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{"title"=>"Iodide protects heart tissue from reperfusion injury", "type"=>"journal", "authors"=>[{"first_name"=>"Akiko", "last_name"=>"Iwata", "scopus_author_id"=>"56235728100"}, {"first_name"=>"Michael L.", "last_name"=>"Morrison", "scopus_author_id"=>"7201675304"}, {"first_name"=>"Mark B.", "last_name"=>"Roth", "scopus_author_id"=>"7401440552"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"25379708", "doi"=>"10.1371/journal.pone.0112458", "pui"=>"600483509", "issn"=>"19326203", "sgr"=>"84911446665", "scopus"=>"2-s2.0-84911446665"}, "id"=>"cc76c780-7ed5-326d-817e-b5729ea1f3c5", "abstract"=>"Iodine is an elemental nutrient that is essential for mammals. Here we provide evidence for an acute therapeutic role for iodine in ischemia reperfusion injury. Infusion of the reduced form, iodide, but not the oxidized form iodate, reduces heart damage by as much as 75% when delivered intravenously following temporary loss of blood flow but prior to reperfusion of the heart in a mouse model of acute myocardial infarction. Normal thyroid function may be required because loss of thyroid activity abrogates the iodide benefit. Given the high degree of protection and the high degree of safety, iodide should be explored further as a therapy for reperfusion injury.", "link"=>"http://www.mendeley.com/research/iodide-protects-heart-tissue-reperfusion-injury", "reader_count"=>12, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>1, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Other"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>1, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Other"=>2}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>6, "Agricultural and Biological Sciences"=>1, "Design"=>1, "Chemistry"=>2, "Computer Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>1}, "reader_count_by_subdiscipline"=>{"Design"=>{"Design"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Chemistry"=>{"Chemistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"United States"=>3}, "group_count"=>3}

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• http://doi.org/10.1016/j.numecd.2017.06.001
• http://doi.org/10.1016/j.freeradbiomed.2017.12.014
• http://doi.org/10.2139/ssrn.3604987
• http://doi.org/10.1016/j.pharmthera.2020.107685
• http://doi.org/10.1097/CCE.0000000000000215
• http://doi.org/10.1016/j.redox.2019.101331
• http://doi.org/10.1089/thy.2020.0131
• http://doi.org/10.1097/CCM.0000000000000971
• http://doi.org/10.1177/0023677215604531
• http://doi.org/10.4236/ns.2015.712055
• http://doi.org/10.1021/acs.langmuir.0c02618
• http://doi.org/10.1097/CCM.0000000000003353
• http://doi.org/10.1002/ddr.21258

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• {"referral"=>"http://www.newscientist.com/article/dn26623-supersafe-iodide-may-save-millions-from-heart-disease.html", "language"=>"English", "title"=>"Super-safe iodide may save millions from heart disease", "type"=>"News", "publication"=>"New Scientist", "published_on"=>"2014-11-27T00:00:00Z", "link_state"=>"APPROVED"}

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• {"id"=>"538061032921767936", "text"=>"Iodide protects heart tissue from reperfusion injury http://t.co/3dEPX6xOx6 in @PLOSONE", "created_at"=>"2014-11-27T20:05:21Z", "user"=>"Helena_LB", "user_name"=>"Helena ", "user_profile_image"=>"http://pbs.twimg.com/profile_images/472742148060626944/MFcaJXPY_normal.jpeg"}
• {"id"=>"552162650176884736", "text"=>"Iodine is an elemental nutrient that is essential for mammals http://t.co/tYoKASOWz5\"", "created_at"=>"2015-01-05T18:00:09Z", "user"=>"thebaybot", "user_name"=>"baybot", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000263061007/bb2880bd6baf8e5298f42b156c5adebe_normal.jpeg"}

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/1783520"], "description"=>"<p>Mice were subjected to 60 minutes of ischemia followed by 120 minutes or 24 hours of reperfusion. Animals were infused with test agents or saline (sodium chloride) 5 minutes before the end of the ischemic period and before reperfusion.</p>", "links"=>[], "tags"=>["thyroid activity abrogates", "blood flow", "heart damage", "Reperfusion Injury Iodine", "Iodide Protects Heart Tissue", "iodide benefit", "Mouse Model", "ischemia reperfusion injury", "Reperfusion injury", "form iodate", "Normal thyroid function"], "article_id"=>1232258, "categories"=>["Uncategorised"], "users"=>["Akiko Iwata", "Michael L. Morrison", "Mark B. Roth"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112458.g001", "stats"=>{"downloads"=>2, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Acute_myocardial_infarction_model_timeline_/1232258", "title"=>"Acute myocardial infarction model timeline.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-07 02:42:45"}
• {"files"=>["https://ndownloader.figshare.com/files/1783521"], "description"=>"<p>Infarct (Inf) and area at risk (AAR) volumes were measured using morphometry after administration of escalating doses of iodide. Y-axis is volume as a percent of total. X-axis labels are AAR/LV (ratio of area at risk volume to left ventricle volume), Inf/AAR (ratio of infarct volume to area at risk volume) and Inf/LV (infarct volume to left ventricular volume). Colored bars describe groups that are listed in the key. The blue bars are saline. All other bars describe groups of animals that received iodide at different concentrations in mg/kg. Parenthetical n numbers define group sizes. The two asterisk brackets over Inf/AAR and Inf/LV are meant to show that all 4 groups under the brackets showed statistically significant differences when compared to control saline (p<0.05).</p>", "links"=>[], "tags"=>["thyroid activity abrogates", "blood flow", "heart damage", "Reperfusion Injury Iodine", "Iodide Protects Heart Tissue", "iodide benefit", "Mouse Model", "ischemia reperfusion injury", "Reperfusion injury", "form iodate", "Normal thyroid function"], "article_id"=>1232259, "categories"=>["Uncategorised"], "users"=>["Akiko Iwata", "Michael L. Morrison", "Mark B. Roth"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112458.g002", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Iodide_reduces_heart_damage_after_MIR_/1232259", "title"=>"Iodide reduces heart damage after MIR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-07 02:42:45"}
• {"files"=>["https://ndownloader.figshare.com/files/1783522"], "description"=>"<p>Infarct (Inf) and area at risk (AAR) volumes were measured using morphometry after administration of iodide. Y-axis is volume as a percent of total. X-axis labels are AAR/LV (ratio of area at risk volume to left ventricle volume), Inf/AAR (ratio of infarct volume to area at risk volume) and Inf/LV (infarct volume to left ventricular volume). The data from 2 hours is the same as shown in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0112458#pone-0112458-g002\" target=\"_blank\">Figure 2</a>. The asterisks indicate a statistically significant difference between saline and iodide treated animals (p<0.05).</p>", "links"=>[], "tags"=>["thyroid activity abrogates", "blood flow", "heart damage", "Reperfusion Injury Iodine", "Iodide Protects Heart Tissue", "iodide benefit", "Mouse Model", "ischemia reperfusion injury", "Reperfusion injury", "form iodate", "Normal thyroid function"], "article_id"=>1232260, "categories"=>["Uncategorised"], "users"=>["Akiko Iwata", "Michael L. Morrison", "Mark B. Roth"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112458.g003", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Iodide_reduces_heart_damage_after_both_2_and_24_hours_of_reperfusion_/1232260", "title"=>"Iodide reduces heart damage after both 2 and 24 hours of reperfusion.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-07 02:42:45"}
• {"files"=>["https://ndownloader.figshare.com/files/1783523"], "description"=>"<p>Infarct (Inf) and area at risk (AAR) volumes were measured using morphometry after administration of 1 mg/kg iodide. Y-axis is volume as a percent of total. X-axis labels are AAR/LV (ratio of area at risk volume to left ventricle volume), Inf/AAR (ratio of infarct volume to area at risk volume) and Inf/LV (infarct volume to left ventricular volume). Blue bars describe the data from control animals. Red bars describe the data from iodide treated animals. Parenthetical n numbers define group sizes. Inf/LV and Inf/AAR showed statistically significant differences between saline and iodide treated animals (p<0.05).</p>", "links"=>[], "tags"=>["thyroid activity abrogates", "blood flow", "heart damage", "Reperfusion Injury Iodine", "Iodide Protects Heart Tissue", "iodide benefit", "Mouse Model", "ischemia reperfusion injury", "Reperfusion injury", "form iodate", "Normal thyroid function"], "article_id"=>1232262, "categories"=>["Uncategorised"], "users"=>["Akiko Iwata", "Michael L. Morrison", "Mark B. Roth"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112458.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Measurement_of_heart_damage_after_blinded_iodide_treatment_/1232262", "title"=>"Measurement of heart damage after blinded iodide treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-07 02:42:45"}
• {"files"=>["https://ndownloader.figshare.com/files/1783525"], "description"=>"<p>Infarct (Inf) and area at risk (AAR) volumes were measured using morphometry after administration of iodate and iodide. Y-axis is volume as a percent of total. X-axis labels are AAR/LV (ratio of area at risk volume to left ventricle volume), Inf/AAR (ratio of infarct volume to area at risk volume) and Inf/LV (infarct volume to left ventricular volume). Colored bars describe groups that are listed in the key. The blue bars are saline. Animals that received either 1 mg/kg iodate (tan) or iodide (orange). Parenthetical n numbers define group sizes. The two asterisks indicate that iodide shows a statistically significant difference when compared to control saline (p<0.05).</p>", "links"=>[], "tags"=>["thyroid activity abrogates", "blood flow", "heart damage", "Reperfusion Injury Iodine", "Iodide Protects Heart Tissue", "iodide benefit", "Mouse Model", "ischemia reperfusion injury", "Reperfusion injury", "form iodate", "Normal thyroid function"], "article_id"=>1232263, "categories"=>["Uncategorised"], "users"=>["Akiko Iwata", "Michael L. Morrison", "Mark B. Roth"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112458.g005", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Oxidized_iodine_iodate_does_not_reduce_heart_damage_after_MIR_/1232263", "title"=>"Oxidized iodine, iodate, does not reduce heart damage after MIR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-07 02:42:45"}
• {"files"=>["https://ndownloader.figshare.com/files/1783526"], "description"=>"<p>Fractional shortening and LV ejection fraction before (baseline) and at 48 hours reperfusion following the MIR procedure with and without iodide (1 mg/kg) administration. Animals were survived following the MIR procedure for 48 hours and then subjected to echocardiography. Fractional shortening (A) and ejection fraction (B) are presented. * P<0.001 vs. saline.</p>", "links"=>[], "tags"=>["thyroid activity abrogates", "blood flow", "heart damage", "Reperfusion Injury Iodine", "Iodide Protects Heart Tissue", "iodide benefit", "Mouse Model", "ischemia reperfusion injury", "Reperfusion injury", "form iodate", "Normal thyroid function"], "article_id"=>1232265, "categories"=>["Uncategorised"], "users"=>["Akiko Iwata", "Michael L. Morrison", "Mark B. Roth"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112458.g006", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Echocardiography_48_hours_post_MIR_and_iodide_treatment_/1232265", "title"=>"Echocardiography 48 hours post MIR and iodide treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-07 02:42:45"}
• {"files"=>["https://ndownloader.figshare.com/files/1783528"], "description"=>"<p>Mice were subjected to MIR with 2 hours of reperfusion. At 5 min prior to reperfusion, mice were given either iodide (1 mg/kg) or saline by retro orbital injection. Hearts were sectioned following reperfusion and neutrophils quantitated. *p<0.05.</p>", "links"=>[], "tags"=>["thyroid activity abrogates", "blood flow", "heart damage", "Reperfusion Injury Iodine", "Iodide Protects Heart Tissue", "iodide benefit", "Mouse Model", "ischemia reperfusion injury", "Reperfusion injury", "form iodate", "Normal thyroid function"], "article_id"=>1232266, "categories"=>["Uncategorised"], "users"=>["Akiko Iwata", "Michael L. Morrison", "Mark B. Roth"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112458.g007", "stats"=>{"downloads"=>6, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Neutrophil_accumulation_after_MIR_and_iodide_treatment_/1232266", "title"=>"Neutrophil accumulation after MIR and iodide treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-07 02:42:45"}
• {"files"=>["https://ndownloader.figshare.com/files/1783529"], "description"=>"<p>Mice were subjected to LAD ligation for 60 min following 2 hours of reperfusion. At 5 min prior to reperfusion, mice were given either iodide (1 mg/kg) or saline by retro orbital injection. Following 2 hours of reperfusion, blood was collected and plasma cardiac troponin-I (cTnI ng/mL) measured by ELISA. * p<0.05.</p>", "links"=>[], "tags"=>["thyroid activity abrogates", "blood flow", "heart damage", "Reperfusion Injury Iodine", "Iodide Protects Heart Tissue", "iodide benefit", "Mouse Model", "ischemia reperfusion injury", "Reperfusion injury", "form iodate", "Normal thyroid function"], "article_id"=>1232267, "categories"=>["Uncategorised"], "users"=>["Akiko Iwata", "Michael L. Morrison", "Mark B. Roth"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112458.g008", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Plasma_troponin_I_measurement_after_MIR_and_iodide_treatment_/1232267", "title"=>"Plasma troponin I measurement after MIR and iodide treatment.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-07 02:42:45"}
• {"files"=>["https://ndownloader.figshare.com/files/1783530"], "description"=>"<p>Infarct (Inf) and area at risk (AAR) volumes were measured using morphometry after administration of escalating doses of iodide. Y-axis is volume as a percent of total. X-axis labels are AAR/LV (ratio of area at risk volume to left ventricle volume), Inf/AAR (ratio of infarct volume to area at risk volume) and Inf/LV (infarct volume to left ventricular volume). The blue bars are hearts from normal water drinking animals. Red and tan bars are from animals that drank 0.028 mM or 0.28 mM iodide for 2 days prior to the MIR procedure, respectively. The orange hatched bars are from animals that received 1 mg/kg of iodide intravenously 5 minutes before reperfusion. Numbers in bars define group sizes. The two asterisk brackets over Inf/AAR and Inf/LV indicate that all 3 groups under the brackets show statistically significant improvements compared to control saline (p<0.05).</p>", "links"=>[], "tags"=>["thyroid activity abrogates", "blood flow", "heart damage", "Reperfusion Injury Iodine", "Iodide Protects Heart Tissue", "iodide benefit", "Mouse Model", "ischemia reperfusion injury", "Reperfusion injury", "form iodate", "Normal thyroid function"], "article_id"=>1232268, "categories"=>["Uncategorised"], "users"=>["Akiko Iwata", "Michael L. Morrison", "Mark B. Roth"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112458.g009", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Orally_administered_iodide_reduces_heart_damage_after_MIR_/1232268", "title"=>"Orally administered iodide reduces heart damage after MIR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-07 02:42:45"}
• {"files"=>["https://ndownloader.figshare.com/files/1783531"], "description"=>"<p>Infarct (Inf) and area at risk (AAR) volumes were measured using morphometry after administration of sodium bromide (1 mg/kg). Y-axis is volume as a percent of total. X-axis labels are AAR/LV (ratio of area at risk volume to left ventricle volume), Inf/AAR (ratio of infarct volume to area at risk volume) and Inf/LV (infarct volume to left ventricular volume Blue bars are saline and red bars are bromide. The asterisks indicate statistically significant differences between saline and bromide treated animals (p<0.05).</p>", "links"=>[], "tags"=>["thyroid activity abrogates", "blood flow", "heart damage", "Reperfusion Injury Iodine", "Iodide Protects Heart Tissue", "iodide benefit", "Mouse Model", "ischemia reperfusion injury", "Reperfusion injury", "form iodate", "Normal thyroid function"], "article_id"=>1232269, "categories"=>["Uncategorised"], "users"=>["Akiko Iwata", "Michael L. Morrison", "Mark B. Roth"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112458.g010", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Bromide_reduces_damage_after_MIR_/1232269", "title"=>"Bromide reduces damage after MIR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-07 02:42:45"}
• {"files"=>["https://ndownloader.figshare.com/files/1783532"], "description"=>"<p>Mice fed iodide deficient chow containing 0.15% propylthiouracil were subjected to the MIR procedure with 2 hours of reperfusion. Infarct (Inf) and area at risk (AAR) volumes were measured using morphometry after administration of iodide. Y-axis is volume as a percent of total. X-axis labels are AAR/LV (ratio of area at risk volume to left ventricle volume), Inf/AAR (ratio of infarct volume to area at risk volume) and Inf/LV (infarct volume to left ventricular volume). Blue bars are values from animals administered saline; orange bars are values from iodide treated animals. The difference in infarct volume between saline and iodide treated animals is not significant.</p>", "links"=>[], "tags"=>["thyroid activity abrogates", "blood flow", "heart damage", "Reperfusion Injury Iodine", "Iodide Protects Heart Tissue", "iodide benefit", "Mouse Model", "ischemia reperfusion injury", "Reperfusion injury", "form iodate", "Normal thyroid function"], "article_id"=>1232270, "categories"=>["Uncategorised"], "users"=>["Akiko Iwata", "Michael L. Morrison", "Mark B. Roth"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112458.g011", "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Thyroid_function_is_required_for_iodide_benefit_/1232270", "title"=>"Thyroid function is required for iodide benefit.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-07 02:42:45"}
• {"files"=>["https://ndownloader.figshare.com/files/1783533"], "description"=>"<p>Heart rate and body core temperature were measured using radiotelemetry. Carbon dioxide production was measured using an infrared CO₂ analyzer. Heart rate values (HR) are expressed in beats per minute. CO₂ values are ppm. Body core temperature values (Temp) are expressed in degrees Celsius. Measurements were made for 30 minutes before iodide or saline administration (pre) to determine baseline metabolism, at 30 minutes after iodide/saline administration and at 180 minutes after administration. Values shown are average +/− standard deviation and p value.</p><p>Iodide reduces metabolism.</p>", "links"=>[], "tags"=>["thyroid activity abrogates", "blood flow", "heart damage", "Reperfusion Injury Iodine", "Iodide Protects Heart Tissue", "iodide benefit", "Mouse Model", "ischemia reperfusion injury", "Reperfusion injury", "form iodate", "Normal thyroid function"], "article_id"=>1232271, "categories"=>["Uncategorised"], "users"=>["Akiko Iwata", "Michael L. Morrison", "Mark B. Roth"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112458.t001", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Iodide_reduces_metabolism_/1232271", "title"=>"Iodide reduces metabolism.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-07 02:42:45"}

PMC Usage Stats | Further Information

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Relative Metric

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F1000Prime