Therapeutic Effect of Vagus Nerve Stimulation on Depressive-Like Behavior, Hyperglycemia and Insulin Receptor Expression in Zucker Fatty Rats
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{"title"=>"Therapeutic effect of vagus nerve stimulation on depressive-like behavior, hyperglycemia and insulin receptor expression in zucker fatty rats", "type"=>"journal", "authors"=>[{"first_name"=>"Shaoyuan", "last_name"=>"Li", "scopus_author_id"=>"55885571300"}, {"first_name"=>"Xu", "last_name"=>"Zhai", "scopus_author_id"=>"49965157400"}, {"first_name"=>"Peijing", "last_name"=>"Rong", "scopus_author_id"=>"35337717600"}, {"first_name"=>"Michael F.", "last_name"=>"McCabe", "scopus_author_id"=>"41561867200"}, {"first_name"=>"Xing", "last_name"=>"Wang", "scopus_author_id"=>"56404937300"}, {"first_name"=>"Jingjun", "last_name"=>"Zhao", "scopus_author_id"=>"56299819600"}, {"first_name"=>"Hui", "last_name"=>"Ben", "scopus_author_id"=>"6603815273"}, {"first_name"=>"Shuxing", "last_name"=>"Wang", "scopus_author_id"=>"7410333302"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84909979354", "pmid"=>"25365428", "isbn"=>"1932-6203", "pui"=>"600373063", "issn"=>"19326203", "scopus"=>"2-s2.0-84909979354", "doi"=>"10.1371/journal.pone.0112066"}, "id"=>"231403db-87d1-316f-9497-97ad3ea5c7cc", "abstract"=>"Depression and type 2 diabetes (T2D) are common comorbid diseases and highly prevalent in the clinical setting with an unclarified mechanism. Zucker diabetic fatty (ZDF, fa/fa) rats natively develop T2D with hyperglycemia and hyperinsulinemia. Here we studied whether ZDF rats also innately develop depression, what a correlation is between depression and T2D, whether insulin receptor (IR) expression is involved in, and whether transcutaneous auricular vagus nerve stimulation (taVNS) would be beneficial in amelioration of the comorbidity. Six week old male ZDF and Zucker lean (ZL, fa/+) littermates were randomly divided into naïve (ZDF, n = 6; ZL, n = 7) and taVNS (ZDF-taVNS, n = 8; ZL-taVNS, n = 6) groups. Once daily 30 min-taVNS sessions were administrated under anesthesia for 34 consecutive days in taVNS groups. Blood glucose levels were tested weekly, and plasma glycosylated hemoglobin (HbAlc) level and immobility time in forced swimming test were determined on day 35 in all groups. The expression of insulin receptor (IR) in various tissues was also detected by immunostaining and Western blot. We found that naïve ZDF rats developed hyperglycemia steadily. These ZDF rats showed a strong positive correlation between longer immobility time and higher plasma HbAlC level. Long term taVNS treatment simultaneously prevented the development of depression-like behavior and progression of hyperglycemia in ZDF rats. The expression of IR in various tissues of naïve ZDF rats is lower than in naïve ZL and long-term taVNS treated ZDF rats. Collectively, our results indicate that in ZDF rats, i) depression and T2D develop simultaneously, ii) immobility time and HbAlc concentrations are highly and positively correlated, iii) a low expression of IR may be involved in the comorbidity of depression and T2D, and iv) taVNS is antidiabetic and antidepressive possibly through IR expression upregulation.", "link"=>"http://www.mendeley.com/research/therapeutic-effect-vagus-nerve-stimulation-depressivelike-behavior-hyperglycemia-insulin-receptor-ex", "reader_count"=>33, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>6, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>3, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>5, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>6, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>3, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>5, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Engineering"=>2, "Nursing and Health Professions"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>9, "Agricultural and Biological Sciences"=>3, "Philosophy"=>1, "Neuroscience"=>4, "Psychology"=>3, "Social Sciences"=>1, "Computer Science"=>1, "Sports and Recreations"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Neuroscience"=>{"Neuroscience"=>4}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>3}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>5}, "Philosophy"=>{"Philosophy"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Portugal"=>1}, "group_count"=>3}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1777492"], "description"=>"<p>Showing the development of hyperglycemia in ZDF rats with or without the taVNS treatment (a) and the effect of taVNS in ZL rats. ZDF, naïve ZDF rats; ZL, naïve ZL rats; taVNS, transcutaneous auricular vagus nerve stimulation; AMS, auricular margin stimulation; Bas, baseline; W1-5, week 1 to week 5 of the experiment. *, **, ***, P<0.05, 0.01, 0.001 <i>vs.</i> Bas; #, ###, P<0.05, 0.001 <i>vs.</i> naïve rats, respectively.</p>", "links"=>[], "tags"=>["insulin receptor", "plasma HbAlC level", "blood glucose levels", "immobility time", "Long term taVNS treatment", "depression", "Vagus Nerve Stimulation", "zl", "type 2 diabetes", "T 2D", "IR expression upregulation", "Insulin Receptor Expression", "transcutaneous auricular vagus nerve stimulation", "ZDF rats", "Zucker Fatty Rats Depression", "plasma glycosylated hemoglobin"], "article_id"=>1227614, "categories"=>["Biological Sciences"], "users"=>["Shaoyuan Li", "Xu Zhai", "Peijing Rong", "Michael F. McCabe", "Xing Wang", "Jingjun Zhao", "Hui Ben", "Shuxing Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112066.g001", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Blood_glucose_change_in_na_239_ve_and_taVNS_treated_rats_/1227614", "title"=>"Blood glucose change in naïve and taVNS treated rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-03 03:51:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/1777520"], "description"=>"<p>Correlations between HbAlc level and immobility time in FST on day 35.</p>", "links"=>[], "tags"=>["insulin receptor", "plasma HbAlC level", "blood glucose levels", "immobility time", "Long term taVNS treatment", "depression", "Vagus Nerve Stimulation", "zl", "type 2 diabetes", "T 2D", "IR expression upregulation", "Insulin Receptor Expression", "transcutaneous auricular vagus nerve stimulation", "ZDF rats", "Zucker Fatty Rats Depression", "plasma glycosylated hemoglobin"], "article_id"=>1227642, "categories"=>["Biological Sciences"], "users"=>["Shaoyuan Li", "Xu Zhai", "Peijing Rong", "Michael F. McCabe", "Xing Wang", "Jingjun Zhao", "Hui Ben", "Shuxing Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112066.t003", "stats"=>{"downloads"=>6, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlations_between_HbAlc_level_and_immobility_time_in_FST_on_day_35_/1227642", "title"=>"Correlations between HbAlc level and immobility time in FST on day 35.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-03 03:51:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/1777500"], "description"=>"<p>(a, b) Immunofluorescent results showing the expression of insulin receptor <b>(IR)</b> in amygdala of naïve ZDF rats (a) and of ZDF rats treated for 5 consecutive weeks with daily half hour taVNS treatment (b). Arrow head, IR-immunopositive neurons. Bar, 100 µm. (c–h) Western blot results showing the expression of insulin receptor in hypothalamus (c, d), liver (e, f), and skeletal muscle (g, h) of naïve rats, or rats treated with taVNS for 34 consecutive days. ZL, naïve ZL rats; ZDF, naïve ZDF rats; taVNS, auricular vagus electronic stimulation. n = 3 each group, Western blot triplicated for each sample. *,** P<0.05, 0.01 <i>vs.</i> ZL; #,## P<0.05, 0.01 <i>vs.</i> ZDF.</p>", "links"=>[], "tags"=>["insulin receptor", "plasma HbAlC level", "blood glucose levels", "immobility time", "Long term taVNS treatment", "depression", "Vagus Nerve Stimulation", "zl", "type 2 diabetes", "T 2D", "IR expression upregulation", "Insulin Receptor Expression", "transcutaneous auricular vagus nerve stimulation", "ZDF rats", "Zucker Fatty Rats Depression", "plasma glycosylated hemoglobin"], "article_id"=>1227622, "categories"=>["Biological Sciences"], "users"=>["Shaoyuan Li", "Xu Zhai", "Peijing Rong", "Michael F. McCabe", "Xing Wang", "Jingjun Zhao", "Hui Ben", "Shuxing Wang"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112066.g003", "stats"=>{"downloads"=>0, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_insulin_receptor_in_various_tissues_of_rats_/1227622", "title"=>"Expression of insulin receptor in various tissues of rats.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-03 03:51:02"}
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PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2014-01-01T00:00:00Z", "end_date"=>"2014-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[282]}, {"subject_area"=>"/Medicine and health sciences/Hematology", "average_usage"=>[256]}, {"subject_area"=>"/Medicine and health sciences/Metabolic disorders", "average_usage"=>[252, 402]}]}
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