Diffusion Tensor Imaging of Parkinson’s Disease, Multiple System Atrophy and Progressive Supranuclear Palsy: A Tract-Based Spatial Statistics Study
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{"title"=>"Diffusion tensor imaging of Parkinson's disease, multiple system atrophy and progressive supranuclear palsy: A tract-based spatial statistics study", "type"=>"journal", "authors"=>[{"first_name"=>"Amanda", "last_name"=>"Worker", "scopus_author_id"=>"56433382400"}, {"first_name"=>"Camilla", "last_name"=>"Blain", "scopus_author_id"=>"15755006300"}, {"first_name"=>"Jozef", "last_name"=>"Jarosz", "scopus_author_id"=>"35599341600"}, {"first_name"=>"K. Ray", "last_name"=>"Chaudhuri", "scopus_author_id"=>"7102516281"}, {"first_name"=>"Gareth J.", "last_name"=>"Barker", "scopus_author_id"=>"34869208000"}, {"first_name"=>"Steve C.R.", "last_name"=>"Williams", "scopus_author_id"=>"35419560700"}, {"first_name"=>"Richard G.", "last_name"=>"Brown", "scopus_author_id"=>"7406363771"}, {"first_name"=>"P. Nigel", "last_name"=>"Leigh", "scopus_author_id"=>"26643325600"}, {"first_name"=>"Flavio", "last_name"=>"Dell'acqua", "scopus_author_id"=>"24757840500"}, {"first_name"=>"Andrew", "last_name"=>"Simmons", "scopus_author_id"=>"7101619950"}], "year"=>2014, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84913541633", "doi"=>"10.1371/journal.pone.0112638", "pui"=>"600550417", "pmid"=>"25405990", "scopus"=>"2-s2.0-84913541633", "issn"=>"19326203", "isbn"=>"9781607507925"}, "id"=>"f918660a-bda7-325d-8da8-a0c5dfffbef1", "abstract"=>"Although often clinically indistinguishable in the early stages, Parkinson's disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) have distinct neuropathological changes. The aim of the current study was to identify white matter tract neurodegeneration characteristic of each of the three syndromes. Tract-based spatial statistics (TBSS) was used to perform a whole-brain automated analysis of diffusion tensor imaging (DTI) data to compare differences in fractional anisotropy (FA) and mean diffusivity (MD) between the three clinical groups and healthy control subjects. Further analyses were conducted to assess the relationship between these putative indices of white matter microstructure and clinical measures of disease severity and symptoms. In PSP, relative to controls, changes in DTI indices consistent with white matter tract degeneration were identified in the corpus callosum, corona radiata, corticospinal tract, superior longitudinal fasciculus, anterior thalamic radiation, superior cerebellar peduncle, medial lemniscus, retrolenticular and anterior limb of the internal capsule, cerebral peduncle and external capsule bilaterally, as well as the left posterior limb of the internal capsule and the right posterior thalamic radiation. MSA patients also displayed differences in the body of the corpus callosum corticospinal tract, cerebellar peduncle, medial lemniscus, anterior and superior corona radiata, posterior limb of the internal capsule external capsule and cerebral peduncle bilaterally, as well as the left anterior limb of the internal capsule and the left anterior thalamic radiation. No significant white matter abnormalities were observed in the PD group. Across groups, MD correlated positively with disease severity in all major white matter tracts. These results show widespread changes in white matter tracts in both PSP and MSA patients, even at a mid-point in the disease process, which are not found in patients with PD.", "link"=>"http://www.mendeley.com/research/diffusion-tensor-imaging-parkinsons-disease-multiple-system-atrophy-progressive-supranuclear-palsy-t-2", "reader_count"=>41, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Researcher"=>10, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>2, "Other"=>4, "Student > Master"=>7, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Researcher"=>10, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>2, "Other"=>4, "Student > Master"=>7, "Student > Bachelor"=>2, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Engineering"=>4, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>13, "Agricultural and Biological Sciences"=>6, "Neuroscience"=>10, "Physics and Astronomy"=>1, "Psychology"=>2, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>4}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Neuroscience"=>{"Neuroscience"=>10}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Austria"=>1, "United Kingdom"=>1}, "group_count"=>4}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/1798747"], "description"=>"<p>Background image corresponds to the mean fractional anisotropy image of all subjects in standard MNI152 space (radiological view). Fractional anisotropy white matter skeleton is represented by green voxels. Blue voxels represent regions of decreased FA and yellow voxels represent regions of increased MD in the PSP group.</p>", "links"=>[], "tags"=>["matter tract degeneration", "matter tract neurodegeneration", "capsule", "MSA patients", "dti", "matter tracts", "corona radiata", "Progressive Supranuclear Palsy", "tbss", "pd", "md", "psp", "disease severity", "fa", "limb", "medial lemniscus", "Diffusion tensor imaging", "thalamic radiation", "cerebellar peduncle", "Multiple System Atrophy", "corpus callosum corticospinal tract"], "article_id"=>1245304, "categories"=>["Biological Sciences"], "users"=>["Amanda Worker", "Camilla Blain", "Jozef Jarosz", "K. Ray Chaudhuri", "Gareth J. Barker", "Steve C. R. Williams", "Richard G. Brown", "P. Nigel Leigh", "Flavio Dell’Acqua", "Andrew Simmons"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112638.g001", "stats"=>{"downloads"=>0, "page_views"=>43, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_White_matter_maps_showing_regions_of_significant_decreased_fractional_anisotropy_and_increased_mean_diffusivity_in_PSP_patients_when_compared_to_healthy_controls_PD_and_MSA_Bonferroni_corrected_alpha_8202_8202_0_0167_/1245304", "title"=>"White matter maps showing regions of significant decreased fractional anisotropy and increased mean diffusivity in PSP patients when compared to healthy controls, PD and MSA (Bonferroni corrected alpha = 0.0167).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-18 03:12:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1798748"], "description"=>"<p>Background image corresponds to the mean fractional anisotropy image of all subjects in standard MNI152 space (radiological view). Fractional anisotropy white matter skeleton is represented by green voxels. Blue voxels represent regions of decreased FA and yellow voxels represent regions of increased MD in the PSP group.</p>", "links"=>[], "tags"=>["matter tract degeneration", "matter tract neurodegeneration", "capsule", "MSA patients", "dti", "matter tracts", "corona radiata", "Progressive Supranuclear Palsy", "tbss", "pd", "md", "psp", "disease severity", "fa", "limb", "medial lemniscus", "Diffusion tensor imaging", "thalamic radiation", "cerebellar peduncle", "Multiple System Atrophy", "corpus callosum corticospinal tract"], "article_id"=>1245305, "categories"=>["Biological Sciences"], "users"=>["Amanda Worker", "Camilla Blain", "Jozef Jarosz", "K. Ray Chaudhuri", "Gareth J. Barker", "Steve C. R. Williams", "Richard G. Brown", "P. Nigel Leigh", "Flavio Dell’Acqua", "Andrew Simmons"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112638.g002", "stats"=>{"downloads"=>1, "page_views"=>44, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_White_matter_maps_showing_regions_of_significant_decreased_fractional_anisotropy_and_increased_mean_diffusivity_in_MSA_patients_when_compared_to_healthy_controls_and_PD_Bonferroni_corrected_alpha_8202_8202_0_0167_/1245305", "title"=>"White matter maps showing regions of significant decreased fractional anisotropy and increased mean diffusivity in MSA patients when compared to healthy controls and PD (Bonferroni corrected alpha = 0.0167).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-18 03:12:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1798749"], "description"=>"<p>Top row coronal view, bottom row axial view. Background image corresponds to the mean fractional anisotropy image of all subjects in standard MNI152 space (radiological view). Fractional anisotropy white matter skeleton is represented by green voxels. Blue voxels represent regions of decreased FA and yellow voxels represent regions of increased MD in the PSP group.</p>", "links"=>[], "tags"=>["matter tract degeneration", "matter tract neurodegeneration", "capsule", "MSA patients", "dti", "matter tracts", "corona radiata", "Progressive Supranuclear Palsy", "tbss", "pd", "md", "psp", "disease severity", "fa", "limb", "medial lemniscus", "Diffusion tensor imaging", "thalamic radiation", "cerebellar peduncle", "Multiple System Atrophy", "corpus callosum corticospinal tract"], "article_id"=>1245306, "categories"=>["Biological Sciences"], "users"=>["Amanda Worker", "Camilla Blain", "Jozef Jarosz", "K. Ray Chaudhuri", "Gareth J. Barker", "Steve C. R. Williams", "Richard G. Brown", "P. Nigel Leigh", "Flavio Dell’Acqua", "Andrew Simmons"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112638.g003", "stats"=>{"downloads"=>0, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_White_matter_maps_showing_regions_of_significant_correlation_between_mean_diffusivity_and_measures_of_disease_severity_Bonferroni_corrected_alpha_8202_8202_0_0167_/1245306", "title"=>"White matter maps showing regions of significant correlation between mean diffusivity and measures of disease severity (Bonferroni corrected alpha = 0.0167).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2014-11-18 03:12:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1798750"], "description"=>"<p>*For patients taking levodopa drug treatment, scores given in the ‘on’ state.</p>†<p>From Parkinson’s Plus Scale (Cerebellar Score, maximum 24; Occulomotor Score, maximum 21).</p><p>MSA = multiple systems atrophy; PSP = progressive supranuclear palsy; PD = Parkinson’s disease; MSA-P = multiple system atrophy parkinsonian variant; MSA-C = multiple system atrophy cerebellar variant; H&Y = Hoehn and Yahr; ADL = activities of daily living; UPDRS III = Unified Parkinson Disease Rating Scale–part III; MMSE = Mini Mental State Examination; DRS = Mattis Dementia Rating Scale.</p><p>Demographic and clinical data of control subjects and patients with PD, MSA and PSP.</p>", "links"=>[], "tags"=>["matter tract degeneration", "matter tract neurodegeneration", "capsule", "MSA patients", "dti", "matter tracts", "corona radiata", "Progressive Supranuclear Palsy", "tbss", "pd", "md", "psp", "disease severity", "fa", "limb", "medial lemniscus", "Diffusion tensor imaging", "thalamic radiation", "cerebellar peduncle", "Multiple System Atrophy", "corpus callosum corticospinal tract"], "article_id"=>1245307, "categories"=>["Biological Sciences"], "users"=>["Amanda Worker", "Camilla Blain", "Jozef Jarosz", "K. Ray Chaudhuri", "Gareth J. Barker", "Steve C. R. Williams", "Richard G. Brown", "P. Nigel Leigh", "Flavio Dell’Acqua", "Andrew Simmons"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112638.t001", "stats"=>{"downloads"=>4, "page_views"=>51, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_and_clinical_data_of_control_subjects_and_patients_with_PD_MSA_and_PSP_/1245307", "title"=>"Demographic and clinical data of control subjects and patients with PD, MSA and PSP.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-18 03:12:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1798751"], "description"=>"<p>All results reported at p<0.05, TFCE and Bonferroni corrected (corrected alpha = 0.0167).</p><p>White matter regions of fractional anisotropy changes between PSP, MSA, PD and HC.</p>", "links"=>[], "tags"=>["matter tract degeneration", "matter tract neurodegeneration", "capsule", "MSA patients", "dti", "matter tracts", "corona radiata", "Progressive Supranuclear Palsy", "tbss", "pd", "md", "psp", "disease severity", "fa", "limb", "medial lemniscus", "Diffusion tensor imaging", "thalamic radiation", "cerebellar peduncle", "Multiple System Atrophy", "corpus callosum corticospinal tract"], "article_id"=>1245308, "categories"=>["Biological Sciences"], "users"=>["Amanda Worker", "Camilla Blain", "Jozef Jarosz", "K. Ray Chaudhuri", "Gareth J. Barker", "Steve C. R. Williams", "Richard G. Brown", "P. Nigel Leigh", "Flavio Dell’Acqua", "Andrew Simmons"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112638.t002", "stats"=>{"downloads"=>1, "page_views"=>49, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_White_matter_regions_of_fractional_anisotropy_changes_between_PSP_MSA_PD_and_HC_/1245308", "title"=>"White matter regions of fractional anisotropy changes between PSP, MSA, PD and HC.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-18 03:12:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1798752"], "description"=>"<p>All results reported at p<0.05, TFCE and Bonferroni corrected (corrected alpha 0.0167).</p><p>White matter regions of mean diffusivity changes between PSP, MSA, PD and HC.</p>", "links"=>[], "tags"=>["matter tract degeneration", "matter tract neurodegeneration", "capsule", "MSA patients", "dti", "matter tracts", "corona radiata", "Progressive Supranuclear Palsy", "tbss", "pd", "md", "psp", "disease severity", "fa", "limb", "medial lemniscus", "Diffusion tensor imaging", "thalamic radiation", "cerebellar peduncle", "Multiple System Atrophy", "corpus callosum corticospinal tract"], "article_id"=>1245309, "categories"=>["Biological Sciences"], "users"=>["Amanda Worker", "Camilla Blain", "Jozef Jarosz", "K. Ray Chaudhuri", "Gareth J. Barker", "Steve C. R. Williams", "Richard G. Brown", "P. Nigel Leigh", "Flavio Dell’Acqua", "Andrew Simmons"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0112638.t003", "stats"=>{"downloads"=>5, "page_views"=>29, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_White_matter_regions_of_mean_diffusivity_changes_between_PSP_MSA_PD_and_HC_/1245309", "title"=>"White matter regions of mean diffusivity changes between PSP, MSA, PD and HC.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2014-11-18 03:12:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/1798753", "https://ndownloader.figshare.com/files/1798754"], "description"=>"<div><p>Although often clinically indistinguishable in the early stages, Parkinson’s disease (PD), Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) have distinct neuropathological changes. The aim of the current study was to identify white matter tract neurodegeneration characteristic of each of the three syndromes. Tract-based spatial statistics (TBSS) was used to perform a whole-brain automated analysis of diffusion tensor imaging (DTI) data to compare differences in fractional anisotropy (FA) and mean diffusivity (MD) between the three clinical groups and healthy control subjects. Further analyses were conducted to assess the relationship between these putative indices of white matter microstructure and clinical measures of disease severity and symptoms. In PSP, relative to controls, changes in DTI indices consistent with white matter tract degeneration were identified in the corpus callosum, corona radiata, corticospinal tract, superior longitudinal fasciculus, anterior thalamic radiation, superior cerebellar peduncle, medial lemniscus, retrolenticular and anterior limb of the internal capsule, cerebral peduncle and external capsule bilaterally, as well as the left posterior limb of the internal capsule and the right posterior thalamic radiation. MSA patients also displayed differences in the body of the corpus callosum corticospinal tract, cerebellar peduncle, medial lemniscus, anterior and superior corona radiata, posterior limb of the internal capsule external capsule and cerebral peduncle bilaterally, as well as the left anterior limb of the internal capsule and the left anterior thalamic radiation. No significant white matter abnormalities were observed in the PD group. Across groups, MD correlated positively with disease severity in all major white matter tracts. These results show widespread changes in white matter tracts in both PSP and MSA patients, even at a mid-point in the disease process, which are not found in patients with PD.</p></div>", "links"=>[], "tags"=>["matter tract degeneration", "matter tract neurodegeneration", "capsule", "MSA patients", "dti", "matter tracts", "corona radiata", "Progressive Supranuclear Palsy", "tbss", "pd", "md", "psp", "disease severity", "fa", "limb", "medial lemniscus", "Diffusion tensor imaging", "thalamic radiation", "cerebellar peduncle", "Multiple System Atrophy", "corpus callosum corticospinal tract"], "article_id"=>1245310, "categories"=>["Biological Sciences"], "users"=>["Amanda Worker", "Camilla Blain", "Jozef Jarosz", "K. Ray Chaudhuri", "Gareth J. Barker", "Steve C. R. Williams", "Richard G. Brown", "P. Nigel Leigh", "Flavio Dell’Acqua", "Andrew Simmons"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0112638.s001", "https://dx.doi.org/10.1371/journal.pone.0112638.s002"], "stats"=>{"downloads"=>9, "page_views"=>29, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Diffusion_Tensor_Imaging_of_Parkinson_8217_s_Disease_Multiple_System_Atrophy_and_Progressive_Supranuclear_Palsy_A_Tract_Based_Spatial_Statistics_Study_/1245310", "title"=>"Diffusion Tensor Imaging of Parkinson’s Disease, Multiple System Atrophy and Progressive Supranuclear Palsy: A Tract-Based Spatial Statistics Study", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2014-11-18 03:12:44"}

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Relative Metric

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