17β-Estradiol Modulates Gene Expression in the Female Mouse Cerebral Cortex
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{"title"=>"17β-estradiol modulates gene expression in the female mouse cerebral cortex", "type"=>"journal", "authors"=>[{"first_name"=>"Gwendolyn I.", "last_name"=>"Humphreys", "scopus_author_id"=>"55626676700"}, {"first_name"=>"Yvonne S.", "last_name"=>"Ziegler", "scopus_author_id"=>"6603644826"}, {"first_name"=>"Ann M.", "last_name"=>"Nardulli", "scopus_author_id"=>"7004345515"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84910636477", "doi"=>"10.1371/journal.pone.0111975", "issn"=>"19326203", "pui"=>"600436072", "pmid"=>"25372139", "scopus"=>"2-s2.0-84910636477"}, "id"=>"9d71ea65-26fd-3c31-abbb-606fff817da9", "abstract"=>"17β-estradiol (E2) plays critical roles in a number of target tissues including the mammary gland, reproductive tract, bone, and brain. Although it is clear that E2 reduces inflammation and ischemia-induced damage in the cerebral cortex, the molecular mechanisms mediating the effects of E2 in this brain region are lacking. Thus, we examined the cortical transcriptome using a mouse model system. Female adult mice were ovariectomized and implanted with silastic tubing containing oil or E2. After 7 days, the cerebral cortices were dissected and RNA was isolated and analyzed using RNA-sequencing. Analysis of the transcriptomes of control and E2-treated animals revealed that E2 treatment significantly altered the transcript levels of 88 genes. These genes were associated with long term synaptic potentiation, myelination, phosphoprotein phosphatase activity, mitogen activated protein kinase, and phosphatidylinositol 3-kinase signaling. E2 also altered the expression of genes linked to lipid synthesis and metabolism, vasoconstriction and vasodilation, cell-cell communication, and histone modification. These results demonstrate the far-reaching and diverse effects of E2 in the cerebral cortex and provide valuable insight to begin to understand cortical processes that may fluctuate in a dynamic hormonal environment.", "link"=>"http://www.mendeley.com/research/17%CE%B2estradiol-modulates-gene-expression-female-mouse-cerebral-cortex", "reader_count"=>16, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>4, "Researcher"=>3, "Student > Ph. D. Student"=>4, "Student > Bachelor"=>4}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>4, "Researcher"=>3, "Student > Ph. D. Student"=>4, "Student > Bachelor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>8, "Medicine and Dentistry"=>4, "Neuroscience"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"South Africa"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1779639"], "description"=>"<p>E2-regulated genes with the most increased expression.</p>", "links"=>[], "tags"=>["transcriptome", "mouse model system", "kinase", "Female adult mice", "rna", "gene", "E 2 treatment", "phosphoprotein phosphatase activity", "term synaptic potentiation", "cortex", "E 2"], "article_id"=>1229307, "categories"=>["Biological Sciences"], "users"=>["Gwendolyn I. Humphreys", "Yvonne S. Ziegler", "Ann M. Nardulli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0111975.t003", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_E2_regulated_genes_with_the_most_increased_expression_/1229307", "title"=>"E2-regulated genes with the most increased expression.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-05 03:18:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1779638"], "description"=>"<p>E2-regulated genes with the most decreased expression.</p>", "links"=>[], "tags"=>["transcriptome", "mouse model system", "kinase", "Female adult mice", "rna", "gene", "E 2 treatment", "phosphoprotein phosphatase activity", "term synaptic potentiation", "cortex", "E 2"], "article_id"=>1229306, "categories"=>["Biological Sciences"], "users"=>["Gwendolyn I. Humphreys", "Yvonne S. Ziegler", "Ann M. Nardulli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0111975.t002", "stats"=>{"downloads"=>3, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_E2_regulated_genes_with_the_most_decreased_expression_/1229306", "title"=>"E2-regulated genes with the most decreased expression.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-05 03:18:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1779631"], "description"=>"<p>(A) Quantitative real-time PCR was conducted with gene-specific primers. The normalized fold change ± SEM was calculated using the delta-delta Ct method with Rpl7 as a control gene. The Student’s t-test was used to detect significant differences in oil- and E2- treated animals (4 animals/treatment, *<i>p</i><0.05).</p>", "links"=>[], "tags"=>["transcriptome", "mouse model system", "kinase", "Female adult mice", "rna", "gene", "E 2 treatment", "phosphoprotein phosphatase activity", "term synaptic potentiation", "cortex", "E 2"], "article_id"=>1229301, "categories"=>["Biological Sciences"], "users"=>["Gwendolyn I. Humphreys", "Yvonne S. Ziegler", "Ann M. Nardulli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0111975.g002", "stats"=>{"downloads"=>4, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Validation_of_transcripts_altered_by_E2_treatment_/1229301", "title"=>"Validation of transcripts altered by E2 treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-05 03:18:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1779630"], "description"=>"<p>Hierarchical clustering was used to visualize the transcript levels of (A) 88 genes that were significantly altered (FDR <i>p</i><0.05) by E2 treatment or (B) 49 genes that were altered 1.2 fold or more by E2 treatment (FDR <i>p</i><0.05). Each column represents cortical tissue from one mouse (8 mice total) and rows indicate genes. Colors symbolize increased (red) or decreased (blue) transcript levels.</p>", "links"=>[], "tags"=>["transcriptome", "mouse model system", "kinase", "Female adult mice", "rna", "gene", "E 2 treatment", "phosphoprotein phosphatase activity", "term synaptic potentiation", "cortex", "E 2"], "article_id"=>1229300, "categories"=>["Biological Sciences"], "users"=>["Gwendolyn I. Humphreys", "Yvonne S. Ziegler", "Ann M. Nardulli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0111975.g001", "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Heatmaps_comparing_cerebral_cortices_from_oil_and_E2_treated_mice_/1229300", "title"=>"Heatmaps comparing cerebral cortices from oil- and E2-treated mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-05 03:18:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1779641", "https://ndownloader.figshare.com/files/1779642"], "description"=>"<div><p>17β-estradiol (E2) plays critical roles in a number of target tissues including the mammary gland, reproductive tract, bone, and brain. Although it is clear that E2 reduces inflammation and ischemia-induced damage in the cerebral cortex, the molecular mechanisms mediating the effects of E2 in this brain region are lacking. Thus, we examined the cortical transcriptome using a mouse model system. Female adult mice were ovariectomized and implanted with silastic tubing containing oil or E2. After 7 days, the cerebral cortices were dissected and RNA was isolated and analyzed using RNA-sequencing. Analysis of the transcriptomes of control and E2-treated animals revealed that E2 treatment significantly altered the transcript levels of 88 genes. These genes were associated with long term synaptic potentiation, myelination, phosphoprotein phosphatase activity, mitogen activated protein kinase, and phosphatidylinositol 3-kinase signaling. E2 also altered the expression of genes linked to lipid synthesis and metabolism, vasoconstriction and vasodilation, cell-cell communication, and histone modification. These results demonstrate the far-reaching and diverse effects of E2 in the cerebral cortex and provide valuable insight to begin to understand cortical processes that may fluctuate in a dynamic hormonal environment.</p></div>", "links"=>[], "tags"=>["transcriptome", "mouse model system", "kinase", "Female adult mice", "rna", "gene", "E 2 treatment", "phosphoprotein phosphatase activity", "term synaptic potentiation", "cortex", "E 2"], "article_id"=>1229309, "categories"=>["Biological Sciences"], "users"=>["Gwendolyn I. Humphreys", "Yvonne S. Ziegler", "Ann M. Nardulli"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0111975.s001", "https://dx.doi.org/10.1371/journal.pone.0111975.s002"], "stats"=>{"downloads"=>7, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_17_946_Estradiol_Modulates_Gene_Expression_in_the_Female_Mouse_Cerebral_Cortex_/1229309", "title"=>"17β-Estradiol Modulates Gene Expression in the Female Mouse Cerebral Cortex", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-11-05 03:18:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1779640"], "description"=>"<p>E2-responsive networks and associated genes.</p>", "links"=>[], "tags"=>["transcriptome", "mouse model system", "kinase", "Female adult mice", "rna", "gene", "E 2 treatment", "phosphoprotein phosphatase activity", "term synaptic potentiation", "cortex", "E 2"], "article_id"=>1229308, "categories"=>["Biological Sciences"], "users"=>["Gwendolyn I. Humphreys", "Yvonne S. Ziegler", "Ann M. Nardulli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0111975.t004", "stats"=>{"downloads"=>4, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_E2_responsive_networks_and_associated_genes_/1229308", "title"=>"E2-responsive networks and associated genes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-05 03:18:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1779637"], "description"=>"<p>88 E2-responsive genes in the cerebral cortex.</p>", "links"=>[], "tags"=>["transcriptome", "mouse model system", "kinase", "Female adult mice", "rna", "gene", "E 2 treatment", "phosphoprotein phosphatase activity", "term synaptic potentiation", "cortex", "E 2"], "article_id"=>1229305, "categories"=>["Biological Sciences"], "users"=>["Gwendolyn I. Humphreys", "Yvonne S. Ziegler", "Ann M. Nardulli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0111975.t001", "stats"=>{"downloads"=>6, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_88_E2_responsive_genes_in_the_cerebral_cortex_/1229305", "title"=>"88 E2-responsive genes in the cerebral cortex.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-05 03:18:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1779633"], "description"=>"<p>(A)Western blot analysis was used to monitor pERK and total ERK levels in the cortices of mice that had been treated with oil or E2 for 7 days. (B) pERK values were normalized to total ERK and are displayed as the normalized fold change ± SEM. The Student’s t-test was used to detect significant differences in oil- and E2- treated animals (*<i>p</i><0.05). The number of animals in each treatment group is indicated at the base of each bar.</p>", "links"=>[], "tags"=>["transcriptome", "mouse model system", "kinase", "Female adult mice", "rna", "gene", "E 2 treatment", "phosphoprotein phosphatase activity", "term synaptic potentiation", "cortex", "E 2"], "article_id"=>1229303, "categories"=>["Biological Sciences"], "users"=>["Gwendolyn I. Humphreys", "Yvonne S. Ziegler", "Ann M. Nardulli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0111975.g004", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_E2_increases_pERK_protein_levels_/1229303", "title"=>"E2 increases pERK protein levels.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-05 03:18:42"}
  • {"files"=>["https://ndownloader.figshare.com/files/1779632"], "description"=>"<p>ClueGO analysis classified the 88 E2-regulated genes into 6 networks. White nodes indicate that a biological process is associated with two networks. Node size indicates the statistical significance of the biological process represented. Thus, larger nodes indicate greater statistical significance.</p>", "links"=>[], "tags"=>["transcriptome", "mouse model system", "kinase", "Female adult mice", "rna", "gene", "E 2 treatment", "phosphoprotein phosphatase activity", "term synaptic potentiation", "cortex", "E 2"], "article_id"=>1229302, "categories"=>["Biological Sciences"], "users"=>["Gwendolyn I. Humphreys", "Yvonne S. Ziegler", "Ann M. Nardulli"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0111975.g003", "stats"=>{"downloads"=>5, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Networks_of_E2_regulated_genes_/1229302", "title"=>"Networks of E2-regulated genes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-05 03:18:42"}

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