Multi-Parametric Representation of Voxel-Based Quantitative Magnetic Resonance Imaging
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{"title"=>"Multi-parametric representation of voxel-based quantitative magnetic resonance imaging", "type"=>"journal", "authors"=>[{"first_name"=>"Maria", "last_name"=>"Engström", "scopus_author_id"=>"55938889600"}, {"first_name"=>"Jan B.M.", "last_name"=>"Warntjes", "scopus_author_id"=>"36852273600"}, {"first_name"=>"Anders", "last_name"=>"Tisell", "scopus_author_id"=>"8046083000"}, {"first_name"=>"Anne Marie", "last_name"=>"Landtblom", "scopus_author_id"=>"57196394994"}, {"first_name"=>"Peter", "last_name"=>"Lundberg", "scopus_author_id"=>"7103192759"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"600506792", "pmid"=>"25393722", "doi"=>"10.1371/journal.pone.0111688", "scopus"=>"2-s2.0-84911934628", "isbn"=>"1932-6203", "issn"=>"19326203", "sgr"=>"84911934628"}, "id"=>"d2cdb39f-d6d4-3bae-b705-cf03b64642ce", "abstract"=>"The aim of the study was to explore the possibilities of multi-parametric representations of voxel-wise quantitative MRI data to objectively discriminate pathological cerebral tissue in patients with brain disorders. For this purpose, we recruited 19 patients with Multiple Sclerosis (MS) as benchmark samples and 19 age and gender matched healthy subjects as a reference group. The subjects were examined using quantitative Magnetic Resonance Imaging (MRI) measuring the tissue structure parameters: relaxation rates, R(1) and R(2), and proton density. The resulting parameter images were normalized to a standard template. Tissue structure in MS patients was assessed by voxel-wise comparisons with the reference group and with correlation to a clinical measure, the Expanded Disability Status Scale (EDSS). The results were visualized by conventional geometric representations and also by multi-parametric representations. Data showed that MS patients had lower R(1) and R(2), and higher proton density in periventricular white matter and in wide-spread areas encompassing central and sub-cortical white matter structures. MS-related tissue abnormality was highlighted in posterior white matter whereas EDSS correlation appeared especially in the frontal cortex. The multi-parameter representation highlighted disease-specific features. In conclusion, the proposed method has the potential to visualize both high-probability focal anomalies and diffuse tissue changes. Results from voxel-based statistical analysis, as exemplified in the present work, may guide radiologists where in the image to inspect for signs of disease. Future clinical studies must validate the usability of the method in clinical practice.", "link"=>"http://www.mendeley.com/research/multiparametric-representation-voxelbased-quantitative-magnetic-resonance-imaging", "reader_count"=>25, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>8, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>2, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>8, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>2, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Medicine and Dentistry"=>12, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>3, "Physics and Astronomy"=>2, "Psychology"=>2, "Chemistry"=>1, "Computer Science"=>3}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Neuroscience"=>{"Neuroscience"=>3}, "Chemistry"=>{"Chemistry"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>3}}, "reader_count_by_country"=>{"New Zealand"=>1, "Sweden"=>1, "Belgium"=>1, "Germany"=>1}, "group_count"=>4}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1791581"], "description"=>"<p>The figure shows differences in R and R values between Multiple Sclerosis (MS) patients and the reference group for three separate cerebral ROIs. A) Caudate nucleus; B) Thalamus; C) Total white matter. The ROIs were all reduced with 2 mm to avoid partial volume effects at the edges. Only the R-R projections of the R-R-PD space are shown. The color scales indicate number of voxels. Blue color indicates a larger number of voxels in the reference group. Red color indicates a larger number of voxels in the MS group.</p>", "links"=>[], "tags"=>["MS patients", "edss", "disability status scale", "subject", "matter", "method", "reference group", "image", "Magnetic resonance imaging", "tissue structure parameters", "data", "proton density", "correlation", "representation", "mri"], "article_id"=>1239337, "categories"=>["Biological Sciences"], "users"=>["Maria Engström", "Jan B. M. Warntjes", "Anders Tisell", "Anne-Marie Landtblom", "Peter Lundberg"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0111688.g005", "stats"=>{"downloads"=>0, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multi_parametrical_representation_of_tissue_parameters_in_regions_of_interest_ROIs_/1239337", "title"=>"Multi-parametrical representation of tissue parameters in regions of interest (ROIs).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-13 02:51:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1791596"], "description"=>"<p>The table shows ROI sizes, mean R, R, and proton density (PD) values, and standard deviations of 15 pre-defined structures in the Montreal Neurological Institute (MNI) standard brain template. All comparisons between the reference group and the multiple sclerosis group were highly significant, p0.001.</p><p>Descriptive data from the region of interest (ROI) analysis using standard templates.</p>", "links"=>[], "tags"=>["MS patients", "edss", "disability status scale", "subject", "matter", "method", "reference group", "image", "Magnetic resonance imaging", "tissue structure parameters", "data", "proton density", "correlation", "representation", "mri"], "article_id"=>1239348, "categories"=>["Biological Sciences"], "users"=>["Maria Engström", "Jan B. M. Warntjes", "Anders Tisell", "Anne-Marie Landtblom", "Peter Lundberg"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0111688.t001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Descriptive_data_from_the_region_of_interest_ROI_analysis_using_standard_templates_/1239348", "title"=>"Descriptive data from the region of interest (ROI) analysis using standard templates.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-13 02:51:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1791569"], "description"=>"<p>The figure shows whole-brain differences in R-R-PD values between the group of Multiple Sclerosis (MS) patients and the reference group. A) R-R values; B) R-PD values; C) R-PD values. The color scales indicate number of voxels. Blue color indicates a larger number of voxels in the reference group. Red color indicates a larger number of voxels in the MS group. The markers indicate the positions of the mean values in cortical grey matter (CGM), thalamus (Tha), putamen (Put), white matter (WM), and corpus callosum (CC). The mean values are taken from the decreased ROIs presented in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0111688#pone-0111688-t002\" target=\"_blank\">Table 2</a>. A square is used for the reference group and a circle for the MS group. The arrows point in the direction from the reference group to the MS group.</p>", "links"=>[], "tags"=>["MS patients", "edss", "disability status scale", "subject", "matter", "method", "reference group", "image", "Magnetic resonance imaging", "tissue structure parameters", "data", "proton density", "correlation", "representation", "mri"], "article_id"=>1239325, "categories"=>["Biological Sciences"], "users"=>["Maria Engström", "Jan B. M. Warntjes", "Anders Tisell", "Anne-Marie Landtblom", "Peter Lundberg"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0111688.g004", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Multi_parametrical_representation_of_tissue_parameters_in_groups_/1239325", "title"=>"Multi-parametrical representation of tissue parameters in groups.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-13 02:51:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1791549"], "description"=>"<p>The figure shows differences in tissue parameters between the group of Multiple Sclerosis (MS) patients and the reference group. Shown as the color overlay is the T-statistics of the voxel-based differences between groups. A) longitudinal relaxation rate (R); B) transversal relaxation rate (R); C) proton density (PD) in one coronal, three axial and one sagittal slice. The color scale represents T  = 0.0–5.0. The figure shows uncorrected statistics, thresholded at T = 2. In the background a synthetic T2-weighted image of the same slice is displayed for visual guidance.</p>", "links"=>[], "tags"=>["MS patients", "edss", "disability status scale", "subject", "matter", "method", "reference group", "image", "Magnetic resonance imaging", "tissue structure parameters", "data", "proton density", "correlation", "representation", "mri"], "article_id"=>1239310, "categories"=>["Biological Sciences"], "users"=>["Maria Engström", "Jan B. M. Warntjes", "Anders Tisell", "Anne-Marie Landtblom", "Peter Lundberg"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0111688.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Geometrical_representation_of_tissue_parameter_differences_between_groups_/1239310", "title"=>"Geometrical representation of tissue parameter differences between groups.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-13 02:51:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1791564"], "description"=>"<p>The figure shows the geometrical representation of the correlation of R–R–PD values with a clinical measure for the group of Multiple Sclerosis (MS) patients. Shown as the color overlay is the slope of the voxel-based correlation with Expanded Disability Status Scale (EDSS). A) longitudinal relaxation rate (R) on a scale r = 0.0 to -0.15; B) transversal relaxation rate (R) on a scale r = 0.0 to -1; C) proton density (PD) on a scale r = 0.0–4.0. The correlation images are shown in the same slices as in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0111688#pone-0111688-g002\" target=\"_blank\">Figure 2</a>. The figure shows uncorrected statistics, thresholded at T = 2. In the background synthetic T2-weighted images of the MS group in the same slices are displayed for visual guidance.</p>", "links"=>[], "tags"=>["MS patients", "edss", "disability status scale", "subject", "matter", "method", "reference group", "image", "Magnetic resonance imaging", "tissue structure parameters", "data", "proton density", "correlation", "representation", "mri"], "article_id"=>1239320, "categories"=>["Biological Sciences"], "users"=>["Maria Engström", "Jan B. M. Warntjes", "Anders Tisell", "Anne-Marie Landtblom", "Peter Lundberg"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0111688.g003", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Geometrical_representation_of_the_correlation_of_tissue_parameters_and_clinical_measures_/1239320", "title"=>"Geometrical representation of the correlation of tissue parameters and clinical measures.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-13 02:51:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1791598"], "description"=>"<p>The table shows ROI sizes, mean R, R, and proton density (PD) values, and standard deviations of 15 pre-defined structures in the Montreal Neurological Institute (MNI) standard brain template. The ROIs were cropped with 2 mm from the standard brain templates. All comparisons between the reference group and the multiple sclerosis group were highly significant, p0.001.</p><p>Descriptive data from the region of interest (ROI) analysis using cropped templates.</p>", "links"=>[], "tags"=>["MS patients", "edss", "disability status scale", "subject", "matter", "method", "reference group", "image", "Magnetic resonance imaging", "tissue structure parameters", "data", "proton density", "correlation", "representation", "mri"], "article_id"=>1239350, "categories"=>["Biological Sciences"], "users"=>["Maria Engström", "Jan B. M. Warntjes", "Anders Tisell", "Anne-Marie Landtblom", "Peter Lundberg"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0111688.t002", "stats"=>{"downloads"=>7, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Descriptive_data_from_the_region_of_interest_ROI_analysis_using_cropped_templates_/1239350", "title"=>"Descriptive data from the region of interest (ROI) analysis using cropped templates.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-13 02:51:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1791595"], "description"=>"<p>The figure shows R–R plots in ROIs for the Multiple Sclerosis (MS) and the reference group, respectively. A) Caudate nucleus; B) Thalamus; C) Total white matter. The color bar shows within-ROI distance from the ROI surface. The circles show mean R and R values in 0, 2, 4, 6, and 8 mm reduced ROIs. Black circles represent 0 mm reduction and white circles represent 8 mm reduction.</p>", "links"=>[], "tags"=>["MS patients", "edss", "disability status scale", "subject", "matter", "method", "reference group", "image", "Magnetic resonance imaging", "tissue structure parameters", "data", "proton density", "correlation", "representation", "mri"], "article_id"=>1239347, "categories"=>["Biological Sciences"], "users"=>["Maria Engström", "Jan B. M. Warntjes", "Anders Tisell", "Anne-Marie Landtblom", "Peter Lundberg"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0111688.g006", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_regions_of_interest_ROI_size_on_tissue_parameters_/1239347", "title"=>"Effect of regions of interest (ROI) size on tissue parameters.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-13 02:51:20"}
  • {"files"=>["https://ndownloader.figshare.com/files/1791539"], "description"=>"<p>The figure shows a selected slice of the quantitative tissue maps in the reference group of healthy subjects (top row) and the group of multiple sclerosis (MS) patients (bottom row). A) longitudinal relaxation rate (R<sub>1</sub>) on a scale 0–3 s<sup>−1</sup>; B) transversal relaxation rate (R<sub>2</sub>) on a scale 0–15 s<sup>−1</sup>; C) proton density (PD) on a scale 50–100, where 100 corresponds to pure water at 37°C.</p>", "links"=>[], "tags"=>["MS patients", "edss", "disability status scale", "subject", "matter", "method", "reference group", "image", "Magnetic resonance imaging", "tissue structure parameters", "data", "proton density", "correlation", "representation", "mri"], "article_id"=>1239300, "categories"=>["Biological Sciences"], "users"=>["Maria Engström", "Jan B. M. Warntjes", "Anders Tisell", "Anne-Marie Landtblom", "Peter Lundberg"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0111688.g001", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Geometrical_representation_of_quantitative_tissue_parameters_/1239300", "title"=>"Geometrical representation of quantitative tissue parameters.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-13 02:51:20"}

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Relative Metric

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