Hematopoietic Stem/Progenitor Cell Sources to Generate Reticulocytes for Plasmodium vivax Culture
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{"title"=>"Hematopoietic stem/progenitor cell sources to generate reticulocytes for Plasmodium vivax culture", "type"=>"journal", "authors"=>[{"first_name"=>"Florian", "last_name"=>"Noulin", "scopus_author_id"=>"36873459600"}, {"first_name"=>"Javed Karim", "last_name"=>"Manesia", "scopus_author_id"=>"56426390600"}, {"first_name"=>"Anna", "last_name"=>"Rosanas-Urgell", "scopus_author_id"=>"23669349400"}, {"first_name"=>"Annette", "last_name"=>"Erhart", "scopus_author_id"=>"6603150712"}, {"first_name"=>"Céline", "last_name"=>"Borlon", "scopus_author_id"=>"57197800949"}, {"first_name"=>"Jan", "last_name"=>"Van Den Abbeele", "scopus_author_id"=>"6602078355"}, {"first_name"=>"Umberto", "last_name"=>"D'Alessandro", "scopus_author_id"=>"7005042050"}, {"first_name"=>"Catherine M.", "last_name"=>"Verfaillie", "scopus_author_id"=>"7004524257"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"25393299", "doi"=>"10.1371/journal.pone.0112496", "issn"=>"19326203", "scopus"=>"2-s2.0-84911905912", "pui"=>"600507547", "sgr"=>"84911905912"}, "id"=>"a382a661-279f-32be-8345-d5e3f49e011e", "abstract"=>"The predilection of Plasmodium vivax (P. vivax) for reticulocytes is a major obstacle for its establishment in a long-term culture system, as this requires a continuous supply of large quantities of reticulocytes, representing only 1-2% of circulating red blood cells. We here compared the production of reticulocytes using an established in vitro culture system from three different sources of hematopoietic stem/progenitor cells (HSPC), i.e. umbilical cord blood (UCB), bone marrow (BM) and adult peripheral blood (PB). Compared to CD34+-enriched populations of PB and BM, CD34+-enriched populations of UCB produced the highest amount of reticulocytes that could be invaded by P. vivax. In addition, when CD34+-enriched cells were first expanded, a further extensive increase in reticulocytes was seen for UCB, to a lesser degree BM but not PB. As invasion by P. vivax was significantly better in reticulocytes generated in vitro, we also suggest that P. vivax may have a preference for invading immature reticulocytes, which should be confirmed in future studies.", "link"=>"http://www.mendeley.com/research/hematopoietic-stemprogenitor-cell-sources-generate-reticulocytes-plasmodium-vivax-culture", "reader_count"=>28, "reader_count_by_academic_status"=>{"Librarian"=>1, "Researcher"=>11, "Student > Ph. D. Student"=>4, "Student > Master"=>5, "Other"=>2, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Librarian"=>1, "Researcher"=>11, "Student > Ph. D. Student"=>4, "Student > Master"=>5, "Other"=>2, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>14, "Medicine and Dentistry"=>7, "Social Sciences"=>1, "Immunology and Microbiology"=>2, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>14}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"Denmark"=>1, "United Kingdom"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1792339"], "description"=>"<p>Results show the mean proportions of reticulocytes observed at the peak of enucleation after 14 days of culture, as well as the increase in total cell number after 5 days of expansion and 7 days of differentiation (3 independent experiments). After 5 days of expansion, the number of cells was counted and divided by the initial number of plated MACS/CD34<sup>+</sup> cells, while after 7 days of HSPC differentiation, the cell count was compared to the number of cells not previously expanded, results are expressed in mean fold increase (± SD).</p><p>Hematopoietic stem progenitor cells (HSPC) expansion and reticulocyte differentiation for three different sources HSPCs (6 independent experiments were carried out for each HSPC source).</p>", "links"=>[], "tags"=>["culture system", "bm", "hspc", "pb", "Plasmodium vivax Culture", "ucb", "reticulocyte", "umbilical cord blood"], "article_id"=>1239823, "categories"=>["Biological Sciences"], "users"=>["Florian Noulin", "Javed Karim Manesia", "Anna Rosanas-Urgell", "Annette Erhart", "Céline Borlon", "Jan Van Den Abbeele", "Umberto D'Alessandro", "Catherine M. Verfaillie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112496.t001", "stats"=>{"downloads"=>4, "page_views"=>33, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hematopoietic_stem_progenitor_cells_HSPC_expansion_and_reticulocyte_differentiation_for_three_different_sources_HSPCs_6_independent_experiments_were_carried_out_for_each_HSPC_source_/1239823", "title"=>"Hematopoietic stem progenitor cells (HSPC) expansion and reticulocyte differentiation for three different sources HSPCs (6 independent experiments were carried out for each HSPC source).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-13 03:18:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1792335"], "description"=>"<p>A) UCB/HSPC, B) BM/HSPC, C) PB/HSPC, D) reticulocytes-enriched UCB and E) reticulocytes-enriched PB. The left panels represent pictures with a 63× magnification and the corresponding right panels represent a 100× of the left picture square. <i>P. vivax</i> infected cells are under arrow.</p>", "links"=>[], "tags"=>["culture system", "bm", "hspc", "pb", "Plasmodium vivax Culture", "ucb", "reticulocyte", "umbilical cord blood"], "article_id"=>1239819, "categories"=>["Biological Sciences"], "users"=>["Florian Noulin", "Javed Karim Manesia", "Anna Rosanas-Urgell", "Annette Erhart", "Céline Borlon", "Jan Van Den Abbeele", "Umberto D'Alessandro", "Catherine M. Verfaillie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112496.g003", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cytopsin_of_the_P_vivax_culture_24_h_post_invasion_for_different_sources_of_reticulocytes_/1239819", "title"=>"Cytopsin of the <i>P. vivax</i> culture 24 h post-invasion for different sources of reticulocytes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-13 03:18:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1792337"], "description"=>"<p>The parasite density was counted for at least 500 red blood cells, dividing the number of infected enucleated cells by the total number of cells and multiplied by 100 (%). a) Parasite density for different sources of HSPC-derived reticulocytes with 1 <i>P. vivax</i> isolate. The mean and SD of 2 different batches of differentiated reticulocytes was calculated for each source of HSPC and tested for invasion with the same <i>P. vivax</i> isolate. b) Parasite density for each source of reticulocytes with different <i>P. vivax</i> isolates. Parasite densities (%) were counted by dividing the number of <i>P. vivax</i> ring-infected cells by the total number of counted RBCs and multiplying the result by 100. Different reticulocyte sources were tested: grey  =  UCB/HSPC-derived reticulocytes; dotted  =  BM/HSPC-derived reticulocytes; squared  =  PBMC/HSPC-derived reticulocytes; white  =  reticulocytes concentrated from UCB, black  =  reticulocytes concentrated from adult peripheral blood. PV1 and PV2 were tested with the same batches of HSPC-derived reticulocytes for the 3 different sources (UCB, BM and PBMC). For PV4, the proportion of reticulocytes was 20% for HSCP-derived reticulocytes and respectively 70% and 60% for reticulocytes concentrated from UCB adult peripheral blood.</p>", "links"=>[], "tags"=>["culture system", "bm", "hspc", "pb", "Plasmodium vivax Culture", "ucb", "reticulocyte", "umbilical cord blood"], "article_id"=>1239821, "categories"=>["Biological Sciences"], "users"=>["Florian Noulin", "Javed Karim Manesia", "Anna Rosanas-Urgell", "Annette Erhart", "Céline Borlon", "Jan Van Den Abbeele", "Umberto D'Alessandro", "Catherine M. Verfaillie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112496.g004", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Parasite_densities_24_hours_post_invasion_with_P_vivax_/1239821", "title"=>"Parasite densities 24 hours post-invasion with <i>P. vivax</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-13 03:18:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1792325"], "description"=>"<p>The Q2 gate represents the population double positive for CD34 (APC) and CD45 (PE).</p>", "links"=>[], "tags"=>["culture system", "bm", "hspc", "pb", "Plasmodium vivax Culture", "ucb", "reticulocyte", "umbilical cord blood"], "article_id"=>1239813, "categories"=>["Biological Sciences"], "users"=>["Florian Noulin", "Javed Karim Manesia", "Anna Rosanas-Urgell", "Annette Erhart", "Céline Borlon", "Jan Van Den Abbeele", "Umberto D'Alessandro", "Catherine M. Verfaillie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112496.g001", "stats"=>{"downloads"=>3, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_FACS_analyses_of_the_CD34_CD45_cells_from_UCB_PBMNC_and_BM_after_isolation_Day_0_and_following_5_days_of_expansion_/1239813", "title"=>"FACS analyses of the CD34<sup>+</sup>/CD45<sup>+</sup> cells from UCB, PBMNC and BM, after isolation (Day 0) and following 5 days of expansion.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-13 03:18:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/1792327"], "description"=>"<p>The Q2 gate represents the population positive for CD235a (Per-CP-Cy5-5) and CD71 (PE).</p>", "links"=>[], "tags"=>["culture system", "bm", "hspc", "pb", "Plasmodium vivax Culture", "ucb", "reticulocyte", "umbilical cord blood"], "article_id"=>1239815, "categories"=>["Biological Sciences"], "users"=>["Florian Noulin", "Javed Karim Manesia", "Anna Rosanas-Urgell", "Annette Erhart", "Céline Borlon", "Jan Van Den Abbeele", "Umberto D'Alessandro", "Catherine M. Verfaillie"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112496.g002", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_FACS_analyses_of_the_CD235a_CD71_cells_from_UCB_PBMNC_and_BM_after_5_days_of_expansion_and_14_days_of_differentiation_/1239815", "title"=>"FACS analyses of the CD235a<sup>+</sup>/CD71<sup>+</sup> cells from UCB, PBMNC and BM, after 5 days of expansion and 14 days of differentiation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-13 03:18:54"}

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