Gut Microbiome in Down Syndrome
Publication Date
November 11, 2014
Journal
PLOS ONE
Authors
Elena Biagi, Marco Candela, Manuela Centanni, Clarissa Consolandi, et al
Volume
9
Issue
11
Pages
e112023
DOI
https://dx.plos.org/10.1371/journal.pone.0112023
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0112023
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/25386941
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227691
Europe PMC
http://europepmc.org/abstract/MED/25386941
Web of Science
000345250400036
Scopus
84911423118
Mendeley
http://www.mendeley.com/research/gut-microbiome-down-syndrome
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Mendeley | Further Information

{"title"=>"Gut microbiome in down syndrome", "type"=>"journal", "authors"=>[{"first_name"=>"Elena", "last_name"=>"Biagi", "scopus_author_id"=>"35916489700"}, {"first_name"=>"Marco", "last_name"=>"Cela", "scopus_author_id"=>"56422112700"}, {"first_name"=>"Manuela", "last_name"=>"Centanni", "scopus_author_id"=>"36243039300"}, {"first_name"=>"Clarissa", "last_name"=>"Consoli", "scopus_author_id"=>"56421958200"}, {"first_name"=>"Simone", "last_name"=>"Rampelli", "scopus_author_id"=>"55240210700"}, {"first_name"=>"Silvia", "last_name"=>"Turroni", "scopus_author_id"=>"16319673700"}, {"first_name"=>"Marco", "last_name"=>"Severgnini", "scopus_author_id"=>"12798920900"}, {"first_name"=>"Clelia", "last_name"=>"Peano", "scopus_author_id"=>"13403279300"}, {"first_name"=>"Alessro", "last_name"=>"Ghezzo", "scopus_author_id"=>"35304817600"}, {"first_name"=>"Maria", "last_name"=>"Scurti", "scopus_author_id"=>"15761089200"}, {"first_name"=>"Stefano", "last_name"=>"Salvioli", "scopus_author_id"=>"7004370294"}, {"first_name"=>"Claudio", "last_name"=>"Franceschi", "scopus_author_id"=>"56236886700"}, {"first_name"=>"Patrizia", "last_name"=>"Brigidi", "scopus_author_id"=>"7003712308"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84911423118", "sgr"=>"84911423118", "pui"=>"600483530", "isbn"=>"1932-6203", "pmid"=>"25386941", "doi"=>"10.1371/journal.pone.0112023"}, "id"=>"71cf614c-22af-37fb-853d-7e8840140add", "abstract"=>"BACKGROUND: Premature aging seriously compromises the health status of Down Syndrome (DS) persons. Since human aging has been associated with a deterioration of the gut microbiota (GM)-host mutualism, here we investigated the composition of GM in DS.\\n\\nMETHODS: The observational study presented involved 17 adult DS persons. We characterized the GM structure by 454 pyrosequencing of the V4 region of the 16S rRNA gene. DS microbiome was compared with that of age-matched healthy non-trisomic adults enrolled in the same geographic area.\\n\\nRESULTS AND CONCLUSIONS: The dominant GM fraction of DS persons showed an overall mutualistic immune-modulatory layout, comparable to that of healthy controls. This makes GM a possible factor counteracting the genetic determined acceleration of immune senescence in DS persons. However, we also found detectable signatures specific for DS among subdominant GM components, such as the increase of Parasporobacterium and Sutterella. In particular, the abundance of this last microorganism significantly correlated with the Aberrant Behavior Checklist (ABC) total score, allowing us to hypothesize a possible role for this microbial genus in behavioral features in DS.", "link"=>"http://www.mendeley.com/research/gut-microbiome-down-syndrome", "reader_count"=>54, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>14, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>2, "Student > Master"=>7, "Other"=>5, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>14, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>12, "Student > Postgraduate"=>2, "Student > Master"=>7, "Other"=>5, "Student > Bachelor"=>4, "Lecturer > Senior Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Agricultural and Biological Sciences"=>23, "Arts and Humanities"=>1, "Chemistry"=>1, "Computer Science"=>2, "Engineering"=>1, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>8, "Medicine and Dentistry"=>11, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Physics and Astronomy"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Engineering"=>{"Engineering"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>23}, "Computer Science"=>{"Computer Science"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>8}}, "reader_count_by_country"=>{"United States"=>3, "Brazil"=>1, "France"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1787905"], "description"=>"<p>Relative abundance of family-level assigned OTUs is reported. Colors were assigned for all families detected.</p>", "links"=>[], "tags"=>["17 adult DS persons", "Aberrant Behavior Checklist", "V 4 region", "DS persons", "16 S rRNA gene", "abc", "subdominant GM components"], "article_id"=>1236053, "categories"=>["Biological Sciences", "Science Policy", "Ecology"], "users"=>["Elena Biagi", "Marco Candela", "Manuela Centanni", "Clarissa Consolandi", "Simone Rampelli", "Silvia Turroni", "Marco Severgnini", "Clelia Peano", "Alessandro Ghezzo", "Maria Scurti", "Stefano Salvioli", "Claudio Franceschi", "Patrizia Brigidi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112023.g001", "stats"=>{"downloads"=>2, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Individual_A_and_average_B_gut_microbiota_profiles_of_the_enrolled_DS_persons_/1236053", "title"=>"Individual (A) and average (B) gut microbiota profiles of the enrolled DS persons.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-11 03:22:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1787914"], "description"=>"<p>Percentage of variance in the dataset shown by the second and third principal component (PC) is reported. Blue, DS persons; red, healthy adults <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0112023#pone.0112023-Schnorr1\" target=\"_blank\">[24]</a>.</p>", "links"=>[], "tags"=>["17 adult DS persons", "Aberrant Behavior Checklist", "V 4 region", "DS persons", "16 S rRNA gene", "abc", "subdominant GM components"], "article_id"=>1236062, "categories"=>["Biological Sciences", "Science Policy", "Ecology"], "users"=>["Elena Biagi", "Marco Candela", "Manuela Centanni", "Clarissa Consolandi", "Simone Rampelli", "Silvia Turroni", "Marco Severgnini", "Clelia Peano", "Alessandro Ghezzo", "Maria Scurti", "Stefano Salvioli", "Claudio Franceschi", "Patrizia Brigidi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112023.g003", "stats"=>{"downloads"=>4, "page_views"=>118, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Weighted_A_and_unweighted_B_UniFrac_distance_PCoA_of_the_fecal_microbiota_of_DS_persons_and_healthy_non_trisomic_adults_/1236062", "title"=>"Weighted (A) and unweighted (B) UniFrac distance PCoA of the fecal microbiota of DS persons and healthy non-trisomic adults.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-11 03:22:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1787911"], "description"=>"<p>(A) Superimposition of the rarefaction curves of different α-diversity metrics (Faith’s phylogenetic diversity (PD whole tree), observed OTUs, the Chao1 measure of microbial richness, and the Shannon index of biodiversity). (B) Hierarchical Ward-linkage clustering based on the Spearman correlation coefficients of genus proportion, showing no separation between DS persons and healthy adults. Blue, DS persons; red, healthy adults <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0112023#pone.0112023-Schnorr1\" target=\"_blank\">[24]</a>.</p>", "links"=>[], "tags"=>["17 adult DS persons", "Aberrant Behavior Checklist", "V 4 region", "DS persons", "16 S rRNA gene", "abc", "subdominant GM components"], "article_id"=>1236059, "categories"=>["Biological Sciences", "Science Policy", "Ecology"], "users"=>["Elena Biagi", "Marco Candela", "Manuela Centanni", "Clarissa Consolandi", "Simone Rampelli", "Silvia Turroni", "Marco Severgnini", "Clelia Peano", "Alessandro Ghezzo", "Maria Scurti", "Stefano Salvioli", "Claudio Franceschi", "Patrizia Brigidi"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112023.g002", "stats"=>{"downloads"=>3, "page_views"=>114, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Similarity_between_the_gut_microbiota_of_DS_persons_and_healthy_non_trisomic_adults_for_diversity_and_overall_community_composition_/1236059", "title"=>"Similarity between the gut microbiota of DS persons and healthy non-trisomic adults for diversity and overall community composition.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-11 03:22:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/1787919", "https://ndownloader.figshare.com/files/1787920", "https://ndownloader.figshare.com/files/1787921", "https://ndownloader.figshare.com/files/1787922", "https://ndownloader.figshare.com/files/1787923", "https://ndownloader.figshare.com/files/1787924"], "description"=>"<div><p>Background</p><p>Premature aging seriously compromises the health status of Down Syndrome (DS) persons. Since human aging has been associated with a deterioration of the gut microbiota (GM)-host mutualism, here we investigated the composition of GM in DS.</p><p>Methods</p><p>The observational study presented involved 17 adult DS persons. We characterized the GM structure by 454 pyrosequencing of the V4 region of the 16S rRNA gene. DS microbiome was compared with that of age-matched healthy non-trisomic adults enrolled in the same geographic area.</p><p>Results and Conclusions</p><p>The dominant GM fraction of DS persons showed an overall mutualistic immune-modulatory layout, comparable to that of healthy controls. This makes GM a possible factor counteracting the genetic determined acceleration of immune senescence in DS persons. However, we also found detectable signatures specific for DS among subdominant GM components, such as the increase of <i>Parasporobacterium</i> and <i>Sutterella</i>. In particular, the abundance of this last microorganism significantly correlated with the Aberrant Behavior Checklist (ABC) total score, allowing us to hypothesize a possible role for this microbial genus in behavioral features in DS.</p></div>", "links"=>[], "tags"=>["17 adult DS persons", "Aberrant Behavior Checklist", "V 4 region", "DS persons", "16 S rRNA gene", "abc", "subdominant GM components"], "article_id"=>1236067, "categories"=>["Biological Sciences", "Science Policy", "Ecology"], "users"=>["Elena Biagi", "Marco Candela", "Manuela Centanni", "Clarissa Consolandi", "Simone Rampelli", "Silvia Turroni", "Marco Severgnini", "Clelia Peano", "Alessandro Ghezzo", "Maria Scurti", "Stefano Salvioli", "Claudio Franceschi", "Patrizia Brigidi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0112023.s001", "https://dx.doi.org/10.1371/journal.pone.0112023.s002", "https://dx.doi.org/10.1371/journal.pone.0112023.s003", "https://dx.doi.org/10.1371/journal.pone.0112023.s004", "https://dx.doi.org/10.1371/journal.pone.0112023.s005", "https://dx.doi.org/10.1371/journal.pone.0112023.s006"], "stats"=>{"downloads"=>13, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gut_Microbiome_in_Down_Syndrome_/1236067", "title"=>"Gut Microbiome in Down Syndrome", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-11-11 03:22:10"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"6", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
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  • {"unique-ip"=>"26", "full-text"=>"27", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"1", "year"=>"2018", "month"=>"11"}
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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Behavior", "average_usage"=>[333]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[286]}, {"subject_area"=>"/Biology and life sciences/Ecology", "average_usage"=>[331]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[285]}, {"subject_area"=>"/People and places/Population groupings", "average_usage"=>[300]}]}
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