Annette S. H. Gouw", "Henri G. D. Leuvenink", "Ton Lisman", "Robert J. Porte"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0110642.t004", "stats"=>{"downloads"=>7, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Criteria_to_Assess_Bile_Production_after_2_5_hours_of_Normothermic_Machine_Perfusion_/1228664", "title"=>"Criteria to Assess Bile Production after 2.5 hours of Normothermic Machine Perfusion.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-04 14:44:02"}

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Relative Metric

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